Category: 30414-53-0

《Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators》 was written by Ulven, Elisabeth Rexen; Quon, Tezz; Sergeev, Eugenia; Barki, Natasja; Brvar, Matjaz; Hudson, Brian D.; Dutta, Palash; Hansen, Anders Hoejgaard; Bielefeldt, Line Oe.; Tobin, Andrew B.; McKenzie, Christine J.; Milligan, Graeme; Ulven, Trond. Category: esters-buliding-blocks And the article was included in Journal of Medicinal Chemistry on April 9 ,2020. The article conveys some information:

Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure-activity relationship of an allosteric modulator series and characterization of physicochem. and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC50 = 145 nM and a solubility of 33μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC50 = 162 nM and a solubility of 9μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia. In the experiment, the researchers used Methyl 3-oxovalerate(cas: 30414-53-0Category: esters-buliding-blocks)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Organocatalytic Atroposelective Synthesis of N-N Axially Chiral Indoles and Pyrroles by De Novo Ring Formation》 was written by Chen, Ke-Wei; Chen, Zhi-Han; Yang, Shuang; Wu, Shu-Fang; Zhang, Yu-Chen; Shi, Feng. Application of 30414-53-0 And the article was included in Angewandte Chemie, International Edition on April 19 ,2022. The article conveys some information:

The first highly atroposelective construction of N-N axially chiral indole scaffolds I [R = H, 4-F, 6-MeO, 7-Br, etc.; R1 = H, Me; R2 = CO2Me, CO2Et, Ph, etc.; R3 = Me, Et, i-Pr, Bn; R4 = Ph, 2-FC6H4, 3-FC6H4, etc.] was established via a new strategy of de novo ring formation. This strategy made use of the organocatalytic asym. Paal-Knorr reaction of well-designed N-aminoindoles with 1,4-diketones, thus affording N-pyrrolylindoles in high yields and with excellent atroposelectivities (up to 98% yield, 96% ee). In addition, this strategy was applicable for the atroposelective synthesis of N-N axially chiral bispyrroles II [R5 = Ph, 3-ClC6H4, 3-MeOC6H4, 1-naphthyl, 2-naphthyl; R6 = Me, Et, Bn; R7 = Me, Et, i-Pr; R8 = Ph, 2-FC6H4, 3-thienyl, etc.; R9 = Me, Et, i-Pr, Bn] (up to 98% yield, 97% ee). More importantly, such N-N axially chiral heterocycles could be converted into chiral organocatalysts with applications in asym. catalysis, and some mols. display potent anticancer activity. This work not only provided a new strategy for the atroposelective synthesis of N-N axially chiral mols. but also offers new members of the N-N atropisomer family with promising applications in synthetic and medicinal chem. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-oxovalerate(cas: 30414-53-0Application of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Catalysis Science & Technology included an article by Mourelle-Insua, Angela; Mendez-Sanchez, Daniel; Galman, James L.; Slabu, Iustina; Turner, Nicholas J.; Gotor-Fernandez, Vicente; Lavandera, Ivan. Product Details of 30414-53-0. The article was titled 《Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions》. The information in the text is summarized as follows:

The biocatalytic stereocontrolled synthesis of various acyclic anti- or syn-α-alkyl-β-amino amides through a dynamic kinetic resolution strategy is demonstrated. A series of com. available and inhouse transaminases (TAs) were employed to perform the transamination of a series of chem. synthesized racemic α-alkyl-β-keto amides. Among them, com. (R)-selective TAs showed the best activities and selectivities, giving access preferentially to the anti-diastereoisomers with low to high diastereomeric ratios (up to 96%) and excellent enantiomeric excess (>99%). The stereoselective biotransamination experiments were successfully demonstrated at a semi-preparative scale (25 mM, 100 mg substrate), leading to the corresponding optically active α-alkyl-β-amino amides in 45-90% isolated yields after a simple liquid-liquid extraction protocol. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0Product Details of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Product Details of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Advanced Synthesis & Catalysis included an article by Mendez-Sanchez, Daniel; Mourelle-Insua, Angela; Gotor-Fernandez, Vicente; Lavandera, Ivan. Category: esters-buliding-blocks. The article was titled 《Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases》. The information in the text is summarized as follows:

Chiral (α-substituted) β-hydroxy amides are interesting derivatives as they are useful building blocks of many biol. active compounds Herein, the biocatalytic stereocontrolled synthesis of various acyclic syn-α-alkyl-β-hydroxy amides through a dynamic kinetic resolution is shown. Hence, a series of overexpressed alc. dehydrogenases (ADHs) in Escherichia coli was used to reduce the corresponding racemic β-keto amides. Among them, ADH-A from Rhodococcus ruber and com. evo-1.1.200 afforded the best activities and selectivities, giving access to the opposite enantiomers with high diastereomeric excess and excellent enantiomeric excess. Some of these compounds were obtained at semipreparative scale. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-oxovalerate(cas: 30414-53-0Category: esters-buliding-blocks)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C6H10O3On September 22, 2021 ,《Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction》 was published in Journal of the American Chemical Society. The article was written by Wang, Xiao-Mei; Zhang, Peng; Xu, Qi; Guo, Chang-Qiu; Zhang, De-Bing; Lu, Chuan-Jun; Liu, Ren-Rong. The article contains the following contents:

Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction is described. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0COA of Formula: C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.COA of Formula: C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chahal, Mandeep K.; Payne, Daniel T.; Matsushita, Yoshitaka; Labuta, Jan; Ariga, Katsuhiko; Hill, Jonathan P. published an article on January 6 ,2020. The article was titled 《Molecular Engineering of β-Substituted Oxoporphyrinogens for Hydrogen-Bond Donor Catalysis》, and you may find the article in European Journal of Organic Chemistry.Application of 30414-53-0 The information in the text is summarized as follows:

A new class of bifunctional hydrogen-bond donor organocatalyst using oxoporphyrinogens having increased intramol. hydrogen-bond donor distances is reported. Oxoporphyrinogens are highly non-planar rigid macrocycles containing a multiple hydrogen bond-forming binding site. In this work, we describe the first example of non-planar OxPs as hydrogen-bond donor catalysts prepared using a mol. engineering approach of the binding site for dual activation of substrates. The introduction of β-substituents is key to the catalytic activity and the catalysts are able to catalyze 1,4-conjugate additions and sulfa-Michael additions, as well as, Henry and aza-Henry reactions at low catalyst loadings (≤ 1 mol-%) under mild conditions (e.g., catalyst I). Preliminary mechanistic studies have been carried out and a possible reaction mechanism has been proposed based on the bi-functional activation of both substrates through hydrogen-bonding interactions. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Application of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Squaramide-decorated covalent organic framework as a new platform for biomimetic hydrogen-bonding organocatalysis》 were Li, Xia; Wang, Zhifang; Sun, Jiaxing; Gao, Jia; Zhao, Yu; Cheng, Peng; Aguila, Briana; Ma, Shengqian; Chen, Yao; Zhang, Zhenjie. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Computed Properties of C6H10O3 The author mentioned the following in the article:

A squaramide-decorated COF was synthesized and used as a highly efficient heterogeneous catalyst for hydrogen-bonding organocatalysis as exemplified in the context of catalyzing Michael addition reactions under mild conditions. Our work lays a foundation for the development of functional COFs as a new platform for biomimetic organocatalysis. After reading the article, we found that the author used Methyl 3-oxovalerate(cas: 30414-53-0Computed Properties of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Computed Properties of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Stereoselective one-pot five-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines with two and three stereocenters》 were Iliyasov, Taigib M.; Karpenko, Kirill A.; Akulinin, Alexander S.; Fakhrutdinov, Artem N.; Korolev, Viktor A.; Elinson, Michail N.; Vereshchagin, Anatoly N.. And the article was published in ARKIVOC (Gainesville, FL, United States) in 2022. Electric Literature of C6H10O3 The author mentioned the following in the article:

A novel five-component stereoselective synthesis of polysubstituted tetrahydropyridines is reported. The Knoevenagel condensation – Michael addition – Mannich reaction – cyclization – dehydration cascade of aldehydes, esters of 3-oxocarboxylic acids C-H acids and ammonium acetate provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine-3-carboxylates with two stereocenters and 3,5-dialkyl (4RS,5SR,6RS)-5-cyano-2,4,6-triaryl-1,4,5,6-tetrahydropyridine-5,3-carboxylates with three stereocenters in 57-84% yields. It was established that formation of products proceeds via substituted 2-hydroxypiperidines with four stereocenters. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Five bonds are formed as a result of multicomponent process. The formation of single diastereomers was confirmed by singe crystal X-ray diffraction studies and 2D-NMR spectroscopy. In the experiment, the researchers used Methyl 3-oxovalerate(cas: 30414-53-0Electric Literature of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Electric Literature of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and antimicrobial activity of some disperse dyes derived from pyridones》 was published in International Journal of ChemTech Research in 2019. These research results belong to Al-Etaibi, Alya M.. Category: esters-buliding-blocks The article mentions the following:

Pyridone derivatives 4a,b are prepared by reacting N-alkyl-2-cyanoacetamide 1a,b with Me propionylacetate. Compounds 4a,b are coupled with aromatic diazonium salts to produce the corresponding new azo disperse dyes 6a,b. The antimicrobial activity of the synthesized azo disperse dyes are evaluated. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Category: esters-buliding-blocks) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2020,Chemical Communications (Cambridge, United Kingdom) included an article by Zhang, Zhicheng; Cepeda, Alexis J.; Robles, Mireya L.; Hirsch, Melissa; Kumru, Kaan; Zhou, Jina A.; Keatinge-Clay, Adrian T.. Safety of Methyl 3-oxovalerate. The article was titled 《General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases》. The information in the text is summarized as follows:

Modular polyketide synthases (PKSs) are enzymic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities. In the experimental materials used by the author, we found Methyl 3-oxovalerate(cas: 30414-53-0Safety of Methyl 3-oxovalerate)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Safety of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics