Category: 29704-38-9

Newman, Melvin S.; Beal, Philip F. III published an article in 1950, the title of the article was Improved Wolff rearrangement in homogeneous medium.HPLC of Formula: 29704-38-9 And the article contains the following content:

The Wolff rearrangement of α-diazo ketones to esters with MeOH and Ag2O gives erratic results. BzOAg (1 g.) in 9.1 g. NEt3 with the diazo ketone in MeOH works much better. The basic properties of NEt3 seem important, as F3CCO2Ag in C6H6 did not react. The reaction can be inhibited by a solution of hydroquinone. The presence in the diazo ketone of a H in the α-position to both the carbonyl and the diazo group is necessary. A possible reaction mechanism is presented. tert-Bu p-nitrophenylacetate b10 164-8°. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).HPLC of Formula: 29704-38-9

tert-Butyl 2-(4-nitrophenyl)acetate(cas:29704-38-9) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. HPLC of Formula: 29704-38-9

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On December 28, 2011, Gao, Lizhu; Hwang, Geum-Sook; Ryu, Do Hyun published an article.Reference of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Oxazaborolidinium Ion-Catalyzed Cyclopropanation of α-Substituted Acroleins: Enantioselective Synthesis of Cyclopropanes Bearing Two Chiral Quaternary Centers. And the article contained the following:

A catalytic synthetic route to highly functionalized chiral cyclopropane derivatives was developed by Michael-initiated cyclopropanation of α-substituted acroleins with aryl- and alkyl diazoacetates. In the presence of chiral (S)-oxazaborolidinium cation I as a catalyst, the reaction proceeded in high yield (up to 93%) with high to excellent diastereoselectivity (up to 98% de) and enantioselectivity (up to 95% ee). The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to alpha substituted acrolein diazoacetate chiral oxazaborolidinium catalyst cyclopropanation, cyclopropane stereoselective preparation, Alicyclic Compounds: Cyclopropanes and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

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Ester – Wikipedia,
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On September 6, 2013, Zhang, Ningning; Yang, Rui; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang published an article.Reference of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Direct Conversion of N-Alkoxyamides to Carboxylic Esters through Tandem NBS-Mediated Oxidative Homocoupling and Thermal Denitrogenation. And the article contained the following:

Treatment of N-alkoxyamides with NBS in toluene was found to conveniently afford the corresponding carboxylic esters, including those bearing a bulky or long-chain substituent, in satisfactory to excellent yields. This approach not only represents a convenient and economical approach to a direct transformation of an alkoxyamide moiety into the carboxylic ester functional group, via oxidative homocoupling and the subsequent thermal denitrogenation, but also facilitates the synthesis of sterically hindered carboxylic esters. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to alkoxy amide preparation conversion carboxylic ester nbs, General Organic Chemistry: Synthetic Methods and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

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Ester – Wikipedia,
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On September 6, 2013, Hama, Takuo; Ge, Shaozhong; Hartwig, John F. published an article.Name: tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Palladium-Catalyzed α-Arylation of Zinc Enolates of Esters: Reaction Conditions and Substrate Scope. And the article contained the following:

The intermol. α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with isolated Reformatsky reagents, with Reformatsky reagents generated from α-bromo esters and activated zinc, and with zinc enolates generated by quenching alkali metal enolates of esters with zinc chloride. The use of zinc enolates, instead of alkali metal enolates, greatly expands the scope of the arylation of esters. The reactions occur at room temperature or at 70° with bromoarenes containing cyano, nitro, ester, keto, fluoro, enolizable hydrogen, hydroxyl, or amino functionality and with bromopyridines. The scope of esters encompasses acyclic acetates, propionates, and isobutyrates, α-alkoxyesters, and lactones. The arylation of zinc enolates of esters was conducted with catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) or the highly reactive dimeric Pd(I) complex {[P(t-Bu)3]PdBr}2. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Name: tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to palladium catalysis alpha arylation ester aryl bromide zinc enolate, General Organic Chemistry: Synthetic Methods and other aspects.Name: tert-Butyl 2-(4-nitrophenyl)acetate

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On March 23, 2022, there was a patent about aldoses.SDS of cas: 29704-38-9 The title of the patent was Molecules with solubility tag and related methods. And the patent contained the following:

The present disclosure relates to mols. comprising a targeting moiety, at least one payload wherein said at least one payload is a therapeutic agent or a detectable lable, a linker/linkers covalently linking said payload/payloads and said targeting moiety, and at least one solubility tag, wherein said solubility tag comprises at least 3 and up to 12 monosaccharide units. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).SDS of cas: 29704-38-9

The Article related to pharmaceutical conjugate solubility tag chitooligosaccharide monosaccharide, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 24, 2022, Deutsch, Carl; Kelly, Sven; Crassier, Helene; Korpus, Christoph; Von Hagen, Joerg; Richter-Sander, Ulrike published a patent.Computed Properties of 29704-38-9 The title of the patent was Molecules with solubility tag and related methods. And the patent contained the following:

The present disclosure relates to mols. with a solubility tag, wherein the solubility tag comprises a chito-oligosaccharide, and to methods for increasing the solubility of a mol. Moreover, the present disclosure relates to antibody-drug conjugates with solubility tag, methods and compounds for preparing such antibody-drug conjugates, methods for increasing the solubility of antibody-drug conjugates, antibody-drug conjugates prepared by such methods, as well as the use of such antibody-drug conjugates in medical treatment. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Computed Properties of 29704-38-9

The Article related to pharmaceutical conjugate solubility tag chitooligosaccharide monosaccharide, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 18, 2020, Wang, Qian; Ni, Chuanfa; Hu, Mingyou; Xie, Qiqiang; Liu, Qinghe; Pan, Shitao; Hu, Jinbo published an article.Computed Properties of 29704-38-9 The title of the article was From C1 to C3: Copper-Catalyzed gem-Bis(trifluoromethyl)olefination of α-Diazo Esters with TMSCF3. And the article contained the following:

A Cu-catalyzed gem-bis(trifluoromethyl)olefination of α-diazo esters, using TMSCF3 as the only fluorocarbon source, was developed and provides an exquisite method to access gem-bis(trifluoromethyl)alkenes. This unprecedented olefination process involves a carbene migratory insertion into “CuCF3” to generate the α-CF3-substituted organocopper species, which then undergoes β-fluoride elimination and two consecutive addition-elimination processes to give the desired products. The key to this efficient one-pot C1-to-C3 synthetic protocol lies in the controllable double (over single and triple) trifluoromethylations of the gem-difluoroalkene intermediates. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Computed Properties of 29704-38-9

The Article related to copper catalyst gemtrifluoromethylolefination alpha diazo ester tmscf, copper, diazo compounds, fluorine, olefins, synthetic methods, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 1996, Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B. published an article.Recommanded Product: 29704-38-9 The title of the article was New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link. And the article contained the following:

Antibody-directed enzyme prodrug therapy (ADEPT) is a two-step approach for the treatment of cancer which seeks to generate a potent cytotoxic agent selectively at a tumor site. In this work described the cytotoxic agent is generated by the action of an enzyme CPG2 on a relatively nontoxic prodrug. The prodrug I (R = MeSO3, X = CO), currently on clin. trial is a benzamide and is cleaved by CPG2 to a benzoic acid mustard drug II (R1 = CO2H). The authors have synthesized a series of new prodrugs I (R = Cl, X = O2C, NHCO, CH2CO, SCO, COS, CH2CS) where the benzamide link has been replaced by, for example, carbamate or ureido. Some of these alternative links are good substrates for CPG2 and therefore new candidates for ADEPT. The active drugs II (R = Cl, R1 = OH, NH2), derived from the best of these prodrugs are potent cytotoxic agents (1-2 μM) some 100 times more than I( R= MeSO3, R1 = CO2H). The prodrugs I (R = Cl, X = O2C, NHCO) are some 100-200-fold less cytotoxic, in a proliferating cell assay, than their corresponding active drugs II. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Recommanded Product: 29704-38-9

The Article related to glutamate mustard prodrug preparation cytotoxicity, antibody directed enzyme prodrug therapy substrate, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 1988, Pozdnev, V. F. published an article.Application of 29704-38-9 The title of the article was Activation of carboxylic acids by pyrocarbonates. Synthesis of tert-butyl esters of N-substituted amino acids from di-tert-butyl pyrocarbonate in the presence of pyridine and 4-(dimethylamino)pyridine. And the article contained the following:

Several N-protected amino acids as well as 4-O2NC6H4CH2CO2H were converted into their tert-Bu esters by treatment with (Boc)2O (Boc = Me3CO2C) in the presence of pyridine and 4-(dimethylamino)pyridine. The Boc-protected amino acid tert-Bu esters were deblocked by treatment with p-MeC6H4SO3H in MeCN. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Application of 29704-38-9

The Article related to tertbutyl ester protected amino acid, ditertbutyl pyrocarbonate esterification amino acid, pyridine tertbutyl esterification agent, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Application of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amin, Hassan B.; Taylor, Roger published an article in 1978, the title of the article was The mechanism of the gas-phase pyrolysis of esters. Part 6. Pyrolysis of 1-arylethyl benzoates and tert-butyl phenylacetates.HPLC of Formula: 29704-38-9 And the article contains the following content:

Rate coefficients for pyrolysis of RC6H4CH(OAc)Me (R = H, p-, m-Me, -Cl, -NO2, p-CF3) were determined at 617.9-68.4 K and the log krelative values give an excellent correlation with σ+ values with ρ -0.72 at 600 K; this confirms that the polarity of the transition state for benzoate pyrolysis is greater than that for acetates and less than for carbonates. Rate coefficients for pyrolysis of RC6H4CH2CO2CMe3 (R = p-OMe, -Me, -F, -Cl, -NO2, m-Me, -Cl, H), determined at 543.3-600.8 K, give log krelative values which correlate with σ0 values with ρ 0.39 at 600 K, confirming that the polarity of the transition state for phenylacetate pyrolysis is less than that for benzoates and N-phenylcarbamates. The phenylacetate data correlate better with σn values, confirming that these are more accurate resonance-free substituent constants than are σ0 values. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).HPLC of Formula: 29704-38-9

The Article related to kinetics pyrolysis phenylethyl benzoate, butyl phenylacetate pyrolysis kinetics, Physical Organic Chemistry: Degradation Reactions and other aspects.HPLC of Formula: 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics