Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2396-83-0, name is Ethyl hex-3-enoate, A new synthetic method of this compound is introduced below., Safety of Ethyl hex-3-enoate
A solution of 2.32 mL (14.5 mmol) ethyl (E)-hex-3-enoate in 30 mL dry dichloromethane under nitrogen was cooled to -78 C and 23.0 mL (23.0 mmol) DIBAL (1 m in dichloromethane) was added over 45 min. After stirring for 1 h methanol (8 mL) was added carefully, followed 50 mL of an aqueous citric acid solution (10 %, m/V). After warming up to room temperature 20 mL brine was added and the organic layer separated. The aqueous layer was extracted with dichloromethane (3 x 30 mL) and the combined organic layers dried over sodium sulfate and evaporated carefully (600 mbar, bath temperature 40 C). The liquid residue was treated with 1.14 g (16.4 mmol) hydroxylamine hydrochloride and 6.0 mL (6.0 mmol) sodium hydroxide solution (6 m) under ice cooling. The mixture was stirred for 4 h at room temperature, then 2 mL glacial acetic acid and 100 mL water added, followed by extraction with ethyl acetate (3 x 30 mL). The combined organic layers were dried over sodium sulfate and evaporated. The residue was purified by FSC (dichloromethane) to give 0.865 g (7.64 mmol, 53%) of the oxime 3 as a 1:1 E/Z mixture as an unstable pale yellow oil.
The synthetic route of 2396-83-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lohrer, Bernhard; Bracher, Franz; Tetrahedron Letters; vol. 60; 51; (2019);,
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