Category: 29704-38-9

On May 4, 1984, Makosza, Mieczyslaw; Winiarski, Jerzy published an article.Quality Control of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Reactions of organic anions. Part 110. Vicarious nucleophilic substitution of hydrogen in nitroarenes with α-substituted nitriles and esters. Direct α-cyanoalkylation and α-carbalkoxyalkylation of nitroarenes. And the article contained the following:

Carbanions generated from alkanenitriles bearing α-chloro, α-OR (R = Me, Ph, chlorophenyl) or α-SR (R = Me, Ph, Me2NCS) groups and from aliphatic esters bearing α-SR groups react with mononitroarenes to replace H atoms of the nitroarom. ring ortho or para to the NO2 group with α-cyanoalkyl or α-carbalkoxyalkyl substituents. The nucleophilic replacement of H with such carbanions proceeds faster than substitution of halogen ortho or para to the NO2 group. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Quality Control of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to vicarious nucleophilic substitution nitroarene, cyanoalkylation nitroarene, carbalkoxyalkylation nitroarene, nitroarene cyanoalkylation carbalkoxyalkylation, alkylation cyano carbalkoxy nitroarene, alkanenitrile chloro oxy thio anion, chloroalkanenitrile anion reaction, oxyalkanenitrile anion reaction, thioalkanenitrile anion reaction and other aspects.Quality Control of tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 4, 2000, Suzuki, Nobuhiro; Takekawa, Shiro; Kubo, Keiji; Imaeda, Yasuhiro published a patent.Product Details of 29704-38-9 The title of the patent was Preparation of imidazole derivatives as gonadotropin-releasing hormone antagonists. And the patent contained the following:

Claimed are gonadotropin-releasing hormone (GnRH) antagonists containing the title compounds [I; ring A = (un)substituted Ph; ring B = (un)substituted cyclic group; R4 , R6 = H, (un)substituted C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, (un)substituted C7-13 aralkyl, C2-7 alkoxycarbonyl; R5 = H, halo, (un)substituted C1-6 alkyl, C1-6 alkoxy, C2-7 alkoxycarbonyl, etc.; X = bond, C1-6 alkylene, C2-6 alkenylene, C1-6 alkylene-NHCO, C1-6 alkylene-O2NH; Y = CO, SO2, NHCO, C1-6 alkylene-CO, C2-6 alkylene-CO, C1-6 alkylene] or pharmacol. acceptable salts thereof. These compounds are useful for the treatment or prevention of gonadotropin-releasing hormone-related diseases such as sex hormone-dependent cancer, prostate cancer, uterine cancer, breast cancer, prostatic hypertrophy, true precocious puberty, endometriosis, hysteromyoma, pregnancy regulators, and menstruation regulators. Thus, 5-amino-2-(4-methoxyphenyl)benzimidazole was condensed with 4-pyrrolidinobenzoic acid using di-Et cyanophosphate in the presence of Et3N and 4-dimethylaminopyridine in DMF at room temperature for 1 h to give 41% 2-(4-methoxyphenyl)-5-((4-pyrrolidinobenzoyl)amino)benzimidazole (II). II in vitro showed IC50 of μg/mL for inhibiting the binding of [125I]leuprolelin to a membrane sample of CHO cell expressing human GnRH receptor. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Product Details of 29704-38-9

The Article related to antitumor agents, benign prostatic hyperplasia, endometriosis, mammary gland neoplasm, menstruation (regulators), myoma (hysteromyoma), neoplasm (sex hormone-dependent), precocious puberty (true), pregnancy (regulators), prostate gland neoplasm, uterus neoplasm and other aspects.Product Details of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics