Category: 2873-29-2

Kumar, Manoj; Reddy, Thurpu Raghavender; Gurawa, Aakanksha; Kashyap, Sudhir published an article in 2020, the title of the article was Copper(II)-catalyzed stereoselective 1,2-addition vs. Ferrier glycosylation of “armed” and “disarmed” glycal donors.Related Products of 2873-29-2 And the article contains the following content:

Selective activation of “armed’ and ”disarmed” glycal donors enabling the stereo-controlled glycosylations by employing Cu(II)-catalyst as the promoter has been realized. The distinctive stereochem. outcome in the process is mainly influenced by the presence of diverse protecting groups on the donor and the solvent system employed. The protocol is compatible with a variety of aglycons including carbohydrates, amino acids, and natural products to access deoxy-glycosides and glycoconjugates with high α-anomeric selectivity. Notably, the synthetic practicality of the method is amply verified for the stereoselective assembling of trisaccharides comprising 2-deoxy components. Mechanistic studies involving deuterated experiments validate the syn-diastereoselective 1,2-addition of acceptors on the double bond of armed donors. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to trisaccharide stereoselective addition copper catalyzed glycoconjugate glycal nucleoside, amino acid glycoside preparation stereoselective glycosylation ferrier glycal alc and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Harikesh; Dubey, Atul; Prajapati, Gurudayal; Kant, Ruchir; Ampapathi, Ravi S.; Mandal, Pintu Kumar published an article in 2022, the title of the article was Regioselective direct sulfenylation of glycals using arylsulfonyl chlorides in the presence of triphenylphosphine: access to C2-thioaryl glycosides.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:

Direct triphenylphosphine-mediated regioselective sulfenylation of glycals by using various cheap and easily available aryl sulfonyl chlorides as a sulfur source to generate different C2-S-aryl-glycosides was developed. Notably, the features of this protocol offer a milder and easier operational procedure, and broad substrate scope with complete regioselectivity at C-2. Experiments and DFT calculations supported the proposed mechanism and regioselectivity for the formation of C2-S-aryl-glycosides. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to regioselective sulfenylation glycal arylsulfonyl chloride phenylphosphine aryl thioglycoside, crystal structure transition state glycal monosaccharide preparation thioaryl glycoside and other aspects.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 7, 2021, Chen, Peiran; Dai, Xueqi published an article.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Site-specific synthesis of 3-Se-1,2-unsaturated glycosides with R-Se-Se-R as the nucleophile precursors promoted by InCl3/Hf(OTf)4. And the article contained the following:

By using Hf(OTf)4 as the catalyst, a series of 3-Se 1,2-unsaturated glucosides, e.g. I, have been synthesized site-specifically from tri-O-acetyl-D-glucal, 3,4-di-O-acetyl-L-rhamnal or 2,4,6-tri-O-benzyl-D-glucal with alkyl(aryl) hydroselenides as the nucleophile precursors in good yield. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to substitution catalyst selenoglycoside preparation hafnium triflate indium chloride catalyst, selenoglycoside preparation hafnium triflate indium chloride catalyst selenylation glycal and other aspects.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 25, 2022, Addanki, Rupa Bai; Halder, Suvendu; Kancharla, Pavan K. published an article.SDS of cas: 2873-29-2 The title of the article was TfO-···H-O-H Interaction-Assisted Generation of a Silicon Cation from Allylsilanes: Access to Phenylallyl Ferrier Glycosides from Glycals. And the article contained the following:

We demonstrate here that the strained and bulky protonated 2,4,6-tri-tert-butylpyridine (TTBPy) triflate salt serves as a mild and efficient organocatalyst for the diastereoselective C-Ferrier glycosylation of various glycals. The criticality of the role of 1/2 H2O mol. trapped in the catalyst has been disclosed. The mechanism of action involves unique anionic triflate and H2O hydrogen bond interactions assisting the activation of allylsilanes that provides unprecedented access to diastereoselective phenylallyl Ferrier glycosides. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).SDS of cas: 2873-29-2

The Article related to organocatalyst diastereoselective ferrier glycosylation glycal allylsilane hydrogen bond, crystal structure diastereoselective phenylallyl ferrier glycoside allylsilane silicon cation and other aspects.SDS of cas: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Wang; Wang, Hao; Zeng, Jing; Wan, Qian published an article in 2021, the title of the article was Practical synthesis of 2-deoxy sugars via metal free deiodination reactions.Formula: C12H16O7 And the article contains the following content:

2-Deoxy-glycosides, in which the C-2 hydroxyl group is replaced with a hydrogen atom, are important motifs in numerous bioactive natural products and pharmaceutical mols. Herein, an improved dilauroyl peroxide-mediated radical deiodination reaction by using cyclohexane and Et acetate as co-solvent is reported. This is an environmentally benign protocol, which operates smoothly under mild conditions and allows efficient preparation of a series of 2-deoxy-glycosides in up to 98% yields. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7

The Article related to solvent effect iodination deiodination dilauroyl peroxide catalyst glycoside preparation, deoxyglycoside preparation reductive deiodination lauroyl peroxide catalyst glycoside preparation and other aspects.Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2020, Arribas, Raquel L.; Bordas, Anna; Domenech Omella, Judit; Cedillo, Jose Luis; Janssens, Veerle; Montiel, Carmen; de los Rios, Cristobal published an article.Formula: C12H16O7 The title of the article was An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells. And the article contained the following:

We herein report the design, synthesis, and functional impact of an okadaic acid (OA) small analog, ITH12680, which restores the activity of phosphoprotein phosphatase 2A (PP2A), whose deficient activity has been implicated in nicotine-mediated tumor progression and chemoresistance in non-small cell lung cancer (NSCLC). For its design, we paid attention to the structure of the PP2A-OA complex, where the C16-C38 OA fragment confers PP2A affinity and selectivity, but it is not involved in the inhibitory effect. Confirming this hypothesis, PP2A activity was not inhibited by ITH12680. By contrast, the compound partially restored OA-exerted PP2A inhibition in vitro. Moreover, flow cytometry and immunoblotting experiments revealed that ITH12680 reversed nicotine-induced cisplatin resistance in NSCLC cells, as it prevented nicotine-induced reduction of Bax expression and inhibited nicotine-mediated activation of cell survival and proliferation kinases, Akt and ERK1/2. Our findings suggest that the rescue of nicotine-inhibited PP2A activity could diminish the resistance to cisplatin treatment observed in NSCLC patients who continue smoking. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7

The Article related to drug design nsclc pp2a chemoresistance cisplatin okadaic acid, chemoresistance, cisplatin, computer-aided drug design, non-small cell lung cancer, okadaic acid, phosphoprotein phosphatase 2a and other aspects.Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 2, 2020, Singh, Adesh Kumar; Kanaujiya, Vimlesh Kumar; Tiwari, Varsha; Sabiah, Shahulhameed; Kandasamy, Jeyakumar published an article.COA of Formula: C12H16O7 The title of the article was Development of Routes for the Stereoselective Preparation of β-Aryl-C-glycosides via C-1 Aryl Enones. And the article contained the following:

A wide range of enones derived from D-glucal, D-galactal, L-rhamnal, D-rhamnal, and L-arabinal underwent Heck-coupling with various arylboronic acids bearing electron-donating and -withdrawing groups in the presence of palladium acetate and 1,10-phenanthroline. These reactions provided synthetically useful C-1 aryl enones in good yields. Many sensitive functional groups as well as protecting groups present in arylboronic acids and enones, resp., remained intact under optimized conditions. The stereoselective hydrogenation of C-1 aryl enones with Pd-C/H2 provides the β-isomer of 2-deoxy-aryl-C-glycosides in excellent yield. The C-1 aryl enones were also used as precursors for the synthesis of 2-hydroxy-β-aryl-C-glycosides. Regioselective C-2 halogenation and vinylation of C-1 aryl enones were achieved in excellent yields. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).COA of Formula: C12H16O7

The Article related to protecting group arylboronic acid stereoselective hydrogenation halogenation vinylation glycal, arylglycoside stereoselective arylboronic acid heck coupling phenanthroline palladium catalyst and other aspects.COA of Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2020, Shiozaki, Yoko; Sakurai, Shunya; Sakamoto, Ryu; Matsumoto, Akira; Maruoka, Keiji published an article.Synthetic Route of 2873-29-2 The title of the article was Iron-Catalyzed Radical Cleavage/C-C Bond Formation of Acetal-Derived Alkylsilyl Peroxides. And the article contained the following:

A novel radical-based approach for the Fe-catalyzed selective cleavage of acetal-derived alkylsilyl peroxides, followed by the formation of a C-C bond is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the acetal moiety and the C electrophile. Mechanistic studies suggest that the present reaction proceeds through a free-radical process involving C radicals generated by the homolytic cleavage of a C-C bond within the acetal moiety. A synthetic application of this method to sugar-derived alkylsilyl peroxides is also described. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to iron catalyzed radical cleavage bond formation acetal alkylsilyl peroxide, c−c bond cleavage, c−c bond formation, alkylsilyl peroxides, iron-catalysis, radical reaction, sugar derivatives and other aspects.Synthetic Route of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 5, 2021, Ghouilem, Juba; Tran, Christine; Grimblat, Nicolas; Retailleau, Pascal; Alami, Mouad; Gandon, Vincent; Messaoudi, Samir published an article.Product Details of 2873-29-2 The title of the article was Diastereoselective Pd-Catalyzed Anomeric C(sp3)-H Activation: Synthesis of α-(Hetero)aryl C-Glycosides. And the article contained the following:

Anomeric C-H bond activation is an unsolved long-standing synthetic challenge. Herein, we report a diastereoselective Pd-catalyzed anomeric C(sp3)-H activation methodol. that allows the synthesis of elusive C-(hetero)aryl glycosides with an exclusive α-selectivity. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Product Details of 2873-29-2

The Article related to palladium catalyst stereoselective glycosylation heteroaryl aminoglycoside preparation, aryl aminoglycoside preparation crystal structure arylation stereoselective glycosylation heteroaryl and other aspects.Product Details of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 17, 2019, Yalamanchili, Subbarao; Lloyd, Dina; Bennett, Clay S. published an article.Related Products of 2873-29-2 The title of the article was Synthesis of the Hexasaccharide Fragment of Landomycin A Using a Mild, Reagent-Controlled Approach. And the article contained the following:

The synthesis of the hexasaccharide fragment of landomycin A is reported. Using p-toluenesulfonyl chloride mediated dehydrative glycosylation, we constructed the deoxy-sugar linkages in a stereoselective fashion without the need for temporary prosthetic groups to control selectivity. Through this approach, the hexasaccharide was obtained in 28 steps and 8.9% overall yield, which is an order of magnitude higher than that of previously reported approaches. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to catalyst stereoselective dehydrative glycosylation toluenesulfonyl chloride, landomycin hexasaccharide synthesis synthon stereoselective glycosylation toluenesulfonyl chloride oligosaccharide and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics