Category: 30414-53-0

Vu, Cuong M. published the artcileRecyclable CuFe₂O₄ for the synthesis of 2,3-disubstituted indoles, Related Products of esters-buliding-blocks, the publication is Tetrahedron Letters (2020), 61(50), 152629, database is CAplus.

A method for the CuFe₂O₄-catalyzed coupling of 2-iodo- or 2-bromoanilines 2-X-RC₆H₃NH₂ (R = H, 4-trifluoromethoxy, 5-trifluoromethyl, etc.; X = I or Br) and acetylacetone or isosteric 1,3-diketones R¹C(O)CH₂C(O)R² (R¹ = Me, ethyl; R² = ethoxy, methoxy) to afford 2,3-disubstituted indoles I (R³ = H, 5-bromo, 6-Me, etc.) has been developed. The superparamagnetic material showed superior activity in comparison to other ferrites or copper-based metal-organic frameworks. Functionalities including ester, cyano, and halogen groups were compatible with the reaction conditions. The CuFe₂O₄ catalyst was easily recoverable and reusable and offers a convenient pathway to afford synthetically useful heterocycles.

Tetrahedron Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C9H10O3S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lan, Jin published the artcileSelective synthesis of functionalized quinazolinone derivatives via biocatalysis, SDS of cas: 30414-53-0, the publication is Molecular Catalysis (2020), 111261, database is CAplus.

A novel and efficient biocatalyzed methodol. for the construction of functionalized quinazolinone derivatives via tandem / hydrolysis / decarboxylation / cyclization and transesterification reactions has been developed that works with a variety of 2-aminobenzamide and β-dicarbonyl compounds This method requires mild conditions, and has demonstrated high catalytic activity, excellent yields, excellent chemoselectivity, and a broad substrate scope. Addnl., biocatalyzed decarboxylation does not require high temperatures or light activation, giving it a substantial advantage over alternative techniques. Most importantly, it offers a new example for the exploration of simple, convenient, and environmentally friendly synthetic routes utilizing enzymes in organic chem.

Molecular Catalysis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, SDS of cas: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Iliyasov, Taigib M. published the artcileStereoselective one-pot five-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines with two and three stereocenters, COA of Formula: C6H10O3, the publication is ARKIVOC (Gainesville, FL, United States) (2022), 232-244, database is CAplus.

A novel five-component stereoselective synthesis of polysubstituted tetrahydropyridines is reported. The Knoevenagel condensation – Michael addition – Mannich reaction – cyclization – dehydration cascade of aldehydes, esters of 3-oxocarboxylic acids C-H acids and ammonium acetate provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine-3-carboxylates with two stereocenters and 3,5-dialkyl (4RS,5SR,6RS)-5-cyano-2,4,6-triaryl-1,4,5,6-tetrahydropyridine-5,3-carboxylates with three stereocenters in 57-84% yields. It was established that formation of products proceeds via substituted 2-hydroxypiperidines with four stereocenters. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Five bonds are formed as a result of multicomponent process. The formation of single diastereomers was confirmed by singe crystal X-ray diffraction studies and 2D-NMR spectroscopy.

ARKIVOC (Gainesville, FL, United States) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Weiping published the artcileFe-Catalyzed Dicarbofunctionalization of Vinylarenes with Alkylsilyl Peroxides and β-Keto Carbonyl Substrates, Related Products of esters-buliding-blocks, the publication is Organic Letters (2022), 24(14), 2641-2645, database is CAplus and MEDLINE.

The formation of two carbon-carbon bonds using vinylarenes with alkylsilyl peroxides and β-keto carbonyl substrates is effected in the presence of catalytic Fe(OTf)₂ under mild reaction conditions. A variety of vinylarenes with different substituents can be utilized in combination with several different alkylsilyl peroxides and β-keto carbonyl substrates.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C9H22OSi, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Giannopoulos, Vasileios published the artcileDichlorination of β-Keto Esters and 1,3-Diketones Mediated by Oxone/Aluminum Trichloride Mixture in Aqueous Medium, Quality Control of 30414-53-0, the publication is Synthesis (2022), 54(10), 2457-2463, database is CAplus.

A new method for the α,α-dichlorination of β-keto esters using oxone/aluminum trichloride mixture in aqueous medium had been developed. This useful process had also been applied successfully for the dichlorination of 1,3-diketones. The dichlorinated compds of formula I [R¹ = CH₃, C₂H₅, vinyl, etc.; R² = CH₃, C₂H₅, t-Bu]. had been produced in one step, high yields, and short reaction times.

Synthesis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Quality Control of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Zhidong published the artcileRadiosynthesis of a carbon-11 labeled PDE5 inhibitor [¹¹C]TPN171 as a new potential PET heart imaging agent, Recommanded Product: Methyl 3-oxovalerate, the publication is Applied Radiation and Isotopes (2020), 109190, database is CAplus and MEDLINE.

To develop PET tracers for imaging of heart disease, a new carbon-11 labeled potent and selective PDE5 inhibitor [¹¹C]TPN171 ([¹¹C]9) has been synthesized. The reference standard TPN171 (9) and its corresponding precursor desmethyl-TPN171 (11) were synthesized from Me 3-oxovalerate and 2-hydroxybenzonitrile in 9 and 10 steps with 31% and 25% overall chem. yield, resp. The radiotracer [¹¹C]TPN171 was prepared from desmethyl-TPN171 with [¹¹C]CH₃OTf through N-¹¹C-methylation and isolated by HPLC purification followed by SPE formulation in 45-55% radiochem. yield, based on [¹¹C]CO₂ and decay corrected to EOB. The radiochem. purity was >99%, and the molar activity (A_m) at EOB was in a range of 370-740 GBq/μmol.

Applied Radiation and Isotopes published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C22H18O2, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kantankar, Abhijit published the artcileRational design, synthesis, biological evaluation and molecular docking studies of chromone-pyrimidine derivatives as potent anti-cancer agents, COA of Formula: C6H10O3, the publication is Journal of Molecular Structure (2021), 130502, database is CAplus.

A series of pyrimidine based chromone hybrids I [R = Me, methoxymethyl, 4-fluorophenyl, etc.; R¹ = H, methoxycarbonyl, ethoxycarbonyl, etc.] were synthesized from 7-methoxy-8-formyl-chromone using facile multi-component modified Biginelli reaction. All the synthesized compounds I were characterized and evaluated for their in-vitro anti-cancer activity against three cancer cell lines, human cervical (HeLa), lung (A549), myelogenous leukemia (K562) cancer cell lines and on a normal cell line(HEK-293) for the selectivity reference Among them, compounds I [R = 4-fluorophenyl, 2-fluorophenyl, 4-methoxyphenyl, 4-(trifluoromethoxy)phenyl; R¹ = H] and I [R = methoxymethyl, methyl; R¹ = methoxycarbonyl, ethoxycarbonyl] exhibited potent anti-cancer activities against A549, HeLa and K562 cell lines with IC₅₀ values in micro molar range. The compounds I were displayed selective anti-cancer activity against K562 cell line compared to on other cancer cell lines. All the compounds I showed relative non-toxicity against normal cell line. The selectivity of the compounds against K562 cell line has been substantiated by mol. docking in BCR-ABL Tyrosine kinase using genetic algorithm program (GOLD 3.0.1). These results indicated that the chromones I were promised as the anti-cancer agents for the effective treatment of different types of cancers.

Journal of Molecular Structure published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vereshchagin, Anatoly N. published the artcileHighly diastereoselective four-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines, Formula: C6H10O3, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2021), 57(9), 929-933, database is CAplus.

A novel four-component diastereoselective synthesis of polysubstituted tetrahydropyridines (4SR,6RS)-I (R = H, 3-F, 4-Me, 4-Cl, etc.; R¹ = Me, Et, Ph, 4-bromophenyl; R² = Me, Et) is reported. The Michael addition – Mannich reaction – cyclization – dehydration cascade of benzylidenemalononitriles RC₆H₄CH=C(CN)₂, esters of 3-oxocarboxylic acids R¹C(O)CH₂C(O)OR², aromatic aldehydes RC₆H₄CHO, and ammonium acetate in methanol provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine- 3-carboxylates (4SR,6RS)-I with two stereocenters in 66-92% yields. The formation of products was highly stereoselective, with only one diastereomer formed. Ammonium acetate plays dual role acting as a base and as a nitrogen source. The formation of single diastereomer was confirmed by singe crystal X-ray diffraction studies.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C8H17Br, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lin, Chih-Yu published the artcileRhodium-Catalyzed [4+2] Annulation of N-Aryl Pyrazolones with Diazo Compounds To Access Pyrazolone-Fused Cinnolines, Recommanded Product: Methyl 3-oxovalerate, the publication is European Journal of Organic Chemistry (2021), 2021(35), 4984-4992, database is CAplus.

An efficient synthesis of novel dinitrogen-fused heterocycles such as pyrazolo[1,2-a]cinnoline derivatives have been accomplished by the rhodium(III)-catalyzed reaction of N-arylpyrazol-5-ones with α-diazo compounds This reaction proceeds through a cascade C-H activation/intramol. cyclization with a broad substrate scope. Furthermore, this protocol is successfully extended to the unusual phosphorus-containing α-diazo compounds and cyclic diazo compounds as the cross-coupling partners to deliver the two new kinds of pyrazolo[1,2-a]cinnolinones. The control experiments were performed to reveal insight into the mechanism of this reaction, involving reversible C-H activation, migratory insertion of the diazo compound, and cascade cyclization as the key steps of the transformation. Moreover, gram-scale synthesis and further transformation of the target product demonstrate the synthetic utility of the present protocol.

European Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Zhiyan published the artcileSynthesis of indoles and carbazoles from a lignin model compound α-hydroxyacetophenone, COA of Formula: C6H10O3, the publication is Green Chemistry (2022), 24(7), 2919-2926, database is CAplus.

Herein an efficient strategy of using an oxidized lignin model compound, α-hydroxyacetophenone, as starting material to synthesize indoles or carbazoles in conjunction with using pyrroles or indoles as counterpart reagents was described. The reactions were performed using Sc(OTf)₃ as a catalyst in a bio-based green solvent, glycerol, and moderate to excellent yields were obtained. At the end of the reaction, both solvent and catalyst was recovered and reused. The novel approach presented here not only provided an eco-efficient route for the value-added conversion of lignin degradation products, but also extends the diversity of indole and carbazole derivatives, which are of potential importance in the development of functional photo-elec. materials.

Green Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics