Category: 2915-53-9

Electric Literature of 2915-53-9, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2915-53-9, Name is Dioctyl maleate, SMILES is O=C(OCCCCCCCC)/C=CC(OCCCCCCCC)=O, belongs to esters-buliding-blocks compound. In a article, author is Nija, B., introduce new discover of the category.

Development, Characterization, and Pharmacological Investigation of Sesamol and Thymol Conjugates of Mefenamic Acid

BACKGROUND Prodrug technology was extensively employed in the drug discovery processes and many approved drugs in the pharmaceutical industry were developed by the prodrug based synthetic approach. The current research work investigates the effect of the prodrug approach on the mefenamic acid by synthesizing the ester conjugates with natural antioxidants such as sesamol and thymol. METHODS Synthesis of two ester prod rugs, mefenamic acid-sesamol conjugate and mefenamic acid-thymol conjugate by coupling method using DCC / DMAP, subjected to physicalchemical characterization, spectral characterization (IR, H-1 NMR, C-13 NMR and Mass spectra), in-silico studies, in-vivo biodistribution studies and pharmacological evaluation such as anti-inflammatory, ulcerogenecity, activity in the brain as well as histopathological evaluation. RESULTS The ester prodrugs of mefenamic acid which upon administration would release the parent drug as a result of enzymatic or non-enzymatic hydrolysis in the desired areas with enhanced anti-inflammatory activity and reduction in the gastro intestinal toxicity. In-silico studies showed the docking score of mefenamic acid on the beta-secretase enzyme is – 7.834 and the bio-distribution study showed the enhanced distribution of the mefenamic acid in the brain. Pharmacological study and histopathology studies using the brain tissues showed the protective effect of mefenamic acid in the brain. CONCLUSIONS Antioxidant conjugates of mefenamic acid showed sustained release of the mefenamic acid and enhanced anti-inflammatory activity with reduction in the gastric toxicity. The present investigation also revealed that the enhanced transport profile across blood brain barrier and considerable protective effect in the brain against neurodegenerative conditions.

Electric Literature of 2915-53-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2915-53-9 is helpful to your research.

Application of 2915-53-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 2915-53-9, Name is Dioctyl maleate, SMILES is O=C(OCCCCCCCC)/C=CC(OCCCCCCCC)=O, belongs to esters-buliding-blocks compound. In a article, author is Shimamoto, Kei, introduce new discover of the category.

Preparation and characterization of composite quasi-solid electrolytes composed of 75Li(2)S center dot 25P(2)S(5) glass and phosphate esters

Mechanical properties and ionic conductivities of solid electrolytes are important factors influencing the performance of all-solid-state batteries. This study investigates composite quasi-solid electrolytes composed of Li2S-P2S5 glass and a phosphate ester, prepared via planetary ball milling, and the relative densities of the powder-compressed pellets, formed using the composite quasi-solid electrolytes. Dense pellets of the Li2S-P2S5 glass electrolyte are obtained via addition of phosphate esters; the relative densities increase from 90.6% to 93.1%, without the ionic conductivities decreasing, upon addition of a small quantity of tris (2, 2, 2-trifluoroethyl) phosphate to the Li3PS4 glass. The addition of small quantities of phosphate esters to sulfide solid electrolytes is effective in improving the formability of these solid electrolytes.

Application of 2915-53-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2915-53-9.