Category: 29823-21-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29823-21-0, name is Ethyl 8-Bromooctanoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H19BrO2

1h: Preparation of Compound 8 A 3-neck 300 mL round-bottomed flask equipped with a reflux condenser, magnetic stir bar and a nitrogen inlet was charged with 5 g (1 equivalent) of 4-hydroxybenzonitrile, absolute ethanol 150 mL, and 15.7 mL (1 equivalent) of sodium ethoxide. This mixture was stirred at 25 C. for 15 minutes. Ethyl 8-bromooctanoate (10.5 g, 1 equivalent) was then added dropwise over 10 minutes. The resulting mixture was heated to reflux (75 C.) for 72 hours. The reaction mixture was cooled and the solids filtered off. The solvent was removed on a rotary evaporator. The crude residue was dissolved in methylene chloride (200 mL) and washed with saturated NaHCO3 (2*75 mL), H2O (1*100 mL) and brine (1*100 mL). The crude material was then dissolved in ethanol (125 mL) and water (10 mL). LiOH (5 g) was added and the resulting mixture was heated to reflux (75 C.) for 1 hour then stirred at ambient temperature overnight. The solvent was evaporated and 75 mL of H2O was added. The aqueous solution was acidified to a pH of about 3 with concentrated HCl and the flask cooled to 4 C. An off-white colored solid precipitated. This material was collected by vacuum filtration and dried on the high vacuum overnight to give the crude acid. These solids were further purified by recrystallization from Ethyl acetate/hexanes (95/5) and again with chloroform to give 4.5 g of the product, 8-(4-cyanophenoxy)octanoic acid (41% yield). Melting point: 137-140 C. Molecular Formula: C15H19NO3. Combustion analysis: %C: 68.94 (calc’d), 68.57 (found); %H: 7.33(calc’d), 7.13(found); %N: 5.36 (calc’d), 5.28 (found).

The synthetic route of 29823-21-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Moye-Sherman, Destardi; Gschneidner, David; US2003/199427; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29823-21-0, name is Ethyl 8-Bromooctanoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H19BrO2

a) 4,5-Bis(4-methoxyphenyl)-2-phenylimidazole (7 g) (J. Med. Chem., 1974, 17, 1182-8) and ethyl 8-bromo-octanoate (9.9 g) were reacted in a method similar to Example 9. Column chromatography on silica gel eluted with a hexane:ethyl acetate gradient gave 1-(7-ethoxy-carbonylheptyl)-4,5-bis(4-methoxyphenyl)-2-phenyl-imidazole (10.3 g, 100%) as an oil. NMR d (CDCl3) 0.8-1.5 (13H, m, 5*CH2, CH3), 2.18 (2H, t, CH2 =O), 3.75 (3H, s, OCH3), 3.88 (5H, m, NCH2, OCH3), 4.1 (2H, q, CH2 OC=O), 6.7-7.7 (13H, m, ArH) ppm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 29823-21-0.

Reference:
Patent; SmithKline Beecham Corporation; The Johns Hopkins University; US5648373; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 29823-21-0, name is Ethyl 8-Bromooctanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H19BrO2

General procedure: 2,6-dichloro-9H-purine (5 mmol) or intermediates 5 was dissolved in 20 mL anhydrous DMF, then K2CO3 (8 mmol) was added, and ethyl 4-bromobutanoate or ethyl 8-bromooctanoate(8 mmol) was dropped into the solution. Cut off from the air, the solution was stirred at room temperature for overnight,and then adjusted to pH 7-8 with HCl (1 mol/L), then extracted with 50 mL ×3 ethyl acetate and the organic phase was combined, and washed with brine, dried over MgSO4 and evaporated. The crude product was purified by chromatography on a silica gel column (EtOAc/petroleum ether, 1 : 1) to give desired compounds 6a-6p.

The synthetic route of Ethyl 8-Bromooctanoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Zhaoxing; Yang, Yongchao; Mai, Xi; Liu, Bin; Xiong, Yuanzhen; Feng, Lihuang; Liao, Yijing; Zhang, Yu; Wang, Huanlu; Ouyang, Leiting; Liu, Shuhao; Chemical and Pharmaceutical Bulletin; vol. 66; 4; (2018); p. 439 – 451;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 29823-21-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 29823-21-0 as follows.

To a solution of sodium ethoxide (1.422 g, 20.9 mmol) in EtOH (10 mL) was added diethyl acetonedicarboxylate (4.23 g, 3.800 mL, 20.9 mmole). The stirred solution was heated to the reflux temperature, and then ethyl 8-bromooctanoate (XD-013-19, 5.24 g, 20.9 mmol) was added slowly. Stirring and heating were continued for two hours. After another solution of sodium ethoxide (20.9 mmole in 10 mL of EtOH) was added at reflux temperature, another 20.9 mmole of ethyl 8-bromooctanoate was added dropwise. The mixture was heated and stirred for 16 hours after addition was complete. Most of the ethanol was removed under reduced pressure. To the residue were added water (70 mL) and ether (250 mL). Saturated NH4C1 solution was added to adjust to pH 7. The two layers were separated. The ethereal solution was washed again with dilute NH4C1, brine. Concentration led to a brownish oil (11.44 g). The oil was hydrolyzed by boiling for 18 hours with a mixture of concentrated hydrochloric acid (21 mL) and glacial acetic acid (10.5 mL). The hydrolysis mixture was evaporated to dryness under reduced pressure, and the solid residue was washed with water and was crystallized from acetone. The product was dried well and was obtained as a pale solid (1.74 g).

According to the analysis of related databases, 29823-21-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALNYLAM PHARMACEUTICALS, INC.; ANSELL, Steven, Michial; DU, Xinyao; WO2013/86322; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29823-21-0, name is Ethyl 8-Bromooctanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 29823-21-0

A mixture of ethyl 8-bromooctanoate (5g, 19.9mmol) and sodium iodide (2.98g, 19.9mmol) in Acetone (5OmL) was heated at 60C under nitrogen for 18h. The reaction mixture was then concentrated under vacuum. Purification by silica gel column chromatography, using EtOAc/Hexane (1:90) as eluant, provided ethyl 8- iodooctanoate as a colourless liquid (5.5g, 93.2 %).LCMS (ES): Found 299.2 [MH]+.

The synthetic route of 29823-21-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; TOMASSI, Cyrille Davy; CECIL, Alexander Richard Liam; MACCORMICK, Somhairle; NODES, William John; SILVA, Franck Alexandre; WO2014/72714; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29823-21-0, name is Ethyl 8-Bromooctanoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 29823-21-0

EXAMPLE 76 Ethyl 8-(4-phenylimidazol-1-yl)octanoate 4-Phenylimidazole was treated with ethyl 8-bromooctanoate and potassium carbonate in butanone to give after work-up the title compound, m.p. 56-57 C., Found: C, 72.8; H, 8.4; N, 9.0%; C19 H26 N2 O2 Requires: C, 72.6; H, 8.3;N, 8.9%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 29823-21-0.

Reference:
Patent; SmithKline Beecham Corporation; The Johns Hopkins University; US5648373; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29823-21-0, name is Ethyl 8-Bromooctanoate, A new synthetic method of this compound is introduced below., Recommanded Product: 29823-21-0

Example 15Synthesis of Ethyl 8-nitrooxy-octanoate; 20.0 mmol Ethyl 8-bromooctanoate dissolved in 80 ml acetonitrile and 50.0 mmol silver nitrite were added into a flask protected from light. This suspension was stirred for 18 hours at 70 C. After cooling to room temperature the suspension was filtrated over silica gel, washed with Ethylacetate and concentrated in vacuo.The crude product was purified by flash chromatography on silica gel using heptane/ethyl acetate 4:1; Yield: 4.35 g (18.6 mmol, 93.2%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Duval, Stephane; Kindermann, Maik; US2012/315339; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29823-21-0, name is Ethyl 8-Bromooctanoate, A new synthetic method of this compound is introduced below., Recommanded Product: 29823-21-0

a) 2-(4-Methoxyphenyl)-4,5-diphenylimidazole (10 g) (J. Org. Chem., 1964, 29, 1926-30) was reacted with sodium hydride (1.7 g) and ethyl 8-bromooctanoate (9.6 g) in a method similar to Example 12. Chromatography on silica gel eluted with chloroform gave 1-(7-ethoxy-carbonylheptyl)2-(4-methoxyphenyl)-4,5-diphenylimidazole (12.9 g, 85%) as an oil.

The synthetic route of 29823-21-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SmithKline Beecham Corporation; The Johns Hopkins University; US5648373; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29823-21-0, name is Ethyl 8-Bromooctanoate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Ethyl 8-Bromooctanoate

a) 4,5-Bis(4-methoxyphenyl)-2-phenylimidazole (7 g) (J. Med. Chem., 1974, 17, 1182-8) and ethyl 8-bromo-octanoate (9.9 g) were reacted in a method similar to Example 9. Column chromatography on silica gel eluted with a hexane:ethyl acetate gradient gave 1-(7-ethoxy-carbonylheptyl)-4,5-bis(4-methoxyphenyl)-2-phenyl-imidazole (10.3 g, 100%) as an oil. NMR d (CDCl3) 0.8-1.5 (13H, m, 5*CH2, CH3), 2.18 (2H, t, CH2 =O), 3.75 (3H, s, OCH3), 3.88 (5H, m, NCH2, OCH3), 4.1 (2H, q, CH2 OC=O), 6.7-7.7 (13H, m, ArH) ppm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 29823-21-0.

Reference:
Patent; SmithKline Beecham Corporation; The Johns Hopkins University; US5648373; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29823-21-0, name is Ethyl 8-Bromooctanoate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 8-Bromooctanoate

1h: Preparation of Compound 8 A 3-neck 300 mL round-bottomed flask equipped with a reflux condenser, magnetic stir bar and a nitrogen inlet was charged with 5 g (1 equivalent) of 4-hydroxybenzonitrile, absolute ethanol 150 mL, and 15.7 mL (1 equivalent) of sodium ethoxide. This mixture was stirred at 25 C. for 15 minutes. Ethyl 8-bromooctanoate (10.5 g, 1 equivalent) was then added dropwise over 10 minutes. The resulting mixture was heated to reflux (75 C.) for 72 hours. The reaction mixture was cooled and the solids filtered off. The solvent was removed on a rotary evaporator. The crude residue was dissolved in methylene chloride (200 mL) and washed with saturated NaHCO3 (2*75 mL), H2O (1*100 mL) and brine (1*100 mL). The crude material was then dissolved in ethanol (125 mL) and water (10 mL). LiOH (5 g) was added and the resulting mixture was heated to reflux (75 C.) for 1 hour then stirred at ambient temperature overnight. The solvent was evaporated and 75 mL of H2O was added. The aqueous solution was acidified to a pH of about 3 with concentrated HCl and the flask cooled to 4 C. An off-white colored solid precipitated. This material was collected by vacuum filtration and dried on the high vacuum overnight to give the crude acid. These solids were further purified by recrystallization from Ethyl acetate/hexanes (95/5) and again with chloroform to give 4.5 g of the product, 8-(4-cyanophenoxy)octanoic acid (41% yield). Melting point: 137-140 C. Molecular Formula: C15H19NO3. Combustion analysis: %C: 68.94 (calc’d), 68.57 (found); %H: 7.33(calc’d), 7.13(found); %N: 5.36 (calc’d), 5.28 (found).

The synthetic route of 29823-21-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Moye-Sherman, Destardi; Gschneidner, David; US2003/199427; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics