Bell, Ian M. et al. published their research in Journal of Medicinal Chemistry in 1998 | CAS: 28478-46-8

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 28478-46-8

Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2-methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines was written by Bell, Ian M.;Erb, Jill M.;Freidinger, Roger M.;Gallicchio, Steven N.;Guare, James P.;Guidotti, Maribeth T.;Halpin, Rita A.;Hobbs, Doug W.;Homnick, Carl F.;Kuo, Michelle S.;Lis, Edward V.;Mathre, David J.;Michelson, Stuart R.;Pawluczyk, Joseph M.;Pettibone, Douglas J.;Reiss, Duane R.;Vickers, Stanley;Williams, Peter D.;Woyden, Carla J.. And the article was included in Journal of Medicinal Chemistry in 1998.Related Products of 28478-46-8 This article mentions the following:

The previously reported oxytocin antagonist L-371,257 has been modified at its acetylpiperidine terminus to incorporate various pyridine N-oxide groups. This modification has led to the identification of compounds with improved pharmacokinetics and excellent oral bioavailability. The pyridine N-oxide series is exemplified by L-372,662 (I), which possessed good potency in vitro (Ki = 4.1 nM, cloned human oxytocin receptor) and in vivo (i.v. AD50 = 0.71 mg/kg in the rat), excellent oral bioavailability (90% in the rat, 96% in the dog), good aqueous solubility (>8.5 mg/mL at pH 5.2) which should facilitate formulation for i.v. administration, and excellent selectivity against the human arginine vasopressin receptors. Incorporation of a 5-fluoro substituent on the central benzoyl ring of this class of oxytocin antagonists enhanced in vitro and in vivo potency but was detrimental to the pharmacokinetic profiles of these compounds Although lipophilic substitution around the pyridine ring of I gave higher affinity in vitro, such substituents were a metabolic liability and caused shortfalls in vivo. Two approaches to prevent this metabolism, addition of a cyclic constraint and incorporation of trifluoromethyl groups, were examined The former approach was ineffective because of metabolic hydroxylation on the constrained ring system, whereas the latter showed improvement in plasma pharmacokinetics in some cases. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Related Products of 28478-46-8).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 28478-46-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Piao, Yuan Zhe et al. published their research in Journal of Agricultural and Food Chemistry in 2009 | CAS: 28478-46-8

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 28478-46-8

Development of ELISAs for the class-specific determination of organophosphorus pesticides was written by Piao, Yuan Zhe;Kim, Yoo Jung;Kim, Young Ah;Lee, Hye-Sung;Hammock, Bruce D.;Lee, Yong Tae. And the article was included in Journal of Agricultural and Food Chemistry in 2009.Application of 28478-46-8 This article mentions the following:

Enzyme-linked immunosorbent assays (ELISAs) for the class-specific determination of organophosphorus (OP) pesticides were developed from monoclonal antibodies raised against haptens with the functional group common to OP pesticides. To develop antigen-coated, indirect, competitive ELISAs, four haptens with different spacer arm structures were used to prepare antibodies, while eight haptens were tested for use as coating antigens. A total of 32 ELISAs were developed with one selected as the most suitable one based on average IC50 and % CV values. The chosen ELISA showed class-selective response to O,O-di-Et phosphorothioate and phosphorodithioate OP pesticides with negligible cross-reactivity to other types of pesticides. Average IC50 and % CV values of this ELISA for the 12 OP pesticides were 89 ng/mL and 96%, resp. Compared to ELISAs previously developed with the same objective, the current ELISA demonstrates better sensitivity based on much lower mean IC50 values in addition to improved class-selective determination based on considerably lower % CV values as well as precise discrimination against other types of pesticides. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Application of 28478-46-8).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 28478-46-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Piao, Yuan Zhe et al. published their research in Journal of Agricultural and Food Chemistry in 2009 | CAS: 28478-46-8

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 28478-46-8

Development of ELISAs for the class-specific determination of organophosphorus pesticides was written by Piao, Yuan Zhe;Kim, Yoo Jung;Kim, Young Ah;Lee, Hye-Sung;Hammock, Bruce D.;Lee, Yong Tae. And the article was included in Journal of Agricultural and Food Chemistry in 2009.Application of 28478-46-8 This article mentions the following:

Enzyme-linked immunosorbent assays (ELISAs) for the class-specific determination of organophosphorus (OP) pesticides were developed from monoclonal antibodies raised against haptens with the functional group common to OP pesticides. To develop antigen-coated, indirect, competitive ELISAs, four haptens with different spacer arm structures were used to prepare antibodies, while eight haptens were tested for use as coating antigens. A total of 32 ELISAs were developed with one selected as the most suitable one based on average IC50 and % CV values. The chosen ELISA showed class-selective response to O,O-di-Et phosphorothioate and phosphorodithioate OP pesticides with negligible cross-reactivity to other types of pesticides. Average IC50 and % CV values of this ELISA for the 12 OP pesticides were 89 ng/mL and 96%, resp. Compared to ELISAs previously developed with the same objective, the current ELISA demonstrates better sensitivity based on much lower mean IC50 values in addition to improved class-selective determination based on considerably lower % CV values as well as precise discrimination against other types of pesticides. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Application of 28478-46-8).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 28478-46-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, De-Jun et al. published their research in Research on Chemical Intermediates in 2016 | CAS: 28478-46-8

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate

One-pot syntheses of 2,6-diiododiaryl ethers from para-EWG-substituted phenols by diacetoxyiodobenzene was written by Zhou, De-Jun;Yin, Shu-Qiang;Fan, Yun-Chang;Wang, Qiang. And the article was included in Research on Chemical Intermediates in 2016.Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate This article mentions the following:

2,6-Diiododiaryl ethers are not only useful blocks for construction of substituted diaryl ethers but are also characteristic drug precursors. In this research, a one-pot tandem oxidation of phenols substituted with electron-withdrawing group at the para position by excess diacetoxyiodobenzene is proven as a novel and efficient method for preparing 2,6-diiododiaryl ethers. Using this method, three new 2,6-diiododiaryl ethers, namely, Me 3,5-diiodo-2-methoxy-4-phenoxybenzoate, Me 3,5-diiodo-4-phenoxybenzoate, and 1-(2,6-diiodo-4-nitrophenoxy)benzene were readily obtained from the corresponding phenols, and the yields were good. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Legrand, Sacha et al. published their research in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 2004 | CAS: 28478-46-8

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C9H10O4

Hydroxy-methoxybenzoic methyl ester: Synthesis and antifeedant activity on the pine weevil, Hylobius abietis was written by Legrand, Sacha;Nordlander, Goeran;Nordenhem, Henrik;Borg-Karlson, Anna-Karin;Unelius, C. Rikard. And the article was included in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 2004.Electric Literature of C9H10O4 This article mentions the following:

Ten regioisomers of Me (hydroxy)(methoxy)benzoate were prepared and bioassayed for antifeedant effect on pine weevil (Hylobius abietis), which is the economically most important forestry restocking pest in large parts in Europe. Bioassays were performed on com. and synthetic Me hydroxy-methoxybenzoates in order to determine their possible antifeedant activity. Dihydroxybenzoic acids were esterificated by DCC/DMAP protocol followed by regioselective pivaloylation of the less-hindered hydroxyl group and MeI etherification. The five synthesized Me hydroxy-methoxybenzoic esters were complemented with com. samples of the five other isomers; spectroscopic data were collected for the complete set of isomers. All ten isomers were tested for their antifeedant effect on the pine weevil. The effect varied considerably among the hydroxy-methoxybenzoic esters. Me 2-hydroxy-3-methoxybenzoate showed the highest effect and may thus be a candidate for practical use in pine weevil pest management. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Electric Literature of C9H10O4).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C9H10O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Legrand, Sacha et al. published their research in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 2004 | CAS: 28478-46-8

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C9H10O4

Hydroxy-methoxybenzoic methyl ester: Synthesis and antifeedant activity on the pine weevil, Hylobius abietis was written by Legrand, Sacha;Nordlander, Goeran;Nordenhem, Henrik;Borg-Karlson, Anna-Karin;Unelius, C. Rikard. And the article was included in Zeitschrift fuer Naturforschung, B: Chemical Sciences in 2004.Electric Literature of C9H10O4 This article mentions the following:

Ten regioisomers of Me (hydroxy)(methoxy)benzoate were prepared and bioassayed for antifeedant effect on pine weevil (Hylobius abietis), which is the economically most important forestry restocking pest in large parts in Europe. Bioassays were performed on com. and synthetic Me hydroxy-methoxybenzoates in order to determine their possible antifeedant activity. Dihydroxybenzoic acids were esterificated by DCC/DMAP protocol followed by regioselective pivaloylation of the less-hindered hydroxyl group and MeI etherification. The five synthesized Me hydroxy-methoxybenzoic esters were complemented with com. samples of the five other isomers; spectroscopic data were collected for the complete set of isomers. All ten isomers were tested for their antifeedant effect on the pine weevil. The effect varied considerably among the hydroxy-methoxybenzoic esters. Me 2-hydroxy-3-methoxybenzoate showed the highest effect and may thus be a candidate for practical use in pine weevil pest management. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Electric Literature of C9H10O4).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C9H10O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics