Category: 26218-04-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 26218-04-2

Example 2Synthesis of 2, 5, 8-tris- (4- (2- ethylhexyloxycarbonyl) phenylamino) -1,3,4,6,7,9, 9b- heptaazaphenalene .A mixture of 2, 5, 8-trichloro-l, 3, 4, 6, 7, 9, 9b- heptaazaphenalene (50 mg, 0.18 mmol) and 2-ethylhexyl 4- aminobenzoate (270 mg, 1.08 mmol) in toluene (2 mL) is refluxed for 1 hour. The solvent is evaporated in vacuo and the crude product is purified by silica gel column chromatography, eluting with hexane / ethyl acetate 2 / 1. 2,5, 8-tris- (4- (2-ethylhexyloxycarbonyl) phenylamino) – 1, 3, 4, 6, 7, 9, 9b-heptaazaphenalene is obtained (160 mg, 0.17 mmol, 97%) . M. P. 183-186 C.1H NMR (300 MHz, DMSO-d6): ? 0,93 (m, 18H), 1,30 (m, 24H), 1,62 (m, 3H), 4,18 (d, J = 5.4 Hz, 6H), 7,95 (m, 12H), 10,85 (m, 3H) .MS-EI (m/z) : 916 (M+l) . UV: ?max = 326 nm; ? = 95000 M”1 cm”1 (CHCl3) .

The synthetic route of 26218-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISDIN, S.A.; WO2007/6807; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 26218-04-2, The chemical industry reduces the impact on the environment during synthesis 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, I believe this compound will play a more active role in future production and life.

In a reactor, cyanuric chloride (18.4 g, 0.1 mole) is dissolved in 150 ml of acetone at 0 C.-5 C. Sodium bicarbonate (10.6 g, 0.1 mole) is added, then a solution of 2-ethylhexyl para-aminobenzoate (24.9 g, 0.1 mole) dissolved in 150 ml of acetone is added drop by drop at a temperature below 10 C. in 10 minutes. Next the heterogeneous mixture is left for 3 hours at laboratory temperature. 500 ml of water are poured in. The precipitate formed is filtered off, then washed with water. After drying under vacuum, 38 g of an off-white solid are obtained. After recrystallization of this solid from 1,2-dichloroethane, 25.2 g (yield 63%) of 2,4-dichloro-6-(2-ethylhexyl 4′-aminobenzoate)-s-triazine are obtained in the form of a white powder: UV (Ethanol/DMSO): lambdamax=291 nm, E1%=732, and used as such in the following stage.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethylhexyl 4-aminobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; L’OREAL; US2008/8669; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C15H23NO2

Cyanuryl chloride (18.4 g, 0.1 mol) is dissolved at 0 C.-5 C. in 150 ml of acetone in a reactor. Sodium bicarbonate (10.6 g, 0.1 mol) is added thereto and then a solution of 2-ethylhexyl para-aminobenzoate (24.9 g, 0.1 mol) dissolved in 150 ml of acetone is added dropwise at a temperature of less than 10 C. over 10 minutes. Subsequently, the heterogeneous mixture is left at laboratory temperature for 3 hours. 500 ml of water are run in. The precipitate formed is filtered off and then washed with water. After drying under vacuum, 38 g of an off-white solid are obtained. After recrystallizing this solid from 1,2-dichloroethane, 25.2 g (63% yield) of 2,4-dichloro-6-(2-ethylhexyl 4′-aminobenzoate)-s-triazine are obtained in the form of a white powder: UV (ethanol/DMSO): lambdamax=291 nm, E1%=732, which is used as is in the following stage.

According to the analysis of related databases, 26218-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; L’OREAL; US2007/196294; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 26218-04-2,Some common heterocyclic compound, 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, molecular formula is C15H23NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2, 4-dichloro-6- (l-methyl-lH-pyrazol-5- yl) -1, 3, 5-triazine (0.23 g, 1 mmol) , 2-ethylhexyl 4- aminobenzoate (0.50 g, 2 mmol) and potassium carbonate(0.30 g, 2.17 mmol) in dioxane (15 mL) is heated to 900C for 4 hours following the reaction by TLC. The solvent is evaporated at low pressure, the residue is diluted in methylene chloride and the organic phase is washed with water. The solvent is removed at low pressure and the resulting crude product is purified by silica gel chromatography to yield 2, 4-bis{4- [ (2- ethylhexyloxy) carbonyl]phenylamino}-6- (1-methyl-lH- pyrazol-5-yl) -1, 3, 5-triazine (0.56 g, 0.85 mmol, 85%, thick oil) .1H RMN (300 MHz, DMSO-d6) : delta 0.82-0.94 (m, 12H), 1.23- 1.46 (m, 16H), 1.67 (m, 2H), 4.17 (d, J= 4.4 Hz, 4H), 4.30 (s, 3H), 7.06 (br s, IH), 7.54 (d, J= 1.9 Hz, IH), 7.94 (br s, 8H), 10.29 (br s, 2H) .UV lambdamax= 293 nm epsilon= 59000 M’1 cm”1 (methanol) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethylhexyl 4-aminobenzoate, its application will become more common.

Reference:
Patent; ISDIN, S.A.; WO2006/64366; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26218-04-2, name: 2-Ethylhexyl 4-aminobenzoate

200 mL of toluene was added to the flask, the water was refluxed for 1.0 hour,Cooled to about 80 ,Into the intermediate III79.30g (0.20mol);The intermediate II 104.58g (0.42mol), 200mL toluene was placed in a beaker and stirred until fully soluble constant pressure dropping funnel; when the temperature reached 80 ,A solution of isooctyl p-aminobenzoate in toluene, the reaction 7-8h. Add water and separate the organic phase.The organic phase was distilled under atmospheric pressure to obtain crude toluene, suction filtered;The crude product was added 950g ethanol heated to full solubility,Then add 10g of activated carbon and 10g clay reflux bleaching 1h,The octyl triazone was filtered off with suction, white solid with HPLC purity of 99.45% and yield of 88.1%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; China Three Gorges University; Li Dejiang; Liu Yiwen; Xie Yibi; (7 pag.)CN104860893; (2017); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, A new synthetic method of this compound is introduced below., Product Details of 26218-04-2

Example 2Synthesis of 2, 5, 8-tris- (4- (2- ethylhexyloxycarbonyl) phenylamino) -1,3,4,6,7,9, 9b- heptaazaphenalene .A mixture of 2, 5, 8-trichloro-l, 3, 4, 6, 7, 9, 9b- heptaazaphenalene (50 mg, 0.18 mmol) and 2-ethylhexyl 4- aminobenzoate (270 mg, 1.08 mmol) in toluene (2 mL) is refluxed for 1 hour. The solvent is evaporated in vacuo and the crude product is purified by silica gel column chromatography, eluting with hexane / ethyl acetate 2 / 1. 2,5, 8-tris- (4- (2-ethylhexyloxycarbonyl) phenylamino) – 1, 3, 4, 6, 7, 9, 9b-heptaazaphenalene is obtained (160 mg, 0.17 mmol, 97%) . M. P. 183-186 C.1H NMR (300 MHz, DMSO-d6): ? 0,93 (m, 18H), 1,30 (m, 24H), 1,62 (m, 3H), 4,18 (d, J = 5.4 Hz, 6H), 7,95 (m, 12H), 10,85 (m, 3H) .MS-EI (m/z) : 916 (M+l) . UV: ?max = 326 nm; ? = 95000 M”1 cm”1 (CHCl3) .

The synthetic route of 26218-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISDIN, S.A.; WO2007/6807; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 26218-04-2, The chemical industry reduces the impact on the environment during synthesis 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, I believe this compound will play a more active role in future production and life.

In a reactor, cyanuric chloride (18.4 g, 0.1 mole) is dissolved in 150 ml of acetone at 0 C.-5 C. Sodium bicarbonate (10.6 g, 0.1 mole) is added, then a solution of 2-ethylhexyl para-aminobenzoate (24.9 g, 0.1 mole) dissolved in 150 ml of acetone is added drop by drop at a temperature below 10 C. in 10 minutes. Next the heterogeneous mixture is left for 3 hours at laboratory temperature. 500 ml of water are poured in. The precipitate formed is filtered off, then washed with water. After drying under vacuum, 38 g of an off-white solid are obtained. After recrystallization of this solid from 1,2-dichloroethane, 25.2 g (yield 63%) of 2,4-dichloro-6-(2-ethylhexyl 4′-aminobenzoate)-s-triazine are obtained in the form of a white powder: UV (Ethanol/DMSO): lambdamax=291 nm, E1%=732, and used as such in the following stage.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethylhexyl 4-aminobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; L’OREAL; US2008/8669; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26218-04-2, Recommanded Product: 26218-04-2

15.5 g of the compound of Example 7 and 15.3 g of 2-ethylhexyl 4-aminobenzoate are reacted under stirring in 200 ml of xylene at reflux, gradually adding 100.0 g of 2.4 wt % aqueous sodium hydroxide. The water is eliminated by azeotropic distillation. The xylene solution is filtered hot to clarify it. When the solution is cooled, a precipitate forms which is washed with cold xylene and dried at 60 C. under vacuum. 23 g of a white crystalline solid with a melting point of 146 C. is obtained. The NMR spectrum confirms the identity of the compound obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethylhexyl 4-aminobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; 3V Sigma S.P.A.; Maestri, Francesco; Berte’, Ferruccio; (8 pag.)US2018/30001; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, This compound has unique chemical properties. The synthetic route is as follows., category: esters-buliding-blocks

568 g of anhydrous xylene and 139.0 g of the product prepared in example 1 were loaded into a 2-litre flask fitted with a stirrer, thermometer, dropping funnel and condenser. 645 g of a 30% xylene solution of 2-ethyl hexyl 4-aminobenzoate was added in 30 minutes to the mixture, stirred at 90C. When the addition had been completed, the mixture was maintained at 90C for 15 min and then heated to 125C in 60 minutes, obtaining a thick whitish suspension. The mixture was maintained under stirring at 125C for 3 hours, during which time a gradual reduction in the development of hydrochloric acid and an increase in the fluidity of the mixture was observed. After cooling to 80-90C, 280 g of 15% aqueous sodium carbonate was added cautiously. After 30 minutes’ mixing at 70-80C, stirring was interrupted and the underlying alkaline aqueous phase was discharged. After two further aqueous washes, the residual water was removed by azeotropic distillation under atmospheric pressure, followed by distillation of xylene to concentrate the solution. 680 g of whitish dispersion was obtained, containing approx. 275 g of the desired product, which was characterised by UPLC-MS. The dispersion “as is” was used for the subsequent stages of synthesis.

According to the analysis of related databases, 26218-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3V SIGMA S.P.A.; MAESTRI, Francesco; BEMPORAD, Luca; BERTE’, Ferruccio; WO2013/156272; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26218-04-2, Product Details of 26218-04-2

77.5 g of a 20 wt % aqueous solution of Na2CO3, 190.0 g of xylene and 68.5 g of 2-ethylhexyl 4-aminobenzoate are loaded into a 1 litre flask equipped with mechanical stirrer, thermometer, reflux condenser and dropping funnel. Keeping the mixture stirred at 65 C., a solution of 47.1 g of 4-nitrobenzoyl chloride is added to 47.0 g of xylene. The resulting mixture is then heated to reflux for 1 h. The organic phase is cooled, and the reaction product precipitates. The product is recovered by filtration, washing with xylene and drying at 110 C. under vacuum, to obtain 83 g of yellow powder corresponding to 2-ethylhexyl 4-(4-nitrobenzamido) benzoate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethylhexyl 4-aminobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; 3V Sigma S.P.A.; Maestri, Francesco; Berte’, Ferruccio; (8 pag.)US2018/30001; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics