Category: 2358-84-1

On December 31, 2022, Hadland, Brandon; Varnum-Finney, Barbara; Dozono, Stacey; Dignum, Tessa; Nourigat-McKay, Cynthia; Heck, Adam M.; Ishida, Takashi; Jackson, Dana L.; Itkin, Tomer; Butler, Jason M.; Rafii, Shahin; Trapnell, Cole; Bernstein, Irwin D. published an article.HPLC of Formula: 2358-84-1 The title of the article was Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics. And the article contained the following:

Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify the signals responsible for HSC formation, here we use single cell RNA-sequencing to simultaneously analyze the transcriptional profiles of AGM-derived cells transitioning from hemogenic endothelium to HSCs, and AGM-derived endothelial cells which provide signals sufficient to support HSC maturation and self-renewal. Pseudotemporal ordering reveals dynamics of gene expression during the hemogenic endothelium to HSC transition, identifying surface receptors specifically expressed on developing HSCs. Transcriptional profiling of niche endothelial cells identifies corresponding ligands, including those signaling to Notch receptors, VLA-4 integrin, and CXCR4, which, when integrated in an engineered platform, are sufficient to support the generation of engrafting HSCs. These studies provide a transcriptional map of the signaling interactions necessary for the development of HSCs and advance the goal of engineering HSCs for therapeutic applications. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1

The Article related to hematopoietic stem cell aorta endothelium transcriptomics engineering therapeutics, Mammalian Biochemistry: Development and Aging and other aspects.HPLC of Formula: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Trus, Ivan; Berube, Nathalie; Jiang, Peng; Rak, Janusz; Gerdts, Volker; Karniychuk, Uladzimir published an article in 2020, the title of the article was Zika virus with increased CpG dinucleotide frequencies shows oncolytic activity in glioblastoma stem cells.Recommanded Product: 2358-84-1 And the article contains the following content:

We studied whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that previously showed genetic stability and safety in animal models. In vitro, one of the CpG-recoded Zika virus variants had reduced infection kinetics in nonmalignant brain cells but high infectivity and oncolytic activity in GSCs as represented by reduced cell proliferation. The recoded virus also efficiently replicated in GSC-derived tumors in ovo with a significant reduction of tumor growth. We also showed that some GSCs may be resistant to Zika virus oncolytic activity, emphasizing the need for personalized oncolytic therapy or a strategy to overcome resistance in GSCs. Collectively, we demonstrated the potential of the CpG recoding approach for oncolytic virus development that encourages further research towards a better understanding of host-tumor-CpG-recoded virus interactions. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: 2358-84-1

The Article related to sox2 tgm2 cytosine phosphate guanine glioblastoma cell zika virus, cam, cpg recoding, zika virus, egg, glioblastoma, oncolytic virus, stem cells, Mammalian Pathological Biochemistry: Oncology and other aspects.Recommanded Product: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Bai, Hualong; Sun, Peng; Wu, Haoliang; Wei, Shunbo; Xie, Boao; Wang, Wang; Hou, Yachen; Li, Jing’an; Dardik, Alan; Li, Zhuo published an article.HPLC of Formula: 2358-84-1 The title of the article was The application of tissue-engineered fish swim bladder vascular graft. And the article contained the following:

Small diameter (< 6 mm) prosthetic vascular grafts continue to show very low long-term patency, but bioengineered vascular grafts show promising results in preclin. experiments To assess a new scaffold source, we tested the use of decellularized fish swim bladder as a vascular patch and tube in rats. Fresh goldfish (Carassius auratus) swim bladder was decellularized, coated with rapamycin and then formed into patches or tubes for implantation in vivo. The rapamycin-coated patches showed decreased neointimal thickness in both the aorta and inferior vena cava patch angioplasty models. Rapamycin-coated decellularized swim bladder tubes implanted into the aorta showed decreased neointimal thickness compared to uncoated tubes, as well as fewer macrophages. These data show that the fish swim bladder can be used as a scaffold source for tissue-engineering vascular patches or vessels. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1

The Article related to tissue engineering fish swim bladder vascular graft application, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.HPLC of Formula: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vouzara, Triantafyllia; Roussou, Konstantina; Nikolaidis, Alexandros K.; Tolidis, Kosmas; Koulaouzidou, Elisabeth A. published an article in 2020, the title of the article was Organic eluates derived from intermediate restorative dental materials.Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

A great number of different types of materials have been used in dentistry as intermediate restoratives. Among them, new resin-based bases have been released in the dental market. The present study focuses on the identification of the organic eluates released from such materials and the study of their surface microstructure in combination with their corresponding elemental composition For this purpose, the following materials were used:ACTIVABioACTIVE-BASE/LINER, KetacBond Glass Ionomer, SDR and VitrebondLight Cure Glass Ionomer Liner/Base. Methanolic leachates derived from polymerized materials were analyzed by means of gas chromatog.-mass spectrometry (GC-MS). SEM(SEM) was used for the surface monitoring of suitably prepared specimens. The GC-MS anal. revealed the elution of twenty different substances from the three resin-based materials, while none was eluted from the glass ionomer base. The SEM anal. for Vitrebond presented small pits, the one for KetacBond presented elongated cracks, while no voids were present for ACTIVABioACTIVE-BASE/LINER and SDR. Moreover, the resin matrix of some dental materials may inhibit elements’ accumulation on the surface layers. Particularly, the detected organic eluents may be related to potential toxic effects. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to resin organic eluate microstructure dental material, gas chromatography, intermediate restorative dental materials, organic eluates, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Quijada, Pearl; Trembley, Michael A.; Misra, Adwiteeya; Myers, Jacquelyn A.; Baker, Cameron D.; Perez-Hernandez, Marta; Myers, Jason R.; Dirkx, Ronald A. Jr.; Cohen, Ethan David; Delmar, Mario; Ashton, John M.; Small, Eric M. published an article.Recommanded Product: 2358-84-1 The title of the article was Coordination of endothelial cell positioning and fate specification by the epicardium. And the article contained the following:

The organization of an integrated coronary vasculature requires the specification of immature endothelial cells (ECs) into arterial and venous fates based on their localization within the heart. It remains unclear how spatial information controls EC identity and behavior. Here we use single-cell RNA sequencing at key developmental timepoints to interrogate cellular contributions to coronary vessel patterning and maturation. We perform transcriptional profiling to define a heterogenous population of epicardium-derived cells (EPDCs) that express unique chemokine signatures. We identify a population of Slit2+ EPDCs that emerge following epithelial-to-mesenchymal transition (EMT), which we term vascular guidepost cells. We show that the expression of guidepost-derived chemokines such as Slit2 are induced in epicardial cells undergoing EMT, while mesothelium-derived chemokines are silenced. We demonstrate that epicardium-specific deletion of myocardin-related transcription factors in mouse embryos disrupts the expression of key guidance cues and alters EPDC-EC signaling, leading to the persistence of an immature angiogenic EC identity and inappropriate accumulation of ECs on the epicardial surface. Our study suggests that EC pathfinding and fate specification is controlled by a common mechanism and guided by paracrine signaling from EPDCs linking epicardial EMT to EC localization and fate specification in the developing heart. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: 2358-84-1

The Article related to endothelial cell epicardium emt, Mammalian Biochemistry: Composition and Products and other aspects.Recommanded Product: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 16, 2022, Dussoyer, Melissa; Page, Adeline; Delolme, Frederic; Rousselle, Patricia; Nystrom, Alexander; Moali, Catherine published an article.COA of Formula: C12H18O5 The title of the article was Comparison of extracellular matrix enrichment protocols for the improved characterization of the skin matrisome by mass spectrometry. And the article contained the following:

A striking feature of skin organization is that the extracellular matrix (ECM) occupies a larger volume than the cells. Skin ECM also directly contributes to aging and most cutaneous diseases. In recent years, specific ECM enrichment protocols combined with in silico approaches allowed the proteomic description of the matrisome of various organs and tumor samples. Nevertheless, the skin matrisome remains under-studied and protocols allowing the efficient recovery of the diverse ECM found in skin are still to be described. Here, we compared four protocols allowing the enrichment of ECM proteins from adult mouse back skin and found that all protocols led to a significant enrichment (up to 65%) of matrisome proteins when compared to total skin lysates. The protocols based on decellularization and solubility profiling gave the best results in terms of numbers of proteins identified and confirmed that skin matrisome proteins exhibit very diverse solubility and abundance profiles. We also report the first description of the skin matrisome of healthy adult mice that includes 236 proteins comprising 95 core matrisome proteins and 141 associated matrisome proteins. These results provide a reliable basis for future characterizations of skin ECM proteins and their dysregulations in disease-specific contexts. Extracellular matrix proteins are key players in skin physiopathol. and have been involved in several diseases such as genetic disorders, wound healing defects, scleroderma and skin carcinoma. However, skin ECM proteins are numerous, diverse and challenging to analyze by mass spectrometry due to the multiplicity of their post-translational modifications and to the heterogeneity of their solubility profiles. Here, we performed the thorough evaluation of four ECM enrichment protocols compatible with the proteomic anal. of mouse back skin and provide the first description of the adult mouse skin matrisome in homeostasis conditions. Our work will greatly facilitate the future characterization of skin ECM alterations in preclin. mouse models and will inspire new optimizations to analyze the skin matrisome of other species and of human clin. samples. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to skin matrisome extracellular matrix mass spectrometry, decellularization, extracellular matrix, matrisome, mouse, proteomics, skin, Biochemical Methods: Spectral and Related Methods and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Yijun; Wang, Youbin; Xiao, Yingjie; Shan, Mengjie; Hao, Yan; Zhang, Lingyun published an article in 2022, the title of the article was Identification of a diagnostic signature and immune cell infiltration characteristics in keloids.Electric Literature of 2358-84-1 And the article contains the following content:

Keloid disorder is a recurrent fibroproliferative cutaneous tumor. Due to the lack of early identification of keloid patients before the formation of keloids, it is impossible to carry out pre-traumatic intervention and prevention for these patients. This led us to identify and determine signatures with diagnostic significance for keloids. Public series of matrix files were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were calculated from expression profiling data, and the diagnostic signature was identified by constructing a protein-protein interaction (PPI) network. The diagnostic efficacy of the screened signature was assessed by employing receiver operating characteristic (ROC) curves. Furthermore, we calculated the proportion of different immune cells in the gene expression matrix microenvironment by the “ssGSEA” algorithm, and assessed the difference in immune cell abundance between keloids and control groups and the relationship between the signature and immune cell infiltration. Clin. keloid and normal skin tissues were collected, and the expression of the screened diagnostic signature was validated by RT-qPCR and immunohistochem. assay. By screening the key genes in PPI, TGM2 was recognized and validated as a diagnostic signature and the infiltrating abundance of 10 immune cells was significantly correlated with TGM2 expression. Gene ontol. enrichment anal. demonstrated that TGM2 and mols. interacting with it were mainly enriched in processes involving wound healing and collagen fiber organization. TGM2 correlated pos. with HIF-1A (R = 0.82, p-value = 1.4e-05), IL6 (R = 0.62, p-value = 0.0053), and FN1 (R = 0.66, p-value = 0.0019). Besides, TGM2 was significantly upregulated in clin. keloid samples compared to normal skin tissues. TGM2 may serve as an auxiliary diagnostic indicator for keloids. However, the role of TGM2 in keloids has not been adequately reported in the current literature, which may provide a new direction for mol. studies of keloids. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to immune cell infiltration protein interaction skin keloids diagnosis human, tgm2, diagnostic signature, immune cell infiltration, keloid, ssgsea, Mammalian Pathological Biochemistry: Skin Diseases and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2020, Sar, Pintu; Roy, Saswati Ghosh; De, Priyadarsi; Ghosh, Sipra published an article.SDS of cas: 2358-84-1 The title of the article was Synthesis of Glutamic Acid Derived Organogels and their Applications in Dye Removal from Aqueous Medium. And the article contained the following:

To develop glutamic acid derived crosslinked polymeric organogels for dye adsorption from aqueous media, di-Me 2-(methacrylamido)pentanedioate (Glu-MAC) is polymerized using diethylene glycol dimethacrylate as crosslinker via the reversible addition-fragmentation chain transfer (RAFT) technique to synthesize crosslinked polymeric organogels with pendant glutamate moieties. The mech. properties of organogels are examined by rheol. study. The organogels exhibit higher value of storage modulus (G’) than the loss modulus (G”) within the linearity limits of deformation, and strong dependence of G’ values on the extent of crosslinking in the gel matrix. Field emission SEM shows porous structure of the gel matrix, therefore, organogels are able to exhibit swelling behaviors in organic solvents such as dichloromethane, N,N-dimethylformamide, THF, acetone, and methanol. Dye adsorption properties of these organogels are investigated using different aqueous dye solutions, such as crystal violet (CV), malachite green (MG), rhodamine-B, and uranine. The gels show high dye adsorption capacities (≥97%) toward cationic dyes like CV and MG. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).SDS of cas: 2358-84-1

The Article related to glutamic acid derived organogel adsorbent dye removal raft polymerization, swelling rheol property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.SDS of cas: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Shin Heon; Kwon, Hyung Joon; Park, Saewhan; Kim, Chan Il; Ryu, Haseo; Kim, Sung Soo; Park, Jong Bae; Kwon, Jeong Taik published an article in 2021, the title of the article was Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme.Electric Literature of 2358-84-1 And the article contains the following content:

Radiation therapy is among the most essential treatment methods for glioblastoma multiforme (GBM). Radio-resistance and cancer stem cell properties can cause therapeutic resistance, cancer heterogeneity, and poor prognoses in association with GBM. Furthermore, the GBM subtype transition from proneural to the most malignant mesenchymal subtype after radiation therapy also accounts for high resistance to conventional treatments. Here, we demonstrate that the inhibition of macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) by 4-iodo-6-phenylpyrimidine (4-IPP), a dual inhibitor targeting MIF and DDT, downregulates stemness phenotype, intracellular signaling cascades, mesenchymal trans-differentiation, and induces apoptosis in proneural glioma stem cells (GSCs). In an anal. of The Cancer Genome Atlas, high MIF and DDT expression were associated with poor prognosis. GSC growth was effectively inhibited by 4-IPP in a time- and dose-dependent manner, and 4-IPP combined with radiation therapy led to significantly reduced proliferation compared with radiation therapy alone. The expression of stemness factors, such as Olig2 and SOX2, and the expression of pAKT, indicating PI3K signaling pathway activation, were decreased in association with both 4-IPP monotherapy and combination treatment. The expression of mesenchymal markers, TGM2 and NF-κB, and expression of pERK (indicating MAPK signaling pathway activation) increased in association with radiation therapy alone but not with 4-IPP monotherapy and combination therapy. In addition, the combination of 4-IPP and radiation therapy significantly induced apoptosis compared to the monotherapy of 4-IPP or radiation. In vivo results demonstrated a significant tumor-suppressing effect of 4-IPP when combined with radiation therapy. Collectively, our results showed that the targeted inhibition of MIF and DDT has the potential to strengthen current clin. strategies by enhancing the anticancer effects of radiation therapy. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to macrophage migration inhibitory factor phenylpyrimidine stemness phenotype glioblastoma multiforme, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ham, Seungmin; Harrison, Craig; de Kretser, David; Wallace, Euan M.; Southwick, Graeme; Temple-Smith, Peter published an article in 2021, the title of the article was Potential treatment of keloid pathogenesis with follistatin 288 by blocking the activin molecular pathway.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Keloids are benign tumors caused by abnormal wound healing driven by increased expression of cytokines, including activin A. This study compared effects of activins on normal and keloid-derived human dermal fibroblasts and investigated a novel treatment for keloids using follistatin. Normal skin and keloid tissue samples from 11 patients were used to develop primary fibroblast cultures, which were compared in terms of their histol. and relevant gene (qRT-PCR and RNAseq) and protein (ELISA) expression. Activin A (INHBA) and connective tissue growth factor (CTGF) gene expression were significantly upregulated in keloid fibroblasts, as was activin A protein expression in cell lysates and culture medium. Activator protein 1 inhibitor (SR11302) significantly decreased INHBA and CTGF expression in keloid fibroblasts and a single treatment of follistatin over 5 days significantly inhibited activin and various matrix-related genes in keloid fibroblasts when compared to controls. Follistatin, by binding activin A, suppressed CTGF expression suggesting a novel therapeutic role in managing keloids and perhaps other fibrotic diseases. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to follistatin keloid pathogenesis activin mol pathway, rnaseq and elisa, activins, follistatin, gene expression, human dermal fibroblasts, keloid, Mammalian Pathological Biochemistry: Surgery and Trauma and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics