Category: 2901-13-5

Electric Literature of 2901-13-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 2-(4-Formylphenyl)-2-Methylpropionate (formula II; R1 =COOEt) (alternate synthesis): Ethyl 2-phenyl-2-methylpropionate (10 g) was dissolved in 50 mL of dichloromethane and cooled to 5 C. Titanium tetrachloride (10.5 mL) and 1,1-dichloromethyl methyl ether (7.5 mL) were added and the mixture was stirred at room temperature for 60 hours. The resulting dark solution was diluted with 50 mL of dichloromethane and washed twice with 50 mL of water. The organic solution was concentrated to give an oil which was treated with 30 mL of saturated aqueous sodium bisulfite solution for 12 hours. The precipitate was collected by filtration, washed with hexane, suspended in ethyl acetate and treated with excess potassium carbonate. The organic phase was separated, dried with sodium sulfate and stripped to provide 2 g of product. Ethyl 2-[3-(1,3-Dioxolan-2-yl)-1-HydroxyPropylphenyl]-2-Methylpropionate:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-methyl-2-phenylpropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sepracor Inc.; US5925761; (1999); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 2901-13-5, These common heterocyclic compound, 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution – o’f 1 g- 2-methyl-2-phenyl-propionic acid ethyl ester in a mixture of 14 ml ‘sulfuric acid and 1 ml nitric acid was stirred at room temperature for 4 hours. The mixture was added to ice water and extracted with ethyl acetate. The organic layer wa’s washed with a satured aqueous solution of sodium hydrogen carbonate and dried over – anhydrous sodium sulfate. Filtration and concentration of the solvent under reduced pressure yielded a yellow solid;. The residue was purified- by, .flash chromatography on silica gel with a n-heptane/ dichloro-methane gradient. The fractions containing the product were combined and evaporated . to yield a yellow solid. Yield: 560 -mg.’- ‘ ‘ ‘M+H+. measured = ? ? ? ?1H-NMR’ (400 MHz, DMSO/TMS.)’1: ‘d = 8.69 (d, 1H) ; 8.5.3. (dd,’1H-); 8.10 ? (d, ‘1H) ; -”4 I 02 (q,–2H); 1.65 (s, 6H) ; ,1> 12 (t,

Statistics shows that Ethyl 2-methyl-2-phenylpropanoate is playing an increasingly important role. we look forward to future research findings about 2901-13-5.

Reference:
Patent; AVENTIS PHARMA S.A.; WO2006/10642; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 2901-13-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.

4-Iodo-(1′-carboxy-1′-methyl)ethylbenzene. A mixture of (1′-ethoxycarbonyl-1′-methyl)ethylbenzene (28.0 g, 146 mmol), iodine (24.7 g), sodium iodate (7.1 g) and concentrated sulfuric acid (4 ML) in acetic acid (200 ML) was stirred and heated at 55 C for 90 hours.. The solvent was evaporated and the residue was partitioned between water and hexane.. The organic phase was washed with aqueous sodium thiosulfate, dried, filtered, and evaporated.. The residue was taken up in ethanol (200 ML) and water (100 ML), and potassium hydroxide (20 g) was added.. The mixture was heated under reflux for 5 hours, and cooled to rt.. The mixture was washed with hexane.. The aqueous phase was acidified with concentrated hydrochloric acid, and extracted with hexane.. The organic phase was dried, filtered and evaporated to give 4-iodo-(1′-carboxy-1′-methyl)ethylbenzene as a solid (19.6 g, 67 mmol, 46%).

The chemical industry reduces the impact on the environment during synthesis Ethyl 2-methyl-2-phenylpropanoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; EP1171113; (2004); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2901-13-5

Place aluminum chloride (586 g, 4.4 moles) and methylene chloride (300 mL) in a 2 L 3-neck round bottom flask equipped with an overhead stirrer, dry ice condenser, and nitrogen atmosphere. Cool to 10 C. and add, by dropwise addition, chlorobutyryl chloride (338 g, 2.4 moles), keeping the temperature below 15 C. After addition is complete, add, by dropwise addition, ethyl 2-methyl-2-phenylpropionate (384 g, 2 mol), keeping the temperature below 15 C. After addition was complete, warm the reaction mixture to 22 C. and stir for 1 hour. Raise the temperature to 90 C., stir for 90 minutes, cool to room temperature and slowly pounr into a 6 L stirred flask containing ice/water (4 kg). Filter through a celite precoat, separate the organic phase and wash the aqueous phase with methylene chloride (50 mL). Evaporate the solvent in vacuo to give a mixture of 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-proprionic acid, ethyl ester and 2-[3-(4-chloro-butyryl)-phenyl]-2-methyl-proprionic acid, ethyl ester.

The synthetic route of 2901-13-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merrell Pharmaceuticals, Inc.; US6348597; (2002); B2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 2901-13-5, These common heterocyclic compound, 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2: Synthesis of 2-(4-(chloroacetyl)phenyl)-2-methylpropionic acid ethyl esterIn a 5L reaction flask, add 2,2-dimethylphenylacetic acid ethyl ester (542g, 2.8mol), 2L dichloromethane solution. Stir. Add anhydrous aluminum chloride (600g, 4.5mol), then add dropwise a chloroacetyl chloride (318.6g,2.8mol) in 500mL of methylene chloride mixture. After reacting for a period,detection by TLC finish the reaction was stopped, the organic layer was separated, and the organic layer washed with water, saturated sodium bicarbonate solution , washed with saturated sodium chloride solution, dried and concentrated to give 2-(4-(chloroacetyl)phenyl)-2-methylpropionic acid ethyl ester (660g, 87%).

The synthetic route of 2901-13-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Huawe Medicine Technology Development Co., Ltd.; Xu, Feng; Hu, Dandan; Huang, Hui; Jiang, Yuwei; Zhang, Xiaoqing; (6 pag.)CN104276952; (2016); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics