Category: 24812-89-3

Discovery of 24812-89-3

Synthetic Route of 24812-89-3,Some common heterocyclic compound, 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthetic Route of 24812-89-3,Some common heterocyclic compound, 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Scheme 26, step A. To a solution of 5-bromo-2-(trifluoromethyl)benzoic acid(1.00 g, 0. 00371 mol) in CH2Ch (15 mL) at room temperature are added methyl4-amino-3,5-dimethylbenzoate (0.46 g, 0.00260 mol, see preparation 12) and triethylamine (1.10 ml, 0.00743 mol). After stirring the reaction mixture for 10 minutes, 1-propanephosphonic acid cyclic anhydride (50% solution in ethyl acetate, 6.00 ml,0.00929 mol) is added via syringe and stirred at room temperature. After 14 hours, thereaction mixture is diluted with water and extracted with dichloromethane. The organic layers are combined and dried over magnesium sulfate, filtered, and concentrated underreduced pressure. The resulting residue is purified by flash chromatography (silica gel)with 10-15% EtOAc to give the title compound as an off-white solid (0.45 g, 27.67 %).Mass spectrum (m/z): 430.0 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-amino-2,4-dimethylbenzoate, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee; WO2014/4230; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The origin of a common compound about Methyl 3-amino-2,4-dimethylbenzoate

Application of 24812-89-3, These common heterocyclic compound, 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Application of 24812-89-3, These common heterocyclic compound, 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Scheme 23. step A. To a solution of 2-chloroquinoline-4-carboxylic acid (0.40 g,0.0019 mol) in CH2Ch (8 mL) at 0C are added methyl3-amino-2,4-dimethylbenzoate(0.31 g, 0. 0017 mol, see preparation 10) and triethylamine (0.80 ml, 0.0058 mol). After stirring the reaction mixture for 10 minutes, 1-propanephosphonic acid cyclic anhydride(50% solution in ethyl acetate, 2.45 ml, 0.0038 mol) is added via syringe and stirred at room temperature. After 16 hours, the reaction is diluted with water and extracted twicewith dichloromethane. The organic layers are combined and dried over magnesiumsulfate, filtered, and concentrated under reduced pressure. The resulting residue istriturated with 20% diethyl ether in pentane and filtered to give the title compound as an off-white solid (0.55 g, 77 %). Mass spectrum (m/z): 369.1 (M+1).

Statistics shows that Methyl 3-amino-2,4-dimethylbenzoate is playing an increasingly important role. we look forward to future research findings about 24812-89-3.

Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee; WO2014/4230; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sources of common compounds: Methyl 3-amino-2,4-dimethylbenzoate

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24812-89-3.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 24812-89-3

To a solution of 6-chloro-3-methyl-pyridine-2-carboxylic acid (0.8 g, 4.6 mmol) in CH2CI2 (4 mL) at room temperature are added methyl 3-amino-2,4- dimethyl-benzoate (0.84 g, 4.6 mmol) and TEA (945.0 mg, 9.3 mmol). After stirring 10 minutes, 1-propanephosphonic acid cyclic anhydride (50% solution in EtOAc, 2.97 g, 9.3 mmol) is added via syringe. After 2 hours at 35 C, the reaction mixture is diluted with saturated NaHC03 solution and extracted with CH2C12. The combined organic layers are dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue is purified by silica gel flash chromatography, eluting with 10% EtOAc in hexanes to give methyl 3-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-2,4-dimethyl-benzoate as a colorless oil (1.1 g, 72%). Mass spectrum (m/z): 333.3 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24812-89-3.

Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; MANNINEN, Peter Rudolph; SCHIFFLER, Matthew Allen; VETMAN, Tatiana Natali; WARSHAWSKY, Alan M.; YORK, Jeremy Schulenburg; WO2015/94912; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics