Category: 2873-29-2

On August 21, 2020, Vetter, Natasha D.; Jagdhane, Rajendra C.; Richter, Brett J.; Palmer, David R. J. published an article.Application of 2873-29-2 The title of the article was Carbocyclic Substrate Analogues Reveal Kanosamine Biosynthesis Begins with the α-Anomer of Glucose 6-Phosphate. And the article contained the following:

NtdC is an NAD-dependent dehydrogenase that catalyzes the conversion of glucose 6-phosphate (G6P) to 3-oxo-glucose 6-phosphate (3oG6P), the first step in kanosamine biosynthesis in Bacillus subtilis and other closely-related bacteria. The NtdC-catalyzed reaction is unusual because 3oG6P undergoes rapid ring opening, resulting in a 1,3-dicarbonyl compound that is inherently unstable due to enolate formation. We have reported the steady-state kinetic behavior of NtdC, but many questions remain about the nature of this reaction, including whether it is the α-anomer, β-anomer, or open-chain form that is the substrate for the enzyme. Here, we report the synthesis of carbocyclic G6P analogs by two routes, one based upon the Ferrier II rearrangement to generate the carbocycle and one based upon a Claisen rearrangement. We were able to synthesize both pseudo-anomers of carbaglucose 6-phosphate (C6P) using the Ferrier approach, and activity assays revealed that the pseudo-α-anomer is a good substrate for NtdC, while the pseudo-β-anomer and the open-chain analog, sorbitol 6-phosphate (S6P), are not substrates. A more efficient synthesis of α-C6P was achieved using the Claisen rearrangement approach, which allowed for a thorough evaluation of the NtdC-catalyzed oxidation of α-C6P. The requirement for the α-anomer indicates that NtdC and NtdA, the subsequent enzyme in the pathway, have co-evolved to recognize the α-anomer in order to avoid mutarotation between enzymic steps. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Application of 2873-29-2

The Article related to glucose 6phosphate dehydrogenase anomer bacillus kanosamine, Placeholder for records without volume info and other aspects.Application of 2873-29-2

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Deoghare, Chetana; Balaji, Shruti; Dhandapani, Savitha; Srivastava, Honey; Ganguly, Anasuya; Chauhan, Rashmi published an article in 2022, the title of the article was Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-d-glucal and itaconic anhydride.Product Details of 2873-29-2 And the article contains the following content:

This paper reports the synthesis and characterization of monomers itaconic anhydride (IA) and tri-O-acetyl-d-glucal (TAG) as well as 4,6-di-O-acetyl-d-glucal (PSG). The homopolymers and copolymers of IA and TAG were synthesized via free radical copolymerization in bulk, using azobisisobutyronitrile as an initiator with different feed ratios of monomers. Their structural, mol. and thermal characterization was done using 1H-NMR spectroscopy, gel permeation chromatog. and differential scanning calorimetry, resp. The glass transition temperature (Tg) of copolymers was found in the range of 139-145 °C. The highest Tg was found for IA-TAG2 copolymers, whereas IA-TAG4 copolymer showed lowest Tg. The mol. weight of the copolymers was in the range 5157-5499 g mol-1. The monomer TAG undergoes Ferrier rearrangement in water to give PSG. The antimicrobial activity of IA, TAG, PSG and IA-TAG copolymers was studied using the min. microbicidal concentration-broth dilution method. TAG, IA and PSG, as well as homopolymer and copolymers of IA and TAG are excellent antimicrobial agents. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Product Details of 2873-29-2

The Article related to triacetylglucal itaconic anhydride copolymer antimicrobial anticancer activity, Placeholder for records without volume info and other aspects.Product Details of 2873-29-2

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Zurawska, Katarzyna; Stokowy, Marcin; Kapica, Patryk; Olesiejuk, Monika; Kudelko, Agnieszka; Papaj, Katarzyna; Skonieczna, Magdalena; Szeja, Wieslaw; Walczak, Krzysztof; Kasprzycka, Anna published an article in 2021, the title of the article was Synthesis and Preliminary Anticancer Activity Assessment of N-Glycosides of 2-Amino-1,3,4-thiadiazoles.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:

The addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals has been achieved using a double molar excess of mol. iodine under mild conditions. The corresponding thiadiazole derivatives of N-glycosides were obtained in good yields and anomeric selectivity. The usage of iodine as a catalyst makes this method easy, inexpensive, and successfully useable in reactions with sugars. Thiadiazole derivatives were tested in a panel of three tumor cell lines, MCF-7, HCT116, and HeLa. These compounds initiated biol. response in investigated tumor models in a different rate. The MCF-7 is resistant to the tested compounds, and the cytometry assay indicated low increase in cell numbers in the sub- G1 phase. The most sensitive are HCT-116 and HeLa cells. The thiadiazole derivatives have a pro-apoptotic effect on HCT-116 cells. In the case of the HeLa cells, an increase in the number of cells in the sub-G1- phase and the induction of apoptosis was observed The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to aminothiadiazole glycoside anticancer activity, 1,3,4-thiadiazole, n-glycosides, glycal, molecular iodine, Placeholder for records without volume info and other aspects.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

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On March 1, 2021, Cao, Rong-An; Ji, RuiXue; Tabarsa, Mehdi; Zhang, JianQiang; Meng, LingQi; Zhang, ChengTai; Zhang, JiaMiao; Wang, LiDong; Wu, Rui; Wang, ChangYuan; Jin, ChengHao; You, SangGuan published an article.Recommanded Product: 2873-29-2 The title of the article was Purification, characterization and immunostimulatory effects of polysaccharides from Anemarrhena asphodeloides rhizomes. And the article contained the following:

The crude polysaccharide was extracted from A. asphodeloides rhizomes and further purified to produce two fractions F1 (50.0%) and F2 (19.6%). The chem. constitutions of the polysaccharides were neutral sugars (51.4%-89.7%), uronic acids (1.0%-30.2%) and sulfate esters (3.4%-8.1%), with various ratios of monosaccharides including rhamnose (1.4%-6.1%), arabinose (7.1%-21.2%), xylose (0.2%-4.8%), mannose (39.9%-79.0%), glucose (6.0%-11.1%) and galactose (2.6%-22.0%). The mol. properties of the polysaccharides were investigated by the HPSEC-UV-MALLS-RI system, revealing the Mw 130.0 × 103-576.5 × 103 g/moL, Rg 87.6-382.6 nm and SVg 0.3-54.3 cm3/g. The polysaccharides stimulated RAW264.7 cells to produce considerable amounts of NO and up-regulate the expression of TNF-α, IL-1 and COX-2 genes. Polysaccharides exhibited the growth inhibitory effects on cancer cells lines of AGS, MKN-28 and MKN-45, in which F2 fraction exhibited prominent bioactivities. The AGS cells treated with F2 experienced condensed cytoplasm, shrinkage of nucleus and chromatin marginalization with the highest number of cells at early-stage apoptosis reaching 54.6%. The inhibitory effect of F2 polysaccharide on AGS cells was through MAPKs and STAT3 signaling pathways. The backbone of the F2 was mainly linked by (1 → 4)-linked mannopyranosyl and (1 → 3)-linked galactopyranosyl. Taken together, the polysaccharide from A. asphodeloides rhizomes could be utilized as medicinal, pharmacol. and functional food ingredients. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: 2873-29-2

The Article related to polysaccharide anemarrhena asphodeloides rhizome immunostimulatory purification characterization, characterization, immunostimulatory, polysaccharides, Placeholder for records without volume info and other aspects.Recommanded Product: 2873-29-2

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On April 5, 2019, Gavel, Marine; Courant, Thibaut; Joosten, Antoine Yvan Philippe; Lecourt, Thomas published an article.Related Products of 2873-29-2 The title of the article was Regio- and Chemoselective Deprotection of Primary Acetates by Zirconium Hydrides. And the article contained the following:

A combination of DIBAL-H and Cp2ZrCl2 is shown to promote the regioselective cleavage of primary acetates on a broad scope of substrates, ranging from carbohydrates to terpene derivatives, with a high tolerance toward protecting groups and numerous functionalities found in natural products and bioactive compounds Apart from providing highly valuable building blocks in only two steps from biosourced raw materials, this selective de-O-acetylation should also be strongly helpful to solve selectivity issues in organic synthesis. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to alc preparation, acetate deprotection zirconium hydride dibalh deacetylation, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 2873-29-2

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Darbem, Mariana P.; Kanno, Karina S.; de Oliveira, Isadora M.; Esteves, C. Henrique A.; Pimenta, Daniel C.; Stefani, Helio A. published an article in 2019, the title of the article was Synthesis of amidoglucals and glucal esters via carbonylative coupling reactions of 2-iodoglucal using Mo(CO)6 as a CO source.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate And the article contains the following content:

The synthesis of amidoglucals and glucal esters in good to high yields using 2-iodo-3,4,6-tri-O-acetyl-D-glucal as a substrate, Mo(CO)6 as a carbon monoxide source and PdCl2 as a catalyst is reported. This procedure shows advantages when compared to other published methodologies, as it was carried out in one pot relying on short reaction times at mild temperatures, under ligand-free conditions and with only one equivalent of Mo(CO)6. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to amidoglucal glucal ester preparation carbonylative coupling iodoglucal molybdenum hexacarbonyl, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2022, Ul Lah, Hafiz; Mir, Shabir Ahmad; Hussain, Gulzar; Wani, Rafiq Ahmad; Yousuf, Syed Khalid published an article.Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals. And the article contained the following:

A highly chemo- and diastereoselective vic-dibromination of olefins was developed. The process employed a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to alkene bromosuccinimide chemoselective diastereoselective dibromination, organodibromide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Name: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Yufeng; Wang, Yufan; Lu, Xunbo; Zhang, Yulong; Wu, Yuzhou; Zhong, Fangrui published an article in 2019, the title of the article was Rhodium-catalyzed aminohydroxylation of unactivated alkenes in aqueous media for the benign synthesis of 1,2-amino alcohols.Product Details of 2873-29-2 And the article contains the following content:

An efficient catalytic aminohydroxylation reaction of alkenes in aqueous media is disclosed for the first time. The water plays multiple roles as a reaction medium, nucleophile, and Bronsted acid catalyst provide high reactivity and chemo- and regioselectivities to this transformation. This method provides easy access to various valuable vicinal amino alcs. in a sustainable manner. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Product Details of 2873-29-2

The Article related to amino alc preparation chemoselective regioselective green chem, alkene aminohydroxylation rhodium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 2873-29-2

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On July 6, 2020, Tsui, Elaine; Metrano, Anthony J.; Tsuchiya, Yuto; Knowles, Robert R. published an article.Synthetic Route of 2873-29-2 The title of the article was Catalytic Hydroetherification of Unactivated Alkenes Enabled by Proton-Coupled Electron Transfer. And the article contained the following:

The authors report a catalytic, light-driven method for the intramol. hydroetherification of unactivated alkenols to furnish cyclic ether products. These reactions occur under visible-light irradiation in the presence of an IrIII-based photoredox catalyst, a Bronsted base catalyst, and a hydrogen-atom transfer (HAT) co-catalyst. Reactive alkoxy radicals are proposed as key intermediates, generated by direct homolytic activation of alc. O-H bonds through a proton-coupled electron-transfer mechanism. This method exhibits a broad substrate scope and high functional-group tolerance, and it accommodates a diverse range of alkene substitution patterns. Results demonstrating the extension of this catalytic system to carboetherification reactions are also presented. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to alkene hydroetherification iridium catalyst proton coupled electron transfer, alcohols, ethers, hydroetherification, photocatalysis, radicals, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2873-29-2

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghosh, Arun K.; Allu, Srinivasa Rao; Reddy, Guddeti Chandrashekar; Lopez, Adriana Gamboa; Mendez, Patricia; Jurica, Melissa S. published an article in 2021, the title of the article was Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing.Synthetic Route of 2873-29-2 And the article contains the following content:

Herboxidiene is a potent antitumor agent that targets the SF3B subunit of the spliceosome. Herboxidiene possesses a complex structural architecture with nine stereocenters and design of potent less complex structures would be of interest as a drug lead as well as a tool for studying SF3B1 function in splicing. We investigated a number of C-6 modified herboxidiene derivatives in an effort to eliminate this stereocenter and, also to understand the importance of this functionality. The syntheses of structural variants involved a Suzuki-Miyaura cross-coupling reaction as the key step. The functionalized THF core has been constructed from com. available optically active tri-O-acetyl-D-glucal. We investigated the effect of these derivatives on splicing chem. The C-6 alkene derivative showed very potent splicing inhibitory activity similar to herboxidiene. Furthermore, the C-6 gem-di-Me derivative also exhibited very potent in vitro splicing inhibitory activity comparable to herboxidiene. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to herboxidiene derivative preparation splicing inhibitor suzuki miyaura cross coupling, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Synthetic Route of 2873-29-2

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Ester – an overview | ScienceDirect Topics