Category: 2358-84-1

Mohr, Margaret A.; Wong, Angela M.; Sukumar, Gauthaman; Dalgard, Clifton L.; Hong, Weizhe; Wu, T. John; Wu, Ye Emily; Micevych, Paul E. published an article in 2021, the title of the article was RNA-sequencing of AVPV and ARH reveals vastly different temporal and transcriptomic responses to estradiol in the female rat hypothalamus.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

In females, estrogens have two main modes of action relating to gonadotropin secretion: pos. feedback and neg. feedback. Estrogen pos. and neg. feedback are controlled by different regions of the hypothalamus: the preoptic area/anterior portion (mainly the anteroventral periventricular nucleus, AVPV) of the hypothalamus is associated with estrogen pos. feedback while the mediobasal hypothalamus (mainly the arcuate nucleus of the hypothalamus, ARH), is associated with estrogen neg. feedback. In this study, we examined the temporal pattern of gene transcription in these two regions following estrogen treatment. Adult, ovariectomized, Long Evans rats received doses of estradiol benzoate (EB) or oil every 4 days for 3 cycles. On the last EB priming cycle, hypothalamic tissues were dissected into the AVPV+ and ARH+ at 0 h (baseline/oil control), 6 h, or 24 h after EB treatment. RNA was extracted and sequenced using bulk RNA sequencing. Differential gene anal., gene ontol., and weighted correlation network anal. (WGCNA) was performed. Overall, we found that the AVPV+ and ARH+ respond differently to estradiol stimulation. In both regions, estradiol treatment resulted in more gene up-regulation than down-regulation. S100g was very strongly up-regulated by estradiol in both regions at 6 and 24 h after EB treatment. In the AVPV+ the highest number of differentially expressed genes occurred 24 h after EB. In the ARH+, the highest number of genes differentially expressed by EB occurred between 6 and 24 h after EB, while in the AVPV+, the fewest genes changed their expression between these time points, demonstrating a temporal difference in the way that EB regulates transcription these two areas. Several genes strongly implicated in gonadotropin release were differentially affected by estradiol including Esr1, encoding estrogen receptor-α and Kiss1, encoding kisspeptin. As an internal validation, Kiss1 was up-regulated in the AVPV+ and down-regulated in the ARH+. Gene network anal. revealed the vastly different clustering of genes modulated by estradiol in the AVPV+ compared with the ARH+. These results indicate that gene expression in these two hypothalamic regions have specific responses to estradiol in timing and direction. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to estradiol rat hypothalamus avpv arh rna sequencing temporal transcriptomics, Mammalian Biochemistry: Classical Genetics and Phylogeny and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Zhang, Yu-Hang; Hoopmann, Michael R.; Castaldi, Peter J.; Simonsen, Kirsten A.; Midha, Mukul K.; Cho, Michael H.; Criner, Gerard J.; Bueno, Raphael; Liu, Jiangyuan; Moritz, Robert L.; Silverman, Edwin K. published an article.Computed Properties of 2358-84-1 The title of the article was Lung proteomic biomarkers associated with chronic obstructive pulmonary disease. And the article contained the following:

Identifying protein biomarkers for chronic obstructive pulmonary disease (COPD) has been challenging. Most previous studies have used individual proteins or preselected protein panels measured in blood samples. Mass spectrometry proteomic studies of lung tissue have been based on small sample sizes. Author used mass spectrometry proteomic approaches to discover protein biomarkers from 150 lung tissue samples representing COPD cases and controls. Top COPD-associated proteins were identified based on multiple linear regression anal. with false discovery rate (FDR) < 0.05. Correlations between pairs of COPD-associated proteins were examined Machine learning models were also evaluated to identify potential combinations of protein biomarkers related to COPD. Author identified 4,407 proteins passing quality controls. Twenty-five proteins were significantly associated with COPD at FDR < 0.05, including interleukin 33, ferritin (light chain and heavy chain), and two proteins related to caveolae (CAV1 and CAVIN1). Multiple previously reported plasma protein biomarkers for COPD were not significantly associated with proteomic anal. of COPD in lung tissue, although RAGE was borderline significant. Eleven pairs of top significant proteins were highly correlated (r > 0.8), including several strongly correlated with RAGE (EHD2 and CAVIN1). Machine learning models using Random Forests with the top 5% of protein biomarkers demonstrated reasonable accuracy (0.707) and area under the curve (0.714) for COPD prediction. Mass spectrometry-based proteomic anal. of lung tissue is a promising approach for the identification of biomarkers for COPD. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Computed Properties of 2358-84-1

The Article related to proteome chronic obstructive pulmonary disease, biomarkers, chronic obstructive pulmonary disease, machine learning, mass spectrometry, proteomics, Mammalian Pathological Biochemistry: Respiratory Diseases and other aspects.Computed Properties of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2021, Sun, Guanqing; Wu, Xingyi; Liu, Ren published an article.Computed Properties of 2358-84-1 The title of the article was A comprehensive investigation of acrylates photopolymerization shrinkage stress from micro and macro perspectives by real time MIR-photo-rheology. And the article contained the following:

The acrylate photocuring system with the high curing rate are widely used in various industries. However, the rapid polymerization kinetics can cause the surge of resin viscosity and the gel point can be reached in advance. This can results in the restriction of mol. chain movement and internal stress release is thus hindered during the photopolymerization Finally, it usually leads to the poor performance of UV-cured materials with lower double bond conversion and large volume shrinkage and shrinkage stress. In order to understand the relationship between properties and polymerization process, this paper employed the combined technique of the mid-IR spectrometer and photo-rheometer to monitor the acrylate free radical photopolymerization process. The effects of curing conditions (curing temperature, radiant intensity and sample thickness) and system compositions (diluent functionality, diluent segment length) on the rheol. properties and chem. conversion of materials were fully investigated. Finally, a standard protocol is established to evaluate the reactivity, mech. properties and volume shrinkage of the photocuring system. Simultaneously, the double bond conversion of the reaction system can be achieved through calculation of peak area of IR absorption. A complex nonlinear relationship between the storage modulus, shrinkage stress and double bond conversion is established. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Computed Properties of 2358-84-1

The Article related to acrylate photopolymerization shrinkage stress rheol property, Coatings, Inks, and Related Products: Epoxy Resin Coatings and other aspects.Computed Properties of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 3, 2020, Okten Besli, Nur Sena; Orakdogen, Nermin published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Thermomechanical analysis and pH-triggered elastic response of charge-balanced sulfonated poly(tertiary amine-methacrylate)-based terpolymer cryogels. And the article contained the following:

PH-responsive terpolymer poly(hydroxyethyl methacrylate-2-acrylamido-2-methyl-propanosulfonic acid-diethylaminoethyl methacrylate) cryogels and hydrogels (named as CGs-PHA/Dm and HGs-PHA/Dm) were synthesized in ethanol-water mixture using different monomer feed compositions By the combination of three monomers, an interesting system was designed with tunable pH/temperature responsiveness and elasticity. ATR-FTIR spectra obtained after swelling in pH buffer solution of 2.1 indicated -R2NH+ stretching of DEAEMA moities in terpolymer matrixes. By incorporation of DEAEMA units with ionizable amino groups, terpolymer CGs-PHA/Dm and HGs-PHA/Dm gels exhibited pH-responsive swelling behavior. Inclusion of DEAEMA dramatically altered pH-responsiveness of terpolymers in simulated intestinal fluid at pH 6.6. Dependence of interaction parameter χon terpolymer volume fraction in gel ν2by a linear function and its enthalpic/entropic components with swelling pH were determined At pH < 6.6, dependence of χ parameter on the swelling was evaluated as χ = 1.097 - 2.965ν2, while at basic pH region, pH > 6.6, χ = 0.576 + 0.459ν2. Both pH of swelling medium and the amount of DEAEMA in terpolymer composition affected the compression moduli of terpolymer gels. Flory-Rehner theory extended to correlate the compressive modulus with swelling pH and the dependence of the effective crosslink d. νeon mol% DEAEMA was expressed in both acidic and basic conditions. pH-triggered swelling/shrinking of terpolymer gels were studied as reversible cycles in buffer solutions of pH 2.1 and 9.8. DEAEMA-rich terpolymer gels showed overshooting phenomena due to dynamic conformational changes of diethylaminoethyl units. Terpolymer cryogels exhibited much faster swelling kinetics than that of terpolymer hydrogels in simulated gastric fluid at pH 2.1. The values of diffusion coefficient seemed to be strongly dependent of terpolymer composition The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to thermomech ph triggered elastic charge balanced sulfonated terpolymer, Plastics Manufacture and Processing: Preparation Of Resins and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 11, 2021, Riechert, Eva; Kmietczyk, Vivien; Stein, Frank; Schwarzl, Thomas; Sekaran, Thileepan; Juergensen, Lonny; Kamuf-Schenk, Verena; Varma, Eshita; Hofmann, Christoph; Rettel, Mandy; Guer, Kira; Oelschlaeger, Julie; Kuehl, Friederike; Martin, Judit; Ramirez-Pedraza, Marta; Fernandez, Mercedes; Doroudgar, Shirin; Mendez, Raul; Katus, Hugo A.; Hentze, Matthias W.; Voelkers, Mirko published an article.Related Products of 2358-84-1 The title of the article was Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. And the article contained the following:

RNA-binding proteins (RBPs) control critical aspects of cardiomyocyte function, but the repertoire of active RBPs in cardiomyocytes during the growth response is largely unknown. We define RBPs in healthy and diseased cardiomyocytes at a system-wide level by RNA interactome capture. This identifies 67 cardiomyocyte-specific RBPs, including several contractile proteins. Furthermore, we identify the cytoplasmic polyadenylation element-binding protein 4 (Cpeb4) as a dynamic RBP, regulating cardiac growth both in vitro and in vivo. We identify mRNAs bound to and regulated by Cpeb4 in cardiomyocytes. Cpeb4 regulates cardiac remodeling by differential expression of transcription factors. Among Cpeb4 target mRNAs, two zinc finger transcription factors (Zeb1 and Zbtb20) are discovered. We show that Cpeb4 regulates the expression of these mRNAs and that Cpeb4 depletion increases their expression. Thus, Cpeb4 emerges as a critical regulator of cardiomyocyte function by differential binding to specific mRNAs in response to pathol. growth stimulation. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Related Products of 2358-84-1

The Article related to cpeb rna binding protein cardiomyocyte cell growth, cpeb4, rbps, zeb1, cardiomycoytes, pathological hypertrophy, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Related Products of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 31, 2022, Wang, Shengxuan; Liu, Tingjun; Sun, Lili; Du, Hongxia; Xu, Zhongjin; Li, Ranran; Yu, Ying; Mao, Yongjiang; Shi, Kerong published an article.Application of 2358-84-1 The title of the article was Menin regulates lipid deposition in mouse hepatocytes via interacting with transcription factor FoxO1. And the article contained the following:

Non-alc. fatty liver disease (NAFLD) is rapidly being recognized as the leading cause of chronic liver disease worldwide. Men1, encoding protein of menin, is a key causative gene of multiple endocrine neoplasia type 1 syndrome including pancreatic tumor. It is known that insulin that secretes by endocrine tissue pancreatic islets plays a critical role in hepatic metabolism Mouse model of hemizygous deletion of Men1 was shown to have severe hepatic metabolism disorders. However, the mol. function of menin on lipid deposition in hepatocytes needs to be further studied. Transcriptome sequencing does show that expression suppression of Men1 in mouse hepatocytes widely affect signaling pathways involved in hepatic metabolism, such as fatty acid metabolism, insulin response, glucose metabolism and inflammation. Further mol. studies indicates that menin overexpression inhibits expressions of the fat synthesis genes Srebp-1c, Fas, and Acc1, the fat differentiation genes Pparγ1 and Pparγ2, and the fat transport gene Cd36, thereby inhibiting the fat accumulation in hepatocytes. The biol. process of menin regulating hepatic lipid metabolism was accomplished by interacting with the transcription factor FoxO1, which is also found to be critical for lipid metabolism Moreover, menin responds to insulin in hepatocytes and mediates its regulatory effect on hepatic metabolism Our findings suggest that menin is a crucial mediation factor in regulating the hepatic fat deposition, suggesting it could be a potential important therapeutic target for NAFLD. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1

The Article related to menin lipid deposition hepatocyte transcription factor, foxo1, hepatocyte, lipid metabolism, menin, non-alcoholic fatty liver disease (nafld), Mammalian Pathological Biochemistry: Digestive Tract Diseases and other aspects.Application of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2021, Zong, Zhaoyun; Liu, Jing; Wang, Ning; Yang, Changmei; Wang, Qingtao; Zhang, Wenhao; Chen, Yuling; Liu, Xiaohui; Deng, Haiteng published an article.Application of 2358-84-1 The title of the article was Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE2 degradation. And the article contained the following:

Liver fibrosis is a reversible wound-healing response to acute or chronic liver injury that can progress to cirrhosis and liver cancer. Finding new strategies for prevention and management of liver fibrosis is urgently needed. It is known that hepatic stellate cell (HSC) is the primary source of extracellular matrix that drives liver fibrosis progression. Herein, we carried out a comprehensive secretome profiling to identify NMN-induced changes in secretory proteins and found that NMN suppressed the secretion of profibrotic protein and oxidoreductase in activated HSC (LX-2) cells, while real-time quant. PCR anal. revealed that NMN downregulated profibrotic gene expression, resulting in HSC inactivation. Next, we demonstrated that NMN (NMN) reduced the accumulation of liver extracellular matrix in thioacetamide (TAA) and carbon tetrachloride (CCl4) induced mouse models for liver fibrosis. Furthermore, we determined that NMN inhibited oxidation-mediated 15-PGDH degradation to promote prostaglandin E2 degradation and suppress HSC activation. In summary, our results propose that NMN supplementation is a new therapeutic approach for liver fibrosis prevention. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1

The Article related to nicotinamide mononucleotide stellate cell liver fibrosis pge2, 15-pgdh, hepatic stellate cells, liver fibrosis, nicotinamide mononucleotide, prostaglandin e(2), Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Application of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shield, William P. III; Cellini, Ashley; Tian, Hongying; Wilson, Kim; Dan, Yang; Abzug, Joshua M.; Garcia, Sonia; Moritani, Norifumi; Alferiev, Ivan; Chorny, Michael; Takigawa, Masaharu; Ng, Vincent Y.; Iwamoto, Masahiro; Enomoto-Iwamoto, Motomi published an article in 2020, the title of the article was Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS-2/8 Chondrosarcoma Cells.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Chondrosarcoma is the second most common primary bone sarcoma. Treatment of chondrosarcoma is limited to surgery due to radiation and chemotherapy resistance of this cancer. An ideal treatment for chondrosarcoma would be a well-tolerated, minimally invasive local or systemic treatment modality to halt or slow tumor growth prior to resection of local, unresectable local, or metastatic disease. Palovarotene, an agonist of nuclear retinoic acid receptor γ (RARγ) has shown therapeutic action for treatment of heterotopic ossification and osteochondroma without serious adverse effects in animal models. We hypothesized that selective agonists of RARγ would have an inhibitory effect on chondrosarcoma. All human chondrosarcoma specimens expressed RARγ as determined by immunohistochem. staining. The ΗCS-2/8 chondrosarcoma cell line, established from low-grade human chondrosarcoma, was used to examine the actions of RARγ agonists. In ΗCS2/8 pellet cultures, RARγ agonist treatment reduced the mass size and significantly decreased total glycosaminoglycan, protein amounts, and gene expression levels of cartilage matrix mols. when compared with control groups. Systemic treatment with RARγ agonists significantly inhibited the growth of ΗCS-2/8 cell transplants in vivo. Furthermore, local injection of RARγ agonist-loaded poly-lactic acid nanoparticles induced regression of the mass size of the transplants. Histol. anal. demonstrated that RARγ agonist treatment inhibited cell proliferation activity and stimulated encapsulation of the tumor. These findings indicate that RARγ agonists, including palovarotene, may have an anti-tumor effect on low-grade chondrosarcomas. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to chondrosarcoma cell nuclear retinoic acid receptor gamma inhibit growth, chondrosarcoma, nanoparticles, palovarotene, retinoic acid receptor agonist, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Yanyan; Wu, Wendan; Liang, Liping; Tao, Shuqi; Meng, Xu published an article in 2020, the title of the article was Preparation and adsorption properties of polyacrylamide/graphene oxide composite aerogel.Electric Literature of 2358-84-1 And the article contains the following content:

Graphene oxide (GO) and acrylamide (AM) were polymerized and crosslinked to form a composite aerogel. The microscopic properties and thermal stability of the composite aerogel were characterized by IR spectroscopy, thermogravimetric instrument and SEM. The adsorption properties of the composite aerogel were tested. The effects of temperature, GO/AM ratios, pH values, feed amounts, dye liquor concentrations and times on the adsorption properties of composite aerogels were investigated. The results showed that under the same exptl. conditions, the more the aerogel dosage and the longer the adsorption time, the better the adsorption performance of the composite aerogel on the active yellow dye liquor; the temperature had little effect on the adsorption of the dye liquor. The gel had the greatest adsorption effect under acidic conditions. The pH was 0.99, the dosage was 0.25g, the concentration of the dye solution was 40mg/L, and the adsorption rate reached 65.51% after adsorption for 24 h. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to polyacrylamide graphene oxide composite aerogel adsorption, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 22, 2020, de los Reyes Jimenez, Marta; Lechner, Antonie; Alessandrini, Francesca; Bohnacker, Sina; Schindela, Sonja; Trompette, Aurelien; Haimerl, Pascal; Thomas, Dominique; Henkel, Fiona; Mourao, Andre; Geerlof, Arie; da Costa, Clarissa Prazeres; Chaker, Adam M.; Bruene, Bernhard; Nuesing, Rolf; Jakobsson, Per-Johan; Nockher, Wolfgang A.; Feige, Matthias J.; Haslbeck, Martin; Ohnmacht, Caspar; Marsland, Benjamin J.; Voehringer, David; Harris, Nicola L.; Schmidt-Weber, Carsten B.; Esser-von Bieren, Julia published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. And the article contained the following:

Eicosanoids are key mediators of type-2 inflammation, e.g., in allergy and asthma. Helminth products have been suggested as remedies against inflammatory diseases, but their effects on eicosanoids are unknown. Here, we show that larval products of the helminth Heligmosomoides polygyrus bakeri (HpbE), known to modulate type-2 responses, trigger a broad anti-inflammatory eicosanoid shift by suppressing the 5-lipoxygenase pathway, but inducing the cyclooxygenase (COX) pathway. In human macrophages and granulocytes, the HpbE-driven induction of the COX pathway resulted in the production of anti-inflammatory mediators [e.g., prostaglandin E2 (PGE2) and IL-10] and suppressed chemotaxis. HpbE also abrogated the chemotaxis of granulocytes from patients suffering from aspirin-exacerbated respiratory disease (AERD), a severe type-2 inflammatory condition. Intranasal treatment with HpbE extract attenuated allergic airway inflammation in mice, and intranasal transfer of HpbE-conditioned macrophages led to reduced airway eosinophilia in a COX/PGE2-dependent fashion. The induction of regulatory mediators in macrophages depended on p38 mitogen-activated protein kinase (MAPK), hypoxia-inducible factor-1α (HIF-1α), and Hpb glutamate dehydrogenase (GDH), which we identify as a major immunoregulatory protein in HpbE. Hpb GDH activity was required for anti-inflammatory effects of HpbE in macrophages, and local administration of recombinant Hpb GDH to the airways abrogated allergic airway inflammation in mice. Thus, a metabolic enzyme present in helminth larvae can suppress type-2 inflammation by inducing an anti-inflammatory eicosanoid switch, which has important implications for the therapy of allergy and asthma. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to helminth larval product antiinflammatory eicosanoid inflammation suppression, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics