Wang, Xinmou’s team published research in Organic Letters in 2021-11-05 | 2743-40-0

Organic Letters published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Wang, Xinmou; Yu, Mo; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Radical Transformation of Aliphatic C-H Bonds to Oxime Ethers via Hydrogen Atom Transfer>, HPLC of Formula: 2743-40-0, the main research area is oxime ether preparation regioselective; alkane oxime radical transformation.

Herein, a strategy for conversion of aliphatic C-H bonds to oxime ethers via hydrogen atom transfer was described. In this strategy, the decatungstate anion and sulfate radical played complementary roles in the abstraction of hydrogen atoms from primary, secondary, and tertiary C-H bonds of alkanes. The easy accessibility of alkanes and the broad substrate scope, mild conditions, and excellent regioselectivity of these reactions made this strategy applicable for the transformation of raw materials to high-value chems.

Organic Letters published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luginina, Jevgenija’s team published research in Monatshefte fuer Chemie in 2019-01-31 | 2743-40-0

Monatshefte fuer Chemie published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Quality Control of 2743-40-0.

Luginina, Jevgenija; Vasiljevs, Deniss; Ivanovs, Ilgvalds; Mishnev, Anatoly; Turks, Maris published the artcile< Diastereoselective aza-Michael addition for synthesis of carbohydrate-derived spiropiperazinones>, Quality Control of 2743-40-0, the main research area is glycoside spiropiperazinone diastereoselective synthesis aza Michael addition; aza Michael addition nitromethylene glucofuranoside amino acid ester.

3-Deoxy-3-C-nitromethylene-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose reacts with amino acid esters according to the aza-Michael addition pathway. The obtained adducts after reduction of the nitro group spontaneously lactamize and provide novel carbohydrate-derived spiropiperazinones.

Monatshefte fuer Chemie published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Quality Control of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yuan’s team published research in Chemistry – A European Journal in 2021-04-04 | 2743-40-0

Chemistry – A European Journal published new progress about Chiral amino acids Role: ANT (Analyte), ANST (Analytical Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, COA of Formula: C8H18ClNO2.

Chen, Yuan; Fu, Lulu; Sun, Baobao; Qian, Cheng; Pangannaya, Srikala; Zhu, Hong; Ma, Jing; Jiang, Juli; Ni, Zhigang; Wang, Ruibing; Lu, Xiancai; Wang, Leyong published the artcile< Selection of Planar Chiral Conformations between Pillar[5,6]arenes Induced by Amino Acid Derivatives in Aqueous Media>, COA of Formula: C8H18ClNO2, the main research area is selection planar chiral conformation pillararene induced amino acid derivative; amino acids; chiral conformations; chiral induction; chiral inversion; pillararenes.

Chiral α-amino acids play critical roles in the metabolic process in nearly all life forms. So far, chiral recognition of α-amino acids has mainly focused on the determination of L/D enantiomers. Herein, selection of planar chiral conformations between water-soluble pillar[5]arene WP5 and pillar[6]arene WP6 was observed due to α-side chain or Et ester moieties of L-α-amino acid Et ester hydrochlorides binding with WP5 and WP6, resp. Therefore, α-side chain and Et ester moieties of L-α-amino acid Et ester hydrochlorides were recognized by observing the induced CD signal and its inversion. This is a rare example of being able to detect the chiral region around α-carbon of a chiral α-amino acid mol.

Chemistry – A European Journal published new progress about Chiral amino acids Role: ANT (Analyte), ANST (Analytical Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, COA of Formula: C8H18ClNO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mohamed, Yasser Mahmoud A’s team published research in Applied Organometallic Chemistry in 2020-09-30 | 2743-40-0

Applied Organometallic Chemistry published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Synthetic Route of 2743-40-0.

Mohamed, Yasser Mahmoud A.; Attia, Yasser A. published the artcile< The influence of ultrasonic irradiation on catalytic performance of ZnO nanoparticles toward the synthesis of chiral 1-substituted-1H-tetrazole derivatives from α-amino acid ethyl esters>, Synthetic Route of 2743-40-0, the main research area is tetrazole preparation green chem enantioselective ultrasonic irradiation; amino acid ethyl ester triethyl orthoformate zinc oxide nanocatalyst.

In this work, a simple and greener protocol for the synthesis of 1-substituted 1H-tetrazole derived I (R = H, 2-methylpropyl, benzyl, 1H-indol-2-ylmethyl, etc.) from α-amino acid Et esters CH3CH2OC(O)CH(R)NH2.HCl was demonstrated in the presence of zinc oxide nanoparticles (ZnO NPs) under conventional conditions, with heating (at 60 and 80°C and under reflux) compared with ultrasonic. The effect of solvent was investigated to reveal that the solvent system CH3CN/H2O was optimum to obtain 1-substituted 1H-tetrazole I in high yield. In addition, the effect of irradiation power was studied, which showed that the yield of the reaction was improved at 200 W and the reaction time was shortened to be 30 min. Also, an improvement in the rate of the reaction and the yield of the products was observed when reactions were carried out under sonication conditions in the presence of ZnO NPs compared with conventional methods using various zinc salts as catalysts. The yields of tetrazole compounds I under sonication were determined (88-96%). Furthermore, the investigated heterogeneous catalytic system was recycled and reused for five runs with significant production of tetrazole I as a model target compound in excellent yields at each reaction cycle. In general, the investigated synthetic strategy for the heterocyclization of α-amino acid Et ester derivatives to 1-substituted 1H-tetrazoles I was in agreement with the green chem. point of view.

Applied Organometallic Chemistry published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Synthetic Route of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rachedi, Khadidja Otmane’s team published research in Journal of Molecular Structure in 2019-12-05 | 2743-40-0

Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.

Rachedi, Khadidja Otmane; Ouk, Tan-Sothea; Bahadi, Rania; Bouzina, Abdeslem; Djouad, Seif-Eddine; Bechlem, Khaoula; Zerrouki, Rachida; Ben Hadda, Taibi; Almalki, Faisal; Berredjem, Malika published the artcile< Synthesis, DFT and POM analyses of cytotoxicity activity of α-amidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site>, Reference of 2743-40-0, the main research area is acylaminoester preparation phosphorylation ethylphosphite; amidophosphonate preparation anticancer agent optimized geometry DFT; amino acid acylation phosphorylation reaction.

The authors studied the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. However, DFT calculation was used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound These results will be correlated with the exptl. values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil.

Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rachedi, Khadidja Otmane’s team published research in Journal of Molecular Structure in 2019-12-05 | 2743-40-0

Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.

Rachedi, Khadidja Otmane; Ouk, Tan-Sothea; Bahadi, Rania; Bouzina, Abdeslem; Djouad, Seif-Eddine; Bechlem, Khaoula; Zerrouki, Rachida; Ben Hadda, Taibi; Almalki, Faisal; Berredjem, Malika published the artcile< Synthesis, DFT and POM analyses of cytotoxicity activity of α-amidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site>, Reference of 2743-40-0, the main research area is acylaminoester preparation phosphorylation ethylphosphite; amidophosphonate preparation anticancer agent optimized geometry DFT; amino acid acylation phosphorylation reaction.

The authors studied the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. However, DFT calculation was used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound These results will be correlated with the exptl. values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil.

Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rachedi, Khadidja Otmane’s team published research in Journal of Molecular Structure in 2019-12-05 | 2743-40-0

Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.

Rachedi, Khadidja Otmane; Ouk, Tan-Sothea; Bahadi, Rania; Bouzina, Abdeslem; Djouad, Seif-Eddine; Bechlem, Khaoula; Zerrouki, Rachida; Ben Hadda, Taibi; Almalki, Faisal; Berredjem, Malika published the artcile< Synthesis, DFT and POM analyses of cytotoxicity activity of α-amidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site>, Reference of 2743-40-0, the main research area is acylaminoester preparation phosphorylation ethylphosphite; amidophosphonate preparation anticancer agent optimized geometry DFT; amino acid acylation phosphorylation reaction.

The authors studied the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. However, DFT calculation was used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound These results will be correlated with the exptl. values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil.

Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xi’s team published research in RSC Advances in 2021 | 2743-40-0

RSC Advances published new progress about Amino acid esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Recommanded Product: H-Leu-OEt.HCl.

Zhang, Xi; Liu, Dong-yun; Shang, Hai; Jia, Yi; Xu, Xu-Dong; Tian, Yu; Guo, Peng published the artcile< Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation>, Recommanded Product: H-Leu-OEt.HCl, the main research area is amino acid ester coupled caffeoylquinic derivative hypolipidemic agent.

Pandanus tectorius (L.) Parkins.(PTPs) is rich in caffeoylquinic acids and amino acids, especially some essential amino acids, such as valine, phenylalanine, and so forth. A series of novel amino acid ester-coupled caffeoylquinic acid derivatives have been designed and synthesized. Biol. evaluation suggested that some amino acid ester-coupled derivatives exhibited varying degrees of lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 6c, 6d, 6e and 6f exhibited comparable potential lipid-lowering effect with the pos. control simvastatin and chlorogenic acid. Further studies on the mechanism of 6c, 6d, 6e and 6f revealed that the lipid-lowering effects were related to their regulation of TG levels and mRNA levels of lipometabolic-modulating genes, and merit further investigation.

RSC Advances published new progress about Amino acid esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Recommanded Product: H-Leu-OEt.HCl.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Chang-Xia’s team published research in Macromolecules (Washington, DC, United States) in 2019-06-11 | 2743-40-0

Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Shi, Chang-Xia; Guo, Yu-Ting; Wu, Yu-Huan; Li, Zhao-Yue; Wang, Yao-Zong; Du, Fu-Sheng; Li, Zi-Chen published the artcile< Synthesis and Controlled Organobase-Catalyzed Ring-Opening Polymerization of Morpholine-2,5-Dione Derivatives and Monomer Recovery by Acid-Catalyzed Degradation of the Polymers>, HPLC of Formula: 2743-40-0, the main research area is acid catalyzed degradation polymer morpholine dione ring opening polymerization.

Polydepsipeptides (PDPs) are strictly alternating copolymers of α-hydroxy acids and α-amino acids produced via the ring-opening polymerization (ROP) of morpholino-2,5-dione derivatives (MDs). They have been used as promising biomaterials for their combined high thermal stability and good mech. properties of polyamides as well as the inherent degradability of polyesters. ROP of MDs is usually carried out at high temperatures with metal catalysts or enzymes, with less control over the polymer mol. weights and dispersities. In this work, we developed a simple and efficient synthetic strategy of a new platform MD via the Passerini-type reaction between an isocyano derivative of the amino acid and an aldehyde, followed by intramol. esterification. Nine new MDs were synthesized by using this method, and the organobase-catalyzed ROP of these MDs was investigated. When the ROPs of these MDs were catalyzed by either triazabicyclo[4.4.0]dec-5-ene (TBD) or diazabicyclo[5.4.0]undec-7-ene (DBU) in the presence of benzyl alc. as an initiator, the polymerizations were uncontrolled with the formation of both linear PDPs and cyclic PDPs. By using binary catalytic systems of 1-(3,5-bis(trifluoromethyl)-phenyl-3-cyclohexyl-2-thiourea) (TU) with DBU or TBD ([TU]/[TBD] or [DBU] > 3), the polymerizations became well-controlled, allowing the synthesis of PDPs with controlled mol. weights, low dispersities, as well as block copolymers. Furthermore, cyclic PDPs were obtained when the ROP of these MDs was catalyzed with TBD in the absence of both TU and an initiator. Finally, we used two methods to recover the monomer precursors or pure MD monomers: the TBD-catalyzed alcoholysis of PDPs was very fast and generated the monomer precursors quant., while the acid-catalyzed depolymerization of PDPs led to pure and quant. monomer recovery.

Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Feipeng’s team published research in Organic Letters in 2019-12-06 | 2743-40-0

Organic Letters published new progress about Acylation. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Application of C8H18ClNO2.

Yuan, Feipeng; Hou, Zhen-Lin; Pramanick, Pranab K.; Yao, Bo published the artcile< Site-selective modification of α-amino acids and oligopeptides via native amine-directed γ-C(sp3)-H arylation>, Application of C8H18ClNO2, the main research area is amino acid functionalization arylation aryl iodide amine directed acylation; peptide coupling functionalization arylation aryl iodide amine solvent effect.

Site-selective modification of chem. and biol. valuable α-amino acids and peptides is of great importance for biochem. study and pharmaceutical development. Few methods based on remote C(sp3)-H functionalization of aliphatic side-chains of peptides has been disclosed in recent years. In this report, we developed a novel approach for γ-C(sp3)-H and γ-/δ-C(sp2)-H arylation of α-amino acids with α-hydrogen by native amine-directed C-H functionalization and further realized the γ-C(sp3)-H arylation of N-terminally unprotected peptides.

Organic Letters published new progress about Acylation. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Application of C8H18ClNO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics