Category: 31600-43-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31600-43-8, name is Methyl 2-(benzyloxy)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H12O3

A mixture of 70 (2.75 g, 15.3 mmol) in methanol (50 mL) and hydrazine hydrate (65% in water, 2.3 g, 30 mmol) was heated under reflux for 3 h. The reaction mixture was concentrated under reduced pressure and the residue was diluted with benzene. The solvent was evaporated and the crude product was further dried under high vacuum (6 h) to give 71 (2.75 g), as a light yellow waxy material, which was used in the next step without further purification.1H NMR (500 MHz5 CDCl3) delta 7.72 (br s, IH5 NH), 7.39-7.29 (m, 5H)5 4.56 (s5 2H), 4.07 (s, 2H)5 3.82 (br s, 2H5 NH2).

The synthetic route of 31600-43-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF CONNECTICUT; WO2008/13963; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 31600-43-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31600-43-8 as follows.

[00459] Methyl 2-(benzyloxy)acetate (112) (5.5 g, 30.6 mmol) was dissolved in THF (30 mL). LiAlD4 (1.4 g, 35 mmol) was added at 0 C and the reaction mixture was stirred for 3 h. Water (1.4 mL) was added to quench the reaction. 10% aqueous NaOH solution (2.8 mL) and water (4.2 mL) were added. The mixture was filtered through a pad of CELITE, and the precipitate was washed with THF. The filtrate was dried over anhydrous Na2S04, and concentrated to give crude product, which was purified by silica gel chromatography (30% EtO Ac/petroleum ether) to obtain 2-(benzyloxy)-l,l-dideuteroethanol (113) Yield (3.4 g, 74%). LCMS: m/z 177.1 [M+Na]+; tR = 1.40 min.

According to the analysis of related databases, 31600-43-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; MCCAULEY, Dilara; LANDESMAN, Yosef; GOLAN, Gali; KALID, Ori; SHECHTER, Sharon; WO2015/42414; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics