Category: 30414-53-0

Behbehani, Haider published the artcileSynthetic Strategy for Pyrazolo[1,5-a]pyridine and Pyrido[1,2-b]indazole Derivatives through AcOH and O₂-Promoted Cross-dehydrogenative Coupling Reactions between 1,3-Dicarbonyl Compounds and N-Amino-2-iminopyridines, Safety of Methyl 3-oxovalerate, the publication is ACS Omega (2019), 4(12), 15289-15303, database is CAplus and MEDLINE.

An efficient method has been developed for the synthesis of uniquely substituted pyrazolo[1,5-a]pyridine and pyrido[1,2-b]indazole derivatives, which involves acetic acid and mol. oxygen promoted cross-dehydrogenative coupling reactions of resp. β-ketoesters and β-diketones (like Et acetoacetate, Et benzoylacetate, Me propionylacetate, acetylacetone, dimedone, 1,3-cyclohexanedione, and 1,3-cyclopentanedione) with N-amino-2-iminopyridines. The proposed tentative mechanism involves formal acetic acid-promoted oxidative C(sp³)-C(sp²) dehydrogenative coupling followed by dehydrative cyclization under a catalyst-free condition within high atom economy processes.

ACS Omega published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Safety of Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Ke-Wei published the artcileOrganocatalytic Atroposelective Synthesis of N-N Axially Chiral Indoles and Pyrroles by De Novo Ring Formation, HPLC of Formula: 30414-53-0, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202116829, database is CAplus and MEDLINE.

The first highly atroposelective construction of N-N axially chiral indole scaffolds I [R = H, 4-F, 6-MeO, 7-Br, etc.; R¹ = H, Me; R² = CO₂Me, CO₂Et, Ph, etc.; R³ = Me, Et, i-Pr, Bn; R⁴ = Ph, 2-FC₆H₄, 3-FC₆H₄, etc.] was established via a new strategy of de novo ring formation. This strategy made use of the organocatalytic asym. Paal-Knorr reaction of well-designed N-aminoindoles with 1,4-diketones, thus affording N-pyrrolylindoles in high yields and with excellent atroposelectivities (up to 98% yield, 96% ee). In addition, this strategy was applicable for the atroposelective synthesis of N-N axially chiral bispyrroles II [R⁵ = Ph, 3-ClC₆H₄, 3-MeOC₆H₄, 1-naphthyl, 2-naphthyl; R⁶ = Me, Et, Bn; R⁷ = Me, Et, i-Pr; R⁸ = Ph, 2-FC₆H₄, 3-thienyl, etc.; R⁹ = Me, Et, i-Pr, Bn] (up to 98% yield, 97% ee). More importantly, such N-N axially chiral heterocycles could be converted into chiral organocatalysts with applications in asym. catalysis, and some mols. display potent anticancer activity. This work not only provided a new strategy for the atroposelective synthesis of N-N axially chiral mols. but also offers new members of the N-N atropisomer family with promising applications in synthetic and medicinal chem.

Angewandte Chemie, International Edition published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, HPLC of Formula: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Zhan-Ku published the artcilePretreatment of sweet sorghum stalk with aqueous hydrogen peroxide for enhancing methanolysis and property of the bio-oil, Recommanded Product: Methyl 3-oxovalerate, the publication is Renewable Energy (2021), 1127-1136, database is CAplus.

Alcoholysis is a promising approach for converting biomass into fuels and/or chems. under mild conditions. However, the effect of pretreatment on biomass alcoholysis was rarely reported. Herein, the effect of pretreatment with H₂O₂ on sweet sorghum stalk (SSS) methanolysis was examined The results show that the pretreatment could markedly improve the bio-oil (BO) yield and decrease the appropriate temperature for obtaining maximum BO yield. The appropriate temperature for pretreated SSS methanolysis was determined to be 280 °C and the maximum BO yield is 44 wt%. In addition, higher heating values of the BOs were also enhanced based on elemental anal. According to anal. with gas chromatograph/mass spectrometer, phenolic compounds, esters, and sugars are predominant in the BOs, and the yield of phenolic compounds significantly increased from 91.75 to 111.68 mg·g^-1 by the pretreatment. Moreover, polar species in the BOs decreased and deoxygenation occurred during pretreated SSS methanolysis. Analyses with scanning electron microscope and N₂ physisorption reveal that pretreated SSS has more grooves and higher sp. surface area and anomalous porosity than SSS. According to analyses with Fourier transform IR spectrometer and X-ray photoelectron spectrometer, oxygen functional groups mainly in the forms of C=O and COO were introduced into SSS by the pretreatment. The changes of phys. and chem. structures should be responsible for enhancing SSS methanolysis and property of the BO.

Renewable Energy published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ye, Chen-Xi published the artcileAtroposelective Synthesis of Axially Chiral N-Arylpyrroles by Chiral-at-Rhodium Catalysis, Computed Properties of 30414-53-0, the publication is Angewandte Chemie, International Edition (2020), 59(32), 13552-13556, database is CAplus and MEDLINE.

A transformation of fluxional into configurationally stable axially chiral N-arylpyrroles was achieved with a highly atroposelective electrophilic aromatic substitution catalyzed by a chiral-at-metal rhodium Lewis acid. Specifically, N-arylpyrroles were alkylated with N-acryloyl-1H-pyrazole electrophiles in up to 93% yield and with up to >99.5% ee, and follow-up conversions reveal the synthetic utility of this new method [e.g., I + N-acryloyl-1H-pyrazole �II (up to 93% yield, 92% isolated, 99% ee)]. DFT calculations elucidate the origins of the observed excellent atroposelectivity.

Angewandte Chemie, International Edition published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H8O6, Computed Properties of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Hao-Nan published the artcileCu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N²-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis, Application In Synthesis of 30414-53-0, the publication is Organic Letters (2020), 22(4), 1396-1401, database is CAplus and MEDLINE.

A Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts was described, both of which were readily available substrates. Furthermore, alkyl 2-aminoacrylates were also viable substrates. Diverse alkyl N²-aryl 1,2,3-triazole-carboxylates and their analogs was rapidly prepared under mild conditions. Especially, this protocol allowed one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Application In Synthesis of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Zhicheng published the artcileGeneral chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases, Quality Control of 30414-53-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(1), 157-160, database is CAplus and MEDLINE.

Modular polyketide synthases (PKSs) are enzymic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C8H11BO2, Quality Control of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pertschi, Romain published the artcileSpirocyclic Amide Acetal Synthesis by [CpRu]-Catalyzed Condensations of α-Diazo-β-Ketoesters with γ-Lactams, Application of Methyl 3-oxovalerate, the publication is Helvetica Chimica Acta (2021), 104(10), e2100122, database is CAplus.

The synthesis of spirocyclic amide acetals (33-93%) has been achieved through Ru(II)-catalyzed condensations of N-carbamate protected pyrrolidinones with metal carbenes derived from α-diazo-β-ketoesters. Thanks to the mildness of the diazo decomposition conditions induced by a 1 : 1 combination of [CpRu(MeCN)₃][BArF] and 1,10-phenanthroline, the formation of the sensitive products is possible. Full characterization of this carbonyl-ylide mediated process is provided by DFT calculations

Helvetica Chimica Acta published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Application of Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fobi, Kwabena published the artcileDomino Nitro Reduction-Friedlander Heterocyclization for the Preparation of Quinolines, Formula: C6H10O3, the publication is Molecules (2022), 27(13), 4123, database is CAplus and MEDLINE.

The Friedlander synthesis offers efficient access to substituted quinolines from 2-aminobenzaldehydes and activated ketones in the presence of a base. The disadvantage of this procedure lies in the fact that relatively few 2-aminobenzaldehyde derivatives are readily available. To overcome this problem, authors report a modification of this process involving the in situ reduction of 2-nitrobenzaldehydes with Fe/AcOH in the presence of active methylene compounds (AMCs) to produce substituted quinolines in high yields. The conditions are mild enough to tolerate a wide range of functionality in both reacting partners and promote reactions not only with Ph and benzyl ketones, but also with β-keto-esters, β-keto-nitriles, β-keto-sulfones and β-diketones. The reaction of 2-nitroarom. ketones with unsym. AMCs is less reliable, giving a competitive formation of substituted quinolin-2(1H)-ones from the cyclization of the Z Knoevenagel intermediate which appears to be favored when certain large groups are adjacent to the AMC ketone carbonyl.

Molecules published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

El-Hefnawy, Mohamed E. published the artcileEndogenous bioethanol production by solid-state prefermentation for enhanced crude bio-oil recovery through integrated hydrothermal liquefaction of seaweeds, Synthetic Route of 30414-53-0, the publication is Journal of Cleaner Production (2022), 131811, database is CAplus.

The present study evaluated the action of endogenous bioethanol produced during solid-state fermentation of Ulva spp. on subsequent hydrothermal liquefaction (HTL). HTL of raw biomass (RB) was compared with HTL of the fermented biomass after bioethanol separation (F-Aqua) and HTL of the whole fermentation broth containing the bioethanol (F-Eth). Optimization of fermentation conditions increased the ethanol yield efficiency (Y_eff) and specific ethanol yield (SEY) from 23.55% and 0.120 g g^-1 sugar consumed to 43.97% and 0.224 g g^-1 sugar consumed, resp. TGA and FTIR anal. confirmed noticeable changes in the thermal profile and functional groups of the fermented residue with increased volatiles and lower ash content. Among different HTL treatments, F-Eth showed the highest bio-oil yield of 24.96% at 250°C, which was 37.7% and 39.0% higher than that of RB and F-Aqua, resp. In addition, hydrocarbons and esters in the bio-oil represented the dominant compounds in F-Aqua and F-Eth, altogether 28.28% and 68.58%, resp., compared to 17.96% in RB. Economic anal. for a proposed 100 ton year^-1 plant confirmed that HTL of the whole fermentation broth containing endogenous bioethanol enhanced the gross energy output to 8.152 GJ ton^-1, which represented 4.2-time, 51.1%, and 23.3% higher than individual bioethanol production, individual bio-oil production, and sequential bioethanol/bio-oil recovery, with the highest net annual profit of 29553 US$ compared to 23391 US$ for the sequential production

Journal of Cleaner Production published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Synthetic Route of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics