Category: 2555-28-4

Application of 2555-28-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2555-28-4, name is 7-Methoxy-4-methylcoumarin belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N-Bromosuccinimide (224 mg, 1.26 mmol) was added slowly to a suspension of 7-methoxy-4-methyl-2H-chromen-2-one (17) (200 mg, 1.05 mmol) in PEG-400 (6 mL). The reaction mixture was stirred at rt for 2 h. The reaction mixture was extracted with H2O (25 mL) and EtOAc (3 * 25 mL) and the combined organic phases were washed with brine (30 mL). The organic phase was dried over Na2SO4. After concentration in vacuo the crude product was purified by column chromatography on silica gel. This afforded the titled compound as a white solid (130 mg, 0.48 mmol, 46% yield); Rf = 0.35 (EtOAc/heptane 1:2); mp 144-146 C (decomposed); 1H NMR (300 MHz, CDCl3) delta 2.60 (s, 3H), 3.88 (s, 3H), 6.81 (d, J = 2.7 Hz, 1H), 6.88 (dd, J = 9.0, 2.7 Hz, 1H), 7.54 (d, J = 9.0 Hz, 1H); 13C NMR (75 MHz, CDCl3) delta 19.5, 55.8, 100.7, 109.7, 112.9, 113.4, 126.0, 151.1, 153.6, 157.3, 162.7; LC-MS [M+H]+ calcd for C11H9BrO3: 269.0, found: 269.0; Anal. calcd for C11H9BrO3: C, 49.10, H, 3.37, found: C, 48.76; H, 3.13.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Methoxy-4-methylcoumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Huynh, Tri H.V.; Abrahamsen, Bjarke; Madsen, Karsten K.; Gonzalez-Franquesa, Alba; Jensen, Anders A.; Bunch, Lennart; Bioorganic and Medicinal Chemistry; vol. 20; 23; (2012); p. 6831 – 6839;,
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Synthetic Route of 2555-28-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2555-28-4, name is 7-Methoxy-4-methylcoumarin belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 4-Methyl-6,7-dimethoxycoumarin (0.05 g, 0.227 mmol) was dissolved in acetonitrile (5 ml) in a microwave vessel. N-Bromosuccinimide (0.06 g, 0.340 mmol) was added to the mixture and the vessel inserted into the microwave at 250 W for 5 min at 80 C. The reaction was monitored by thin layer chromatography (silica gel, 3:1 CH2Cl2/EtOAc). Upon completion, the reaction mixture was cooled and the resultant precipitate was collected by vacuum filtration. The crude product was then recrystallized from a mixture of CH2Cl2/MeOH to yield 3-bromo-4-methyl-6,7-dimethoxycoumarin (1a, 0.060 g, 89%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Methoxy-4-methylcoumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Marriott, Karla-Sue C.; Bartee, Rena; Morrison, Andrew Z.; Stewart, Leonard; Wesby, Julian; Tetrahedron Letters; vol. 53; 26; (2012); p. 3319 – 3321;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2555-28-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2555-28-4, name is 7-Methoxy-4-methylcoumarin belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A general procedure for preparation of compounds 5, 9a-b and13: the corresponding N-bromosuccinimide (1.2 equiv) was addedslowly to a solution of 7-methoxycoumarin (1 equiv) and sodiumacetate (0.05 equiv) in DMF, and the mixture was stirred at 75 Cfor 6 h. After pouring into brine, and washing, then mixture wasextracted with ethyl acetate. The combined organic layers werewashed with brine, dried over anhydrous Na2SO4 and then filteredand concentrated in vacuum. The product was purified by columnchromatography (0-20% ethyl acetate in petroleum ether).

The synthetic route of 7-Methoxy-4-methylcoumarin has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Lu; Hu, Zhiye; Luo, Junjie; Tang, Chu; Zhang, Silong; Ning, Wentao; Dong, Chune; Huang, Jian; Liu, Xianjun; Zhou, Hai-Bing; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3531 – 3539;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2555-28-4,Some common heterocyclic compound, 2555-28-4, name is 7-Methoxy-4-methylcoumarin, molecular formula is C11H10O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(0.95 g, 5 mmol) of 4a, 50 mL of xylene was added to a round bottom flask,Stir and heat, so that it gradually dissolved.Then, selenium dioxide (0.55 g, 5 mmol) was added and the reaction was refluxed for 12 h.Stop heating, hot suction filter, the filtrate cold with yellow solid precipitation, The filtrate was concentrated under reduced pressure to give a yellow solid 4b (0.85 g, yield 84%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2555-28-4, its application will become more common.

Reference:
Patent; Shandong He Bentang Biological Technology Co., Ltd.; Pan Xuan; Zhang Chengrui; Wang Huili; (9 pag.)CN106317029; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2555-28-4, A common heterocyclic compound, 2555-28-4, name is 7-Methoxy-4-methylcoumarin, molecular formula is C11H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of compound 22b (1.0 g, 5.3 mmol), NBS (1.4 g, 7.9 mmol) and BPO (20 mg) in CHCl3(30 mL) was heated to reflux at 70C for 8 hours. The reaction mixture was cooled to 0C, diluted with water, and extracted with CHCl3. The organic phase was concentrated in vacuo to afford compound 22c (1.0 g, 71 %).

The synthetic route of 2555-28-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KOZLOWSKI, Joseph; COBURN, Craig; YU, Wensheng; TONG, Ling; HU, Bin; ZHONG, Bin; HAO, Jinglai; WANG, Dahai; JI, Tao; WO2015/89810; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics