Category: 30095-98-8

Hu, Longqin; Liu, Bin; Hacking, Douglas R. published the artcile< 5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation>, COA of Formula: C9H9NO4, the main research area is nitrophenylmethylpropionyl deoxyfluorouridine preparation FUDR prodrug; anticancer FUDR reductive activation nitrophenylmethylpropionyl deoxyfluorouridine.

5′-[2-(2-Nitrophenyl)-2-methylpropionyl]-2′-deoxy-5-fluorouridine was synthesized as a potential bioreductively activated prodrug of 5-fluoro-2′-deoxyuridine (FUDR). The target compound was stable in both phosphate buffer and human serum and was found to release quickly the parent drug FUDR in quant. yield upon mild chem. reduction

Bioorganic & Medicinal Chemistry Letters published new progress about Prodrugs. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niu, Teng-fei; Li, Liang; Ni, Bang-qing; Bu, Mei-jie; Cai, Chun; Jiang, Hui-liang published the artcile< Visible-Light-Induced Meerwein Cascade Reactions for the Preparation of α-Aryl Esters>, Application In Synthesis of 30095-98-8, the main research area is alpha aryl ester preparation visible light induced Meerwein cascade; oxindole preparation cascade reaction mol oxygen oxidant.

A practical strategy has been developed for preparation of α-aryl ester derivatives by using a visible-light-induced Meerwein cascade reaction. This method uses mol. oxygen as an oxidant at room temperature without the need of hazardous reagents or harsh reaction conditions and provides a straightforward approach to pharmaceutically and synthetically useful α-aryl esters in moderate to good yields from simple and readily available starting materials. Oxindoles were also prepared by this protocol.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application In Synthesis of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shang, Rui; Huang, Zheng; Chu, Ling; Fu, Yao; Liu, Lei published the artcile< Palladium-Catalyzed Decarboxylative Coupling of Potassium Nitrophenyl Acetates with Aryl Halides>, HPLC of Formula: 30095-98-8, the main research area is palladium catalyzed decarboxylative cross coupling diaryl methane preparation; potassium nitrophenylacetate aryl halide reactant palladium catalyzed decarboxylative coupling.

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes, e.g. 1-nitro-2-(4-vinylbenzyl)benzene, and their derivatives

Organic Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Czyzyk, D. J.; Valhondo, M.; Deiana, L.; Tirado-Rives, J.; Jorgensen, W. L.; Anderson, K. S. published the artcile< Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is structure preparation thymidylate synthase inhibitor cryptosporidiosis; Antifolate; Cryptosporidium hominis; SAR study; Thymidylate synthase; X-ray crystallography.

Cryptosporidiosis is a human gastrointestinal disease caused by protozoans of the genus Cryptosporidium, which can be fatal in immunocompromised individuals. The essential enzyme, thymidylate synthase (TS), is responsible for de novo synthesis of deoxythymidine monophosphate. The TS active site is relatively conserved between Cryptosporidium and human enzymes. In previous work, we identified compound 1, (2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidin-methyl-phenyl-L-glutamic acid), as a promising selective Cryptosporidium hominis TS (ChTS) inhibitor. In the present study, we explore the structure-activity relationship around 1 glutamate moiety by synthesizing and biochem. evaluating the inhibitory activity of analogs against ChTS and human TS (hTS). X-Ray crystal structures were obtained for compounds bound to both ChTS and hTS. We establish the importance of the 2-phenylacetic acid moiety methylene linker in optimally positioning compounds 23, 24, and 25 within the active site. Moreover, through the comparison of structural data for 5, 14, 15, and 23 bound in both ChTS and hTS identified that active site rigidity is a driving force in determining inhibitor selectivity.

European Journal of Medicinal Chemistry published new progress about Coccidiostats. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Soderberg, Bjorn C. G.; Banini, Serge R.; Turner, Michael R.; Minter, Aaron R.; Arrington, Amanda K. published the artcile< Palladium-catalyzed synthesis of 3-indolecarboxylic acid derivatives>, Category: esters-buliding-blocks, the main research area is nitroaryl tertbutyl chloroacetate vicarious nucleophilic substitution; ethanoate nitroaryl preparation ethylsulfone acetonitrile aldehyde trioxane Knoevenagel condensation; tributylstannane aryl alkenyl iodide Stille coupling; unsaturated ester sulfone nitrile preparation palladium phenanthroline triphenyl phosphine; reductive heteroannulation aza indole carboxylate sulfone nitrile preparation; heteroannulation reductive catalyst palladium phenanthroline triphenyl phosphine.

Indoles having an ester functionality in the 3-position, e.g., I, were prepared from 2-(2-nitrophenyl)propenoic acid derivatives via a palladium-catalyzed reductive N-heteroannulation using carbon monoxide as the ultimate reducing agent. The starting materials were prepared either by a Stille coupling of 2-halo-1-nitrobenzenes with Et 2-(tributylstannyl)-2-propenoate or by vicarious nucleophilic substitution of nitrobenzenes followed by a Knoevenagel-type condensation with an aldehyde. Synthesis of an example of a 3-nitrile- and a 3-sulfone-substituted indole is also described using the same type of methodologies.

Synthesis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strazzolini, P.; Giumanini, A. G.; Runcio, A. published the artcile< Nitric acid in dichloromethane solution. Facile preparation from potassium nitrate and sulfuric acid>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arene potassium nitrate sulfuric acid nitration; ester potassium nitrate sulfuric acid nitrolysis; nitro arene preparation.

Pure dry HNO3 can be liberated from KNO3 with 96% H2SO4 directly into CH2Cl2 to yield solutions of variable concentration for use in a number of organic reactions. The present method efficiently replaces the employment of 100% HNO3 in some synthetic applications, avoiding the problems associated in storage and handling the acid. The procedure is exemplified by nitration of arenes and nitrolysis of tert-Bu esters.

Tetrahedron Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nykaza, Trevor V.; Li, Gen; Yang, Junyu; Luzung, Michael R.; Radosevich, Alexander T. published the artcile< PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles>, Application In Synthesis of 30095-98-8, the main research area is azaheterocycle preparation organophosphorus catalyst cascade; cross-coupling; cyclization; nitrogen heterocycles; organocatalysis; phosphorus.

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermol. reductive C-N cross coupling with boronic acids, followed by intramol. cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Angewandte Chemie, International Edition published new progress about Aromatic nitro compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-acylamino). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application In Synthesis of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Zhengren; Wang, Qian; Zhu, Jieping published the artcile< Palladium-Catalyzed Decarboxylative Vinylation of Potassium Nitrophenyl Acetate: Application to the Total Synthesis of (±)-Goniomitine>, Product Details of C9H9NO4, the main research area is vinylation palladium catalyst decarboxylative potassium nitrophenyl acetate; goniomitine total synthesis decarboxylative vinylation potassium nitrophenyl acetate; oxidation reduction cyclization stereoselective total synthesis goniomitine.

A seven step total synthesis of (±)-goniomitine has been accomplished via novel palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates and vinyl triflates and a one-pot multiple bond forming integrated oxidation/reduction/cyclization process. Thus, reacting potassium (2-nitrophenyl)acetate with cyclohex-1-en-1-yl triflate in the presence of [{PdCl(allyl)}2]/XPhos in DMF gave 1-[(2-nitrophenyl)methyl]-1-cyclohexene.

Angewandte Chemie, International Edition published new progress about Cyclization, stereoselective. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kammel, Richard; Tarabova, Denisa; Broz, Bretislav; Hladikova, Veronika; Hanusek, Jiri published the artcile< Formation of 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-ones involving ring transformation of 2-aryl-5-(2-aminophenyl)-4-hydroxy-1,3-thiazoles>, Product Details of C9H9NO4, the main research area is Hammett correlation kinetics ring transformation aryl aminophenyl hydroxythiazole; amino arylmethylidene indolone preparation Eschenmoser coupling; ring transformation aryl aminophenyl hydroxythiazole kinetics.

The reaction of 3-bromooxindole with substituted (hetero)aromatic thioamides in acetonitrile was studied. At room temperature the reaction preferably gives products of ring transformation i.e. 2-aryl-5-(2-aminophenyl)-4-hydroxy-1,3-thiazoles whereas at elevated temperature products of an Eschenmoser coupling reaction, i.e. 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-ones, are formed exclusively. There exist only two exceptions (4-methoxy and 2-pyridinthioamide) in which the Eschenmoser coupling reaction always takes place. Also N-methylation of the starting 3-bromooxindole completely prevents formation of thiazoles. The prepared thiazoles are unstable in solution and they undergo slow ring transformation to the expected Eschenmoser coupling products. The rate limiting step of this rearrangement involves cleavage of an intermediary thiirane ring, which is slowed down by electron-withdrawing substituents on the thioamide (ρ = -1.15).

Tetrahedron published new progress about C-S bond (cleavage). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Dong Ung; Mayer, Klaus K.; Wiegrebe, Wolfgang; Lauber, Rolf; Schlunegger, Urs P. published the artcile< Mass-spectrometric investigations on derivatives of phenylacetic acid. II. Ortho effects of ionized phenylacetates>, Safety of Methyl 2-(2-nitrophenyl)acetate, the main research area is mass spectra benzeneacetate substituent effect; metastable ion mass spectra phenylacetate; collisional activation mass spectra benzeneacetate.

The mol. ions of 2-RC6H4CH2CO2R1 (I; R = Cl, R1 = Me, Et; R = Br, NO2, R1 = Me) lost R to give strong [M-R]+ signals. I (R = Me2N, R1 = Me; R = MeO, R1 = Et) did not lose R, and 3-ClC6H4CH2CO2Me did not lose Cl. The metastable-ion and collisional-activation spectra were discussed.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Mass spectra. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Safety of Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics