Category: 30095-98-8

Nakamura, Seikou; Kozuka, Mutsuo; Bastow, Kenneth F.; Tokuda, Harukuni; Nishino, Hoyoku; Suzuki, Madoka; Tatsuzaki, Jin; Morris Natschke, Susan L.; Kuo, Sheng-Chu; Lee, Kuo-Hsiung published the artcile< Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters>, Application of C9H9NO4, the main research area is antitumor quinolone acridine derivative preparation SAR.

2-Phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives were synthesized and screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Interestingly, compounds 14, 15, and 17 showed similar inhibitory effects (89-92%, 66-69%, and 24-29% at 1000, 500, and 100 mol ratio to TPA, resp.) against EBV-EA with potencies comparable to those of glycyrrhetic acid, a known natural antitumor-promoter.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mayer, Guido; Hinze, Claudia; Polborn, Kurt; Steglich, Wolfgang published the artcile< Unexpected Formation of the Arcyriacyanin System by Condensation of a 3-Bromo-4-(indol-3-yl)maleimide with (2-Nitrophenyl)acetates>, Formula: C9H9NO4, the main research area is arcyriacyanin alkaloid condensation bromoindolylmaleimide nitrophenyl acetate.

The reaction of an N-protected 3-bromo-4-(indol-3-yl)maleimide with Me (2-nitrophenyl)acetates in the presence of base affords condensed cycloheptatriene derivatives which can be transformed into arcyriacyanin-type alkaloid I. The unusual reaction sequence implies a heptatrienyl-cycloheptadienyl anion rearrangement followed by a 1,5-sigmatropic shift to yield the thermodynamically more stable cycloheptatriene derivative

Australian Journal of Chemistry published new progress about Crystal structure. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santi, Micol; Ould, Darren M. C.; Wenz, Jan; Soltani, Yashar; Melen, Rebecca L.; Wirth, Thomas published the artcile< Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones>, Category: esters-buliding-blocks, the main research area is benzofuranone preparation; diazoester preparation tandem rearrangement lactonization; benzofuranone; boron; diazo compounds; metal-free conditions; rearrangement.

A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting α-aryl-α-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in α-arylations of α-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramol. rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.

Angewandte Chemie, International Edition published new progress about Arylation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Munaretto, Laieli S.; dos Santos, Caio Y.; Gallo, Rafael D. C.; Okada, Celso Y. Jr.; Deflon, Victor M.; Jurberg, Igor D. published the artcile< Visible-Light-Mediated Strategies to Assemble Alkyl 2-Carboxylate-2,3,3-Trisubstituted β-Lactams and 5-Alkoxy-2,2,4-Trisubstituted Furan-3(2H)-ones Using Aryldiazoacetates and Aryldiazoketones>, Safety of Methyl 2-(2-nitrophenyl)acetate, the main research area is alkyl carboxylate lactam preparation photochem diastereoselective; alkoxy furanone preparation photochem; aryldiazoacetate aryldiazoketone Wolff rearrangement.

Two new visible-light-mediated strategies are described starting from aryldiazoacetates ArC(R)=N2 (Ar = Ph, 4-chlorophenyl, 3,4-difluorophenyl, etc.; R = CF3, C(O)OMe, C(O)OBn, etc.). The first approach describes their reaction with azides R1N3 (R1 = 2-cyanoethyl, Cy, Ph, etc.) to afford the corresponding imines (Z)-ArC(R)=NR1, and then reaction with aryldiazoketones R2C(O)C(=N2)C6H5 (R2 = Me, Ph, 4-methoxyphenyl), produces alkyl 2-carboxylate-2,3,3-trisubstituted β-lactams I. The second approach describes the reaction with sulfoxides R3S(O)R4 (R3 = Me, n-Bu, Ph, 4-chlorophenyl; R4 = Me, n-Bu, Ph, 4-chlorophenyl; R3R4 = -(CH2)4-) to afford the corresponding sulfoxonium ylides ArC(R)=S(O)(R3)R4, followed by reaction with aryldiazoketones to produce 5-alkoxy-2,2,4-trisubstituted furan-3(2H)-ones II (R5 = Me, i-Pr, Bn). These protocols take advantage of the photolysis of aryldiazoacetates and the photochem. promoted Wolff rearrangement of aryldiazoketones.

Organic Letters published new progress about Azetidines Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Safety of Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selvakumar, N.; Azhagan, A. Malar; Srinivas, D.; Krishna, G. Gopi published the artcile< A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is coerulescine synthesis; horsfiline synthesis; arylpropenoic acid ester nitro preparation; propenoic acid ester arylnitro preparation.

A short synthesis of 2-arylpropenoic acid esters that possess nitro groups in their Ph ring using common and less expensive reagents is described. The usefulness of this methodol. is substantiated by the efficient total syntheses of (±)-coerulescine (I) and (±)-horsfiline from the 2-arylpropenoic acid esters obtained.

Tetrahedron Letters published new progress about Nitro group. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bing; Williams, John D.; Peet, Norton P. published the artcile< Two concise total syntheses of the wasabi phytoalexin methyl 1-methoxyindole-3-carboxylate>, Formula: C9H9NO4, the main research area is nitrophenylacrylate preparation reductive cyclization; wasabi phytoalexin methoxyindolecarboxylate total synthesis.

Two new syntheses of the phytoalexin Me 1-methoxyindole-3-carboxylate (I) were developed that employ the same key intermediate. Me 2-(2-nitrophenyl)acrylate (II) was directly converted into I using modified Cadogan-Sundberg indole synthesis conditions with P(OMe)3. Acrylate II also underwent reductive cyclization with SnCl2 to give Me 1-hydroxyindole-3-carboxylate, which was methylated to produce I.

Tetrahedron Letters published new progress about Reductive cyclization. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Surakanti, Ramu; Sanivarapu, Sumalatha; Thulluri, Chiranjeevi; Iyer, Pravin S.; Tangirala, Raghuram S.; Gundla, Rambabu; Addepally, Uma; Murthy, Y. L. N.; Velide, Lakshmi; Sen, Subhabrata published the artcile< Corrigendum: Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis [Erratum to document cited in CA159:742720]>, Related Products of 30095-98-8, the main research area is pyrrolidine indoline cyclotryptamine preparation anticancer antibacterial erratum; spiro indoline preparation anticancer antibacterial erratum.

In the Supporting Information, spectra for 1, 5, 7, 8, 11, 16, 17, 18a, 20, 21and 24 were found to have been edited to remove solvents and minor impurities. Original spectra were located and replaced for all the compounds The spectra editing does not affect the conclusions of the published paper and all yields were found to be correct.

Chemistry – An Asian Journal published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Related Products of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biswas, Kallolmay; Kumar, Arvind; Das Sarma, Koushik published the artcile< One-Pot High-Throughput Synthesis of a 160-Membered Library of Methyl 3,5-Diaryl-isoxazoline-5-carboxylate Pharmacophores by a 2·2·2-Component Reaction>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is aryl aldehyde arylacetate high throughput multicomponent reaction; oxime arylacrylate intermediate sequential two component reaction; diaryloxazoline carboxylate library one pot preparation.

A simple and efficient methodol. has been developed for the synthesis of Me 3,5-diaryl-isoxazoline-5-carboxylates in a high-throughput fashion from aryl aldehydes and Me arylacetates. This was accomplished in one-pot by a sequence of three 2-component reactions steps (2·2·2-CR), through oxime and α-arylacrylate intermediates, whereby compounds were obtained in overall 30-66% isolated yields. The functional group diversity was established by synthesizing a 160-membered library.

ACS Combinatorial Science published new progress about 1,3-Dipolar cycloaddition reaction. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Weihua; Jiang, Zhigan; He, Haiying; Xiao, Fubiao; Lin, Fusen; Sun, Ya; Hou, Lijuan; Shen, Liang; Han, Lixia; Zeng, Minggao; Lai, Kunmin; Gu, Zhengxian; Chen, Xinsheng; Zhao, Tao; Guo, Li; Yang, Chun; Li, Jian; Chen, Shuhui published the artcile< Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection>, Electric Literature of 30095-98-8, the main research area is spiro azetidine indoline fusion inhibitor respiratory syncytial virus.

A new series of 3,3′-spirocyclic 2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which exhibited excellent in vitro potency with an EC50 value of 0.8 nM and demonstrated 71% oral bioavailability in mice. In a mouse challenge model of RVS infection, 14h demonstrated superior efficacy with a 3.9log RSV virus load reduction in the lung following an oral dose of 50 mg/kg.

ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xing, Shuya; Zhu, Yu-Yi; Liu, Wen; Liu, Yong; Zhang, Jing; Zhang, Huarong; Wang, Yan; Ni, Shao-Fei; Shao, Xinxin published the artcile< C-H Fluoroalkylsulfinylation/Intramolecular Rearrangement for Precise Synthesis of Fluoroalkyl Sulfoxides>, Computed Properties of 30095-98-8, the main research area is fluoroalkyl sulfoxide preparation; arylhydroxylamine fluoroalkylsulfinylation intramol rearrangement.

An efficient methodol. to access various fluoroalkyl sulfoxides bearing ortho/para-functionalized amine scaffolds, e.g. I from arylhydroxylamines was described. The transformation was featured with new electrophilic trifluoromethylthiolated reagents, good functional group tolerance, and late-stage modification of complex bioactive scaffolds, providing a rapid access to prepare numerous trifluoromethyl- and difluoromethyl-substituted sulfoxides. Mechanism studies and d. functional theory calculations suggest this reaction goes through a nucleophilic trifluoromethylthiolation of arylhydroxylamine and subsequent internal 2,3-sigmatropic rearrangement involving a sulfur and oxygen transfer process.

Organic Letters published new progress about Hydroxylamines Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Computed Properties of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics