Category: 26662-94-2

Developing Nanodisc-ID for label-free characterizations of membrane proteins was written by Bao, Huan. And the article was included in Communications Biology in 2021.SDS of cas: 26662-94-2 The following contents are mentioned in the article:

Membrane proteins (MPs) influence all aspects of life, such as tumorigenesis, immune response, and neural transmission. However, characterization of MPs is challenging, as it often needs highly specialized techniques inaccessible to many laboratories We herein introduce nanodisc-ID that enables quant. anal. of membrane proteins using a gel electrophoresis readout. By leveraging the power of nanodiscs and proximity labeling, nanodisc-ID serves both as scaffolds for encasing biochem. reactions and as sensitive reagents for detecting membrane protein-lipid and protein-protein interactions. We demonstrate this label-free and low-cost tool by characterizing a wide range of integral and peripheral membrane proteins from prokaryotes and eukaryotes. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2SDS of cas: 26662-94-2).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 26662-94-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of Cholesterol on the Structure of Networked Water at the Surface of a Model Lipid Membrane was written by Oh, Myong In;Oh, Chang In;Weaver, Donald F.. And the article was included in Journal of Physical Chemistry B in 2020.COA of Formula: C39H76NO8P The following contents are mentioned in the article:

Using all-atom mol. dynamics simulations and network anal., we investigated the effect of membrane cholesterol level on the structure of organized water at the interface between bulk water and a model lipid membrane. Irresp. of membrane cholesterol content, interfacial water structure is largely perturbed by the presence of the membrane surface due to water-phospholipid interactions, which deplete the chance of hydrogen bonding among water mols. In contrast, the addition of cholesterol suppresses the disturbing effect of the membrane on water-water hydrogen bonding as cholesterol provides a more bulklike environment for the interfacial water mols., as evidenced by enhancement of local water d., a reduction in their orientational bias, and increases in both the number of hydrogen bonds and the topol. complexity of the hydrogen bond network. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2COA of Formula: C39H76NO8P).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C39H76NO8P

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quantification of in-plane flexoelectricity in lipid bilayers was written by Thomas, Nidhin;Agrawal, Ashutosh. And the article was included in EPL in 2021.Safety of (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate The following contents are mentioned in the article:

Lipid bilayers behave as 2D dielec. materials that undergo polarization and deformation in the presence of an elec. field. This effect has been previously modeled by continuum theories which assume a polarization field oriented normal to the membrane surface. However, the mol. architecture of the lipids reveals that the headgroup dipoles are primarily oriented tangential to the membrane surface. Here, we perform atomistic and coarse-grained mol. dynamics simulations to quantify the in-plane polarization undergone by a flat bilayer and a spherical vesicle in the presence of an applied elec. field. We use these predictions to compute an effective in-plane flexoelec. coefficient for four different lipid types. Our findings provide the first mol. proof of the in-plane polarization undergone by lipid bilayers and furnish the material parameter required to quantify membrane-elec. field interactions. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Safety of (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane was written by Gabba, Matteo;Frallicciardi, Jacopo;van ‘t Klooster, Joury;Henderson, Ryan;Syga, Lukasz;Mans, Robert;van Maris, Antonius J. A.;Poolman, Bert. And the article was included in Biophysical Journal in 2020.Product Details of 26662-94-2 The following contents are mentioned in the article:

The authors present a fluorescence-based approach for determination of the permeability of small mols. across the membranes of lipid vesicles and living cells. With properly designed experiments, the method allows the authors to assess the membrane phys. properties both in vitro and in vivo. The permeability of weak acids increases in the order of benzoic > acetic > formic > lactic, both in synthetic lipid vesicles and the plasma membrane of Saccharomyces cerevisiae, but the permeability is much lower in yeast (one to two orders of magnitude). A relation between the mol. permeability and the saturation of the lipid acyl chain (i.e., lipid packing) in the synthetic lipid vesicles. were observed By analyzing wild-type yeast and a manifold knockout strain lacking all putative lactic acid transporters, the yeast plasma membrane is impermeable to lactic acid on timescales up to �.5 h. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Product Details of 26662-94-2).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 26662-94-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

PLD2-PI(4,5)P2 interactions in fluid phase membranes: Structural modeling and molecular dynamics simulations was written by Han, Kyungreem;Pastor, Richard W.;Fenollar-Ferrer, Cristina. And the article was included in PLoS One in 2020.Synthetic Route of C39H76NO8P The following contents are mentioned in the article:

Interaction of phospholipase D2 (PLD2) with phosphatidylinositol (4,5)-bisphosphate (PIP2) is regarded as the critical step of numerous physiol. processes. Here we build a full-length model of human PLD2 (hPLD2) combining template-based and ab initio modeling techniques and use microsecond all-atom mol. dynamics (MD) simulations of the protein in contact with a complex membrane to determine hPLD2-PIP2 interactions. MD simulations reveal that the intermol. interactions preferentially occur between specific PIP2 phosphate groups and hPLD2 residues; the most strongly interacting residues are arginine at the pbox consensus sequence (PX) and pleckstrin homol. (PH) domain. Interaction networks indicate formation of clusters at the protein-membrane interface consisting of amino acids, PIP2, and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid (POPA); the largest cluster was in the PH domain. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Synthetic Route of C39H76NO8P).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C39H76NO8P

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterizing Membrane Association and Periplasmic Transfer of Bacterial Lipoproteins through Molecular Dynamics Simulations was written by Rao, Shanlin;Bates, George T.;Matthews, Callum R.;Newport, Thomas D.;Vickery, Owen N.;Stansfeld, Phillip J.. And the article was included in Structure (Oxford, United Kingdom) in 2020.HPLC of Formula: 26662-94-2 The following contents are mentioned in the article:

Escherichia coli lipoprotein precursors at the inner membrane undergo three maturation stages before transport by the Lol system to the outer membrane. Here, we develop a pipeline to simulate the membrane association of bacterial lipoproteins in their four maturation states. This has enabled us to model and simulate 81 of the predicted 114 E. coli lipoproteins and reveal their interactions with the host lipid membrane. As part of this set we characterize the membrane contacts of LolB, the lipoprotein involved in periplasmic translocation. We also consider the means and bioenergetics for lipoprotein localization. Our calculations uncover a preference for LolB over LolA and therefore indicate how a lipoprotein may be favorably transferred from the inner to outer membrane. Finally, we reveal that LolC has a role in membrane destabilization, thereby promoting lipoprotein transfer to LolA. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2HPLC of Formula: 26662-94-2).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 26662-94-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of nisin and potassium sorbate additions on lipids and nutritional quality of Tan sheep meat was written by Jia, Wei;Wu, Xixuan;Li, Ruiting;Liu, Shuxing;Shi, Lin. And the article was included in Food Chemistry in 2021.Recommanded Product: 26662-94-2 The following contents are mentioned in the article:

Nisin and potassium sorbate as preservatives are used in a broad range of meat. A lipidomic evaluation was performed on Tan sheep meat treated by two types of preservatives. The addition of potassium sorbate resulted in higher lipid losses compared with nisin treatment. Furthermore, 106 significant lipids of 12 lipid classes (PC, PS, LPS, LPC, PE, PI, LPE, TG, Cer, DG, SM, Sph) with variable importance in projection scores greater than 1.0 were detected and qualified to distinguish different preservatives added meat using UHPLC-Q-Orbitrap MS/MS. LOD and LOQ were 0.12-0.32μg kg-1 and 0.35-0.89μg kg-1, indicating high sensitivity and excellent anal. characteristics in the study. Nisin was confirmed to be the better preservative for prolonging the shelf life of Tan sheep meat while reducing the loss of nutrients. These results could provide a strong cornerstone for future research on preservatives in meat products. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Recommanded Product: 26662-94-2).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 26662-94-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A peptide from budding yeast gapdh serves as a promising antifungal against Cryptococcus neoformans was written by Zhang, Yang;Zhou, Liyan;Liu, Yan;Zhao, Xi;Lian, Xianqiang;Zhang, Jie;Zhao, De;Wang, Yujuan;Zhong, Jin;Wang, Junfeng;Wang, Hongli;Wang, Linqi;Fu, Yu V.. And the article was included in Microbiology Spectrum in 2022.Formula: C39H76NO8P The following contents are mentioned in the article:

Infection of Cryptococcus neoformans is one of the leading causes of morbidity and mortality, particularly among immunocompromised patients. However, currently available drugs for the treatment of C. neoformans infection are minimal. Here, we report SP1, a peptide derived from glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Saccharomyces cerevisiae, efficiently kills C. neoformans and Cryptococcus gattii. SP1 causes damages to the capsule. Unlike many antimicrobial peptides, SP1 does not form pores on the cell membrane of C. neoformans. It interacts with membrane ergosterol and enters vacuole possibly through membrane trafficking. C. neoformans treated with SP1 show the apoptotic phenotypes such as imbalance of calcium ion homeostasis, reactive oxygen increment, phosphatidylserine exposure, and nuclear fragmentation. Our data imply that SP1 has the potential to be developed into a treatment option for cryptococcosis. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Formula: C39H76NO8P).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C39H76NO8P

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Binding of SecA ATPase monomers and dimers to lipid vesicles was written by Roussel, Guillaume;White, Stephen H.. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2020.Category: esters-buliding-blocks The following contents are mentioned in the article:

The Escherichia coli SecA ATPase motor protein is essential for secretion of proteins through the SecYEG translocon into the periplasmic space. Its function relies upon interactions with the surrounding lipid bilayer as well as SecYEG translocon. That neg. charged lipids are required for bilayer binding has been known for >25 yr, but little systematic quant. data is available. We have carried out an extensive investigation of SecA partitioning into large unilamellar vesicles (LUV) using a wide range of lipid and electrolyte compositions, including the principal cytoplasmic salt of E. coli, potassium glutamate, which we have shown stabilizes SecA. The water-to-bilayer transfer free energy is about -7.5 kcal/mol for typical E. coli lipid compositions Although it has been established that SecA is dimeric in the cytoplasm, we find that the most widely cited dimer form (PDB 1M6N) binds only weakly to LUVs formed from E. coli lipids. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Category: esters-buliding-blocks).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape was written by Lorent, J. H.;Levental, K. R.;Ganesan, L.;Rivera-Longsworth, G.;Sezgin, E.;Doktorova, M. D.;Lyman, E.;Levental, I.. And the article was included in Nature Chemical Biology in 2020.Electric Literature of C39H76NO8P The following contents are mentioned in the article:

A fundamental feature of cellular plasma membranes (PMs) is an asym. lipid distribution between the bilayer leaflets. However, neither the detailed, comprehensive compositions of individual PM leaflets nor how these contribute to structural membrane asymmetries have been defined. We report the distinct lipidomes and biophys. properties of both monolayers in living mammalian PMs. Phospholipid unsaturation is dramatically asym., with the cytoplasmic leaflet being approx. twofold more unsaturated than the exoplasmic leaflet. Atomistic simulations and spectroscopy of leaflet-selective fluorescent probes reveal that the outer PM leaflet is more packed and less diffusive than the inner leaflet, with this biophys. asymmetry maintained in the endocytic system. The structural asymmetry of the PM is reflected in the asym. structures of protein transmembrane domains. These structural asymmetries are conserved throughout Eukaryota, suggesting fundamental cellular design principles. This study involved multiple reactions and reactants, such as (2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2Electric Literature of C39H76NO8P).

(2R,9Z)-1-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(palmitoyloxy)propan-2-yl oleate (cas: 26662-94-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C39H76NO8P

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics