Category: 2557-13-3

Jud, Wolfgang; Maljuric, Snjezana; Kappe, C. Oliver; Cantillo, David published the artcile< Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex>, Recommanded Product: Methyl 3-(trifluoromethyl)benzoate, the main research area is cathodic fluoromethylation arene heteroarene in situ triflyltriethylammonium complex.

While several trifluoromethylation reactions involving the electrochem. generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochem. reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Recommanded Product: Methyl 3-(trifluoromethyl)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Mi-Li; Li, Yu-Qin; Li, He; Jiang, Li; Wang, Zheng; Jin, Lu; Wang, Huan-huan; Zhou, Rong published the artcile< CuCl-Catalyzed Conversion of Aryl Boronic Acids and Carbon Dioxide to Carboxylate Esters>, Category: esters-buliding-blocks, the main research area is arylboronic acid carbon dioxide iodomethane copper catalyst esterification; aryl methyl carboxylate ester preparation.

The CuCl-catalyzed reaction of arylboronic acids with carbon dioxide to form carboxylate ester after treatment with CH3I was developed. The procedure featured mild conditions and good functional group tolerances. A diverse range of arylboronic acids were effectively converted into carboxylate esters. Even those bearing sensitive groups such as carbonyl, ester and amide could produce the desired products in good yields.

European Journal of Organic Chemistry published new progress about Aromatic carboxylic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C9H7F3O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Application of C9H7F3O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C9H7F3O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Application of C9H7F3O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Mi-Li; Li, Yu-Qin; Li, He; Jiang, Li; Wang, Zheng; Jin, Lu; Wang, Huan-huan; Zhou, Rong published the artcile< CuCl-Catalyzed Conversion of Aryl Boronic Acids and Carbon Dioxide to Carboxylate Esters>, Category: esters-buliding-blocks, the main research area is arylboronic acid carbon dioxide iodomethane copper catalyst esterification; aryl methyl carboxylate ester preparation.

The CuCl-catalyzed reaction of arylboronic acids with carbon dioxide to form carboxylate ester after treatment with CH3I was developed. The procedure featured mild conditions and good functional group tolerances. A diverse range of arylboronic acids were effectively converted into carboxylate esters. Even those bearing sensitive groups such as carbonyl, ester and amide could produce the desired products in good yields.

European Journal of Organic Chemistry published new progress about Aromatic carboxylic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C9H7F3O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Application of C9H7F3O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Mi-Li; Li, Yu-Qin; Li, He; Jiang, Li; Wang, Zheng; Jin, Lu; Wang, Huan-huan; Zhou, Rong published the artcile< CuCl-Catalyzed Conversion of Aryl Boronic Acids and Carbon Dioxide to Carboxylate Esters>, Category: esters-buliding-blocks, the main research area is arylboronic acid carbon dioxide iodomethane copper catalyst esterification; aryl methyl carboxylate ester preparation.

The CuCl-catalyzed reaction of arylboronic acids with carbon dioxide to form carboxylate ester after treatment with CH3I was developed. The procedure featured mild conditions and good functional group tolerances. A diverse range of arylboronic acids were effectively converted into carboxylate esters. Even those bearing sensitive groups such as carbonyl, ester and amide could produce the desired products in good yields.

European Journal of Organic Chemistry published new progress about Aromatic carboxylic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C9H7F3O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Application of C9H7F3O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C9H7F3O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Application of C9H7F3O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Ya-Fang; Li, Ling-Jun; Liu, Min; Xu, Hui; Dai, Hui-Xiong published the artcile< Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates>, Application In Synthesis of 2557-13-3, the main research area is palladium catalyst copper methoxycarbonylation arylboronic acid Me aryl thiocarbonate.

Here, we report O-Me S-aryl thiocarbonates as a versatile esterification reagent for palladium-catalyzed methoxycarbonylation of arylboronic acid in the presence of copper(I) thiophene-2-carboxylate (CuTC). The reaction condition is mild, and a variety of substituents including sensitive -Cl, -Br, and free -NH2 could be tolerated. Further applications in the late-stage esterification of some pharmaceutical drugs demonstrate the broad utility of this method.

Journal of Organic Chemistry published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Application In Synthesis of 2557-13-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics