Category: 29704-38-9

On October 15, 2008, Riss, Patrick J.; Kroll, Carsten; Nagel, Verena; Roesch, Frank published an article.Formula: C12H15NO4 The title of the article was NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. And the article contained the following:

This report concerns synthesis, 68Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothio-cyanatophenyl-acetic acid (NODAPA-NCS), 1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenyl-acetic acid (NODAPA-(NCS)2) and 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid (NODAPA-OH), versatile bifunctional chelators with potential for mol. imaging. Protein binding and exemplified conjugation are also reported. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4

The Article related to nodapa oh ncs preparation chelator gallium 68 imaging, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Formula: C12H15NO4

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Claveau, Romain; Twamley, Brendan; Connon, Stephen J. published an article in 2018, the title of the article was Dynamic kinetic resolution of bis-aryl succinic anhydrides: enantioselective synthesis of densely functionalised γ-butyrolactones.SDS of cas: 29704-38-9 And the article contains the following content:

The efficient Dynamic Kinetic Resolution (DKR) of disubstituted anhydrides has been shown to be possible for the first time. Using an ad hoc designed organocatalyst and an enantio- and diastereoselective cycloaddition process with aldehydes, stereochem. complex γ-butyrolactone derivatives can be obtained – with control over three contiguous stereocentres, one of which is all carbon quaternary. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).SDS of cas: 29704-38-9

The Article related to butyrolactone enantioselective preparation, bisarylsuccinic anhydride preparation arylaldehyde dynamic kinetic resolution organocatalyst, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.SDS of cas: 29704-38-9

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On May 26, 2000, Kubo, Keiji; Hori, Akira; Kusaka, Masami published a patent.Category: esters-buliding-blocks The title of the patent was Benzimidazole derivatives as neovascularization inhibitors and pharmaceutical compositions containing them. And the patent contained the following:

Neovascularization inhibitors contain the derivatives I [ring A = (un)substituted phenyl; ring B = (un)substituted cyclyl; R4, R6 = (1) H, (ii) C1-6 alkyl which may have substituents selected from mono- or di(C1-6 alkyl)amino, 5-7-membered cyclic amino, CO2H, or C2-7 alkoxycarbonyl, (iii) C2-6 alkenyl, (iv) C3-7 cycloalkyl, (v) C7-13 aralkyl which may have 1-5 substituents selected from halo, C1-6 alkoxy, C1-6 alkyl, mono- or di(C1-6 alkyl)amino, (vi) C2-7 alkoxycarbonyl; R5 = (i) H, (ii) halo, (iii) C1-6 alkyl which may have substituents selected from mono- or di(C1-6 alkyl)amino and halo, (iv) C1-6 alkoxy, (v) C2-7 alkoxycarbonyl, (vi) mono- or di(C1-6 alkyl)amino, (vii) carbamoyl which may be substituted with C1-6 alkyl or C7-13 aralkyl; X = (i) direct bond, (ii) C1-6 alkylene, (iii) C2-6 alkenylene, (iv) C1-6 alkylene-aminocarbonyl, (v) C1-6 alkylene-oxycarbonylamino; Y = CO, SO2, NHCO, C1-6 alkylenecarbonyl, C2-6 alkenylenecarbonyl, C1-6 alkylene] or their pharmaceutically acceptable salts. Also claimed are pharmaceutical compositions containing I or their salts for treatment of neoplasm, inflammatory diseases, diabetic retinopathy, etc. IC50 of 2-(4-methoxyphenyl)-5-[3-methoxy-4-(4-pyridyl)methoxybenzoyl]aminobenzimidazole (preparation given) against recombinant VEGF-induced proliferation of HUVEC was 0.012 μM. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Category: esters-buliding-blocks

The Article related to benzimidazole derivative preparation neovascularization inhibitor, angiogenesis inhibitor benzimidazole derivative preparation, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Category: esters-buliding-blocks

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On January 5, 1986, Iwasaki, Genji; Saeki, Seitaro; Hamana, Masatomo published an article.Safety of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Nucleophilic substitution of p-dinitrobenzene with some carbanions. Formation of p-substituted nitrobenzenes. And the article contained the following:

Treatment of p-O2NC6H4NO2 with RH (R = CH2COMe, CHMeCOEt, CHEtCOMe, CMe2COCHMe2, CH2CO2Et, CH2CO2CMe3, CH2CN, CHPhCN, CMePhCN, PhNH 2-oxocyclopentyl, 2-oxocyclohexyl, cyano-1-naphthylmethyl, 2-pyridylamino) in the presence of Me3COK in liq NH3 at -70° gave p-O2NC6H4R in 18-97.6% yields. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Safety of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to nitrobenzene nucleophile substitution, carbanion substitution dinitrobenzene, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Safety of tert-Butyl 2-(4-nitrophenyl)acetate

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Wu, Jianhong; Chen, Dongyin; Li, Fei published an article in 2016, the title of the article was Synthesis of tert-butyl ethers and tert-butyl esters catalyzed by acid-treated montmorillonite supported zinc chloride.Reference of tert-Butyl 2-(4-nitrophenyl)acetate And the article contains the following content:

With acid-treated montmorillonite supported zinc chloride (H-mont/ZnCl2) as the catalyst, phenols, alcs., and carboxylic acid were reacted with di-tert-Bu bicarbonate to give tert-Bu ether and tert-Bu ester derivatives at 120°C in sealed tube with yields ranging from 61% to 75%, which was simple and environmentally friendly. All the compounds synthesized were confirmed by 1H NMR and ESI-MS. The effects of solvent, temperature, metal ion and some other factors to the reaction were investigated. A possible mechanism for this reaction was proposed. The study provided a new method for this type of synthesis in the future. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to tert butyl ether ester synthesis montmorillonite zinc chloride catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

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On December 31, 1988, Mudryk, B.; Makosza, M. published an article.Reference of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Reactions of organic anions. 156. A simple and efficient synthesis of alkyl (2-nitroaryl)acetates and alkyl 2-(2-nitroaryl)propanoates via vicarious nucleophilic substitution of hydrogen in nitroarenes by carbanions of alkyl chloroacetates or alkyl 2-chloropropanoates. And the article contained the following:

Reaction of RC6H4NO2 (R = 4-Cl, 4-F, H, 3-CF3) with ClCHR1CO2R2 (R1 = H, Me; R2 = CMe3, Et) gave the 2-nitroarylalkanoates I. Small amounts of the 4-nitroarylalkanoates II (R = H, CF3, R1 = H, R2 = CMe3; R = H, R1 = Me, R2 = Et) were also formed. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to chloroalkanoate substitution nitrobenzene, nitrophenylalkanoate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 17, 2022, Chen, Xiangyang; Pang, Yucheng published a patent.Electric Literature of 29704-38-9 The title of the patent was Pyridazine-3-carboxamide compound, its preparation and application in medicine. And the patent contained the following:

Disclosed in the present invention are a pyridazine-3-formamide compound suitable for inhibiting or regulating the Janus kinase (JAK), in particular tyrosine kinase 2 (TYK2), and a preparation method therefor and the medical use thereof. In particular, disclosed in the present invention are a compound as represented by general formula I and a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof, a method for treating and/or preventing Janus kinase-mediated related diseases, in particular autoimmune diseases, inflammatory diseases and cancers, by means of using the compound or the pharmaceutically acceptable salt thereof, and a method for preparing the compound or the pharmaceutically acceptable salt thereof. Each substituent of general formula I has the same definition as that in the description. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Electric Literature of 29704-38-9

The Article related to pyridazine carboxamide preparation janus kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 29704-38-9

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On February 21, 2020, Chen, Xiangyang; Pang, Yucheng published a patent.Synthetic Route of 29704-38-9 The title of the patent was Pyridazine-3-carboxamide compound, its preparation and application in medicine. And the patent contained the following:

The invention relates to pyridazine-3-carboxamide compound of formula I as Janus Kinase inhibitor, its preparation and application for treatment of Janus Kinase-mediated diseases. Compounds I, wherein Z is N or CR1; ring A is substituted C6-10 aromatic ring or 5-10-membered aromatic hetero-ring; L is a bond or substituted C1-6 alkylene; R is H, halogen, cyano, SF5, etc.; R1 is H, halo, CN, etc.; Ra, Rb, Rc , Rd and Re are independently H, halo, CN, etc.; their pharmaceutically acceptable salts, prodrug, isomers or mixtures, are claimed. The inventive compound is capable of inhibiting or controlling Janus kinase, especially tyrosine kinase 2, and can be applied to the prevention and treatment of Janus kinase-mediated diseases, especially autoimmune disease, inflammatory disease and cancer. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Synthetic Route of 29704-38-9

The Article related to pyridazine carboxamide preparation janus kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Synthetic Route of 29704-38-9

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Numata, Youhei; Ashraful, Islam; Shirai, Yasuhiro; Han, Liyuan published an article in 2011, the title of the article was Preparation of donor-acceptor type organic dyes bearing various electron-withdrawing groups for dye-sensitized solar cell application.Name: tert-Butyl 2-(4-nitrophenyl)acetate And the article contains the following content:

Novel donor-π-spacer-acceptor type organic dyes bearing various electron-withdrawing groups on their acceptor part were synthesized by Knoevenagel condensation with acetic acid silyl ester derivatives Dye-sensitized solar cells with the new dyes present solar light-to-electricity conversion efficiency of 2.51-4.05%. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Name: tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to donor acceptor type organic dye electron withdrawing group, triphenylamine bithiophene based dye sensitized solar cell, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Name: tert-Butyl 2-(4-nitrophenyl)acetate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 5, 1986, Iwasaki, Genji; Saeki, Seitaro; Hamana, Masatomo published an article.Quality Control of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was A novel nucleophilic substitution of the formyl group in p-nitrobenzaldehyde with some carbanions. And the article contained the following:

p-O2NC6H4CHO (I) reacted with some active methylene compounds in the presence of a strong base at low temperatures to give p-substituted nitrobenzenes by a 2-step course involving the initial formation of the aldol adducts and the subsequent displacement of the carbinol moieties with excess carbanions. p-O2NC6H4CHROH were formed preferentially from RH (R = CHMeCOPh, CHMeCOEt, CH2CO2CMe3) or exclusively from RH [R = CMe2, COCHMe2, CH(CN)2]. Thus, I was added to MeCOPr in Me3COK in liquid NH3 at -70° to give 85% p-O2NC6H4CH2COPr. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Quality Control of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to nucleophile substitution nitrobenzaldehyde carbanion, formyl group substitution carbanion, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Aldehydes and Derivatives, Including Sulfur Analogs and other aspects.Quality Control of tert-Butyl 2-(4-nitrophenyl)acetate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics