Extracurricular laboratory: Synthetic route of 2396-84-1

The synthetic route of 2396-84-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2396-84-1, These common heterocyclic compound, 2396-84-1, name is Ethyl sorbate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of diisopropyl amine (3.5 mL, 25.0 mmol) in dry THF (12 mL) cooled at -10 ¡ãC under a nitrogen atmosphere was added a solution of n-BuLi (10 mL, 2.5 M in hexanes, 25.0 mmol) followed by stirring for 30 min at the same temperature. The resultant LDA solution was then cooled to -78 ¡ãC, and, after adding HMPA (4 mL), was stirred for another 20 min at -78 ¡ãC.To the above prepared LDA-HMPA solution was added a solution of ethyl sorbate (8, 1.50 mL, 10.0 mmol) in dry THF (5 mL). After stirring at -78 ¡ãC for 1.5 h, the reaction was quenched by adding a mixed solution of water (22 mL) and acetic acid (4 mL). The reaction mixture was extracted with hexane (30 mL.x.3) and the combined organic layer was washed with saturated aqueous NaHCO3 and brine, dried over anhydrous Na2SO4, filtered off, and concentrated under reduced pressure to give the crude deconjugate ester, which was used for next reaction without purification.

The synthetic route of 2396-84-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wu, Jinlong; Jiang, Xiuqing; Xu, Jingjing; Dai, Wei-Min; Tetrahedron; vol. 67; 1; (2011); p. 179 – 192;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics