Category: 31566-31-1

Medium and large scale preparation of Nanostructured Lipid Carriers of asenapine maleate: Quality-by-design based optimization, production, characterization and performance evaluation was written by Rao, Rajat Radhakrishna;Pisay, Muralidhar;Kumar, Sunil;Kulkarni, Sanjay;Pandey, Abhijeet;Kulkarni, Vijay Induvadan;Mutalik, Srinivas. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Computed Properties of C21H44O5 The following contents are mentioned in the article:

In the present study, scale-up of preparation of Asenapine maleate (ASPM) loaded Nanostructured lipid carriers (NLCs) to medium as well as the large scale was performed with the aid of Quality-by-Design (QbD) approach. High-pressure homogenization (HPH) was used to scale up the ASPM loaded NLCs to medium (40 mL) and large-scale (300 mL) batches. The statistical exptl. design was employed to optimize the HPH parameters and the results of the design showed that the size of ASPM loaded NLCs decreased with the increase in pressure and number of cycles of HPH. Also, increasing the number of cycles resulted in a slight increase in the %drug entrapped. FTIR and DSC were used to assess the compatibility between drug and excipients. The shape and surface morphol. of NLCs studied by Transmission Electron Microscope revealed a spherical shape with an approx. size of less than 100 nm. The cytotoxicity of NLCs using MTT assay in Caco2 cells demonstrated the safety of ASPM-NLCs. Further, in vivo pharmacokinetics and efficacy studies strengthened the applicability of ASPM-NLCs produced at a large scale for further in vivo and clin. environments. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enhancing the nutritional and quality profiles of buckwheat noodles: Studies on the effects of methods of milling and improvers was written by Thanushree, M. P.;Sudha, M. L.;Martin, Asha;Vanitha, T.;Kasar, Crassina. And the article was included in LWT–Food Science and Technology in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:

This study investigated the impact of methods of milling and improvers on the quality characteristics and nutritional properties of buckwheat noodles made from fine flour (FFN) and whole groat flour (WGFN). The FFN was found to be lighter in color with a finer and continuous structure while WGFN which has higher fiber content exhibited a coarser and disrupted pattern under SEM. The amount of rutin detected in WGFN was significantly higher (998.22 mg/100 g) than that of FFN (148.21 mg/100 g). Addition of gluten powder at 2-4% levels decreased the cooking loss while guar gum and xanthan gum resulted in the highest water absorption capacity. Rather than the individual emulsifiers, their combination (SSL + GMS) had a better effect on the overall quality. The contents of dietary fiber, slowly digestible starch, resistant starch, total polyphenol, total flavonoid and minerals were higher in WGFN. The most abundant essential amino acids were leucine (7.23-8.52%), phenylalanine (6.93-7.27%) and lysine (5.83-6.03%). This study confirmed the possible use of high buckwheat level (75%) in producing buckwheat noodles with enhanced nutritional profile. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nanostructured-lipid carriers-Chitosan hydrogel beads carrier system for loading of resveratrol: A new method of topical application was written by Wu, Bi;Li, Yang;Li, Yuan Y.;Shi, Zhi H.;Bian, Xiao H.;Xia, Qiang. And the article was included in Journal of Biomaterials Applications in 2022.Related Products of 31566-31-1 The following contents are mentioned in the article:

The aim of this study was to develop nanostructured-lipid carriers (NLC) encapsulated by Chitosan hydrogel beads for the efficient topical carrier. Dynamic light scattering (DLS), X-ray diffraction (XRD), Differential scanning calorimetry (DSC), and attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) were conducted to study the influence of the encapsulation on the characteristic of resveratrol-loaded NLC, and the results showed that there was no impact on resveratrol-loaded NLC. Chitosan hydrogel beads could significantly improve the phys. stability of resveratrol-loaded NLC. In vitro release study revealed that resveratrol-loaded NLC-Chitosan hydrogel beads had a more significant sustained-release effect on resveratrol. In vitro transdermal studies suggested that the skin permeation of resveratrol was promoted by the effect of Chitosan hydrogel beads and increased resveratrol distribution in the skin. In vitro cytotoxicity showed that resveratrol-loaded NLC-Chitosan hydrogel beads did not exert a hazardous effect on L929 cells. Hence, NLC-Chitosan hydrogel beads might be a promising method for topical applications of resveratrol. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Related Products of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palm Olein Organogelation Using Mixtures of Soy Lecithin and Glyceryl Monostearate was written by Ghan, Sheah Yee;Siow, Lee Fong;Tan, Chin Ping;Cheong, Kok Whye;Thoo, Yin Yin. And the article was included in Gels in 2022.HPLC of Formula: 31566-31-1 The following contents are mentioned in the article:

The present work investigated the interaction between soy lecithin (SL), glyceryl monostearate (GMS), and water in structuring palm olein (PO) to create an organogel having similar mech. properties to com. spread. Extreme vertices mixture design was used to optimize the composition of PO-based organogel. The resulting model showed a good fit to the predicted data with R2 ≥ 0.89. The optimum composition was 8% SL, 22% GMS, 28% water, and 42% PO (weight/weight) to produce a mean firmness of 1.91 N, spreadability of 15.28 N s^-1, and oil binding capacity (OBC) of 83.83%. The OBC of optimized organogel was 10% higher than com. spread product, and no significant difference was observed in the mech. properties (p > 0.05). The microstructure, as well as the rheol. and thermal properties of the optimized organogel were characterized. Fourier transform IR anal. indicated that hydrogen bonding and van der Waals interactions were the key driving forces for organogelation. The mixture of SL and GMS favored the formation of β’ + β form crystals with a predominance of the β’ form. These results have important implications for the development of PO-based organogel as a potential fat replacer in the production of low-fat spread. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1HPLC of Formula: 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Utilization of oleogels with binary oleogelator blends for filling creams low in saturated fat was written by Kim, Minhyo;Hwang, Hong-Sik;Jeong, Sungmin;Lee, Suyong. And the article was included in LWT–Food Science and Technology in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:

The binary blends of candelilla wax (CDW) and glycerol monostearate (GMS) at varying ratios were utilized to prepare canola oil oleogels whose feasibility as a shortening replacer in filling creams was evaluated. The blending ratio of 60:40 (CDW-60:GMS-40) generated oleogels with the highest hardness and the lowest melting temperature The replacement of shortening with CDW-60:GMS-40 oleogel produced filling creams with textural properties similar to those of the shortening one. These textural properties could alleviate the oil separation from the filling creams. The level of saturated fatty acids in the filling creams prepared with oleogels was distinctly reduced from 36.17% to 10.30%. The tomog. anal. demonstrated that the filling creams prepared with 100% GMS oleogel (CDW-0:GMS-100) exhibited a better aerated structure than those with CDW-60:GMS-40 oleogel, implying that the proportions of GMS in the oleogels pos. contributed to the aerated structure of the filling creams. The morphol. properties of the filling creams were linearly correlated with the sp. gr. (Pearson correlation coefficients >0.98) and seemed to be affected primarily by the level of saturated fatty acids (specifically, stearic and palmitic acids) of the oleogels. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid nanoparticles was written by Shahab, Mohammed Shadab;Rizwanullah, Md;Sarim Imam, Syed. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Application of 31566-31-1 The following contents are mentioned in the article:

Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification method and optimized statistically by Box-Behnken design (3 factors at three levels BBD). Glyceryl monostearate (GMS; A), D-a-Tocopherol polyethylene glycol 1000 succinate (TPGS; B), and sonication time (ST; C) were chosen as independent variables while particles size (PS; R₁), polydispersity index (PDI; R₂), and encapsulation efficiency (EE%; R₃) were selected as dependent variables/responses. The optimized DRZ-SLNs showed the PS, PDI, and EE of 175.38 ± 5.42 nm, 0.19 ± 0.05, and 80.47 ± 3.57%, resp. The optimized DRZ-SLNs represented initially fast release within 2 h and then a sustained release profile from 2 h to 10 h in simulated tear fluids (STF). DRZ-SLNs revealed 2.87-fold higher trans corneal permeation enhancement compared to DRZ solution Furthermore, HET-CAM study and the histopathol. study revealed that optimized DRZ-SLNs was found to be non-irritant and safe for ocular delivery. Therefore, it was concluded that the DRZ SLNs can be a promising and effective nanoplatform for ocular administration. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Application of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A smart O₂-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving was written by Zhang, Xiaojuan;He, Chuanchuan;Sun, Yun;Liu, Xiaoguang;Chen, Yan;Chen, Chen;Yan, Ruicong;Fan, Ting;Yang, Tan;Lu, Yao;Luo, Jun;Ma, Xiang;Xiang, Guangya. And the article was included in Acta Pharmaceutica Sinica B in 2021.Computed Properties of C21H44O5 The following contents are mentioned in the article:

Drug transportation is impeded by various barriers in the hypoxic solid tumor, resulting in compromised anticancer efficacy. Herein, a solid lipid monostearin (MS)-coated CaO2/MnO2 nanocarrier was designed to optimize doxorubicin (DOX) transportation comprehensively for chemotherapy enhancement. The MS shell of nanoparticles could be destroyed selectively by highly-expressed lipase within cancer cells, exposing water-sensitive cores to release DOX and produce O2. After the cancer cell death, the core-exposed nanoparticles could be further liberated and continue to react with water in the tumor extracellular matrix (ECM) and thoroughly release O2 and DOX, which exhibited cytotoxicity to neighboring cells. Small DOX mols. could readily diffuse through ECM, in which the collagen deposition was decreased by O2-mediated hypoxia-inducible factor-1 inhibition, leading to synergistically improved drug penetration. Concurrently, DOX-efflux-associated P-glycoprotein was also inhibited by O2, prolonging drug retention in cancer cells. Overall, the DOX transporting processes from nanoparticles to deep tumor cells including drug release, penetration, and retention were optimized comprehensively, which significantly boosted antitumor benefits. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design and development of surface modified epigallocatechin 3-gallate NanoCubogel for localized delivery to oral submucous fibrosis therapy was written by Mehta, Chetan Hasmukh;Narayan, Reema;Acharya, Shruthi;Nayak, Usha Yogendra. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Electric Literature of C21H44O5 The following contents are mentioned in the article:

The present study is aimed at the development of stearylamine (SA) modified epigallocatechin 3-gallate (EGCG) loaded NanoCubes incorporated in mucoadhesive hydrogel (NanoCubogel), for the local treatment of oral submucous fibrosis (OSF) owing to its anti-fibrotic, anti-inflammatory, and oxygen radical scavenging properties with a better safety profile. The prepared NanoCubes and mucoadhesive NanoCubogel were evaluated and characterized for various parameters including in-vitro release and ex-vivo permeation studies. The optimized NanoCubes had a particle size, polydispersity index, zeta potential, and entrapment efficiency of 140.3 ± 1.12 nm, 0.173± 0.08, 46.9 ± 1.69 mV, and 59.0 ± 1.73%, resp. with cube-shaped morphol. The viscosity of the NanoCubogel was found to be 9253 ±112 cps. The SA modified NanoCubogel showed slower and sustained release of EGCG with higher permeation across buccal mucosa when compared to that of unmodified and pure EGCG. The formulation was found to be stable during the storage period. The developed NanoCubogel was capable of getting retained at the diseased site for a longer duration and releasing the EGCG locally for the desired time. Thus, the developed formulation may be used as an alternative treatment for OSF. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

From By-Products to Fertilizer: Chemical Characterization Using UPLC-QToF-MS via Suspect and Non-Target Screening Strategies was written by Panara, Anthi;Gikas, Evagelos;Thomaidis, Nikolaos S.. And the article was included in Molecules in 2022.Name: Glyceryl monostearate The following contents are mentioned in the article:

The increasing demands of agriculture and the food market have resulted in intensive agricultural practices using synthetic fertilizers to maximize production However, significant efforts have been made to implement more environmentally friendly procedures, such as composting, to overcome the adverse impact of these invasive practices. In the terms of this research, composting was applied to the production of two biofertilizers, using onion and mushroom byproducts as raw materials resp. The main purposes of this work were to identify the compounds that pass from the raw materials to the final products (onion-based and mushroom-based), as well as the characterization of the chem. profile of these final products following suspect and non-target screening workflows via UPLC-qToF-MS. Overall, 14 common compounds were identified in the onion and its final product, while 12 compounds were found in the mushroom and its corresponding product. These compounds belong to fatty acids, organic acids, and flavonoids, which could be beneficial to plant health. The determination of parameters, such as the pH, conductivity, organic matter, nitrogen content, and elemental anal., were conducted for the overall characterization of the aforementioned products. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Name: Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Astragali Radix-Codonopsis Radix-Jujubae Fructus water extracts ameliorate exercise-induced fatigue in mice via modulating gut microbiota and its metabolites was written by He, Pan;Chen, Lei;Qin, Xuemei;Du, Guanhua;Li, Zhenyu. And the article was included in Journal of the Science of Food and Agriculture in 2022.Recommanded Product: 31566-31-1 The following contents are mentioned in the article:

Astragali Radix (AR) and Codonopsis Radix (CR) are widely used as the tonic herbal medicine with efficacy of tonifying qi in traditional Chinese medicine (TCM), which showed significant antifatigue activities. In this study, AR and CR were combined, with Jujubae Fructus (JF) further added to improve the taste, to afford the ACJ extracts in the ratio of 2:1:2. The results showed that ACJ water extract exhibited antifatigue effect by the weight-loaded exhaustive swimming test in mice. The untargeted fecal metabolomic approach and 16S rRNA gene sequencing anal. showed that ACJ could improve exercise performance by regulating changes of gut metabolites and microbiota to alleviate fatigue. Four pathways were determined as the key pathways relating with its antifatigue effect, which included sphingolipid metabolism, glycerophospholipid metabolism, valine, leucine and isoleucine biosynthesis and D-arginine and D-ornithine metabolism Correlation anal. showed the complex association among bacteria, metabolites and phenotypes. In conclusion, this study revealed new perspectives to study the antifatigue mechanism of ACJ extracts from the gut microbiota, which provided the basis for further functional food development. 2022 Society of Chem. Industry. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics