Category: 227940-70-7

On April 7, 2002, Huttenloch, Oliver; Laxman, Eltepu; Waldmann, Herbert published an article.COA of Formula: C19H26N2O3 The title of the article was Combinatorial development of chiral phosphoramidite-ligands for enantioselective conjugate addition reactions. And the article contained the following:

Chiral phosphoramidite ligands embodying bispidine frame work and a binaphthyl phosphoramidite for Cu-catalyzed enantioselective conjugate addition reactions were developed employing principles of combinatorial and solid phase chem. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).COA of Formula: C19H26N2O3

The Article related to combinatorial phosphoramidite ligand enantioselective conjugate addition reaction, Alicyclic Compounds: Cyclohexanes and other aspects.COA of Formula: C19H26N2O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 20, 2000, Bjore, Annika; Granath, Anna-Karin published a patent.SDS of cas: 227940-70-7 The title of the patent was A dried or frozen pharmaceutical preparation containing a class III antiarrhythmic compound. And the patent contained the following:

The present invention relates to dried preparations containing a class III antiarrythmic compound in the form of crystalline or amorphous salt or any combination thereof, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. The present invention also relates to frozen preparations containing a class III antiarrhythmic compound in the form of salt solution, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. Preferred preparations contain a salt of the compound 3,7-diazabicyclo[3.3.1]-nonane-3-carboxylic acid 7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-1,1-dimethylethyl ester (Compound A). Further aspects of the present invention include salts of Compound A per se, processes for preparing the preparation, as well as use of the preparations for prophylaxis and/or treatment of cardiac arrhythmia. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).SDS of cas: 227940-70-7

The Article related to antiarrhythmic diazabicyclononanecarboxylate freeze dried pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haridas, V.; Yadav, Anita; Sharma, Sakshi; Pandey, Siddharth published an article in 2016, the title of the article was A tryptophan-containing fluorescent intramolecular complex as a designer peptidic proton sensor.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate And the article contains the following content:

Pyrene and tryptophan groups judiciously placed on a novel mol. scaffold, namely, bispidine exhibited fluorescence due to the formation of an unprecedented emissive intramol. complex in polar solvents. Upon protonation, the emission signal from the pyrene unit enhances at the expense of the emission signal from the complex. The probe demonstrates good sensitivity, excellent selectivity, and adequate reversibility towards proton sensing. The present design based on the bispidine scaffold opens up newer opportunities for the design of novel bispidine-peptide sensors. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to proton fluorescence probe bispidine peptide, Biochemical Methods: Spectral and Related Methods and other aspects.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 21, 2019, Mishra, Rituraj; Singh, Maninder; Singh, Hanuman; Haridas, V.; Kurur, Narayanan D. published an article.Application of 227940-70-7 The title of the article was Revealing Signs and Hidden 1H NMR Coupling Constants in Three-Spin Systems Using Long-Lived Coherences. And the article contained the following:

Long-lived coherences (LLCs) in a pair of coupled protons have long lifetimes and hence decreased line width and increased spectral resolution Fourier transformation of the damped oscillatory decay of the LLC also provides coupling information on the spin system. In a three-spin system, unlike in the two-spin case, the peaks in an LLC spectrum are observed at combinations of the coupling constants This attribute is used to determine the relative signs of the coupling constants in weakly and strongly coupled model systems. In addition, it is shown that a coupling constant in a three-spin system that is unobservable in the 1H NMR spectrum, as is the case in bispidinone, a mol. of significance in peptidomimetics, may be determined from the LLC spectrum. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application of 227940-70-7

The Article related to nmr three spin coupling constant long lived coherence, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 11, 2019, Juneja, Shreya; Singh, Hanuman; Palui, Sayan; Trivedi, Shruti; Singh, Sharan S.; Haridas, V.; Pandey, Siddharth published an article.Electric Literature of 227940-70-7 The title of the article was Unprecedented Intramolecular Association-Induced Fluorescence in Tryptophan-Conjugated Peptidomimetics. And the article contained the following:

We report herewith tryptophan (Trp)-conjugated peptidomimetics that show intramol. through-space association between the Trp units. Our investigation revealed that the proximal placement of Trp can lead to the emergence of a new and unanticipated fluorescent entity constituting a Trp-Trp dimer. Proton-induced modulation of fluorescence is a consequence of this work. Investigations with control compounds unequivocally revealed that the fluorescence property is not originated from the localized excited state but from the unprecedented Trp-Trp intramol. dimer in the ground state itself. The present findings will initiate the biophys. scientists to have a relook at the fluorescence properties of Trp-containing proteins. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Electric Literature of 227940-70-7

The Article related to intramol fluorescence tryptophan conjugated peptidomimetic, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 29, 2005, Stead, Darren; O’Brien, Peter; Sanderson, Adam J. published an article.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Concise Synthesis of (±)-Cytisine via Lithiation of N-Boc-bispidine. And the article contained the following:

(±)-Cytisine (I) has been synthesized in 19% overall yield via a six-step approach from com. available materials. Key features of this new strategy are as follows: (i) initial construction of the bispidine core, (ii) lithiation-transmetalation-allylation of an N-Boc-bispidine, and (iii) a Pd/C-mediated dihydropyridone oxidation-N-debenzylation process. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to cytisine synthesis lithiation transmetalation allylation stereoselective, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2017, Srivastava, Ankit; Sharma, Sakshi; Sadanandan, Sandhya; Gupta, Sakshi; Singh, Jasdeep; Gupta, Sarika; Haridas, V.; Kundu, Bishwajit published an article.COA of Formula: C19H26N2O3 The title of the article was Modulation of prion polymerization and toxicity by rationally designed peptidomimetics. And the article contained the following:

Misfolding and aggregation of cellular prion protein is associated with a large array of neurol. disorders commonly called the transmissible spongiform encephalopathies. Designing inhibitors against prions has remained a daunting task owing to limited information about mechanism(s) of their pathogenic self-assembly. Here, we explore the anti-prion properties of a combinatorial library of bispidine-based peptidomimetics (BPMs) that conjugate amino acids with hydrophobic and aromatic side chains. Keeping the bispidine unit unaltered, a series of structurally diverse BPMs were synthesized and tested for their prion-modulating properties. Administration of Leu- and Trp-BPMs delayed and completely inhibited the amyloidogenic conversion of human prion protein (HuPrP), resp. We found that each BPM induced the HuPrP to form unique oligomeric nanostructures differing in their biophys. properties, cellular toxicities and response to conformation-specific antibodies. While Leu-BPMs were found to stabilize the oligomers, Trp-BPMs effected transient oligomerization, resulting in the formation of non-toxic, non-fibrillar aggregates. Yet another aromatic residue, Phe, however, accelerated the aggregation process in HuPrP. Mol. insights obtained through MD (mol. dynamics) simulations suggested that each BPM differently engages a conserved Tyr 169 residue at the α2-β2 loop of HuPrP and affects the stability of α2 and α3 helixes. Our results demonstrate that this new class of mols. having chem. scaffolds conjugating hydrophobic/aromatic residues could effectively modulate prion aggregation and toxicity. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).COA of Formula: C19H26N2O3

The Article related to prion protein aggregation secondary structure bispidine peptidomimetics, amyloid, bispidine, cytotoxicity, oligomer, prion, protein misfolding, General Biochemistry: Proteins and Their Constituents and other aspects.COA of Formula: C19H26N2O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Gonglin; Zhang, Yan; Zeng, Hongkun; Feng, Xiaoming; Su, Zhishan; Lin, Lili published an article in 2022, the title of the article was Water enables diastereodivergency in bispidine-based chiral amine-catalyzed asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones.Product Details of 227940-70-7 And the article contains the following content:

A diastereodivergent asym. Mannich reaction of cyclic N-sulfonyl ketimines I (R1 = Me, Et, i-Pr, Bn, etc.; R2 = H, 5-OMe, 7-Cl, 6-Me, etc.) with ketones such as cyclohexanone, tert-Bu 4-oxopiperidine-1-carboxylate, thian-4-one, etc. catalyzed by a bispidine-based chiral amine catalyst, in which addnl. water switches the diastereoselectivity efficiently was reported. Synthesis of chiral anti- benzosultams and syn-benzosultams II (X = CH2, O, NCO2t-Bu, etc.) with potential anti-HIV-1 activity is obtained in excellent yields and good to excellent ee values. Control experiments and d. functional theory (DFT) calculations were applied to study the diastereodivergent mechanism, which reveal that the diastereodivergent catalysis should be state-determined, and the water reverses the energies of states to realize the diastereodivergency. The findings are quite new and might inspire more diastereodivergent asym. synthesis. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Product Details of 227940-70-7

The Article related to benzosultam preparation diastereoselective enantioselective, cyclic sulfonyl ketimine ketone mannich reaction bispidine amine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Product Details of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2016, Bulygina, L. A.; Khrushcheva, N. S.; Peregudov, A. S.; Sokolov, V. I. published an article.SDS of cas: 227940-70-7 The title of the article was Cyclopalladate complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane. And the article contained the following:

A new (C,N,N)-pincer cyclopalladate unsym. complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane (3-benzyl-7-methylbispidine) was synthesized and characterized. Catalytic performance of this complex was examined in the Heck and Suzuki reactions and in the norbornene hydroarylation. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).SDS of cas: 227940-70-7

The Article related to benzylmethyldiazabicyclononane cyclopalladate complex preparation coupling catalyst, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.SDS of cas: 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2015, Stead, Darren; O’Brien, Peter; Sanderson, Adam published an article.Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Investigation of the Lithiation-Trapping of an N-BOC Bispidine-Ketal: Reactivity and Diastereoselectivity. And the article contained the following:

The lithiation-trapping of an N-BOC bispidine-ketal using BuLi/TMEDA has been studied. Key findings include an activating effect of the 4-ketal group on the lithiation and complete diastereoselectivity with methylation and Cu-mediated allylation. In contrast, reduced diastereoselectivity was noted for direct allylation and silylation; mechanistic explanations are proposed. The synthesis of the target compounds was achieved using 7-(phenylmethyl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid 1,1-dimethylethyl ester (i.e., a bispidine carboxylic acid ester derivative), 9-oxo-7-(phenylmethyl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid 1,1-dimethylethyl ester (i.e., a bispidine-ketone derivative), 7-(phenylmethyl)Spiro[3,7-diazabicyclo[3.3.1]nonane-9,2′-[1,3]dioxolane]-3-carboxylic acid 1,1-dimethylethyl ester (i.e., a cyclic-ketal-bispidine derivative) as starting materials. The title compounds thus formed included bispidine-diastereomer derivatives, such as (1R,2S,5S)-rel-7-(phenylmethyl)-2-(2-propen-1-yl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid 1,1-dimethylethyl ester. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to lithiation bispidine ketal diastereoselectivity, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics