Category: 27829-72-7

Adding a certain compound to certain chemical reactions, such as: 27829-72-7, name is Ethyl E-hex-2-enoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27829-72-7, SDS of cas: 27829-72-7

Example D: (S)-3-Amino-hexanoic acid ethyl ester To a solution of (S)-(-)-N-benzyl-alpha-methyl-benzylamine (50 mL, 239 mmol) in THF (150 mL) at 00C is added nBuLi (2.5 M in THF) (100 mL, 250 mmol) under nitrogen atmosphere. The solution is cooled to -78°C and ethyl trans-2-hexenoate (16.6 g, 117 mmol) is added. The solution is stirred for 1 hour and saturated NH4Cl solution is added. The solution is warmed to room temperature and is extracted with EtOAc. The combined organic layer is dried with MgSO4 and is filtered. The filtrate is concentrated and the residue is purified by flash chromatography with 5percent EtOAc in Hexane as the eluent to afford the (S)-3-[Benzyl-((S)-l- phenyl-ethyl)-amino]-hexanoic acid ethyl ester (20.8 g, 50percent) as a colorless oil.

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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/23655; (2009); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27829-72-7, name is Ethyl E-hex-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Ethyl E-hex-2-enoate

To a stirred solution of l-l,2-benzisoxazol-3-ylmethyl-l,3-dihydro-benzimidazol-2-one (lOOmg, 0.38mmol) in DMF (5ml) was added ethyl trans-2-hexenoate (80mg, 0.57mmol) followed by benzyltrimethylammonium hydroxide (Triton B, 40 wtpercent in MeOH, 17.OuI). The resulting mixture was warmed to 6O0C for 12h and cooled to ambient temperature. The reaction was diluted with NH4Cl (sat.) and the product was extracted into ethyl acetate (2x). The combined organics were dried (MgSO4), filtered and concentrated to give the crude product which was purified via column chromatography (silica gel, 5percent EtOAc/dichloromethane). The product- containing fractions were combined and concentrated to give 70mg (46percent) of the desired product.

The synthetic route of 27829-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/147697; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 27829-72-7, name is Ethyl E-hex-2-enoate, molecular formula is C8H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H14O2

(1) Ethyl 2,3-methanohexanoate 15.6 g. of sodium hydride (content 65.1percent, 0.423 mol) were suspended in 800 ml. of dimethyl sulphoxide, and there were added, with stirring, 154 g. (0.7 mol) of trimethyloxosulphonium iodide in small portions at 20¡ã to 30¡ãC. over a period of 20 minutes. An exothermic reaction took place with the evolution of hydrogen. After stirring for 10 minutes, there was added, dropwise, a solution of 60 g. (0.423 mol) of ethyl hex-trans-2-enoate in 70 ml. of dimethyl sulphoxide at 20¡ã to 30¡ãC. The reaction mixture was stirred at 40¡ãC. for 3 hours and then poured into 2 litres of ice-water and extracted with diethyl ether. The aqueous layer was treated with 60 ml. of concentrated hydrochloric acid and extracted with diethyl ether. The combined ethereal layer was washed with water, dried with magnesium sulphate and concentrated under reduced pressure. Distillation of the crude product gave 23.2 g. of ethyl 2,3 -methanohexanoate having the following physical characteristics:- b.p. 57¡ã to 60¡ãC./6 mm.Hg; NMR (CDCl3 and CCl4 solution); delta: 4.05 (2H, q), 0.95 (3H, t) and 0.70-0.48 (2H, dd); IR (liquid film); nu: 2950, 1720, 1450, 1405, 1370, 1330, 1265, 1200, 1180, 1100, 1040, 860 cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 27829-72-7, its application will become more common.

Reference:
Patent; Ono Pharmaceutical Co., Ltd.; US3978229; (1976); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 27829-72-7, These common heterocyclic compound, 27829-72-7, name is Ethyl E-hex-2-enoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To ester 6 (1.97 g, 14.86 mmol) in 9:1H2O/MeOH (100 mL), NaHSO3 (40percent w/v aqueous solution, 4.33 mL,16.64 mmol) and Et3N (2.31 mL, 16.64 mmol) were added. The resultingmixture was heated at reflux for 18 h. The solvent was removed in vacuo, andthe crude product was purified using flash chromatography (10:90:1 to20:80:1, MeOH/CH2Cl2/AcOH) to give acid 7 in 31percent yield as a yellow gum. dH(400 MHz; D2O): 0.94 (3H, t, J = 7.4 Hz, 6-CH3), 1.30 (18H, t, J = 7.3 Hz,(N(CH2CH3)3)2) 1.39?1.61 (3H, m, 5-CH2, 4-Ha), 1.83?1.92 (1H, m, 4-Hb), 2.56(1H, dd, J = 6.9, 16.1 Hz, 2-Ha), 2.81 (1H, dd, J = 6.4, 16.1 Hz, 2-Hb), 3.22 (12H, q,J = 7.5 Hz, (N(CH2CH3)3)2), 3.26?3.33 (1H, m, 3-H); dC (100 MHz; D2O) 8.8((N(CH2CH3)3)2), 13.8 (C-6), 20.2 (C-5), 32.7 (C-4), 36.7 (C-2), 47.3((N(CH2CH3)3)2), 57.6 (C-3), 178.2 (C-1); IR: mmax cm1 2987, 2704, 1716,1565, 1389, 1228, 1148; HRMS (ESI) found [MH2(Et3N)]+ 195.0333,C6H11O5S, required 195.0332. In a second fraction was obtained ester 8 (1.20 g,25percent) as a yellow oil. 1H (400 MHz; D2O): 0.95 (3H, t, J = 7.3 Hz, 6-CH3), 1.28?1.32 (12H, m, OCH2CH3, N(CH2CH3)3), 1.38?1.46 (1H, m, 4-Ha), 1.48?1.59 (2H,m, 5-CH2), 1.88?1.89 (1H, m, 4-Hb), 2.65?2.81 (2H, m, 2-CH2), 3.23 (6H, q,J = 7.2 Hz, N(CH2CH3)3), 3.31?3.36 (1H, m, 3-H), 4.20 (2H, q, J = 7.2 Hz,OCH2CH3); 13C (100 MHz; D2O): 8.2 (N(CH2CH3)3), 13.1 (C-6 and OCH2CH3),19.5 (C-5), 31.8 (C-4), 35.4 (C-2), 46.7 (N(CH2CH3)3), 56.8 (C-3), 62.1(OCH2CH3), 177.0 (C-1); IR: mmax cm1 2964, 2708, 1723, 1468, 1375, 1224;HRMS (ESI). Found [MHEt3N]+ 223.0652, C8H15O5S, required 223.0646.

Statistics shows that Ethyl E-hex-2-enoate is playing an increasingly important role. we look forward to future research findings about 27829-72-7.

Reference:
Article; Duhamel, Nina; Piano, Federico; Davidson, Samuel J.; Larcher, Roberto; Fedrizzi, Bruno; Barker, David; Tetrahedron Letters; vol. 56; 13; (2015); p. 1728 – 1731;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics