Category: 3153-37-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3153-37-5, name is Methyl 4-chlorobutyrate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H9ClO2

In a 1000 ml reactor, 1 mol of calcium carbide was added, and after sealing, the air was replaced with nitrogen 3 times.4 mol of methanol was initially added dropwise and acetylene gas was collected until the end of the reaction. Then, 1.8 mol of methyl gamma-chlorobutyrate was added dropwise to the reactor to control the dropping rate and keep the temperature constant at 100 C., while collecting the methanol fraction produced during the dropping process. After the reaction was completed, the temperature was distilled by distillation. Fractions were collected to obtain 170.3 g of methyl cyclopropanecarboxylate in a yield of 94.5%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3153-37-5.

Reference:
Patent; Shandong Guobang Pharmaceutical Co., Ltd.; Lu Huawen; Li Qibin; Wang Weihong; Liao Shixue; Li Jinwei; Liu Cong; (5 pag.)CN107673973; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3153-37-5,Some common heterocyclic compound, 3153-37-5, name is Methyl 4-chlorobutyrate, molecular formula is C5H9ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of the product from step d (100 mg, 0.406 MMOL), K2CO3 (120 mg, 0.88 MMOL), Kl (cat.) and methyl 4-chlorobutyrate (140 mg, 1.02 MMOL) in acetone (2 ML) is heated at reflux for 8 hours. 1N sodium hydroxide (2 ML) is then added, and the mixture is heated at 60C for 2 hours. The reaction mixture is poured into water, acidified to pH 1 and then extracted with ethyl ether. The organic phase is washed with water and concentrated. Recrystallisation from cyclohexane of the residue obtained gives the expected product (40 mg). m. p. =81C 1H NMR-CDCI3- (PPM) : 0.87 (3H, m); 1.12-1. 43 (6H, m); 1.53 (2H, m); 2.09 (2H, m); 2.37-2. 68 (4H, m); 2.85 (2H, m); 3.23 (2H, m); 3.59 (2H, m); 4.03 (2H, m); 6.99 (1 H, s); 7.40 (1 H, s).

The synthetic route of 3153-37-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; WO2004/63148; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3153-37-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3153-37-5, name is Methyl 4-chlorobutyrate, This compound has unique chemical properties. The synthetic route is as follows.

Step A: 1-(S)-(1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-(4-fluorophenyl)-3-(R)-(((3-methoxycarbonylpropyl)methylamino)methyl)cyclopentane To a solution of 65 mg of 1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-(4-fluorophenyl)-3-(R)-((methylamino)methyl)cyclopentane from Example 18, Step B in 1 mL of acetonitrile was added 0.019 mL of methyl 4-chlorobutyrate and 0.037 mL of DIPEA. The reaction was heated at 50 C. for 48 hours, then an additional 0.038 mL of methyl 4-chlorobutyrate, 0.074 mL of DIPEA and 3 mg of tetrabutylammonium iodide were added and heating continued at 70 C. for 48 hours. The reaction was evaporated under a stream of nitrogen and the residue purified by prep TLC (10% methanol in ethyl acetate) to give 41 mg of title compound and 17 mg of recovered starting material. Mass spec (ESI): 564 (M+1).

The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorobutyrate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Finke, Paul E.; Meurer, Laura C.; Mills, Sander G.; MacCoss, Malcolm; Qi, Hongbo; US2002/42431; (2002); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3153-37-5, name is Methyl 4-chlorobutyrate, A new synthetic method of this compound is introduced below., COA of Formula: C5H9ClO2

EXAMPLE 1 Methods for the preparation of the compounds of the invention are disclosed in U.S. Pat. No. 6,147,250. The following is a method of producing Compound A. Probucol (5, 9.69 mmol) and methyl 4-chlorobutyrate (3.1 g. 1.4 eq) were stirred in DMF (15 mL) and potassium fluoride on alumina (7 g, 5 eq) was added. The mixture was stirred at room temperature under nitrogen for 20.5 hours. It was filtered, diluted with ethyl acetate (100 mL), washed with water and brine, dried over sodium sulfate, and evaporated. Chromatography (MPLC, 10% to 80% of dichloromethane in hexanes) gave 0.98 g of methyl 4-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]butyrate. Methyl 4-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]butyrate (0.95 g, obtained above) was dissolved in THI/MeOH/H2O (4:1;1, 15.4 mL) and lithium hydroxide hydrate (0.19 g) was added. The mixture was stirred at room temperature for four hours and then acidified with 0.3 N HCl. The mixture was poured into brine and extracted with ethyl acetate. The organic phase was dried over sodium sulfate and evaporated to give 0.60 g of 4-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]butyric acid (Compound A) as a solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Edwards, David B.; Somers, Patricia K.; Glass, Mitchell; US2002/156022; (2002); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics