Category: 252881-74-6

Some common heterocyclic compound, 252881-74-6, name is tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, molecular formula is C13H27NO5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 252881-74-6

In a solution of tert-butyl 3- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) propanoate (6.00 g, 21.64 mmol) and 3, 3′- ( (oxybis (ethane-2, 1-diyl) ) bis (oxy) ) dipropanoic acid (21.01 g, 84.00 mmol) in DMA (200 ml) were added EDC (18.00 g, 93.75 mmol) and DIPEA (5.00 g, 38.75 mmol) . The mixture was stirred overnight, then concentrated and purified by SiO 2 column chromatography (MeOH: CH 2Cl 2 = 1: 12 to 1: 5) to give the title compound as a white oil (9.15 g, 86%yield) . ESI m/z: calcd for C 23H 44NO 11 [M+H] +: 510.28, found: 510.55.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 252881-74-6, its application will become more common.

Reference:
Patent; HANGZHOU DAC BIOTECH CO., LTD; ZHAO, Robert Yongxin; ZHUO, Xiaotao; YANG, Qingliang; ZHAO, Linyao; HUANG, Yuanyuan; YE, Hangbo; YANG, Chengyu; LEI, Jun; GAI, Shun; GUO, Huihui; JIA, Junxiang; BAI, Lu; XIE, Hongsheng; ZHOU, Xiaomai; GUO, Zhixiang; LI, Wenjun; CAO, Mingjun; ZHENG, Jun; YE, Zhichang; YANG, Yanlei; (325 pag.)WO2020/6722; (2020); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

252881-74-6, A common compound: 252881-74-6, name is tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Compound C (11.5 mg, 20.2 mumol) and HATU (15.4 mg, 54.7 mumol) were dissolved in DMF (2 mL). DIPEA (35.2 muL, 202 mumol) and tert-butyl 12 amino-4,7,10-trioxadodecanoate (theoretical value 80%) (14.0 mg, ?40.3 mumol) were added to the obtained solution, and the obtained mixture was stirred in an argon atmosphere overnight at room temperature. The solvent was removed in a vacuum, and the residue was refined via HPLC (ODS-C18, A (water and 0.1% TFA):B (CH3CN and 0.1% TFA)=99:1 to 1:99; 20 minutes) to obtain a tert-butyl ester constituting Compound D in the form of a red amorphous solid (LRMS (ESI+): calculated [M+H]+ value: 827; measured value: 827).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF TOKYO; Urano, Yasuteru; Nagano, Tetsuo; Asanuma, Daisuke; Hirose, Kenzo; Namiki, Shigeyuki; Takaoka, Yousuke; (28 pag.)US9784732; (2017); B2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics