Category: 2905-67-1

Application of 2905-67-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2905-67-1, name is Methyl 3,5-dichlorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 25 g of 3,5-dichlorobenzoic acid methyl and 22.5 g of trifluoromethyltrimethylsilane in 300 g of dimethoxyethane, 0.37 g of cesium fluoride was added with ice-cooling and the mixture was warmed to room temperature and stirred for 4 hours. After disappearance of the raw material was confirmed, 200 g of water was put into the reaction solution to extract with 200 g of ethyl acetate. After the organic layer was dehydrated and dried with saturated saline followed by anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to obtain 35.5 g of 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-trimethylsilyloxy-1-methoxyethane as yellow liquid matter.

The chemical industry reduces the impact on the environment during synthesis Methyl 3,5-dichlorobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nissan Chemical Industries, Ltd.; EP1975149; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2905-67-1 as follows. Computed Properties of C8H6Cl2O2

Methyl 3,5-dichlorobenzoate (2-D) (1.07 g, 5.0 mmol) was suspended in a vigorously stirring solution of methylamine (40%/H20, 5.0 mL). After heating gently for 10 min, the mixture was stirred at room temperature for 18 h. The mixture was extracted with methylene chloride and the extract dried (MgS04) to provide 3,5-dichloro-N-methylbenzamide (2-E).

According to the analysis of related databases, 2905-67-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2005/97759; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 2905-67-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2905-67-1 as follows.

Step A: Preparation of 1 -(3,5 -dichlorophenyl)-3 -(2-fluorophenyl)- 1,3 -propanedioneTo a solution of tetrahydrofuran (20 mL) and sodium hydride (60% dispersion in mineral oil, 0.35 g, 8.7 mmol) was added 2?-fluoroacetophenone (0.59 mL, 4.9 mmol), followed by 3,5-dichlorobenzoic acid methyl ester (1.0 g, 4.9 mmol). The mixture was heated at reflux for 24 h. After cooling to ambient temperature, 1 N aqueous hydrochloricacid was added, and the mixture was extracted three times with dichloromethane. The extracts were combined, dried with Mg504 and filtered. The filtrate was concentrated to give a tan solid (1.8 g), which was used without further purification.

According to the analysis of related databases, 2905-67-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; SELBY, Thomas Paul; TRAVIS, David Andrew; DEPREZ, Nicholas Ryan; SATTERFIELD, Andrew Duncan; WO2015/167795; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics