Category: 30414-53-0

Kalhapure, Vijay published the artcileSynthesis of Substituted imidazo[1,5-a]pyrimidine-2-(1H)-one Core Structure, Product Details of C6H10O3, the publication is Current Organic Synthesis (2020), 17(1), 23-28, database is CAplus and MEDLINE.

Simple transformation starting from amino acetonitrile hydrochloride led to the synthesis of two different regio-isomers of imidazopyrimidinones I [R = H Ph; R1 = Me, Et, Ph; X = CH, N; Y = CH, N].

Current Organic Synthesis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Product Details of C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, Xiaoqiang published the artcileCBr₄ Promoted α-Acyloxyation of β-Keto Esters and β-Diketones by Sodium Carboxylates, Formula: C6H10O3, the publication is ChemistrySelect (2022), 7(12), e202104498, database is CAplus.

CBr₄ promoted C-O coupling of β-keto esters and β-diketones with sodium carboxylates was developed. This mild and operationally simple methodol., using sodium carboxylates as acyloxyation source and deacid reagent, provides an efficient pathway for the acquisition of prospective α-acyloxylated ketones.

ChemistrySelect published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C15H14O3, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Tianjiao published the artcileRu-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones, Application In Synthesis of 30414-53-0, the publication is Angewandte Chemie, International Edition (2021), 60(43), 23193-23196, database is CAplus and MEDLINE.

The Ru(II)-NHC-catalyzed asym. hydrogenation of 2-quinolones under mild reaction conditions was developed. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones I [R = H, Me; R¹ = Me, Bn; R² = H, Me, Et, i-Pr, Ph; R³ = H; R⁴ = H, Me, Ph, etc.; R⁵ = H, OMe, F, etc.; R⁶ = H, Me; R¹R³ = (CH₂)₃] were obtained in high yields with moderate to excellent enantioselectivities. The reaction provided an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.

Angewandte Chemie, International Edition published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Application In Synthesis of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guo, Yongbiao published the artcileChiral Spirocyclic Phosphoric Acid-Catalyzed Synthesis of 4-Alkyl-3,4-dihydropyrimidin-2(1H)-one Derivatives by Asymmetric Biginelli Reactions, Recommanded Product: Methyl 3-oxovalerate, the publication is Asian Journal of Organic Chemistry (2020), 9(4), 626-630, database is CAplus.

A chiral spirocyclic phosphoric acid-catalyzed asym. Biginelli reaction based on aliphatic aldehydes was realized for the synthesis of biol. important and synthetically useful 4-alkyl-3,4-dihydropyrimidin-2-(1H)-one (4-alkyl-DHPM) skeletons I [R = Et, n-Bu, n-heptyl, etc.; R¹ = Me, Et, t-Bu, etc.; R² = Me, Et] in good yield and with high levels of enantioinduction. The utility of this transformation was further demonstrated by direct thionation and C-C/C-N bond construction to provide a series of 4-alkyl-DHPMs derivatives I without any loss of optical activity, providing streamlined access to the formal synthesis of Batzelladine A.

Asian Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yun-Peng published the artcileAn efficient approach to angular tricyclic molecular architecture via Nazarov-like cyclization and double ring-expansion cascade, HPLC of Formula: 30414-53-0, the publication is Nature Communications (2022), 13(1), 2335, database is CAplus and MEDLINE.

A modular and efficient method for constructing angular tri-carbocyclic architectures containing quaternary carbon center(s), e.g., I (R = Me) from 1,3-dicycloalkylidenyl ketones, e.g., II is established, which involves an unconventional synergistic cascade of a Nazarov cyclization and two ring expansions. It features high selectivity, mild conditions and convenient operation, wide scope and easy availability of substrate. Substitution at the 4πe-system with electron-donating group favors this reaction, while that with electron-withdrawing group or proton disfavors. The electron-donating group directs the initial ring expansion at its own site, while the p-π- or n-π- associated substituent favors selectively the later ring expansion near its location because of the beneficial maintenance of an original conjugated system. The stereoselectivity has proved to be governed by either the steric effect at the expanded rings, or the migration ability of the migrating atom. D. Functional Theory calculation suggests that the initial Nazarov cyclization would be the rate-determining step. A racemic total synthesis of the natural (±)-waihoensene is realized in 18 steps by use of this methodol.

Nature Communications published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C15H14O, HPLC of Formula: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yadav, Kalpana published the artcileNano catalyzed Biginelli type reaction in green reaction media, HPLC of Formula: 30414-53-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2020), 59B(1), 102-109, database is CAplus.

Green chem. approach has been developed by using ionic liquid [MIM-H]CCl₃ (1-methyl-3-hydro-1H-imidazol-3-ium trichloromethanide) and TiO₂ nanoparticles (NPs) for the synthesis of 3,4-dihydropyrimidine-2(1H)-one (DHPMs) derivatives I (R¹ = Me, Et, n-Pr; R² = Me, Et, i-Pr, CH₂CH₂OMe; Ar = Ph, CH:CHC₆H₅, 5-Me-2-furyl).

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C7H8BNO4, HPLC of Formula: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xiong, Mingteng published the artcileSynthesis of Polysubstituted Pyrroles through Electro-Oxidative Annulation of 1,3-Dicarbonyl Compounds and Primary Amines, Synthetic Route of 30414-53-0, the publication is Journal of Organic Chemistry (2021), 86(7), 4986-4993, database is CAplus and MEDLINE.

Synthetic method of polysubstituted pyrroles I [R¹ = H, 2-Me, 2-MeO, etc.; R² = Me, Et; R³ = Me, Et, i-Pr] from easily available materials, 1,3-dicarbonyl compounds and primary amines, via electro-oxidative intermol. annulation was reported. Under similar conditions, enamines were also converted smoothly into desired products I, indicating that in situ formed enamines were crucial intermediates for the first transformation. Neither transition-metal salts nor harsh conditions were required to facilitate the dehydrocyclization process.

Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C10H10O2, Synthetic Route of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xia, Qi published the artcileCopper-Catalyzed Three-Component Reactions of α-Ketoaldehyde, 1,3-Dicarbonyl Compound, and Organic Boronic Acid in Water: A Route to 1,4-Diketones, Recommanded Product: Methyl 3-oxovalerate, the publication is Journal of Organic Chemistry (2021), 86(14), 9914-9923, database is CAplus and MEDLINE.

A novel three-component reaction of α-ketoaldehydes, 1,3-dicarbonyl compounds, and organic boronic acids catalyzed by CuO in water has been developed to give a wide range of products containing 1,3/1,4-diketones. The method has some advantages such as the use of readily available starting materials, wide substrate scopes, excellent yields, gram-scale synthesis, and mild reaction conditions.

Journal of Organic Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C7H5Br2F, Recommanded Product: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Thombal, Raju S. published the artcilePalladium-Catalyzed Direct Oxidative C-H Activation/Annulation for Regioselective Construction of N-Acylindoles, HPLC of Formula: 30414-53-0, the publication is Organic Letters (2020), 22(9), 3397-3401, database is CAplus and MEDLINE.

A Pd(II)-catalyzed C(sp³)-H/C(sp²)-H coupling/annulation of anilides and α-dicarbonyl compounds for the synthesis of diverse N-acyl indoles was described. The reaction was achieved by cascade C-H activation, coupling, and intramol. cyclization. This protocol provided a variety of indoles with high functional group tolerance and excellent regioselectivity. The utility of this protocol was demonstrated by transforming the synthesized compound into diversely functionalized analogs.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C13H16O2, HPLC of Formula: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bendrath, Franziska published the artcileSynthesis and permethylation of methyl 5-(2-chloropyridin-3-yl)pentanoates, Product Details of C6H10O3, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2021), 57(11), 1146-1148, database is CAplus.

Two Me 5-(2-chloropyridin-3-yl)pentanoates were prepared by condensation of 1,3-bis(silyloxy)-1,3-butadienes with 2-chloropyridine-3-carboxylic acid chloride. The permethylation of the products resulted in two completely different products, depending on the substitution pattern of the 1,3,5-tricarbonyl moiety.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Product Details of C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics