Electric Literature of 3095-48-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3095-48-5, name is Methyl 4-amino-3,5-dimethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.
A suspension of 33 g. of dimethylsulfone and 11 g. of sodium hydride (50percent dispersion in oil) in 160 ml. of absolute dimethylsulfoxide was stirred at 50° C. under an atmosphere of nitrogen and the exclusion of moisture for 3 hours. Then, 18 g. of 4-amino-3,5-dimethyl-benzoic acid methyl ester were added. The mixture was stirred at 80° C. for 30 minutes and at room temperature for 1 hour and then dissolved in 400 ml. of water. The solution was neutralized with glacial acetic acid. The precipitate which formed was removed by filtration with suction, washed with water, dried and recrystallized from ethyl acetate, whereby there was obtained 4′-amino-3′,5′-dimethyl-2-(methylsulfonyl)-acetophenone having a melting point of 179°-180° C.
The chemical industry reduces the impact on the environment during synthesis Methyl 4-amino-3,5-dimethylbenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hoffmann-La Roche Inc.; US4515948; (1985); A;,
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