Category: 29704-38-9

On September 17, 2003, Hama, Takuo; Liu, Xiaoxiang; Culkin, Darcy A.; Hartwig, John F. published an article.Formula: C12H15NO4 The title of the article was Palladium-Catalyzed α-Arylation of Esters and Amides under More Neutral Conditions. And the article contained the following:

Two procedures for the α-arylation of carbonyl compounds, under more neutral conditions than those for reactions of aryl halides with alkali metal enolates, are reported. The first procedure rests upon the development of catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos), and the highly reactive dimeric Pd(I) complex {[P(t-Bu)3]PdBr}2. Zinc enolates, prepared from α-bromo esters and amides, react with aryl bromides to form α-aryl esters, e.g., I (R1 = OCMe3, R2 = H), and amides, e.g., I (R1 = NEt2, R2 = Me), in high yields, and with remarkable functional group tolerance. The second procedure; silyl ketenes II (R3 = t-Bu, R4 = H; R3 = R4 = Me) and silyl ketimine acetals react with aryl bromides in the presence of substoichiometric amounts of zinc fluoride, Pd(dba)2, and P(t-Bu)3 to give α-aryl esters and amides. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4

The Article related to zinc enolate aryl bromide arylation, aryl ester preparation, amide aryl preparation, palladium arylation catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C12H15NO4

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 2, 1999, Shirasawa, Eiichi; Konomi, Koji; Ichikawa, Masaki; Suhara, Hiroshi published a patent.Recommanded Product: 29704-38-9 The title of the patent was Preparation of novel 4-propenoylcinnamic acid or 1-propenoyl-4-(phosphonovinyl)benzene derivatives for treatment of glaucoma. And the patent contained the following:

Compounds represented by general formula (I) and salts thereof (wherein R1 is H, lower alkyl or Ph, the Ph being optionally substituted with lower alkyl, hydroxyl, lower alkoxy, halogeno, nitro or phenyl; R2 and R3 are each independently H, halogeno or lower alkyl; R4 and R5 are each independently H, lower alkyl or carboxyl, or a group derived therefrom through esterification; and R6 is carboxyl or phosphono, or a group derived from either through esterification), which decrease intraocular pressure based on the action similar to that of ethacrynic acid and are useful as glaucoma remedies, are prepared Thus, Et 4-carboxycinnamate was refluxed with SOCl2 in the presence of one drop of DMF in CHCl3 for 30 min and concentrated in vacuo to give the acid chloride. A 0.5 M solution of potassium bis(trimethylsilyl)amide in PhMe was added dropwise to a solution of tert-Bu 2,3,4,5,6-pentafluorophenylacetate in THF under dry ice-cooling and after 5 min, treated dropwise with a solution of the acid chloride in THF. In 20 min after completing the addition, the resulting mixture was stirred at room temperature for 20 min to give 4-[(2,3,4,5,6-pentafluorophenyl)acetyl]cinnamic acid which was heated with paraformaldehyde and dimethylamine hydrochloride in dioxane containing one drop of AcOH under stirring overnight to give the title compound (II) in 93% yield. When intracamerally injected in living monkeys, 4-(2-ethylacryloyl)cinnamic effected the greatest mean intraocular pressure reduction (7.0 mmHg) after 6 h vs. 2.0 mmHg for ethacrynic acid. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Recommanded Product: 29704-38-9

The Article related to propenoylcinnamic acid preparation treatment glaucoma, propenoylphosphonovinylbenzene preparation treatment glaucoma, intraocular pressure reduction, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 29704-38-9

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 18, 1984, Entwistle, Ian David; Boehm, Peter published a patent.Application of 29704-38-9 The title of the patent was 3-(1-Tetralinyl)-4-hydroxycoumarins. And the patent contained the following:

Title compounds (n = 0, 1, 2; R = halo; R1 = biphenylyl, halo- or cyanophenyl, phenylfuryl, phenoxyphenyl, benzyloxyphenyl, phenethylphenyl, styrylphenyl), which were prepared, exhibited rodenticidal activity. 3-(4′-Trifluoromethyl-4-biphenylyl)-1-tetralol was treated with PBr3 and 4-hydroxycoumarin to give I [n = 0, R1 = 4-(4-F3CC6H4)C6H4]. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Application of 29704-38-9

The Article related to hydroxyphenylcoumarin preparation rodenticide, coumarin phenyl preparation rodenticide, phenylhydroxycoumarin preparation rodenticide, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Application of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 17, 2008, Hama, Takuo; Hartwig, John F. published an article.Application of 29704-38-9 The title of the article was Palladium-Catalyzed α-Arylation of Esters with Chloroarenes. And the article contained the following:

Palladium-catalyzed α-arylations of esters with chloroarenes are reported. The reactions of chloroarenes with the sodium enolates of tert-Bu propionate and Me isobutyrate occur in high yields with 0.2-1 mol % of {[P(t-Bu)3]PdBr}2 or the combination of Pd(dba)2 and P(t-Bu)3 as catalyst. The reactions of chloroarenes with the Reformatsky reagent of tert-Bu acetate were most challenging but occurred in high yields for chlorobenzene and electron-poor chloroarenes catalyzed by 1 mol % of Pd(dba)2 and pentaphenylferrocenyl di-tert-butylphosphine (Q-phos). The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Application of 29704-38-9

The Article related to ester enolate chloroarene palladium catalyst alpha arylation, reformatsky reagent butyl acetate chloroarene palladium catalyst alpha arylation, alpha aryl ester preparation and other aspects.Application of 29704-38-9

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schank, Kurt published an article in 1970, the title of the article was Base catalyzed rearrangement of α-acetoxy-β-oxosulfones. Signs for the intermediate existence of valence tautomeric α-acetoxyketenes.Category: esters-buliding-blocks And the article contains the following content:

Deprotonation of RCOCH(OAc)SO2R1 with tertiary bases leads to the formation of the shortlived intermediates RCOC-(OAc)SO2R1 ⇌ RC(O-):C(OAc)SO2R1 (I), which were trapped by azo coupling with p-N2+C6H4Cl to give RCO(AcO)C(SO2R1)N:NC6H4Cl-p (where R = Ph, C6H4CH:CH, p-MeOC6H4, or p-O2NC6H4 and R1 = Ph or p-MeC6H4). In inert solvents the tautomeric anions I undergo a fast acyl migration followed by elimination of RSO2-. The formation of the very reactive R(AcO)C:CO (II) is assumed, which can react with RSO2- in a known manner at the O atom or, depending on the p-substituents in II, can lead to the formation of p-O2NC6H4CH(OAc)SO2R (where R = Ph or p-MeC6H4) via valence tautomers of II. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Category: esters-buliding-blocks

The Article related to acetoxy oxo sulfones rearrangement mechanism, oxo acetoxy sulfones rearrangement mechanism, sulfones acetoxy oxo rearrangement mechanism, rearrangement mechanism acetoxy oxo sulfones and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 27, 2004, Bentz, Emilie; Moloney, Mark G.; Westaway, Susan M. published an article.Reference of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Palladium-catalysed α-arylation of esters and amides under microwave conditions. And the article contained the following:

A rapid and convenient approach for the α-arylation of esters and amides using Reformatsky reagents under a microwave accelerated reaction protocol was established. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to ester arylation reformatsky reagent palladium catalyst microwave irradiation, amide arylation reformatsky reagent palladium catalyst microwave irradiation, aryl ester preparation, aromatic amide preparation and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adapa, Srinivas R.; Prasad, Chalasani S. N. published an article in 1989, the title of the article was A mild and convenient preparation of tert-butyl esters by carbonylation of arylhalomethyl derivatives.Recommanded Product: tert-Butyl 2-(4-nitrophenyl)acetate And the article contains the following content:

An exceptionally mild and efficient, single-pot synthetic procedure is described for the tert-butoxycarbonylation of benzyl chloride derivatives Thus, treatment of PhCH2Cl with CO, NaOAc, PPh3, Me3COH, Pd(PPh3)2Cl2 (as catalyst), and Et3NCH2PhCl (as phase-transfer catalyst) at 80° gave 60% PhCH2CO2CMe3. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Recommanded Product: tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to ester tertiary butyl, phenylacetate dimethylethyl, carbonylation benzyl halide derivative catalytic, esterification benzoyl halide derivative, palladium carbonylation catalyst benzyl halide, butoxycarbonylation tertiary benzyl halide derivative and other aspects.Recommanded Product: tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2007, Urade, Yoshihiro; Shigeno, Kazuhiko; Tanaka, Yuki; Kuze, Jiro; Tsuchikawa, Michinori; Hosoya, Toshiyuki published a patent.Computed Properties of 29704-38-9 The title of the patent was Preparation of pyrimidine-5-carboxamide derivatives as prostaglandin D synthase inhibitors. And the patent contained the following:

The title compounds [I; R1 = (un)substituted 5- or 6-membered unsaturated heterocyclyl or Ph; R2 = unsaturated heterocyclyl containing 1-3 heteroatom(s) selected from N, O, and S atoms containing 0-2 number of R3(CH2)m group(s), Ph containing R3(CH2)m group(s) at one or both of 3- and 4-positions; m = 0-4; R3 = halo, cyano, NO2, (un)substituted and (un)saturated heterocyclyl, (un)substituted NH2, COR6, OR7, SR8; R6 = H,HO, (un)substituted C1-6 alkoxy or NH2; R7 = H, (un)substituted C1-6 alkyl, C2-6 alkenyl, (un)substituted carbonyl; R8 = H, (un)substituted C1-6 alkyl] or salts thereof are prepared These compounds exhibit high inhibitory effect on hematopoietic prostaglandin D synthase and are useful for the prevention and/or treatment of allergic diseases, inflammatory diseases, Alzheimer’s disease, or brain injury. Thus, 2-phenoxypyrimidine-5-carboxylic acid was condensed with 4-aminobenzoic acid tert-Bu ester using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 1-hydroxybenzotriazole in pyridine at 60° for 16 h to give 47% 2-phenoxy-N-(4-tert-butoxycarbonylphenyl)-5-pyrimidinecarboxamide (II). II and 2-phenoxy-N-[4-[2-[[(thiophen-2-yl)carbonyl]amino]ethyl]phenyl]-5-pyrimidinecarboxamide showed IC50 of 0.260 and 0.141 μg/mL, resp., against human hematopoietic prostaglandin D. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Computed Properties of 29704-38-9

The Article related to pyrimidinecarboxamide preparation hematopoietic prostaglandin d synthase inhibitor, allergy inflammation prevention treatment pyrimidinecarboxamide preparation, alzheimer disease brain injury prevention treatment pyrimidinecarboxamide preparation and other aspects.Computed Properties of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 10, 2011, Hu, Mingyu; Li, Lin; Wu, Hao; Su, Ying; Yang, Peng-Yu; Uttamchandani, Mahesh; Xu, Qing-Hua; Yao, Shao Q. published an article.Formula: C12H15NO4 The title of the article was Multicolor, one- and two-photon imaging of enzymatic activities in live cells with fluorescently quenched activity-based probes (qABPs). And the article contained the following:

Fluorescence imaging provides an indispensable way to locate and monitor biol. targets within complex and dynamic intracellular environments. Of the various imaging agents currently available, small mol.-based probes provide a powerful tool for live cell imaging, primarily due to their desirable properties, including cell permeability (as a result of their smaller sizes), chem. tractability (e.g., different mol. structures/designs can be installed), and amenability to imaging a wide variety of biol. events. With a few exceptions, most existing small mol. probes are however not suitable for in vivo bioimaging experiments in which high-resolution studies of enzyme activity and localization are necessary. Here, the authors report a new class of fluorescently quenched activity-based probes (qABPs) which are highly modular, and can sensitively image (through multiple enzyme turnovers leading to fluorescence signal amplification) different types of enzyme activities in live mammalian cells with good spatial and temporal resolution The authors also incorporated 2-photon dyes into their modular probe design, enabling for the 1st time activity-based, fluorogenic 2-photon imaging of enzyme activities. Thus, this expands the repertoire of ‘smart’, responsive probes currently available for live cell bioimaging experiments The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4

The Article related to enzyme imaging live cell fluorescently quenched activity based probe, caspase imaging live cell fluorescently quenched activity based probe, phosphatase imaging live cell fluorescently quenched activity based probe, fluorescently quenched activity based probe preparation enzyme imaging cell and other aspects.Formula: C12H15NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 23, 2009, Shishkov, Igor V.; Rominger, Frank; Hofmann, Peter published an article.Synthetic Route of 29704-38-9 The title of the article was Remarkably stable copper(I) α-carbonyl carbenes: synthesis, structure, and mechanistic studies of alkene cyclopropanation reactions. And the article contained the following:

Copper(I) iminophosphinamido α-acylcarbene complexes were prepared by ligand substitution of η2-ethene complex with 2-aryl diazoacetate esters and diazoacetamides; crystal structure, thermal decomposition and cyclopropanation kinetics were examined Reaction of [[tBu2P(NSiMe3)2κN,κN’]Cu(η2-C2H4)] (1) with 4-R1C6H4C(N2)COR2 [7a-g; R1 = NO2, OMe; R2 = OEt, OtBu, NMe2, OMe, OCH(1,4-C6H4Cl)2] gave the corresponding carbene complexes [[tBu2P(NSiMe3)2κN,κN’]Cu:C(COR2)-1,4-C6H4R1] (8a-g) whereas 2-diazo-N,N-diisopropylacetamide was unreactive. The rotation barriers around the Cu-Ccarbene and Ccarbene-CAr bonds or their low limits were determined for some of these compounds by 1H-VT-NMR spectroscopy. Carbene 8g [R1 = OMe, R2 = OCH(p-Cl-C6H4)2] was isolated in anal. pure, crystalline form as the first stable representative of this important class of compounds Its solid-state mol. structure revealed an orthogonal position of the carbene fragment relative to both the ligand plane and the ester C:O group and a remarkably short Cu-Ccarbene distance of 1.822(4) Å. Compound 8g reacted with styrene stereoselectively to give the corresponding trans-cyclopropane derivative and [tBu2P(NSiMe3)2-κ2N]Cu(η2-CH2:CHPh). The stoichiometric cyclopropanation of styrene with 8g and the previously described diarylcarbene [[tBu2P(NSiMe3)2-κ2N]Cu:C(p-NO2C6H4)2] (6) in toluene-d8 revealed that the reactions are first order in both the copper carbenes and the alkene. The activation parameters for 8g (ΔH⧧ = 51.5(9) kJ mol-1 and ΔS⧧ = -127.1(28) J mol-1 K-1) and for 6 (ΔH⧧ = 53.4(8) kJ mol1- and ΔS⧧ = -152.1(23) J mol-1 K-1) were derived from the kinetics of the cyclopropanation processes. Thermal decomposition of carbene 8g in toluene-d8 displayed first-order kinetics until 20-25% conversion with activation parameters ΔH⧧ = 85.5(24) kJ mol-1 and ΔS⧧ = -49.0(76) J mol-1 K-1. Solutions of 6 in toluene-d8 also decompose in a first-order fashion with ΔH⧧ = 66.1(20) kJ mol-1 and ΔS⧧ = -125.5(56) J mol-1 K-1. A Hammett study employing 8g and para-substituted styrenes afforded ρ = -1.06(19), demonstrating the electrophilic nature of α-carbonyl copper(I) carbene (Fischer-type) complexes. The electronic structure of 8 with R1 = R2 = OMe was investigated by DFT methods. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Synthetic Route of 29704-38-9

The Article related to copper carbene acylcarbene carboxycarbene complex preparation cyclopropanation kinetics, thermal decomposition kinetics copper acylcarbene carboxycarbene complex, diazoacetate diazoacetamide aryl complexation copper carbene complex preparation structure, crystal structure copper iminophosphinamide acylcarbene complex and other aspects.Synthetic Route of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics