Category: 2459-25-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2459-25-8, name is Methyl 2-naphthoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C12H10O2

General procedure: To a solution of methyl 4-methylbenzoate (6.0 g, 40mmol, 1.0 equiv) in toluene (200 mL) was added TMSCF3 (11.3 g, 80 mmol, 2.0 equiv) at room temperatureunder Ar. The reaction mixture was cooled to -78 oC, TBAF (4 mL, 1.0 M in THF, 0.1 equiv) was then added.After stirring for 0.5 h at -78 oC, the reaction mixture was allowed to warm to room temperature and stirred forfurther 12 h. Hydrochloric acid (30 mL, 2.0 M, 1.5 equiv) was then added and the resulting mixture stirred forfurther 2 h. The resulting suspension was quenched with saturated aqueous NaHCO3 and extracted with ethylacetate. The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue waspurified by flash column chromatography to give ketone 10a.

The synthetic route of 2459-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gao, Xing; Cheng, Ran; Xiao, Yu-Lan; Wan, Xiao-Long; Zhang, Xingang; Chem; vol. 5; 11; (2019); p. 2987 – 2999;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2459-25-8, name is Methyl 2-naphthoate, A new synthetic method of this compound is introduced below., Formula: C12H10O2

Under a nitrogen atmosphere,Dissolve 50 g of methyl naphthalene-2-carboxylate in 350 mL of tetrahydrofuran.In a three-necked flask, the temperature of the system was reduced to -10C with liquid nitrogen.A 2mol/L solution of lithium diisopropylamide in tetrahydrofuran was added to the reaction system, wherein the volume of lithium diisopropylamide was 173.6mL, and then the temperature was raised to 20C and kept warm for 3 hours and then lowered to -80C and 87g was added. 1,2-Dibromoethane was reacted at -80C for 0.5 h, then allowed to stand at room temperature. The reaction solution was poured into a mixture of 500 mL of ethyl acetate and 2000 mL of a 10% volume aqueous solution of hydrochloric acid.After stirring for 10 minutes, let stand for 0.5h and discard the lower aqueous phase.The organic layer obtained from the upper layer was dried with 40 g of anhydrous sodium sulfate for 0.5 h.After filtration, the filtrate was distilled under reduced pressure at 45 C and -0.08 MPa until no solvent flowed out.The crude product of 3-bromonaphthalene-2-carboxylic acid methyl ester was obtained 69 g ,The crude product was added to 517 mL of ethanol and heated to reflux at 45 C. for 2 h.Then it was cooled to 0C for 1 h, filtered, and the filter cake was dried at 50C for 2 h.Obtained 66.5 g of 3-bromonaphthalene-2-carboxylic acid methyl ester, yield 93.5%, purity >98%.

The synthetic route of 2459-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Liu Ruigang; Zhang Wen; Li Jian; Li Lingang; Xue Zhen; Wang Yalong; (7 pag.)CN107602381; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2459-25-8, name is Methyl 2-naphthoate, A new synthetic method of this compound is introduced below., Safety of Methyl 2-naphthoate

General procedure: The appropriate aryl-ester 18a-e (1 eq), was added of EtOH (2.22 ml*mmol/eq) followed by hydrazine monohydrate (3 eq). The solution was refluxed overnight, then cooled to room temperature. The precipitate obtained was filtered and washed with cold EtOH and n-hexane to give the pure product.

The synthetic route of 2459-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Giancotti, Gilda; Cancellieri, Michela; Balboni, Andrea; Giustiniano, Mariateresa; Novellino, Ettore; Delang, Leen; Neyts, Johan; Leyssen, Pieter; Brancale, Andrea; Bassetto, Marcella; European Journal of Medicinal Chemistry; vol. 149; (2018); p. 56 – 68;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 2459-25-8, The chemical industry reduces the impact on the environment during synthesis 2459-25-8, name is Methyl 2-naphthoate, I believe this compound will play a more active role in future production and life.

4a (1.54 g, 9 mmol) was dissolved in 30 ml of ethanol, hydrazine hydrate was added, and the reaction was refluxed overnight. The next day, TLC monitored the reaction completely. At room temperature, a yellow solid precipitated continuously. Concentrate to a small volume, ice bath for 30 minutes, and filter to obtain a solid. Drying gave 1.21 g of a yellow solid. Yield: 72%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-naphthoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University; Chen Jianzhong; Yang Bo; He Qiaojun; Pan Youlu; Ying Meidan; (29 pag.)CN108329232; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics