High-performance liquid chromatographic enantioseparation of fluorinated cyclic β3-amino acid derivatives on polysaccharide-based chiral stationary phases. Comparison with nonfluorinated counterparts was written by Lajko, Gyula;Orosz, Timea;Kiss, Lorand;Forro, Eniko;Fueloep, Ferenc;Peter, Antal;Ilisz, Istvan. And the article was included in Biomedical Chromatography in 2016.Quality Control of (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate The following contents are mentioned in the article:
The stereoisomers of five fluorinated cyclic β3-amino acid derivatives and their nonfluorinated counterparts were separated on chiral stationary phases containing as chiral selectors cellulose tris-(3,5-dimethylphenyl carbamate), cellulose tris-(3-chloro-4-methylphenyl carbamate), cellulose tris-(4-methylbenzoate), cellulose tris-(4-chloro-3-methylphenyl carbamate), amylose tris-(3,5-dimethylphenyl carbamate) or amylose tris-(5-chloro-2-methylphenyl carbamate). The enantioseparations were carried out in normal-phase mode with n-hexane/alc./alkylamine mobile phases in the temperature range 5-40 °C. The effects of the mobile phase composition, the nature and concentration of the alc. and alkylamine additives, the structures of the analytes and temperature on the separations were investigated. Thermodn. parameters were calculated from plots of ln a vs. 1/T. The Δ(ΔH°) values ranged between -5.0 and +1.6 kJ/mol, while Δ(ΔS°) varied between -12.6 and +5.7 J/mol/K. The enantioseparation was enthalpically controlled, the retention factor and the separation factor decreasing with increasing temperature, but entropically controlled separation was also observed The elution sequence was determined for all of the investigated analytes. This study involved multiple reactions and reactants, such as (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate (cas: 2361926-29-4Quality Control of (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate).
(1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate (cas: 2361926-29-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics