Category: 27492-84-8

These common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Methyl 4-amino-2-methoxybenzoate

Example 286; Preparation of rac 4-{[(2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-2-methoxy-benzoic acid methyl ester To a stirred solution of rac (2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid (100 mg, 0.17 mmol) in methylene chloride (10 mL), HATU (Aldrich,118 mg, 0.31 mmol) was added followed by the addition of DIPEA(0.15 mL, 0.86 mmol) and 4-amino-2-methoxy-benzoic acid (Avocado, 62 mg, 0.34 mmol). The mixture was stirred at rt for overnight. The reaction was quenched with addition of water. The mixture was extracted with methylene chloride (2.x.10 mL) and the extracts were dried with magnesium sulfate. The solvent was removed and the residue was purified on an ISCO machine (40 g column, 5-15percent EtOAc/methylene chloride) to give a white solid. 29 mg.MS (ES+) m/z Calcd: [(M+H)+]: 630.1733, found: 630.1732

The synthetic route of Methyl 4-amino-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ding, Qingjie; Jiang, Nan; Liu, Jin-Jun; Ross, Tina Morgan; Zhang, Jing; Zhang, Zhuming; US2010/75948; (2010); A1;,
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Reference of 27492-84-8, These common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyl 4-amino-2-methoxybenzoate 5 (2.00 g, 11.0 mmol, 1 eq.) in MeCN (70 mL) was added N-iodosuccinimide (5.22 g, 23.2 mmol, 2.1 eq.) in 2 portions over 5 minutes. The resulting mixture was stirred at rt under argon for 1h, then at 55°C. N-iodosuccinimide (1.0 eq.) was added every 5h until completion of the reaction. The reaction mixture was then partitioned between CHCl3 and sat. aq. NaHCO3. A small amount of sat. aq. Na2S2O3 was added to quench potential traces of iodine. The aqueous phase was extracted 3 times. The combined organic phases were dried (MgSO4) and concentrated under reduced pressure. The product (2.10 g, 44percent) was obtained after purification by flash column chromatography (hexane/AcOEt 8:2). Rf 0.4 (hexane/AcOEt, 8:2); 1H NMR (400 MHz, CDCl3) delta 3.85 (s, 3H), 3.88 (s, 3H), 5.15 (br. s., 2H), 8.27 (s, 1H); 13C NMR (100 MHz, CDCl3) delta 52.1, 61.9, 74.0, 81.5, 114.7, 142.4, 151.2, 161.6, 163.7; HRMS (ESI+) m/z calcd for C9H10I2NO3 [M + H]+ 433.8745, found: 433.8746.

Statistics shows that Methyl 4-amino-2-methoxybenzoate is playing an increasingly important role. we look forward to future research findings about 27492-84-8.

Reference:
Article; Baud, Matthias G.J.; Bauer, Matthias R.; Verduci, Lorena; Dingler, Felix A.; Patel, Ketan J.; Horil Roy, Deeptee; Joerger, Andreas C.; Fersht, Alan R.; European Journal of Medicinal Chemistry; vol. 152; (2018); p. 101 – 114;,
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Electric Literature of 27492-84-8, The chemical industry reduces the impact on the environment during synthesis 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, I believe this compound will play a more active role in future production and life.

Iodine monochloride (0.54mL, 10.5mmol)Add to methyl 4-amino-2-methoxybenzoate (1.8 g, 10 mmol)Stirring was continued for 1 hour in the methanol solution. The reaction solution is poured into water,Extracted with ethyl acetate (3×50 mL), washed with saturated brineFilter, spin dry petroleum ether / ethyl acetate (3/1)The compound 68D (2.7 g, 90percent yield) was isolated and purified.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-2-methoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27492-84-8, Product Details of 27492-84-8

Step c) 4-[(Biphenyl-2-carbonyl)-amino]-2-methoxy-benzoic acid methyl ester Into a refluxing solution of 2-biphenylcarboxylic acid (9.2 g, 46 mmol) in dichloromethane was added dimethylformamide (0.1 ml, 1.4 mmol) and then neat oxalyl chloride (8.1 ml, 92 mmol) via syringe. The reaction was refluxed for 10 minutes, then the volatiles removed in vacuo. The residue was redissolved in dichloromethane, concentrated and dried under high vacuum for 15 minutes. The acid chloride was dissolved in dichloromethane (50 ml) and added into a 0° C. solution of 4-amino-2-methoxy-benzoic acid methyl ester (8.4 g, 46 mmol), diisopropyl ethylamine (10.5 ml, 60 mmol) and dichloromethane (200 ml). The reaction was warmed to room temperature and stirred for 16 hours. The reaction was diluted with dichloromethane, washed with water, (1N) sodium hydroxide (1) hydrochloric acid, and brine, and dried (MgSO4). Evaporation gave a yellow foam, which was crystallized from methanol to give a light yellow solid (16.08 g) m.p. 141-142° C. Analysis for: C22 H19 N O4 Calcd: C, 73.12; H, 5.30; N, 3.88. Found: C, 72.93; H, 5.20; N, 3.83.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-2-methoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; American Home Products Corporation; US5880122; (1999); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 27492-84-8, These common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2.1) Diphenyl ether (500 mL, 3.15 mol) was added to a 1 L three-necked flask.After preheating the diphenyl ether in the three-neck flask to 220°C, add step 1.4).Compound II (45.25 g, 0.25 mol) and ethoxylated methyl malonate IIEthyl ester (58.32g, 0.27mol), reaction 1h, to obtain a mixture D;2.2) stirring the mixture D obtained in step 2.1) until it is cooled to 50 ° C to obtain a mixture E;2.3) The mixture E obtained in step 2.2) is filtered, the solid obtained after filtration is washed with methyl tert-butyl ether and dried to obtain compound III (yield 94.59percent)

Statistics shows that Methyl 4-amino-2-methoxybenzoate is playing an increasingly important role. we look forward to future research findings about 27492-84-8.

Reference:
Patent; Chongqing University; Dong Lichun; Hu Geng; Li Qi; Liu Dianqing; Wang Haoyuan; (19 pag.)CN107629001; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 27492-84-8, The chemical industry reduces the impact on the environment during synthesis 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, I believe this compound will play a more active role in future production and life.

To a cooled (0°C) solution of phosgene (20percent solution in toluene, 2.76 ml, 5.52 MMOL) in dry DICHLOROMETHANE (75 ml) was added, under an argon atmosphere, methyl 4-amino-2- methoxybenzoate (1 G, 5.52 MMOL) in one portion, followed by a dropwise addition of diisopropylethylamine (1.92 ML, 11.04 MMOL). The mixture was stirred for 15 minutes at 0°C prior to the addition of 2-bromo-4 (trifluoromethoxy) aniline (0.83 ML, 5.52 MMOL). The reaction mixture was stirred at 0°C for a further 2 hours and then was allowed to stir at room temperature overnight. The organic phase was washed with 1 N aq. HCI (2x), sat. aq. NAHCO3, dried over MGS04 and concentrated in vacuo to give a solid residue which was recrystallized in hot acetonitrile. The fine crystalline solid was filtered off, washed with cold acetonitrile and dried in vacuo to give the title compound Ex 106 as a pale-orange solid (1. 64G, 3.54 mmol, 64percent). ‘H-NMR (DMSO-d6) : 6 3.74 (s, 3H), 3.80 (s, 3H), 7.02 (d, 1H), 7.38 (s, 1H), 7.42 (d, 1H), 7.69 (d, 1H), 7.74 (s, 1H), 8.17 (d, 1H), 8.36 (s, 1H), 9.85 (s, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-2-methoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; 7TM PHARMA A/S; LITTLE, Paul Brian; WO2004/48319; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27492-84-8, Recommanded Product: Methyl 4-amino-2-methoxybenzoate

(a) Synthesis of methyl 4-(benzylamino)-2-methoxybenzoate Benzaldehyde (6.73 ml, 66.2 mmol) and acetic acid (3.77 ml, 66.2 mmol) were added to a solution of methyl 4-amino-2-methoxybenzoate (12 g, 66.2 mmol) in methanol (650 ml), and the resulting mixture was stirred at room temperature for 30 minutes. Then, acetic acid (7.56 ml, 132 mmol) and sodium cyanoborohydride (4.9 g, 79.4 mmol) were added thereto at 0°C and stirred at room temperature for 38 hours. The reaction mixture was concentrated, poured into a 1N-aqueous sodium hydroxide solution and then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate = 2/1) to obtain methyl 4-(benzylamino)-2-methoxybenzoate (16.4 g, 91percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-2-methoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1500643; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 27492-84-8, These common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of the 4 (0.48 g, 2 mmol), 3-fluoroaniline (0.24g,2.2 mmol) in isopropanol (30 ml) were stirred at 90 C for 4 h.Isopropanol was removed under reduced pressure and the residuewas purified through a column chromatography on silica withchloroform/methanol (V:V 50:1) as a white solid (0.58 g, 91.8percentyield).

The synthetic route of 27492-84-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ding, Huai-Wei; Deng, Cheng-Long; Li, Dan-Dan; Liu, Dan-Dan; Chai, Shao-Meng; Wang, Wei; Zhang, Yan; Chen, Kai; Li, Xin; Wang, Jian; Song, Shao-Jiang; Song, Hong-Rui; European Journal of Medicinal Chemistry; vol. 146; (2018); p. 460 – 470;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 27492-84-8,Some common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, molecular formula is C9H11NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 2-methoxy-4-aminobenzoate (10g, 55.25mmol) and hydroxylamine hydrochloride (15.36g, 221mmol) were taken up in MeOH (80ml) and a solution of KOH (15.4g, 275mmol) in MeOH (55ml) was added carefully. The resultant mixture was stirred at reflux for 36hrs. The volatiles were removed in vacuo. The residue was taken up in 1 M NaOH (50ml) and washed with ethyl acetate (EtOAc, 50ml). Concentrated HCl was added slowly until precipitation of a solid (pH was 10). The solid was filtered off, washed with H2O, then methyl-tert-butyl ether (MTBE) and dried under vacuum. 1H NMR showed the solid contained approx. 1/3 molar equivalent of ethyl acetate. The solid was taken up in 1M NaOH (100ml) and the EtOAc was removed in vacuo. Concentrated HCl was added carefully until precipitation of a solid (pH was 8). The solid was collected by filtration, washed with H2O, then MTBE and dried under vacuum to give 4.67g (47%) of the title compound as a dark red solid.1H NMR (delta, 250MHz, d6-DMSO): 3.75 (s, 3-H, OMe), 5.64 (s, 2-H, NH2), 6.14 (dd, 1-H, aromatic), 6.18 (brs, 1-H, aromatic), 7.48 (d, 1-H, aromatic), 8.73 (s, 1-H, NH), 10.06 (s, 1-H, OH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-amino-2-methoxybenzoate, its application will become more common.

Reference:
Patent; Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio; EP1910275; (2013); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In an article, author is Reinisova, Lucie, once mentioned the application of 27492-84-8, HPLC of Formula: C9H11NO3, Name is Methyl 4-amino-2-methoxybenzoate, molecular formula is C9H11NO3, molecular weight is 181.1885, MDL number is MFCD00017202, category is esters-buliding-blocks. Now introduce a scientific discovery about this category.

Poly(trimethylene carbonate-co-valerolactone) copolymers are materials with tailorable properties: from soft to thermoplastic elastomers

Aliphatic poly(ester-carbonates) are receiving extensive research attention as tailorable materials suitable for multiple applications from tissue engineering and 3D scaffold printing to drug delivery. Thus, simple reliable procedures for producing easily tailorable poly(ester-carbonates) without metal residues are continuously sought after. In this work, we report on one-pot synthesis of random copolymers of TMC and delta-VL using metal-free biocompatible 1,5,7-triazabicyclo[4.4.0]dec-5-ene as a catalyst and benzyl alcohol and poly(ethylene oxide) as initiators. Random poly(ester-carbonates) with TMC : VL unit ratios ranging from 80 : 20 to 20 : 80 were synthesized via ring-opening polymerization while displaying excellent agreement of comonomers’ ratios in the feed and copolymer chains. The copolymers’ supramolecular structure, thermal and mechanical properties were thoroughly analyzed by various methods. The obtained results clearly indicated that the physicochemical properties can be controlled simply by varying the ratio of comonomers and the length of segments in the copolymer chain. Several copolymers exhibited behavior of thermoplastic elastomers with the most promising one exhibiting a 2200% increase in elongation at break compared to the poly(valerolactone) homopolymer while retaining tensile strength and Young’s modulus suitable for biomedical applications. Overall, our work contributed to widening the portfolio of tailorable copolymers for specialized bioapplications and possibly paving a way for the use of more sustainable polymers in the biomedical field.

If you are interested in 27492-84-8, you can contact me at any time and look forward to more communication. HPLC of Formula: C9H11NO3.