Category: 2982-53-8

DiMagno, Theodore J. published the artcileNitrobenzene “”Caged”” Compounds as Irreversible Photoreductants: A Rational Approach to Studying Photoinduced Intermolecular Electron-Transfer Reactions in Proteins, Recommanded Product: Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, the main research area is nitrobenzene caged compound photoreductant.

Nitrobenzene “”caged”” compounds are well-known for their use in delivering biol. active substrates to a reaction mixture after photoexcitation. We have discovered that they also behave as photoreductants from the triplet state after photoexcitation. To explore the properties of these newly discovered photoreductants, a series of substituted nitrobenzene derivatives have been synthesized. These nitrobenzene derivatives exhibit many desirable characteristics suitable for the physiol. photoreduction of different proteins, and examples are shown for the photoreduction of cytochrome c and other heme proteins. The observed rate constant for photoreduction of cytochrome c, kobs, ranges from 300 to 36,000 s-1 for the various nitrobenzene derivatives PH and ionic strength experiments are consistent with a bimol. reaction wherein the photoreductant and the protein form an electrostatic complex prior to electron transfer. A kinetic model for this bimol. reaction is described and simulations of the exptl. data for the photoreductant 4,5-dimethoxy-2-nitrophenylacetic acid (DMNPAA) yield an inherent unimol. electron-transfer rate constant (ket) of 14,600 s-1 for the photoreduction of cytochrome c at pH 6.6.

Journal of Physical Chemistry published new progress about Myoglobins Role: RCT (Reactant), RACT (Reactant or Reagent). 2982-53-8 belongs to class esters-buliding-blocks, name is Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, and the molecular formula is C11H13NO6, Recommanded Product: Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewin, Anita H. published the artcileCaged Naloxone: Synthesis, Characterization, and Stability of 3-O-(4,5-Dimethoxy-2-nitrophenyl)carboxymethyl Naloxone (CNV-NLX), Recommanded Product: Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, the main research area is caged naloxone dimethoxynitrophenylcarboxymethyl stability photolability diastereomer; 3-O-(α-carboxy-6-nitroveratryl)naloxone; diastereomers; photolabile.

The photolabile analog of the broad-spectrum opioid antagonist naloxone, 3-O-(4,5-dimethoxy-2-nitrophenyl)carboxymethyl naloxone (also referred to as “”caged naloxone””, 3-O-(α-carboxy-6-nitroveratryl)naloxone, CNV-NLX), has been found to be a valuable biochem. probe. While the synthesis of CNV-NLX is simple, its characterization is complicated by the fact that it is produced as a mixture of αR,5R,9R,13S,14S and αS,5R,9R,13S,14S diastereomers. Using long-range and heteronuclear NMR correlations, the 1H NMR and 13C NMR resonances of both diastereomers have been fully assigned, confirming the structures. Monitoring of solutions of CNV-NLX in saline buffer, in methanol, and in DMSO has shown CNV-NLX to be stable for over a week under fluorescent laboratory lights at room temperature Exposure of such solutions to λ 365 nm from a hand-held UV lamp led to the formation of naloxone and CNV-related breakdown products.

ACS Chemical Neuroscience published new progress about Diastereomers. 2982-53-8 belongs to class esters-buliding-blocks, name is Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, and the molecular formula is C11H13NO6, Recommanded Product: Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nykaza, Trevor V. published the artcilePIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles, Application of Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, the main research area is azaheterocycle preparation organophosphorus catalyst cascade; cross-coupling; cyclization; nitrogen heterocycles; organocatalysis; phosphorus.

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermol. reductive C-N cross coupling with boronic acids, followed by intramol. cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Angewandte Chemie, International Edition published new progress about Benzimidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 2982-53-8 belongs to class esters-buliding-blocks, name is Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate, and the molecular formula is C11H13NO6, Application of Methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics