Category: 2358-84-1

On March 6, 2020, Yang, Jiebin; Lian, Yikai; Yang, Renzhi; Lian, Yifan; Wu, Jingtong; Liu, Jingjing; Wang, Keming; Xu, Hongzhi published an article.Formula: C12H18O5 The title of the article was Upregulation of lncRNA LINC00460 Facilitates GC Progression through Epigenetically Silencing CCNG2 by EZH2/LSD1 and Indicates Poor Outcomes. And the article contained the following:

Non-protein-coding functional elements in the human genome in the postgenomic biol. field have been drawing great attention in recent years. Thousands of long non-coding RNAs (lncRNAs) have been found to be expressed in various tumors. Yet only a small proportion of these lncRNAs have been well characterized. We have demonstrated that LINC00460 could affect cell proliferation through epigenetic regulation of KLF2 and CUL4A in human colorectal cancer. However, the clin. significance and biol. role of LINC00460 in gastric cancer (GC) remain largely unknown. In this research, we discovered that LINC00460 is remarkably upregulated in GC tissues compared to the non-tumor tissues. Addnl., LINC00460 served as an independent prognostic marker in GC. Functionally, proliferation of GC cells could be regulated by LINC00460 both in vitro and in vivo. RNA sequencing (RNA-seq) anal. for the whole transcriptome indicated that LINC00460 may serve as a key regulatory factor in the tumorigenesis of GC. What′s more, the biol. function of LINC00460 was mediated, to certain extent, by the direct interaction with enhancer of zeste homolog 2 (EZH2) and lysine (K)-specific demethylase 1A (LSD1) proteins. Further analyses indicated that LINC00460 promoted GC proliferation at least partly through the downregulation of tumor suppressor-gene Cyclin G2 (CCNG2), which is mediated by EZH2 and LSD1. In conclusion, our results suggested that LINC00460 acted as an oncogene in GC to inhibit the expression of CCNG2 at least partly by binding with EZH2 and LSD1. Our study could provide addnl. insights into the development of novel target therapeutic methods for GC. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Formula: C12H18O5

The Article related to transcriptome linc00460 ccng2 ezh2 lsd1 silencing gastric cancer progression, ezh2, linc00460, lsd1, gastric cancer, proliferation, and other aspects.Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 14, 2020, Zheng, Lifang; Luo, Yan; Chen, Kui; Zhang, Zexin; Chen, Gaojian published an article.Product Details of 2358-84-1 The title of the article was Highly Branched Gradient Glycopolymer: Enzyme-Assisted Synthesis and Enhanced Bacteria-Binding Ability. And the article contained the following:

A one-pot strategy was applied to synchronize enzymic monomer transformation with reversible addition fragmentation chain transfer (RAFT) polymerization for the synthesis of glycopolymers with highly branched gradient architectures. Also, the linear analogs, block glycopolymers, and gradient glycopolymers were also synthesized for comparison. The binding ability of glycopolymers toward bacteria was then studied by optical d. (OD) test, confocal laser scanning microscopy (CLSM), and quartz crystal microbalance with dissipation (QCM-D). The results show that the highly branched gradient glycopolymers have the most remarkable bacteria-binding ability compared with the two linear analogs, gradient glycopolymers, and block glycopolymers. The highly branched glycopolymers were further used as inhibitors in the anti-infection test, demonstrating a significant inhibitory effect on preventing bacteria from infecting the cells. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to highly branched glycopolymer preparation, Pharmaceuticals: Other and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 15, 2020, Zhou, Tingting; Wan, Guofeng; Kong, Xueping; Li, Bao; Wu, Lixin published an article.Computed Properties of 2358-84-1 The title of the article was Biocompatible Polymer Nanocomposites Integrating Magnetic Polyoxomolybdates for Enhanced MRI and On-Site Activated Photothermal Properties. And the article contained the following:

This work reports the ionic composition of a PEGylated and chem. crosslinked polyethyleneimine with a gadolinium-coordinated polyoxomolybdate cluster, K17[Gd(P2Mo17O61)2], via electrostatic interaction. The prepared composites form nanoobjects with an average size of �7 nm at dried state and maintain structural stability in aqueous solution While the biocompatibility on HeLa cells is demonstrated, the polymer-shielded multifunctional nanoplatform shows both the combined magnetic resonance imaging and redox-triggered photothermal conversion effect. As a contrast agent, the T1-weighed relaxivity reaches up to 22.77 mM-1 s-1. The photothermal conversion of the prepared composites can be aroused by yielding a broad near IR (NIR) adsorption through on-site reduction of the glutathione that is enriched in the tumor environment. The high efficiency �1.0% under the irradiation of 808 nm NIR laser illustrates a distinct treatment capability according to cell counting Kit-8 assay while the obvious inhibition for the growth of tumor cells is observed The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Computed Properties of 2358-84-1

The Article related to mri tumor nanocomposite polyoxomolybdate, mri, magnetic polyoxomolybdate, nanocomposites, photothermal effects, redox-activation, Pharmaceuticals: Other and other aspects.Computed Properties of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Akifuji, Chiaki; Iwasaki, Mio; Kawahara, Yuka; Sakurai, Chiho; Cheng, Yu-Shen; Imai, Takahiko; Nakagawa, Masato published an article.HPLC of Formula: 2358-84-1 The title of the article was MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains. And the article contained the following:

Human induced pluripotent stem cells (hiPSCs) can differentiate into cells of the three germ layers and are promising cell sources for regenerative medicine therapies. However, current protocols generate hiPSCs with low efficiency, and the generated iPSCs have variable differentiation capacity among different clones. Our previous study reported that MYC proteins (c-MYC and MYCL) are essential for reprogramming and germline transmission but that MYCL can generate hiPSC colonies more efficiently than c-MYC. The mol. underpinnings for the different reprogramming efficiencies between c-MYC and MYCL, however, are unknown. In this study, we found that MYC Box 0 (MB0) and MB2, two functional domains conserved in the MYC protein family, contribute to the phenotypic differences and promote hiPSC generation in MYCL-induced reprogramming. Proteome analyses suggested that in MYCL-induced reprogramming, cell adhesion-related cytoskeletal proteins are regulated by the MB0 domain, while the MB2 domain regulates RNA processes. These findings provide a mol. explanation for why MYCL has higher reprogramming efficiency than c-MYC. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1

The Article related to mycl ipsc colony formation myc box domain, Mammalian Biochemistry: Blood and other aspects.HPLC of Formula: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Heffron, Sean P.; Weinstock, Ada; Scolaro, Bianca; Chen, Shiyu; Sansbury, Brian E.; Marecki, Greg; Rolling, Christina C.; El Bannoudi, Hanane; Barrett, Tessa; Canary, James W.; Spite, Matthew; Berger, Jeffrey S.; Fisher, Edward A. published an article in 2021, the title of the article was Platelet-conditioned media induces an anti-inflammatory macrophage phenotype through EP4.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Platelets are increasingly recognized as immune cells. As such, they are commonly seen to induce and perpetuate inflammation; however, anti-inflammatory activities are increasingly attributed to them. Atherosclerosis is a chronic inflammatory condition. Similar to other inflammatory conditions, the resolution of atherosclerosis requires a shift in macrophages to an M2 phenotype, enhancing their efferocytosis and cholesterol efflux capabilities. To assess the effect of platelets on macrophage phenotype. In several in vitro models employing murine (RAW264.7 and bone marrow-derived macrophages) and human (THP-1 and monocyte-derived macrophages) cells, we exposed macrophages to media in which non-agonized human platelets were cultured for 60 min (platelet-conditioned media [PCM]) and assessed the impact on macrophage phenotype and function. Across models, we demonstrated that PCM from healthy humans induced a pro-resolving phenotype in macrophages. This was independent of signal transducer and activator of transcription 6 (STAT6), the prototypical pathway for M2 macrophage polarization. Stimulation of the EP4 receptor on macrophages by prostaglandin E2 present in PCM, is at least partially responsible for altered gene expression and associated function of the macrophages-specifically reduced peroxynitrite production, increased efferocytosis and cholesterol efflux capacity, and increased production of pro-resolving lipid mediators (ie, 15R-LXA4). Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. Our findings suggest that therapies targeting hemostatic properties of platelets, while not influencing pro-resolving, immune-related activities, could be beneficial for the treatment of atherothrombotic disease. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to platelet ep4 antiinflammatory macrophage phenotype atherothrombosis, atherosclerosis, inflammation, macrophages, platelets, prostaglandin e2, Immunochemistry: Phagocytosis and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Besli, Nur Sena Okten; Orakdogen, Nermin published an article in 2021, the title of the article was One-shot preparation of polybasic ternary hybrid cryogels consisting of halloysite nanotubes and tertiary amine functional groups: an efficient and convenient way by freezing-induced gelation.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

A convenient method for the preparation of polybasic ternary hybrid cryogels consisting of Halloysite nanotubes (HNTs) and tertiary amine functional groups by freezing-induced gelation is proposed. Ternary hybrid gels were produced via one-shot radical terpolymn. of 2-hydroxyethyl methacrylate (HEMA), 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS), and DEAEMA in the presence of HNTs. The equilibrium swelling in various swelling media and the mech. properties of the produced ternary hybrid gels were analyzed to investigate their network structure and determine their final performance. The swelling ratio of HNT-free gels was significantly higher than the ternary hybrid gels composed of high amount of HNTs. The addition of HNTs to terpolymer network did not suppress pH- and temperature-sensitive behavior. While DEAEMA groups were effective for pH-sensitive swelling, it was determined that both HEMA and DEAEMA groups were effective in temperature-sensitive swelling. Ternary hybrid gels simultaneously demonstrated both neg. and pos. temperature-responsive swelling behavior. The swelling ratio changed considerably according to swelling temperature Both DEAEMA and HEMA monomers in terpolymer structure were dominant in temperature-sensitive swelling. Mech. tests in compression of both as-prepared and swollen-state demonstrated that strength and modulus of hybrid cryogels significantly increased with addition of HNTs without significant loss of mech. strength. Ultimately, the results of the current system can benefit characterization with anal. tools for the application of innovative materials. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to polybasic ternary hybrid cryogels halloysite nanotubes tertiary amine gelation, cryogel, elasticity, halloysite, hybrid, smart-responsive, swelling, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 18, 2020, Roy, Arpita; Samanta, Subhendu; Singha, Koushik; Maity, Pritiprasanna; Kumari, Nimmy; Ghosh, Animesh; Dhara, Santanu; Pal, Sagar published an article.Formula: C12H18O5 The title of the article was Development of a Thermoresponsive Polymeric Composite Film Using Cross-Linked β-Cyclodextrin Embedded with Carbon Quantum Dots as a Transdermal Drug Carrier. And the article contained the following:

Polymeric nanocomposite films are used as promising transdermal drug carriers because of the improved patient compliance, easy application on skin, and noninvasiveness. A thermoresponsive polymeric composite film has been developed here through the deposition of carbon quantum dots (CQDs) on functionalized β-cyclodextrin (β-CD). The composite has been developed by grafting of poly(N-vinyl caprolactam) on β-CD, followed by crosslinking of diethylene glycol dimethacrylate and subsequent deposition of CQDs. CQDs have been prepared from waste pomegranate peels via a hydrothermal method. To enlighten the thermoresponsive nature of the composite film, lower critical solution temperature, as well as temperature-dependent swelling behavior, has been studied. The composite demonstrates excellent rheol. features. The developed polymeric composite film is nontoxic toward NIH 3T3 fibroblast cell lines. On the deposition of CQDs on the copolymer, the penetration power and fluorescent property have been improved, which help to track the cells in vitro. This film is worthy to be applied to the skin. It can efficiently load lidocaine hydrochloride monohydrate (LHM). In vitro and ex vivo skin permeation profiles reveal the sustained release behavior of loaded LHM at average skin temperature and pH. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Formula: C12H18O5

The Article related to field carbon quantum dot transdermal drug carrier polymer cyclodextrin, biocompatible, carbon quantum dots, composite film, cyclodextrin, drug delivery, hydrogel, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Antipchik, Mariia; Polyakov, Dmitry; Sinitsyna, Ekaterina; Dzhuzha, Apollinariia; Shavlovsky, Mikhail; Korzhikova-Vlakh, Evgenia; Tennikova, Tatiana published an article in 2020, the title of the article was Towards the development of a 3-D biochip for the detection of hepatitis C virus.Synthetic Route of 2358-84-1 And the article contains the following content:

The early diagnostics of hepatitis C virus (HCV) infections is currently one of the most highly demanded medical tasks. This study is devoted to the development of biochips (microarrays) that can be applied for the detection of HCV. The anal. platforms of suggested devices were based on macroporous poly(glycidyl methacrylate-co-di(ethylene glycol) dimethacrylate) monolithic material. The biochips were obtained by the covalent immobilization of specific probes spotted onto the surface of macroporous monolithic platforms. Using the developed biochips, different variants of bioassay were investigated. This study was carried out using hepatitis C virus-mimetic particles (VMPs) representing polymer nanoparticles with a size close to HCV and bearing surface virus antigen (E2 protein). At the first step, the main parameters of bioassay were optimized. Addnl., the dissociation constants were calculated for the pairs “ligand-receptor” and “antigen-antibody” formed at the surface of biochips. As a result of this study, the anal. of VMPs in model buffer solution and human blood plasma was carried out in a format of direct and “sandwich” approaches. It was found that bioassay efficacy appeared to be similar for both the model medium and real biol. fluid. Finally, limit of detection (LOD), limit of quantification (LOQ), spot-to-spot and biochip-to-biochip reproducibility for the developed systems were evaluated. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Synthetic Route of 2358-84-1

The Article related to biochip 3d gma degdma antigen antibody hepatitis c virus, biochips, hepatitis c, macroporous monolithic polymer layers, microarray, virus-mimetic particles, Biochemical Methods: Biological and other aspects.Synthetic Route of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2020, Maciuszek, Magdalena; Pijanowski, Lukasz; Pekala-Safinska, Agnieszka; Verburg-van Kemenade, B. M. Lidy; Chadzinska, Magdalena published an article.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was 17β-Estradiol affects the innate immune response in common carp. And the article contained the following:

Abstract: Inflammation is the evolutionary conserved immune response to harmful stimuli such as pathogens or damaged cells. This multistep process acts by removing injurious stimuli and initiating the healing process. In the present work, we studied the immunoregulatory properties of 17β-estradiol (E2) in common carp. We determined the in vitro effects of E2 on the activity/polarization of macrophages and the in vivo effects during Aeromonas salmonicida-induced inflammation. In vitro, E2 reduced the lipopolysaccharide (LPS)-stimulated expression of pro- and anti-inflammatory mediator genes but did not change the gene expression of the estrogen receptors and of aromatase CYP19. In contrast, in vivo in the head kidney of A. salmonicida-infected fish, E2-treated feeding induced an upregulation of gene expression of pro-inflammatory (il-12p35 and cxcb2) and anti-inflammatory (arginase 1, arginase 2, il-10, and mmp9) mediators. Moreover, in infected fish fed with E2-treated food, a higher gene expression of the estrogen receptors and of the aromatase CYP19 was found. Our results demonstrate that estrogens can modulate the carp innate immune response, though the in vitro and in vivo effects of this hormone are contrasting. This implies that estradiol not only induces a direct effect on macrophages but rather exerts immunomodulatory actions through indirect mechanisms involving other cellular targets. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to innate immunity beta estradiol aeromonas infection cyprinus, bacterial infection, estrogens, fish, inflammation, macrophage polarization, Immunochemistry: Immunopathology and other aspects.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Woods, Hannah; Boddorff, Andrew; Ewaldz, Elena; Adams, Zachary; Ketcham, Mitchell; Jang, Dong June; Sinner, Elizabeth; Thadhani, Naresh; Brettmann, Blair published an article in 2020, the title of the article was Rheological Considerations for Binder Development in Direct Ink Writing of Energetic Materials.Synthetic Route of 2358-84-1 And the article contains the following content:

A review. Additive manufacturing is a promising approach to prepare highly specifically defined materials with unique dimensions, gradients in material attributes and on-demand properties. For energetic materials applications, it is particularly exciting for its potential to create lattice and cellular structures and gradient solids to focus or dissipate energy. However, there are significant challenges to overcome, particularly in obtaining the very high particle content (>80 vol % particles), while still being manufacturable. This work focuses on the polymer binder used in an energetic materials system and aims to understand how its characteristics affect the viscosity and printability of the suspension. Two different types of polymer binders are examined: (a) high mol. weight polymer in a solvent and (b) polymerizable smaller mols. that were cured via UV light. We show that the suspension viscosity is primarily controlled by the particle volume fraction for the UV curable binder, while both the particle volume fraction and polymer mol. weight influence the response in the case of the polymer/solvent binder. Both binder types can be tuned to provide printable suspensions that result in lines of consistent width and 3D disk-shaped objects, indicating that both paths are good potential directions for future formulations for polymer bonded explosives prepared via additive manufacturing The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Synthetic Route of 2358-84-1

The Article related to polymer binder suspension viscosity printability explosive formulation review, Propellants and Explosives: Reviews and other aspects.Synthetic Route of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics