S News New learning discoveries about 24807-40-7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, A new synthetic method of this compound is introduced below., Recommanded Product: 24807-40-7

To a solution of dimethyl methylphosphonate (1.16 g, 9.33 mmol) in THF (12.5 mL, 0.25 M) at -78 C was added nBuLi (3.9 mL, 9.33 mmol, 2.5 M in hexane). The mixture was stirred for 30 min after which a THF solution (2.5 mL) of ester 11 (750 mg, 3.10 mmol) was added slowly. The reaction mixture was warmed to RT and let stir for 1h, upon which time TLC indicated complete consumption of 11. The reaction mixture was quenched with saturated aqueous NH4Cl (5 mL). The mixture was diluted with H2O (10 mL) and extracted with EtOAc (4 x 25 mL). The combined organic layers were washed with H2O (50 mL), saturated aqueous NaCl (50 mL), dried over MgSO4, filtered, and concentrated in vacuo. Purification by FCC (EtOAc) yielded 12 (1.09 g, 3.01 mmol, 97%) as a clear oil. Data for 12: Rf 0.45 (1:1 Hexanes: EtOAc); IR (thin film) 3034, 2955, 1714, 1512, 1244 cm-1; 1H NMR (700 MHz, CDCl3) delta 7.44 (d, J = 7.5 Hz, 2 H), 7.39 (t, J = 7.6 Hz, 2 H), 7.34 (t, J = 8.6 Hz, 2 H), 6.91 (d, J = 8.6 Hz, 2 H), 5.05 (s, 2 H), 3.76 (d, J = 11.3 Hz, 6 H), 3.08 (d, J = 22.7 Hz, 2 H), 2.94 (t, J = 7.2 Hz, 2 H), 2.87 (t, J = 7.2 Hz, 2H); 13C NMR (176 MHz, CDCl3) delta 201.1, 157.2, 137.1, 132.9, 129.4, 128.6, 127.9, 127.5, 114.9, 70.0, 53.1 (d, J = 6.3 Hz), 45.8, 41.6 (d, J = 128.0 Hz), 28.6; HRMS (ESI) calcd for C19H24PO5 [M+H]: 363.1357, found 363.1361.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Salih, M. Quamar; Beaudry, Christopher M.; Tetrahedron Letters; vol. 58; 21; (2017); p. 2023 – 2025;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New learning discoveries about Methyl 3-(4-(benzyloxy)phenyl)propanoate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, A new synthetic method of this compound is introduced below., Computed Properties of C17H18O3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, A new synthetic method of this compound is introduced below., Computed Properties of C17H18O3

To a solution of dimethyl methylphosphonate (1.16 g, 9.33 mmol) in THF (12.5 mL, 0.25 M) at -78 C was added nBuLi (3.9 mL, 9.33 mmol, 2.5 M in hexane). The mixture was stirred for 30 min after which a THF solution (2.5 mL) of ester 11 (750 mg, 3.10 mmol) was added slowly. The reaction mixture was warmed to RT and let stir for 1h, upon which time TLC indicated complete consumption of 11. The reaction mixture was quenched with saturated aqueous NH4Cl (5 mL). The mixture was diluted with H2O (10 mL) and extracted with EtOAc (4 x 25 mL). The combined organic layers were washed with H2O (50 mL), saturated aqueous NaCl (50 mL), dried over MgSO4, filtered, and concentrated in vacuo. Purification by FCC (EtOAc) yielded 12 (1.09 g, 3.01 mmol, 97%) as a clear oil. Data for 12: Rf 0.45 (1:1 Hexanes: EtOAc); IR (thin film) 3034, 2955, 1714, 1512, 1244 cm-1; 1H NMR (700 MHz, CDCl3) delta 7.44 (d, J = 7.5 Hz, 2 H), 7.39 (t, J = 7.6 Hz, 2 H), 7.34 (t, J = 8.6 Hz, 2 H), 6.91 (d, J = 8.6 Hz, 2 H), 5.05 (s, 2 H), 3.76 (d, J = 11.3 Hz, 6 H), 3.08 (d, J = 22.7 Hz, 2 H), 2.94 (t, J = 7.2 Hz, 2 H), 2.87 (t, J = 7.2 Hz, 2H); 13C NMR (176 MHz, CDCl3) delta 201.1, 157.2, 137.1, 132.9, 129.4, 128.6, 127.9, 127.5, 114.9, 70.0, 53.1 (d, J = 6.3 Hz), 45.8, 41.6 (d, J = 128.0 Hz), 28.6; HRMS (ESI) calcd for C19H24PO5 [M+H]: 363.1357, found 363.1361.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Salih, M. Quamar; Beaudry, Christopher M.; Tetrahedron Letters; vol. 58; 21; (2017); p. 2023 – 2025;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple exploration of 24807-40-7

Application of 24807-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Application of 24807-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

An aqueous solution of NaOH (1 M, 270 mL) was added to a mixture of the 3-(4-benzyloxyphenyl)propionic acid methyl ester from Step 2 above in MeOH (600 mL) and the reaction was stirred overnight. The crystalline ppt was collected by filtration, air dried and then partitioned between EtOAc/Et2O/1 M HCl (500 mL, 250 mL, 150 mL). The organic phases were dried over MgSO4 and evaporated to give the product as a white solid (16.2 g, 70%, 3 Steps). 1H NMR (CDCl3) delta 2.61-2.68 (m, 2H), 2.86-2.93 (m, 2H), 5.03 (s, 2H), 6.88-6.93 (m, 2H), 7.10-7.15 (m, 2H), 7.28-7.45 (m, 5H).

The synthetic route of Methyl 3-(4-(benzyloxy)phenyl)propanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Agouron Pharmaceuticals, Inc.; US2005/176701; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some tips on 24807-40-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-(4-(benzyloxy)phenyl)propanoate, and friends who are interested can also refer to it.

Related Products of 24807-40-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24807-40-7 name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2 N Sodium hydroxide aqueous solution (3.5 mL) and water (10 mL) were added to a tetrahydrofuran-methanol solution (20 mL-10 mL) of the compound obtained in (1) (1.60 g), and stirred for 1 hour at 60C. The reaction solution was made acidic with 1 N hydrochloric acid, and then extracted with diethyl ether. The extract was washed with saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from diethyl ether-hexane to obtain 3-[4-(benzyloxy)phenyl] propionic acid (1.27 g) as colorless crystals. 1H-NMR (300MHz, CDCl3); delta 2.65 (2H, t, J=7.8Hz), 2.91 (2H, t, J=7.8Hz), 5.04 (2H, s), 6.91 (2H, d, J=8.7Hz), 7.13 (2H, d, J=8.7Hz), 7.29-7.45 (5H., m)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-(4-(benzyloxy)phenyl)propanoate, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1849465; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Continuously updated synthesis method about 24807-40-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(4-(benzyloxy)phenyl)propanoate, its application will become more common.

Related Products of 24807-40-7,Some common heterocyclic compound, 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, molecular formula is C17H18O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 2-((4-((phenylmethyl)oxy)phenyl)methyl)butanoate(32.1).; To a solution of lithium diisopropylamide (6.5 mL, 2.0 M in heptane/THF/ethylbenzene) in THF (25.0 mL) and l,3-dimethyl-3,4,5,6- tetrahydro-2(lH)-pyrimidinone (5.0 mL) was added methyl 3-(4- (benzyloxy)phenyl)propanoate 23.1 (3.00 g, 1 1 mmol) in THF (1OmL) and 1,3- dimethyl-3,4,5,6-tetrahydro-2(lH)-pyrimidinone (2.5 mL) at -780C. The resulting mixture was stirred at -780C for 30 minutes and then iodoethane (1.0 mL, 13 mmol) in THF (5.0 mL) was added. The reaction mixture was stirred at the same temperature for 20 minutes. The reaction was then stirred at room temperature for 16 hours. The reaction was quenched with water (30.0 mL), and the mixture was concentrated in vacuo. The residue was disolved in EtOAc (100 mL), washed with brine (2×25 mL), and dried with Na2SO4. The residue was purified by silica gel column (eluent with hexane/EtOAc; 85/15) to give the title compound 32.1. MS ESI (pos.) m/e: 299.0 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(4-(benzyloxy)phenyl)propanoate, its application will become more common.

Reference:
Patent; AMGEN INC.; WO2008/130514; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New learning discoveries about Methyl 3-(4-(benzyloxy)phenyl)propanoate

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

24807-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24807-40-7, name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, This compound has unique chemical properties. The synthetic route is as follows.

Methyl 2-((4-((phenylmethyl)oxy)phenyI)methyl)-4-pentenoate(33.1); To a solution of lithium diisopropylamide (6.5 mL, 13.0 mmol, 2.0M in heptanelambdaTHF/ethylbenzene) in THF (25.0 mL) and l,3-dimethyl-3,4,5,6- tetrahydro-2(lH)-pyrimidinone (5.0 mL) was slowly added methyl 3-(4- (benzyloxy)phenyl)propanoate 23.1 (3.00 g, 1 1 mmol) in THF (10 mL) and 1 ,3- dimethyl-3,4,5,6-tetrahydro-2(lH)-pyrimidinone (2.5 mL) at -780C. The resulting mixture was stirred at -780C for 30 minutes and then allyl iodide (1.08 mL, 13.0 mmol) in THF (5.0 mL) was added. The reaction mixture was stirred at the same temperature for 20 minutes. The reaction was then stirred at room temperature for 16 hours. The reaction was quenched with water (30.0 mL). The solvent was concentrated in vacuo, and the residue was disolved in EtOAc (100 mL) and washed with brine (2 x 25 mL) and then dried with Na2SO4. The product thus obtained was purified on a silica gel column, to give the title compound 33.1. 1H NMR (500 MHz, CDCl3) delta ppm 2.29 – 2.34 (m, 1 H) 2.39 – 2.44 (m, 1 H) 2.63 – 2.79 (m, 2 H) 2.91- 2.96 (m, 1 H) 3.64 (s, 3 H) 5.06 – 5.18 (m, 4 H) 5.67 – 5.85 (m, 1 H) 6.88 – 7.03 (m, 2 H) 7.03 – 7.18 (m, 2 H) 7.34 – 7.49 (m, 5 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; AMGEN INC.; WO2008/130514; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics