Category: 3052-61-7

Jiang, Ruming published the artcileFacile construction and biological imaging of cross-linked fluorescent organic nanoparticles with aggregation-induced emission feature through a catalyst-free azide-alkyne click reaction, HPLC of Formula: 3052-61-7, the publication is Dyes and Pigments (2018), 52-60, database is CAplus.

The research in fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) feature shows an upward trend due to their outstanding optical properties and potential biomedical applications. In this work, a novel strategy has been developed for the first time through a catalyst-free azide-alkyne click reaction, which could directly conjugate azide containing polymers (PEGMA-AGE-N₃) and alkyne terminating AIE dye (named as PhE-OE) under mild exptl. conditions. The final PEGMA-AGE-PhE copolymers containing AIE-active dye could self-assemble into FONs with intense fluorescence owing to their AIE feature. These PEGMA-AGE-PhE FONs were characterized by a series of characterization techniques in details. The cell viability as well as cell uptake behavior of PEGMA-AGE-PhE FONs was also examined to evaluate their potential for biomedical applications. We demonstrated that the catalyst-free azide-alkyne click reaction is effective for fabrication of AIE-active FONs and these AIE-active FONs showed high water dispersity and AIE feature. Moreover, the PEGMA-AGE-PhE FONs also exhibited low cytotoxicity and great potential for biol. imaging. Taken together, a facile catalyst-free azide-alkyne click reaction with high efficiency has been developed for the preparation of AIE-active FONs, which showed excellent physicochem. properties for biol. imaging applications.

Dyes and Pigments published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Ruming published the artcileFacile fabrication of organic dyed polymer nanoparticles with aggregation-induced emission using an ultrasound-assisted multicomponent reaction and their biological imaging, Synthetic Route of 3052-61-7, the publication is Journal of Colloid and Interface Science (2018), 137-144, database is CAplus and MEDLINE.

Ultrasound as a powerful technique has increasingly been used in both industry and academia in recent years. Herein, an efficient approach to the ultrafast preparation of cross-linked fluorescent copolymers (PEGMA-AEMA-TPE) with aggregation-induced emission (AIE) via an ultrasound-assisted multicomponent reaction (MCR) is described. A number of characterization techniques were carried out to certify the successful preparation of these AIE-active copolymers. Due to the introduction of a hydrophilic PEG fragment and a hydrophobic AIE-active dye, the obtained fluorescent copolymers showed amphiphilic properties and could assemble into organic dyed polymer nanoparticles (ODPNs) with great water dispersibility. The final PEGMA-AEMA-TPE ODPNs demonstrated intense fluorescence, strong photostability, a low critical micelle concentration (CMC) of 0.007 mg mL^-1 and high biocompatibility. More importantly, the PEGMA-AEMA-TPE ODPNs show obvious AIE characteristics, which could elegantly overcome the quenching effect caused by the aggregation of ODPNs based on conventional organic dyes. Considered the above results, we believe that these AIE-active ODPNs should be promising candidates for biol. imaging and other biomedical applications.

Journal of Colloid and Interface Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Synthetic Route of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dong, Jiande published the artcileSynthesis and biological imaging of cross-linked fluorescent polymeric nanoparticles with aggregation-induced emission characteristics based on the combination of RAFT polymerization and the Biginelli reaction, Name: Benzyl diethylcarbamodithioate, the publication is Journal of Colloid and Interface Science (2018), 192-199, database is CAplus and MEDLINE.

Fluorescent probes have long been regarded as tools for imaging living organisms with advantages such as high sensitivity, good designability and multifunctional potential. Many fluorescent probes, especially the probes based on aggregation-induced emission (AIE) dyes, have received increasing attention since the AIE phenomenon was discovered. These AIE dye-based fluorescent probes could elegantly overcome the notorious quenching effect caused by aggregation of conventional organic dyes. However, it is still difficult to directly apply these AIE-active dyes for biomedical applications owing to their hydrophobic nature. Therefore, the development of novel and facile strategies to endow them with water dispersibility is of critical importance. In this work, we exploit an efficient and simple strategy to fabricate an AIE dye-based fluorescent copolymer through the combination of reversible addition-fragmentation chain transfer and the Biginelli reaction. Moreover, the copolymer can self-assemble to fluorescent polymeric nanoparticles (FPNs) in water solution Hydrophilic poly(PEGMA-co-AEMA) was reacted with the AIE-active dye 4′,4”’-(1,2-diphenylethene-1,2-diyl)bis([1,1′-biphenyl]-4-carbaldehyde) (CHO-TPE-CHO) to form amphiphilic luminescent polymers using urea as the connection bridge. The successful synthesis of the final products (poly(PEGMA-co-AEMA-TPE) FPNs) was confirmed by various instruments. Furthermore, Transmission electron microscopy (TEM) images manifest that poly(PEGMA-co-AEMA-TPE) copolymers will self-assemble into spherical nanoparticles in aqueous environments with sizes between 100 nm and 200 nm. The cell uptake and bioimaging experiment confirm that poly(PEGMA-co-AEMA-TPE) FPNs have excellent biocompatibility and emit strong green fluorescence in a cellular environment. Thus, poly(PEGMA-co-AEMA-TPE) FPNs are excellent candidates for biomedical applications.

Journal of Colloid and Interface Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Name: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dong, Jiande published the artcileUltrafast fabrication of fluorescent organic nanoparticles with aggregation-induced emission feature through the microwave-assisted Biginelli reaction, COA of Formula: C12H17NS2, the publication is Dyes and Pigments (2019), 90-96, database is CAplus.

Because of its unique optical properties, the aggregation-induced emission (AIE) dye has attracted extensive attention for various applications. Especially, the utilization of AIE-active dyes for fabrication of fluorescent organic nanoparticles (FONs) has attracted the most research interest for biomedical applications. Therefore, the development of novel and effective strategies to design and prepare AIE-active FONs should be of great importance for the biomedical applications of AIE-active FONs. In this report, we reported an ultrafast strategy that based on the one-pot microwave-assisted Biginelli reaction for fabrication of AIE-active poly(AA-AEMA-TPE) copolymers, which use the 2-(methacryloyoxy)ethylacete, acrylic acid (AA) and 4′,4”’-(1,2-diphenylethene-1,2-diyl) bis([1,1′-biphenyl]-4-carbaldehyde) (TPE-CHO) as the substrates. The microwave-assisted Biginelli reaction is simple, efficient and atom-economical and can be accomplished within 3 min. Owing to their amphiphilicity, poly(AA-AEMA-TPE) copolymers will self-assemble into FONs with small size and high water dispersibility. The proton NMR (¹H NMR) spectroscopy, UV-Vis spectrum and fluorescence spectrometer were used to characterize the resultant copolymers. We demonstrated that poly(AA-AEMA-TPE) FONs possess many excellent properties, such as high water dispersibility, intense fluorescence, obvious AIE feature and favorable biocompatibility. The above results suggest that poly(AA-AEMA-TPE) FONs are of great potential for fluorescent imaging. Moreover, the microwave-assisted Biginelli reaction can occur under a rather benign environment with high efficiency and good substrate adaptability. Therefore, we believe that the method developed in this work could greatly advance the applications of AIE-active functional materials.

Dyes and Pigments published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, COA of Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Ruming published the artcileFacile construction and biological imaging of cross-linked fluorescent organic nanoparticles with aggregation-induced emission feature through a catalyst-free azide-alkyne click reaction, HPLC of Formula: 3052-61-7, the publication is Dyes and Pigments (2018), 52-60, database is CAplus.

The research in fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) feature shows an upward trend due to their outstanding optical properties and potential biomedical applications. In this work, a novel strategy has been developed for the first time through a catalyst-free azide-alkyne click reaction, which could directly conjugate azide containing polymers (PEGMA-AGE-N₃) and alkyne terminating AIE dye (named as PhE-OE) under mild exptl. conditions. The final PEGMA-AGE-PhE copolymers containing AIE-active dye could self-assemble into FONs with intense fluorescence owing to their AIE feature. These PEGMA-AGE-PhE FONs were characterized by a series of characterization techniques in details. The cell viability as well as cell uptake behavior of PEGMA-AGE-PhE FONs was also examined to evaluate their potential for biomedical applications. We demonstrated that the catalyst-free azide-alkyne click reaction is effective for fabrication of AIE-active FONs and these AIE-active FONs showed high water dispersity and AIE feature. Moreover, the PEGMA-AGE-PhE FONs also exhibited low cytotoxicity and great potential for biol. imaging. Taken together, a facile catalyst-free azide-alkyne click reaction with high efficiency has been developed for the preparation of AIE-active FONs, which showed excellent physicochem. properties for biol. imaging applications.

Dyes and Pigments published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Ruming published the artcileFacile fabrication of organic dyed polymer nanoparticles with aggregation-induced emission using an ultrasound-assisted multicomponent reaction and their biological imaging, Synthetic Route of 3052-61-7, the publication is Journal of Colloid and Interface Science (2018), 137-144, database is CAplus and MEDLINE.

Ultrasound as a powerful technique has increasingly been used in both industry and academia in recent years. Herein, an efficient approach to the ultrafast preparation of cross-linked fluorescent copolymers (PEGMA-AEMA-TPE) with aggregation-induced emission (AIE) via an ultrasound-assisted multicomponent reaction (MCR) is described. A number of characterization techniques were carried out to certify the successful preparation of these AIE-active copolymers. Due to the introduction of a hydrophilic PEG fragment and a hydrophobic AIE-active dye, the obtained fluorescent copolymers showed amphiphilic properties and could assemble into organic dyed polymer nanoparticles (ODPNs) with great water dispersibility. The final PEGMA-AEMA-TPE ODPNs demonstrated intense fluorescence, strong photostability, a low critical micelle concentration (CMC) of 0.007 mg mL^-1 and high biocompatibility. More importantly, the PEGMA-AEMA-TPE ODPNs show obvious AIE characteristics, which could elegantly overcome the quenching effect caused by the aggregation of ODPNs based on conventional organic dyes. Considered the above results, we believe that these AIE-active ODPNs should be promising candidates for biol. imaging and other biomedical applications.

Journal of Colloid and Interface Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Synthetic Route of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dong, Jiande published the artcileSynthesis and biological imaging of cross-linked fluorescent polymeric nanoparticles with aggregation-induced emission characteristics based on the combination of RAFT polymerization and the Biginelli reaction, Name: Benzyl diethylcarbamodithioate, the publication is Journal of Colloid and Interface Science (2018), 192-199, database is CAplus and MEDLINE.

Fluorescent probes have long been regarded as tools for imaging living organisms with advantages such as high sensitivity, good designability and multifunctional potential. Many fluorescent probes, especially the probes based on aggregation-induced emission (AIE) dyes, have received increasing attention since the AIE phenomenon was discovered. These AIE dye-based fluorescent probes could elegantly overcome the notorious quenching effect caused by aggregation of conventional organic dyes. However, it is still difficult to directly apply these AIE-active dyes for biomedical applications owing to their hydrophobic nature. Therefore, the development of novel and facile strategies to endow them with water dispersibility is of critical importance. In this work, we exploit an efficient and simple strategy to fabricate an AIE dye-based fluorescent copolymer through the combination of reversible addition-fragmentation chain transfer and the Biginelli reaction. Moreover, the copolymer can self-assemble to fluorescent polymeric nanoparticles (FPNs) in water solution Hydrophilic poly(PEGMA-co-AEMA) was reacted with the AIE-active dye 4′,4”’-(1,2-diphenylethene-1,2-diyl)bis([1,1′-biphenyl]-4-carbaldehyde) (CHO-TPE-CHO) to form amphiphilic luminescent polymers using urea as the connection bridge. The successful synthesis of the final products (poly(PEGMA-co-AEMA-TPE) FPNs) was confirmed by various instruments. Furthermore, Transmission electron microscopy (TEM) images manifest that poly(PEGMA-co-AEMA-TPE) copolymers will self-assemble into spherical nanoparticles in aqueous environments with sizes between 100 nm and 200 nm. The cell uptake and bioimaging experiment confirm that poly(PEGMA-co-AEMA-TPE) FPNs have excellent biocompatibility and emit strong green fluorescence in a cellular environment. Thus, poly(PEGMA-co-AEMA-TPE) FPNs are excellent candidates for biomedical applications.

Journal of Colloid and Interface Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Name: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dong, Jiande published the artcileUltrafast fabrication of fluorescent organic nanoparticles with aggregation-induced emission feature through the microwave-assisted Biginelli reaction, COA of Formula: C12H17NS2, the publication is Dyes and Pigments (2019), 90-96, database is CAplus.

Because of its unique optical properties, the aggregation-induced emission (AIE) dye has attracted extensive attention for various applications. Especially, the utilization of AIE-active dyes for fabrication of fluorescent organic nanoparticles (FONs) has attracted the most research interest for biomedical applications. Therefore, the development of novel and effective strategies to design and prepare AIE-active FONs should be of great importance for the biomedical applications of AIE-active FONs. In this report, we reported an ultrafast strategy that based on the one-pot microwave-assisted Biginelli reaction for fabrication of AIE-active poly(AA-AEMA-TPE) copolymers, which use the 2-(methacryloyoxy)ethylacete, acrylic acid (AA) and 4′,4”’-(1,2-diphenylethene-1,2-diyl) bis([1,1′-biphenyl]-4-carbaldehyde) (TPE-CHO) as the substrates. The microwave-assisted Biginelli reaction is simple, efficient and atom-economical and can be accomplished within 3 min. Owing to their amphiphilicity, poly(AA-AEMA-TPE) copolymers will self-assemble into FONs with small size and high water dispersibility. The proton NMR (¹H NMR) spectroscopy, UV-Vis spectrum and fluorescence spectrometer were used to characterize the resultant copolymers. We demonstrated that poly(AA-AEMA-TPE) FONs possess many excellent properties, such as high water dispersibility, intense fluorescence, obvious AIE feature and favorable biocompatibility. The above results suggest that poly(AA-AEMA-TPE) FONs are of great potential for fluorescent imaging. Moreover, the microwave-assisted Biginelli reaction can occur under a rather benign environment with high efficiency and good substrate adaptability. Therefore, we believe that the method developed in this work could greatly advance the applications of AIE-active functional materials.

Dyes and Pigments published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, COA of Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Ruming published the artcileFacile construction and biological imaging of cross-linked fluorescent organic nanoparticles with aggregation-induced emission feature through a catalyst-free azide-alkyne click reaction, HPLC of Formula: 3052-61-7, the publication is Dyes and Pigments (2018), 52-60, database is CAplus.

The research in fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) feature shows an upward trend due to their outstanding optical properties and potential biomedical applications. In this work, a novel strategy has been developed for the first time through a catalyst-free azide-alkyne click reaction, which could directly conjugate azide containing polymers (PEGMA-AGE-N₃) and alkyne terminating AIE dye (named as PhE-OE) under mild exptl. conditions. The final PEGMA-AGE-PhE copolymers containing AIE-active dye could self-assemble into FONs with intense fluorescence owing to their AIE feature. These PEGMA-AGE-PhE FONs were characterized by a series of characterization techniques in details. The cell viability as well as cell uptake behavior of PEGMA-AGE-PhE FONs was also examined to evaluate their potential for biomedical applications. We demonstrated that the catalyst-free azide-alkyne click reaction is effective for fabrication of AIE-active FONs and these AIE-active FONs showed high water dispersity and AIE feature. Moreover, the PEGMA-AGE-PhE FONs also exhibited low cytotoxicity and great potential for biol. imaging. Taken together, a facile catalyst-free azide-alkyne click reaction with high efficiency has been developed for the preparation of AIE-active FONs, which showed excellent physicochem. properties for biol. imaging applications.

Dyes and Pigments published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Ruming published the artcileFacile fabrication of organic dyed polymer nanoparticles with aggregation-induced emission using an ultrasound-assisted multicomponent reaction and their biological imaging, Synthetic Route of 3052-61-7, the publication is Journal of Colloid and Interface Science (2018), 137-144, database is CAplus and MEDLINE.

Ultrasound as a powerful technique has increasingly been used in both industry and academia in recent years. Herein, an efficient approach to the ultrafast preparation of cross-linked fluorescent copolymers (PEGMA-AEMA-TPE) with aggregation-induced emission (AIE) via an ultrasound-assisted multicomponent reaction (MCR) is described. A number of characterization techniques were carried out to certify the successful preparation of these AIE-active copolymers. Due to the introduction of a hydrophilic PEG fragment and a hydrophobic AIE-active dye, the obtained fluorescent copolymers showed amphiphilic properties and could assemble into organic dyed polymer nanoparticles (ODPNs) with great water dispersibility. The final PEGMA-AEMA-TPE ODPNs demonstrated intense fluorescence, strong photostability, a low critical micelle concentration (CMC) of 0.007 mg mL^-1 and high biocompatibility. More importantly, the PEGMA-AEMA-TPE ODPNs show obvious AIE characteristics, which could elegantly overcome the quenching effect caused by the aggregation of ODPNs based on conventional organic dyes. Considered the above results, we believe that these AIE-active ODPNs should be promising candidates for biol. imaging and other biomedical applications.

Journal of Colloid and Interface Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Synthetic Route of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics