Category: 2358-84-1

On December 31, 2020, Yemanyi, Felix; Vranka, Janice; Raghunathan, Vijay Krishna published an article.COA of Formula: C12H18O5 The title of the article was Glucocorticoid-induced cell-derived matrix modulates transforming growth factor β2 signaling in human trabecular meshwork cells. And the article contained the following:

Aberrant remodeling of trabecular meshwork (TM) extracellular matrix (ECM) may induce ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via a yet unknown mechanism. Here, we show that, in the absence of exogenous transforming growth factor-beta2 (TGFβ2), compared with control matrixes (VehMs), glucocorticoid-induced cell-derived matrixes (GIMs) trigger non-Smad TGFβ 2 signaling in hTM cells, correlated with overexpression/activity of structural ECM genes (fibronectin, collagen IV, collagen VI, myocilin), matricellular genes (connective tissue growth factor [CTGF], secreted protein, acidic and rich in cysteine), crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase-like 2-4, tissue transglutaminase-2), and ECM turnover genes/enzymes (matrix metalloproteinases-MMP2,14 and their inhibitors-TIMP2). However, in the presence of exogenous TGFβ2, VehMs and GIMs activate Smad and non-Smad TGFβ2 signaling in hTM cells, associated with overexpression of α-smooth muscle actin (α-SMA), and differential upregulation of aforementioned ECM genes/proteins with new ones emerging (collagen-I, thrombospondin-I, plasminogen activator inhibitor, MMP1, 9, ADAMTS4, TIMP1); with GIM-TGFβ2-induced changes being mostly more pronounced. This suggests dual glaucomatous insults potentiate profibrotic signaling/phenotypes. Lastly, we demonstrate type I TGFβreceptor kinase inhibition abrogates VehM-/GIM- and/or TGFβ2-induced upregulation of α-SMA and CTGF. Collectively, pathol. TM microenvironments are sufficient to elicit adverse cellular responses that may be ameliorated by targeting TGFβ2 pathway. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to tgfbeta gim signaling human trabecular meshwork, Mammalian Hormones: Corticosteroid, Gonadal, and Placental Hormones and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Sonu; Binder, Wolfgang H. published an article in 2020, the title of the article was Peptide-induced RAFT polymerization via an amyloid-β17-20-based chain transfer agent.Product Details of 2358-84-1 And the article contains the following content:

We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-β (Aβ) protein core sequence Leu-Val-Phe-Phe (LVFF, Aβ17-20) via RAFT polymerization Based on a novel chain transfer-agent, the “grafting-from” approach effectively generates the well-defined peptide-polymer conjugates with appreciably high monomer conversion rate, resulting in mech. stiffer peptide-functional cross-linked polymeric hydrogels. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to peptide induced raft polymerization amyloid chain transfer agent, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 28, 2022, Mimouni, Mourad; Bayou, Samir; Zeroual, Soria; Hamadneh, Imad; Mahboub, Mohammed Sadok; Ramdani, Soumia; Rihia, Ghani; Ghougali, Mebrouk published an article.SDS of cas: 2358-84-1 The title of the article was Synthesis and Characterization of Bulk Bi-2212 Superconducting Ceramic Using Photopolymerization Reaction-Based Method. And the article contained the following:

This study highlights the synthesis of Bi2Sr2CaCu2O8 (Bi-2212) superconducting ceramic using the photopolymerization reaction (PPR) and conventional solid-state reaction (SSR). The PPR sample was carried out by dissolving stoichiometric amounts of Bi, Sr, Ca, and Cu salts with the mixed monomer of DEGDMA and photoinitiator. The mixture was exposed to visible light, forming a rigid polymer. The resulted resin was calcined, palletized, and then sintered. The EDX measurements confirmed the average stoichiometry of the Bi-2212 phase. XRD confirmed the phase formation of the monoclinic phase with Bi 2212% exceeded 98%. SEM micrographs showed an irregular, flake-like structure with an average grain size (7.0μm). The elec. transport behavior for the prepared Bi 2212 showed metallic behavior with a single step feature where the offset temperature, TC(R=0) (65 K), in a single step feature. The PPR method will open the door for bulk HTSC ceramics that can be used for HTSC device applications. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).SDS of cas: 2358-84-1

The Article related to photopolymerization superconducting ceramic preparation property, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.SDS of cas: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2021, Bozbay, Rabia; Orakdogen, Nermin published an article.Related Products of 2358-84-1 The title of the article was Multifunctional poly(methacrylate ester)s-based terpolymer cryogels with basic amino groups: Correlation of elasticity and structural properties with composition. And the article contained the following:

Dual-responsive cryogel-structured materials open up a whole new field of bio-applications. Either dimethylaminoethyl methacrylate (DMAEMA) as a carrier of basic amino groups or glycidyl methacrylate (GMA) as a carrier of epoxy rings was introduced into hydroxypropyl methacrylate (HPMA) skeleton. pH/thermo-responsive cationic terpolymer cryogels were successfully prepared by varying the feeding DMAEMA/GMA mol percent ratio from 80/0 to 0/80. The presence of GMA imparts hydrophobic character that reduces swelling and provides addnl. crosslinks leading to a significant increase in the flexibility. Reducing the polymerization temperature below the f.p. of the solvent resulted in harder and non-brittle cryogels. Up to 48% reduction in hydration was observed for terpolymer cryogels containing 70 mol% DMAEMA upon increasing pH of bathing medium from 2.1 to 8.0. This trend confirmed pH-modulated swelling of amine-containing terpolymer gels, and pH-dependent transition point was found to be 7.7. Oscillating swelling/deswelling in response to pH cycles was studied. The water transport was strongly affected by incorporation of hydrophobic component GMA and protonation of amine functional groups. The swelling mechanism was shifted from anomalous to diffusion controlled with increasing GMA and overall swelling processes followed Schott second order dynamic equation. Lower equilibrium volume swelling at constant temperature was achieved by increasing GMA content of the terpolymers. In low temperature range, while DMAEMA-rich terpolymer gels were swollen, swelling decreased significantly when the gels were enriched in GMA and the temperature was raised above 55°C. Regardless of salt type and Na+ or K+ hydrated ion radii, a significant difference was observed in salt-sensitive swelling in dilute salt solution (below about 10-3 M), which is controlled by the amount of DMAEMA in terpolymer structure. This study would provide novel ideas for the design of (meth)acrylate ester-based cationic terpolymer cryogels and elucidate the relationship between the gel matrix and their special swelling behavior. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Related Products of 2358-84-1

The Article related to polymethacrylate ester cryogel amino elasticity structure swelling thermal, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Related Products of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2021, Mahmood, Malik H.; Himics, Laszlo; Vaczi, Tamas; Rigo, Istvan; Holomb, Roman; Beiler, Barbara; Veres, Miklos published an article.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Raman spectroscopic study of gamma radiation-initiated polymerization of diethylene glycol dimethacrylate in different solvents. And the article contained the following:

In this work, the degree of conversion and polymerization kinetics of diethylene glycol dimethacrylate (DEGDMA) monomer in different solvents upon gamma irradiation with different doses have been studied by Raman spectroscopy and mass difference measurements. D. functional theory calculations were performed on the monomer and the crosslinked structure to obtain the assignment of Raman peaks to specific bonds. The evolution of the bonding configuration of the structure with dose and the composition of the monomer mixture was investigated. The dependence of the polymerization rate on the solvent type was explained by the mechanism of the polymerization affected by the relative solubility of the components of the monomer mixture Raman measurements revealed also that there are not fully crosslinked monomer mols. in the polymer matrix. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to raman spectroscopy gamma radiation diethylene glycol dimethacrylate polymerization solvent, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Safety of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Shevchenko, N. N.; Pankova, G. A.; Laishevkina, S. G. published an article.Recommanded Product: 2358-84-1 The title of the article was Influence of the Structure of a Surface Layer of Methyl Methacrylate-Based Cationic Particles on Adsorption of Biomolecules. And the article contained the following:

Crosslinked cationic particles 200-600 nm in diameter have been synthesized via emulsifier-free copolymerization of Me methacrylate and 2-aminoethyl methacrylate hydrochloride in the presence of crosslinking agents (N,N’-methylenebisacrylamide, triethylene glycol dimethacrylate, and diethylene glycol dimethacrylate). It has been shown that polymer particles with a maximum concentration of surface functional groups (1.42μmol/m2) and a stable structure of a surface layer are formed only in the presence of ethanol (20 vol %). The synthesized particles efficiently adsorb biol. active substances, and their dispersions are stable against aggregation in buffer solutions at pH 7.0. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: 2358-84-1

The Article related to methyl methacrylate crosslinked cationic particle emulsifier free copolymerization, biomol adsorption, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Recommanded Product: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stepanova, Mariia; Solomakha, Olga; Ten, Daria; Tennikova, Tatiana; Korzhikova-Vlakh, Evgenia published an article in 2020, the title of the article was Flow-through macroporous polymer monoliths containing artificial catalytic centers mimicking chymotrypsin active site.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Synthetic catalysts that could compete with enzymes in term of the catalytic efficiency but surpass them in stability have a great potential for the practical application. In this work, we have developed a novel kind of organic catalysts based on flow-through macroporous polymer monoliths containing catalytic centers that mimic the catalytic site of natural enzyme chymotrypsin. It is known that chymotrypsin catalytic center consists of L-serine, L-histidine, and L-aspartic acid and has specificity to C-terminal residues of hydrophobic amino acids (L-phenylalanine, L-tyrosine, and L-tryptophan). In this paper, we have prepared the macroporous polymer monoliths bearing grafted polymer layer on their surface. The last one was synthesized via copolymerization of N-methacryloyl-L-serine, N-methacryloyl-L-histidine, and N-methacryloyl-L-aspartic acid. The spatial orientation of amino acids in the polymer layer, generated on the surface of monolithic framework, was achieved by coordinating amino acid-polymerizable derivatives with cobalt (II) ions without substrate-mimicking template and with its use. The conditions for the preparation of mimic materials were optimized to achieve a mech. stable system. Catalytic properties of the developed systems were evaluated towards the hydrolysis of ester bond in a low mol. substrate and compared to the results of using chymotrypsin immobilized on the surface of a similar monolithic framework. The effect of flow rate increase and temperature elevation on the hydrolysis efficiency were evaluated for both mimic monolith and column with immobilized enzyme. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to chymotrypsin active site monolith, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Other and other aspects.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2022, Chang, Jiali; Ji, Xiaojuan; Deng, Tian; Qiu, Jinxin; Ding, Zhaoyun; Li, Zhao; Ma, Yanhui; Hu, Xiaoyu; Li, Li; Qiu, Ju published an article.Electric Literature of 2358-84-1 The title of the article was Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. And the article contained the following:

Subsets of group 3 innate lymphoid cells (ILC3s) are heterogeneous in development and function and play differential roles in intestinal immunity. Histone modifications are involved in the fate commitment of immune cells, including ILC3s. Here, we report that deletion of Setd2, histone H3K36 methyltransferase, in ILC3s results in increased generation of NKp46+ ILC3s with enhanced cytotoxic signatures and tumor-suppressive capacity. Meanwhile, Rag1-/-RorcCreSetd2flox/flox mice have fewer CCR6+ ILC3s and less defective solitary intestinal lymphoid tissue formation, accompanied by reduced granulocyte-macrophage colony-stimulating factor (GM-CSF) production by NKp46- ILC3s and decreased CD11b+ CD103+ dendritic cell accumulation. The deficiency of Setd2-/-NKp46- ILC3s may contribute to disturbed RORγt+ Treg homeostasis and intestinal inflammation in Rag1-/-RorcCreSetd2flox/flox mice upon T cell reconstitution. Setd2 regulates genome accessibility imprinting gene mRNA expression, with a more profound effect on NKp46+ ILC3s than NKp46- ILC3s. Therefore, Setd2 determines distinct chromatin status and transcriptomic programs of ILC3 subsets to affect their function and intestinal immunity. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to setd2 ilc3 intestinal cell immunity distinct property, cp: immunology, setd2, group 3 innate lymphoid cells, intestinal immunity, regulatory t cells, Immunochemistry: Other (Immunity, Immune Suppression, Tolerance, etc.) and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2021, Scheiblich, Hannah; Dansokho, Cira; Mercan, Dilek; Schmidt, Susanne V.; Bousset, Luc; Wischhof, Lena; Eikens, Frederik; Odainic, Alexandru; Spitzer, Jasper; Griep, Angelika; Schwartz, Stephanie; Bano, Daniele; Latz, Eicke; Melki, Ronald; Heneka, Michael T. published an article.Synthetic Route of 2358-84-1 The title of the article was Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. And the article contained the following:

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern recognition receptor ligation and activation of inflammatory pathways. Here, we studied how microglia handle and cope with α-synuclein (α-syn) fibrils and their clearance. We found that microglia exposed to α-syn establish a cellular network through the formation of F-actin-dependent intercellular connections, which transfer α-syn from overloaded microglia to neighboring naive microglia where the α-syn cargo got rapidly and effectively degraded. Lowering the α-syn burden attenuated the inflammatory profile of microglia and improved their survival. This degradation strategy was compromised in cells carrying the LRRK2 G2019S mutation. We confirmed the intercellular transfer of α-syn assemblies in microglia using organotypic slice cultures, 2-photon microscopy, and neuropathol. of patients. Together, these data identify a mechanism by which microglia create an “on-demand” functional network in order to improve pathogenic α-syn clearance. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Synthetic Route of 2358-84-1

The Article related to microglia alpha synuclein nanotube, lrrk2, alpha-synuclein, cell-to-cell transfer, clearance, degradation, microglia, synucleinopathies, tunneling nanotubes, Mammalian Pathological Biochemistry: Metabolic and Hereditary Diseases and other aspects.Synthetic Route of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 24, 2020, Wang, Hui; Vendrame, Lorenzo; Fliedel, Christophe; Chen, Si; Gayet, Florence; Manoury, Eric; Zhang, Xuewei; DAgosto, Franck; Lansalot, Muriel; Poli, Rinaldo published an article.COA of Formula: C12H18O5 The title of the article was Core-Cross-Linked Micelles Made by RAFT Polymerization with a Polycationic Outer Shell Based on Poly(1-methyl-4-vinylpyridinium). And the article contained the following:

A convergent synthesis of amphiphilic polymers with a polystyrene (PS) core and a polyelectrolytic poly(1-methyl-4-vinylpyridinium iodide) (P4VPMe+I-) shell is reported. The polymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization in water using a trithiocarbonate chain transfer agent [R0-SC(S)SPr, R0 = -C(Me)(CN)CH2CH2COOH]. Two types of particle structure, both having a spherical morphol. and diameters in the 85-150 nm range, have been obtained as stable latexes with polymer content up to 10% in weight The first structure consists of core-crosslinked micelles (CCMs), where amphiphilic P4VPMe+I–b-PS arms are cross-linked at the hydrophobic end by the use of diethylene glycol dimethacrylate. The Coulombic repulsion between the outer shells of the precursor micelles ensures the absence of macrogelation during the crosslinking step. The second structure consists of nanogels (NGs), where the entire hydrophobic core is crosslinked during the last step of simultaneous chain extension and crosslinking of a P4VPMe+I–b-PS intermediate with a short PS block. The lack of radical polymerization for the 4VPMe+I- monomer and the lack of chain extension with styrene for a R0-P4VPMe+I–SC(S)SPr intermediate were circumvented by the synthesis of R0-P4VP-b-PS-SC(S)SPr containing a short PS block by sequential RAFT polymerization of 4-vinylpyridine (4VP) and styrene, followed by quant. cationization of the P4VP block by MeI and subsequent sequential (for the CCMs) or simultaneous (for the NGs) chain extension and crosslinking. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to core crosslinked micelle raft polymerization cationic polyvinylpyridine polystyrene diblock, nanogel polyvinylpyridine polystyrene diblock, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics