Category: 227940-70-7

On December 20, 2012, Atamanyuk, Dmytro; Denis, Alexis; Gerusz, Vincent; Ledoussal, Benoit; Bonvin, Yannick; Desroy, Nicolas; Gold, Johan; Moreau, Francois; Oxoby, Mayalen published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of purine derivatives and their use as pharmaceuticals for prevention or treatment of bacterial infections. And the patent contained the following:

The invention relates to the compounds I [wherein A is Ph, naphthyl and 5-10 membered monocyclic or bicyclic unsaturated heterocycle, optionally substituted by a group R1 which is as defined in the application and is itself optionally substitutes by a group R2 which is as defined in the application and is itself optionally substituted by a group R3 which is defined in the application, Y and W, identical or different, are H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, Ph or 4-10 monocyclic or bicyclic saturated or unsaturated heterocycle, optionally substituted by R1, or Y and/or W form a 4-10 membered cycle with R1, or Y and W form with N a saturated or unsaturated nitrogenous 4-10 membered mono, bi or tricyclic system, fused, bridged or spiro system, said system being optionally substituted by R1, said system being different from morpholine, with the proviso that when Y and A are Ph or heterocycle, W is not H] and their addition salts thereof with acids and bases. The invention also relates to a process and intermediates for their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them. Thus, 6-[4-(methanesulfonyl)phenyl]purine II was prepared from 2,6-dichloro-9H-purine vis tetrahydropyranylation with 3,4-dihydro-2H-pyran in EtOAc containing catalytic PTSA; Suzuki coupling reaction with [4-(MeSO2)C6H4]B(OH)2 in aqueous DME containing K2CO3 and catalytic Pd(PPh3)4; amination with tert-Bu [(piperidin-4-yl)methyl]carbamate in MeCN containing DIPEA; and N-deprotection with HCl in THF/dioxane. The antibacterial activity of II was determined [IC50 = <300 μM vs. dltA gene of S. aureus]. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Category: esters-buliding-blocks

The Article related to purine dimer derivative preparation antibacterial antivirulence agent immunomodulator, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2008, Yang, Zhigang; Liu, Jie; Liu, Xiaohua; Wang, Zhen; Feng, Xiaoming; Su, Zhishan; Hu, Changwei published an article.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Highly efficient amine organocatalysts based on bispidine for the asymmetric Michael addition of ketones to nitroolefins. And the article contained the following:

A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Addnl., a theor. study of transition structures revealed that this bispidine-based primary-secondary amine catalyst could serve through an enamine intermediate and H-bond interaction, which was important for the reactivity and selectivity of this reaction. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to michael stereoselective ketone nitroalkene bispidine catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2007, Liu, Lijun; Li, Ming published an article.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was A facile synthesis of N-substituted bispidine. And the article contained the following:

A method for the synthesis of the title compounds [i.e., bispidine derivatives, 3,7-diazabicyclo[3.3.1]nonane derivatives] is reported here. Several N-benzyl-N’-(alkyl)bispidine derivatives were synthesized from piperidone in two steps involving a double Mannich reaction. Their structures were determined by spectral anal. This method offers an easy and effective synthesis method for such N-substituted bispidine. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to bispidine bispidinone diazabicyclononane preparation mannich reaction, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 13, 2020, Guerin, David J.; Ng, Pui Yee; Wang, Zhongguo; Shelekhin, Tatiana; Caravella, Justin; Zablocki, Mary-Margaret; Downing, Jennifer R.; Li, Hongbin; Ioannidis, Stephanos published a patent.Related Products of 227940-70-7 The title of the patent was Preparation of carboxamides as ubiquitin-specific protease inhibitors. And the patent contained the following:

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The title compounds I [Y = C(R3) and N; R’ = H and Me; R1 = (un)substituted 6-11 membered heteroaryl; R2 = (un)substituted N-linked 4-12 membered heterocyclyl and C-linked 4-12 membered heterocyclyl; each R3 = (independently) H, D, alkyl, alkoxy, etc.; R4 = H, D, alkyl, halo, etc.; n = 0-3; with the proviso] or pharmaceutically acceptable forms thereof, useful as modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, and can be useful in the treatment of cancers, among other ailments, were prepared and/or claimed. E.g., a multi-step synthesis of (R)-II and (S)-II, starting from 4-bromo-2-hydroxybenzaldehyde and acrylonitrile, was described. Exemplified compounds I were tested for their USP28 and USP25 activities (data given for representative compounds I). Pharmaceutical composition comprising compound I was claimed. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Related Products of 227940-70-7

The Article related to carboxamide heteroaryl preparation ubiquitin specific protease inhibitor usp28 usp25, antitumor usp28 usp25 inhibitor carboxamide amide heteroaryl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haridas, V.; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh published an article in 2012, the title of the article was Bispidine as a secondary structure nucleator in peptides.Application of 227940-70-7 And the article contains the following content:

Here we describe bispidine as a scaffold for inducing open turn-like and beta sheet conformations on the attached peptides depending on the mode of attachment of peptides to the scaffold. Various bispidine-peptide conjugates were designed and synthesized to demonstrate the versatility of the scaffold. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application of 227940-70-7

The Article related to crystal structure bispidine secondary structure nucleator peptide, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Application of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 14, 2019, Zablocki, Mary-Margaret; Guerin, David J.; Ng, Pui Yee; Wang, Zhongguo; Shelekhin, Tatiana; Caravella, Justin; Li, Hongbin; Ioannidis, Stephanos published a patent.Electric Literature of 227940-70-7 The title of the patent was Heteroaryl carboxamide derivatives as ubiquitin-specific protease inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I, their use as modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors and methods of using the inhibitors in the treatment of cancers, among other ailments. Compounds of formula I, wherein X is CRARB and O; RA and RB are independently H, halo, hydroxy, etc.; R1 is 6 – 12 membered (un)substituted fused and (un)substituted nonfused heteroaryls, R2 is N-linked (un)substituted 4 – 12 membered heterocyclyls, (un)substituted C-linked 4 – 12 membered heterocyclyls and (un)substituted O-linked 4 – 12 member heterocyclyl; R3 is independently H, C1-6 alkyl, C1-6 alkoxy, etc.; n is 0, 1, 2 and 3; R4 is H, C1-6 alkyl, C1-6 alkoxy, etc.; R5 is H, deuterium and Me; Y1, Y2 and Y3 are independently CR3 and N; and pharmaceutically acceptable salts thereof, are claimed. Compound II was prepared using a multistep procedure (procedure given). Compound II was evaluated for its USP28 and USP25 inhibitory activities giving an IC50 of 0.05-2 μM and 0.2-2 μM, resp. Compounds of the invention were evaluated for their inhibitory activity (data given). The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Electric Literature of 227940-70-7

The Article related to heteroaryl carboxamide preparation usp28 usp25 modulator inhibitor cancer, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Electric Literature of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 3, 2015, Dikshit, Dinesh Kumar; Kumar, K. S. Anil; Dikshit, Madhu; Barthwal, Manoj Kumar; Misra, Ankita; Jain, Manish published a patent.Safety of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the patent was Preparation of 3,7-diazabicyclo[3.3.1]nonane carboxamides as antithrombotic agents. And the patent contained the following:

The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides of formula I as anti-thrombotic (anti-platelet) agents and process for preparation thereof. The invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors both in vitro and in vivo. Compounds of formula I wherein R’ is II and III; R is alkyl, acyl, tosyl, etc; R” is halo, cyano, lower alkyl, etc.; R1 is H and lower alkyl; R2 is lower alkyl and aryl; R3 is tert-butyloxycarbonyl and benzyloxycarbonyl groups; are claimed. Example compound IV was prepared by acylation of N-Bocbispidine with N-benzylpyroglutamic acid. The invention compounds were evaluated for their antithrombotic activity (some data given). The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Safety of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to preparation pyroglutamyldiazabicyclononane carboxamide antithrombotic, collagen induced platelet adhesion aggregation inhibitor preparation pyroglutamyldiazabicyclononane carboxamide and other aspects.Safety of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 2, 2015, Dikshit, Dinesh Kumar; Kumar, K. S. Anil; Dikshit, Madhu; Barthwal, Manoj Kumar; Misra, Ankita; Jain, Manish published a patent.Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the patent was Preparation of 3,7-diazabicyclo[3.3.1]nonane carboxamides as antithrombotic agents. And the patent contained the following:

The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides of formula I as anti-thrombotic (anti-platelet) agents and process for preparation thereof. The invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors both in vitro and in vivo. Compounds of formula I wherein R’ is II and III; R is alkyl, acyl, tosyl, etc; R” is halo, cyano, lower alkyl, etc.; R1 is H and lower alkyl; R2 is lower alkyl and aryl; R3 is tert-butyloxycarbonyl and benzyloxycarbonyl groups; are claimed. Example compound IV was prepared by acylation of N-Bocbispidine with N-benzylpyroglutamic acid. The invention compounds were evaluated for their antithrombotic activity (some data given). The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to preparation pyroglutamyldiazabicyclononane carboxamide antithrombotic, collagen induced platelet adhesion aggregation inhibitor preparation pyroglutamyldiazabicyclononane carboxamide and other aspects.Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 18, 2002, Huttenloch, Oliver; Laxman, Eltepu; Waldmann, Herbert published an article.Electric Literature of 227940-70-7 The title of the article was Solid-phase development of chiral phosphoramidite ligands for enantioselective conjugate addition reactions. And the article contained the following:

The development of a method for the optimization of chiral ligands for the steric steering of enantioselective Cu-catalyzed conjugate additions of Zn-alkyls to enones is described. The method is based on combinatorial principles and solid-phase techniques. It includes the combinatorial synthesis of chiral bispidine-derived ligands embodying a phosphoramidite group on the solid phase and their study in immobilized form in the conjugate addition of ZnEt2 to cyclohexenone as test reaction. The best identified ligands were also synthesized sep. and studied in its soluble form. The results obtained for the polymer-bound ligands correctly mirrored the performance of the soluble ligands. The library embodied members giving ee values varying between 3 and 67%. The positional scanning approach proved to be invalid for the study of the ligand system, indicating that this approach in general should be applied with care. Taken together, the method allowed for rapid and efficient optimization of the ligands and led to the development of the 1st enantioselective, Cu-catalyzed conjugate addition reaction with a polymer-bound ligand. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Electric Literature of 227940-70-7

The Article related to copper catalyzed conjugate addition diethylzinc cyclohexenone chiral phosphoramidite ligand, phosphoramidite ligand preparation combinatorial chem catalyst conjugate addition diethylzinc and other aspects.Electric Literature of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2022, Khokhar, Vaishali; Singh, Hanuman; Haridas, V.; Pandey, Siddharth published an article.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Ratiometric Recognition of Protons by a Multiple Tagged Designer Fluorescent Chemosensor. And the article contained the following:

Mol. architecture with different fluorophoric units can offer improved and effective recognition of biol. important analytes. We present here a new strategy for the design of ratiometric chemosensors that operate by photoinduced electron transfer (PET). This ratiometric sensor endowed with tryptophan and anthracene exhibits high sensitivity, excellent selectivity and remarkable reversibility towards recognition of H+ in methanol. This “Turn-On” type behavior is crafted into the mol. by incorporation of bispidine entity. Effective quenching of the fluorescence of the anthracene by the adjacent amine groups of the bispidine results in negligible fluorescence from the anthracene group leading to highly sensitive recognition of protons by the compound as H+ protonate the amine functionalities giving rise to the emergence of the fluorescence from the anthracene group. This, combined with the reduction in the fluorescence from the Trp group by H+, results in highly sensitive ratiometric nature of the response especially at low [H+]. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to hydrogen proton recognition ratiometric fluorescence chemosensor, bioanalytical sensing, fluorescence-based sensing, photoinduced electron/charge transfer, proton recognition, ratiometric chemosensor and other aspects.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics