Category: 2253-73-8

Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-魏B Activation without Intrinsic Activity was written by Chan, Michael;Ahmadi, Alast;Yao, Shiyin;Sato-Kaneko, Fumi;Messer, Karen;Pu, Minya;Nguyen, Brandon;Hayashi, Tomoko;Corr, Maripat;Carson, Dennis A.;Cottam, Howard B.;Shukla, Nikunj M.. And the article was included in ACS Combinatorial Science in 2017.Computed Properties of C4H7NS The following contents are mentioned in the article:

Most vaccine adjuvants directly stimulate and activate antigen presenting cells, but do not sustain immunostimulation of these cells. A high throughput screening (HTS) strategy was designed to identify compounds that would sustain NF-魏B activation by a stimulus from toll-like receptor (TLR)4 ligand, lipopolysaccharide (LPS). Several pilot studies optimized the parameters and conditions for a cell based NF-魏B reporter assay in human monocytic THP-1 cells. The final assay evaluated prolongation of LPS induced NF-魏B activation at 12h (hours). The dynamic range of the assay was confirmed in a pilot screen of 14,631 compounds, and subsequently in a main extensive screen with 166,304 compounds Hit compounds were identified using an enrichment strategy based on unsupervised chemoinformatic clustering, and also by a naive ‘Top X’ approach. 2011 compounds were then rescreened for levels of co-activation with LPS at 5h and 12h, which provided kinetic profiles. Of the 407 confirmed hits, compounds that showed correlation of the kinetic profiles with the structural similarities led to identification of four chemotypes: pyrimido[5,4-b]indoles; 4H-chromene-3-carbonitriles; benzo[d][1,3]dioxol-2-ylureas; and tetrahydrothieno[2,3-c]pyridines, which were segregated by 5h and 12h kinetic characteristics. Unlike the TLR4 agonistic pyrimidoindoles identified in previous studies, the revealed pyrimidoindoles in the present work did not intrinsically stimulate TLR4 nor induce NF-魏B, but rather prolonged NF-魏B signaling induced by LPS. A 42-member combinatorial library was synthesized which led to identification of potent N3-alkyl substituted pyrimidoindoles that were not only active in vitro but also enhanced antibody responses in vivo when used as a co-adjuvant. The novel HTS strategy led to identification of compounds that are intrinsically quiescent but functionally prolong stimulation by a TLR4 ligand and thereby potentiate vaccine efficacy. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 纬-valerolactone.Computed Properties of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization and comparison of UK, Irish, and French cold pressed rapeseed oils with refined rapeseed oils and extra virgin olive oils was written by McDowell, Daniel;Elliott, Christopher T.;Koidis, Anastasios. And the article was included in European Journal of Lipid Science and Technology in 2017.Computed Properties of C4H7NS The following contents are mentioned in the article:

Various chem. parameters were used to characterize a wide range of cold pressed rapeseed oils and to contrast the findings with refined rapeseed and extra virgin olive oil. There were significant differences between cold pressed rapeseed oils regarding almost all measured parameters. Volatile composition anal. showed that hexanal, 3-Me pentane and 1-butene, 4-isothiocyanato were the most abundant compounds There was no correlation between volatile compounds and geog. region of cold pressed rapeseed oils. French cold pressed rapeseed oils were found in exhibit significantly higher antioxidant activity levels than cold pressed rapeseed oils from other regions. Refined rapeseed oil was found to have a higher antioxidant activity but have significantly lower levels of phenolic acids (0.008 mg/kg oil) than cold pressed rapeseed oil (0.46 mg/kg oil). These phenolic acids appear to be important for oxidative stability as cold pressed rapeseed oil was more stable under heat stress than refined rapeseed oil. Olive oil was the most stable under heat stress, largely due to its comparatively high saturated fat content. Antioxidant potential, phenolic acids and peroxide values were found to be the main factors differentiating cold pressed rapeseed oil from refined rapeseed oil. Practical applications: Cold pressed rapeseed oil is a relatively new oil to the market and this study is the first to examine oils available to the British, Irish and French consumers. It shows the compositional variation of oils on the market by analyzing many parameters important for oil quality and consumer palatability. Antioxidant behavior and phenolic acid identification indicate potential health benefiting properties. This research also compares cold pressed rapeseed oils with market competitors which allows for clear comparison of these widely used edible oils. Cold pressed rapeseed oil is made by mech. crushing rapeseeds at a low temperature, followed by filtering and bottling the oil. This work investigates the chem. composition of cold pressed rapeseed oil, along with its antioxidant capacity and stability under heat stress. Cold pressed rapeseed oil is also compared to market competitors; refined rapeseed oil and extra virgin olive oil. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fe₃O₄/ZnO/MWCNTs magnetic nanocomposites promoted synthesis of new chromeno pyrano [2,3-d]thiazins: Investigation of antioxidant and antibacterial activities was written by Dadashi, Hani;Hajinasiri, Rahimeh;Hossaini, Zinatossadat. And the article was included in Applied Organometallic Chemistry in 2021.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

The Fe₃O₄/ZnO/MWCNTs magnetic nanocomposites as a high-performance organometallic catalyst were employed for the preparation of new chromeno pyrano [2,3-d]thiazins derivatives I (R = Me, OMe, NO₂; R¹ = H, Me; R² = CH₃, C₂H₅, C₆H₅, 4-CH₃C₆H₄, 4-CH₃OC₆H₄, 4-O₂NC₆H₄; R³ = CH(CH₃)₂, C₂H₅, C₆H₅, 4-CH₃C₆H₄, 4-CH₃OC₆H₄, 4-O₂NC₆H₄; X = O, NH) in high yields via the five component reactions of 2-hydroxyacetophenones like 1-(2-Hydroxy-3-methyl-5-nitrophenyl)ethanone, 1-(2-Hydroxy-5-methylphenyl)ethan-1-one, 1-(2-Hydroxy-3,5-dimethylphenyl)ethanone and 1-(2-hydroxy-5-methoxyphenyl)ethanone, di-Me carbonate, aldehydes R²CHO, malononitrile or Et 2-cyanoacetate, and isothiocyanates R³NCS in ionic liquid at room temperature The Fe₃O₄/ZnO/MWCNTs MNCs were synthesized using ionic liquid [OMIM]Br as a stabilizer and soft template. As well Fe₃O₄/ZnO/MWCNTs MNCs show a good improvement in the yield of the product and showed significant reusable ability. Due to having NH group in synthesized compounds, antioxidant property of some synthesized compounds I was investigated by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment Furthermore, the disk diffusion test on Gram-pos. and Gram-neg. bacteria is utilized for investigation of antimicrobial activity of some chromeno pyrano [2,3-d]thiazins I. The achieved outcomes of this experiment demonstrate that these synthesized compounds I could prevent growth of bacteria. Short time of reaction, high yields of product, easy separation of catalyst, and products are some benefits of this process. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fe₃O₄/ZnO/MWCNTs magnetic nanocomposites promoted synthesis of new chromeno pyrano [2,3-d]thiazins: Investigation of antioxidant and antibacterial activities was written by Dadashi, Hani;Hajinasiri, Rahimeh;Hossaini, Zinatossadat. And the article was included in Applied Organometallic Chemistry in 2021.Formula: C4H7NS The following contents are mentioned in the article:

The Fe₃O₄/ZnO/MWCNTs magnetic nanocomposites as a high-performance organometallic catalyst were employed for the preparation of new chromeno pyrano [2,3-d]thiazins derivatives I (R = Me, OMe, NO₂; R¹ = H, Me; R² = CH₃, C₂H₅, C₆H₅, 4-CH₃C₆H₄, 4-CH₃OC₆H₄, 4-O₂NC₆H₄; R³ = CH(CH₃)₂, C₂H₅, C₆H₅, 4-CH₃C₆H₄, 4-CH₃OC₆H₄, 4-O₂NC₆H₄; X = O, NH) in high yields via the five component reactions of 2-hydroxyacetophenones like 1-(2-Hydroxy-3-methyl-5-nitrophenyl)ethanone, 1-(2-Hydroxy-5-methylphenyl)ethan-1-one, 1-(2-Hydroxy-3,5-dimethylphenyl)ethanone and 1-(2-hydroxy-5-methoxyphenyl)ethanone, di-Me carbonate, aldehydes R²CHO, malononitrile or Et 2-cyanoacetate, and isothiocyanates R³NCS in ionic liquid at room temperature The Fe₃O₄/ZnO/MWCNTs MNCs were synthesized using ionic liquid [OMIM]Br as a stabilizer and soft template. As well Fe₃O₄/ZnO/MWCNTs MNCs show a good improvement in the yield of the product and showed significant reusable ability. Due to having NH group in synthesized compounds, antioxidant property of some synthesized compounds I was investigated by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment Furthermore, the disk diffusion test on Gram-pos. and Gram-neg. bacteria is utilized for investigation of antimicrobial activity of some chromeno pyrano [2,3-d]thiazins I. The achieved outcomes of this experiment demonstrate that these synthesized compounds I could prevent growth of bacteria. Short time of reaction, high yields of product, easy separation of catalyst, and products are some benefits of this process. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aerosol-Assisted Chemical Vapor Deposition of ZnS from Thioureide Single Source Precursors was written by Sullivan, Hannah S. I.;Parish, James D.;Thongchai, Prem;Kociok-Kohn, Gabriele;Hill, Michael S.;Johnson, Andrew L.. And the article was included in Inorganic Chemistry in 2019.Computed Properties of C4H7NS The following contents are mentioned in the article:

A family of 12 zinc(II) thioureide complexes, of the general form [{L}ZnMe], [{L}Zn{N(SiMe₃)₂}], and [{L}₂Zn], have been synthesized by direct reaction of the thiourea pro-ligands ⁱPrN(H)CS(NMe₂) H[L¹], CyN(H)CS(NMe₂) H[L³], ^tBuN(H)CS(NMe₂) H[L²], and MesN(H)CS(NMe₂) H[L⁴] with either ZnMe₂ (1:1) or Zn{N(SiMe₃)₂}₂ (1:1 and 2:1) and characterized by elemental anal., NMR spectroscopy, and TGA. The mol. structures of complexes [{L¹}ZnMe]₂ (1), [{L²}ZnMe]₂ (2), [{L³}ZnMe]_{鈭?/sub> (3), [{L⁴}ZnMe]2 (4), [{L¹}Zn{N(SiMe3)2}]2 (5), [{L²}Zn{N(SiMe3)2}]2 (6), [{L³}Zn{N(SiMe3)2}]2 (7), [{L⁴}Zn{N(SiMe3)2}]2 (8), [{L¹}2Zn]2 (9), and [{L⁴}2Zn]2 (12) have been unambiguously determined using single crystal x-ray diffraction studies. TGA has been used to assess the viability of 1–12 as single source precursors for the formation of ZnS. On the basis of TGA data compound 9 was investigated for its utility as a single source precursor to deposit ZnS films on silica-coated glass and crystalline silicon substrates at 150, 200, 250, and 300掳 using an aerosol assisted CVD (AACVD) method. The resultant films are hexagonal-ZnS by Raman spectroscopy and PXRD, and the surface morphologies were examined by SEM and AFM anal. Thin films deposited from (9) at 250 and 300掳 are comprised of more densely packed and more highly crystalline ZnS than films deposited at lower temperatures The electronic properties of the ZnS thin films were deduced by UV-visible spectroscopy to be very similar and displayed absorption behavior and band gap (Eg = 3.711-3.772 eV) values between those expected for bulk cubic-ZnS (Eg = 3.54 eV) and hexagonal-ZnS (Eg = 3.91 eV). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).}

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aerosol-Assisted Chemical Vapor Deposition of ZnS from Thioureide Single Source Precursors was written by Sullivan, Hannah S. I.;Parish, James D.;Thongchai, Prem;Kociok-Kohn, Gabriele;Hill, Michael S.;Johnson, Andrew L.. And the article was included in Inorganic Chemistry in 2019.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

A family of 12 zinc(II) thioureide complexes, of the general form [{L}ZnMe], [{L}Zn{N(SiMe₃)₂}], and [{L}₂Zn], have been synthesized by direct reaction of the thiourea pro-ligands ⁱPrN(H)CS(NMe₂) H[L¹], CyN(H)CS(NMe₂) H[L³], ^tBuN(H)CS(NMe₂) H[L²], and MesN(H)CS(NMe₂) H[L⁴] with either ZnMe₂ (1:1) or Zn{N(SiMe₃)₂}₂ (1:1 and 2:1) and characterized by elemental anal., NMR spectroscopy, and TGA. The mol. structures of complexes [{L¹}ZnMe]₂ (1), [{L²}ZnMe]₂ (2), [{L³}ZnMe]_{鈭?/sub> (3), [{L⁴}ZnMe]2 (4), [{L¹}Zn{N(SiMe3)2}]2 (5), [{L²}Zn{N(SiMe3)2}]2 (6), [{L³}Zn{N(SiMe3)2}]2 (7), [{L⁴}Zn{N(SiMe3)2}]2 (8), [{L¹}2Zn]2 (9), and [{L⁴}2Zn]2 (12) have been unambiguously determined using single crystal x-ray diffraction studies. TGA has been used to assess the viability of 1–12 as single source precursors for the formation of ZnS. On the basis of TGA data compound 9 was investigated for its utility as a single source precursor to deposit ZnS films on silica-coated glass and crystalline silicon substrates at 150, 200, 250, and 300掳 using an aerosol assisted CVD (AACVD) method. The resultant films are hexagonal-ZnS by Raman spectroscopy and PXRD, and the surface morphologies were examined by SEM and AFM anal. Thin films deposited from (9) at 250 and 300掳 are comprised of more densely packed and more highly crystalline ZnS than films deposited at lower temperatures The electronic properties of the ZnS thin films were deduced by UV-visible spectroscopy to be very similar and displayed absorption behavior and band gap (Eg = 3.711-3.772 eV) values between those expected for bulk cubic-ZnS (Eg = 3.54 eV) and hexagonal-ZnS (Eg = 3.91 eV). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).}

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reactions of Iso(thio)cyanates with Dialanes: Cycloaddition, Reductive Coupling, or Cleavage of the C=S or C=O Bond was written by Dodonov, Vladimir A.;Chen, Weixing;Liu, Li;Sokolov, Vladimir G.;Baranov, Evgeny V.;Skatova, Alexandra A.;Zhao, Yanxia;Wu, Biao;Yang, Xiao-Juan;Fedushkin, Igor L.. And the article was included in Inorganic Chemistry in 2021.Category: esters-buliding-blocks The following contents are mentioned in the article:

The dialanes [(dpp-Bian)Al-Al(dpp-Bian)] (1) and [(dpp-dad)Al(THF)-(THF)Al(dpp-dad)] (2) (dpp-Bian = 1,2-[(2,6-iPr₂C₆H₃)NC]₂C₁₂H₆, dpp-dad = [(2,6-iPr₂C₆H₃)NC(CH₃)]₂) react with some isothiocyanates, isocyanates, and diphenylketene via [2 + 4] cycloaddition of the C=O or C=S bond across the C=C-N-Al fragment to afford complexes [L(X=C-Y)Al-Al(X=C-Y)L] with an intact Al-Al single bond (L = dpp-Bian, X = PhN, Y = O (3); L = dpp-Bian, X = Ph₂C, Y = O (4); L = dpp-dad, X = BnN, Y = S (6); L = dpp-dad, X = tBuN, Y = O (7); L = dpp-dad, X = iPrN, Y = S (8); and L = dpp-dad, X = CyN, Y = S (9)). A mixed C=N and C=O mode cycloadduct, [(dpp-Bian)(TosN=C-O)Al-Al(TosN-C=O)(dpp-Bian)] (5), was obtained in the reaction of 1 with tosylisocyanate. Heating the solution of 3 resulted in a thermal transformation and a change of the cycloaddition mode from C=O to C=N to give the product [(dpp-Bian)(PhN-C=O)Al(O)Al(PhN-C=O)(dpp-Bian)] (10). The reduction of 7 and 8 with Na yielded the products [Na(THF)_n]₂[(dpp-dad^-H)(X=C-Y)Al]₂ (X = iPrN, Y = S, n = 2 (12) and X = tBuN, Y = O, n = 3 (13)) in which one of the Me groups of the backbone of the initial dpp-dad ligand was dehydrogenated. When 2 was reacted with the bulky adamantyl isocyanate AdNCO, the C-C coupling of two substrates occurred to form [(dpp-dad)Al(O=C-NAd)₂Al(dpp-dad)] (14) in which the coupled dianionic oxamide ligand bridged two Al atoms in a μ,η⁴-N,O/N,O mode. Moreover, in the presence of 2.0 equiv of Na metal, precursor 2 reacts with tBuNCS, p-TolylNCS, or Me₃SiNCO, possibly through the reduced Al^I intermediate, to yield the sulfur- or oxygen-bridged dimer [Na(solv)_n]₂[(dpp-dad)Al(μ-E)]₂ (E = S, solv = THF, n = 3 (15) and E = O, solv = DME, n = 2 (16)) upon C=S or C=O bond cleavage. Dialane 1 reacts with dimethylsulfone to give a Lewis adduct [(dpp-Bian)(Me₂SO₂)Al]₂ (17), which releases dimethylsulfone upon heating. The diamagnetic compounds 3–10 and 12–17 were characterized by NMR and IR spectroscopy. The mol. structures of 3–17 were established by single-crystal X-ray diffraction anal. Electronic structures of the compounds and possible isomers were examined by DFT calculations This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reactions of Iso(thio)cyanates with Dialanes: Cycloaddition, Reductive Coupling, or Cleavage of the C=S or C=O Bond was written by Dodonov, Vladimir A.;Chen, Weixing;Liu, Li;Sokolov, Vladimir G.;Baranov, Evgeny V.;Skatova, Alexandra A.;Zhao, Yanxia;Wu, Biao;Yang, Xiao-Juan;Fedushkin, Igor L.. And the article was included in Inorganic Chemistry in 2021.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

The dialanes [(dpp-Bian)Al-Al(dpp-Bian)] (1) and [(dpp-dad)Al(THF)-(THF)Al(dpp-dad)] (2) (dpp-Bian = 1,2-[(2,6-iPr₂C₆H₃)NC]₂C₁₂H₆, dpp-dad = [(2,6-iPr₂C₆H₃)NC(CH₃)]₂) react with some isothiocyanates, isocyanates, and diphenylketene via [2 + 4] cycloaddition of the C=O or C=S bond across the C=C-N-Al fragment to afford complexes [L(X=C-Y)Al-Al(X=C-Y)L] with an intact Al-Al single bond (L = dpp-Bian, X = PhN, Y = O (3); L = dpp-Bian, X = Ph₂C, Y = O (4); L = dpp-dad, X = BnN, Y = S (6); L = dpp-dad, X = tBuN, Y = O (7); L = dpp-dad, X = iPrN, Y = S (8); and L = dpp-dad, X = CyN, Y = S (9)). A mixed C=N and C=O mode cycloadduct, [(dpp-Bian)(TosN=C-O)Al-Al(TosN-C=O)(dpp-Bian)] (5), was obtained in the reaction of 1 with tosylisocyanate. Heating the solution of 3 resulted in a thermal transformation and a change of the cycloaddition mode from C=O to C=N to give the product [(dpp-Bian)(PhN-C=O)Al(O)Al(PhN-C=O)(dpp-Bian)] (10). The reduction of 7 and 8 with Na yielded the products [Na(THF)_n]₂[(dpp-dad^-H)(X=C-Y)Al]₂ (X = iPrN, Y = S, n = 2 (12) and X = tBuN, Y = O, n = 3 (13)) in which one of the Me groups of the backbone of the initial dpp-dad ligand was dehydrogenated. When 2 was reacted with the bulky adamantyl isocyanate AdNCO, the C-C coupling of two substrates occurred to form [(dpp-dad)Al(O=C-NAd)₂Al(dpp-dad)] (14) in which the coupled dianionic oxamide ligand bridged two Al atoms in a μ,η⁴-N,O/N,O mode. Moreover, in the presence of 2.0 equiv of Na metal, precursor 2 reacts with tBuNCS, p-TolylNCS, or Me₃SiNCO, possibly through the reduced Al^I intermediate, to yield the sulfur- or oxygen-bridged dimer [Na(solv)_n]₂[(dpp-dad)Al(μ-E)]₂ (E = S, solv = THF, n = 3 (15) and E = O, solv = DME, n = 2 (16)) upon C=S or C=O bond cleavage. Dialane 1 reacts with dimethylsulfone to give a Lewis adduct [(dpp-Bian)(Me₂SO₂)Al]₂ (17), which releases dimethylsulfone upon heating. The diamagnetic compounds 3–10 and 12–17 were characterized by NMR and IR spectroscopy. The mol. structures of 3–17 were established by single-crystal X-ray diffraction anal. Electronic structures of the compounds and possible isomers were examined by DFT calculations This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Exploring “Triazole-Thiourea” Based Ligands for the Self-Assembly of Photoluminescent Hg(II) Coordination Compounds was written by Benaissa, Houria;Adarsh, Nayarassery N.;Robeyns, Koen;Zakrzewski, Jakub J.;Chorazy, Szymon;Hooper, James G. M.;Sagan, Filip;Mitoraj, Mariusz P.;Wolff, Mariusz;Radi, Smaail;Garcia, Yann. And the article was included in Crystal Growth & Design in 2021.COA of Formula: C4H7NS The following contents are mentioned in the article:

This study represents the first explorative investigation on the supramol. structural diversity in Hg(II) coordination chem. with triazole-thiourea ligands leading to a variety of mononuclear, binuclear, and coordination polymers: {[Hg(L1)₂(L1^–)₂]} (1), {[Hg₂(L1)₂(μ₂-I)₂I₂]·DMSO} (2), {[Hg(L2)(μ₂-I)I]·MeOH}_∝ (3), {[Hg₂(μ-L3^–)₄]}_∝ (4), {[HgCl(L4^–)L4]·MeOH} (5), {[Hg₂(L4)₂(μ₂-I)₂(I)₂]·2MeOH} (6), {[Hg₂(μ₂–L5^–)₄]}_∝ (7), {[Hg₂(μ₂-Cl)₂(L6^–)₂(L6)₂]} (8), {[Hg₂(μ₂-Br)₂(L6^–)₂(L6)₂]} (9), and {[Hg₂(μ₂-I)₂(L6^–)₂(L6)₂]} (10). A reaction mechanism was suggested for the unexpected ligand rearrangement occurring in {[Hg₂I₃(μ₃–L5‘)]}_∝ (11). The ligands were fully characterized including by x-ray crystallog. and computational means. This includes six new triazole-thiourea based ligands, namely, 1-R-3-(4H-1,2,4-triazol-4-yl)thiourea (where R = Me (L1), Et (L2), Pr (L3), iso-Pr (L4), and its polymorph (L4-poly), allyl (L5), Et acetate (L6), and its solvate (L6_MeOH)). Under UV light excitation, 7, 10, and 11 exhibit visible photoluminescence of wide origin, ranging from ligand-centered (LC) fluorescence combined with organic-ligand-to-metal charge transfer (LMCT) emissive states in 7 and 10, up to halide-to-metal charge transfer (XMCT) combined with halide-to-ligand charge transfer (XLCT) emissive states in 11. The variable emission mechanisms in the obtained coordination polymers were elucidated by exptl. proofs confronted with theor. calculations of the electronic densities of states, proving that Hg(II) halide coordination polymers involving flexible 1,2,4-triazole-based ligands form a promising class of luminescent mol. materials. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Exploring “Triazole-Thiourea” Based Ligands for the Self-Assembly of Photoluminescent Hg(II) Coordination Compounds was written by Benaissa, Houria;Adarsh, Nayarassery N.;Robeyns, Koen;Zakrzewski, Jakub J.;Chorazy, Szymon;Hooper, James G. M.;Sagan, Filip;Mitoraj, Mariusz P.;Wolff, Mariusz;Radi, Smaail;Garcia, Yann. And the article was included in Crystal Growth & Design in 2021.Reference of 2253-73-8 The following contents are mentioned in the article:

This study represents the first explorative investigation on the supramol. structural diversity in Hg(II) coordination chem. with triazole-thiourea ligands leading to a variety of mononuclear, binuclear, and coordination polymers: {[Hg(L1)₂(L1^–)₂]} (1), {[Hg₂(L1)₂(μ₂-I)₂I₂]·DMSO} (2), {[Hg(L2)(μ₂-I)I]·MeOH}_∝ (3), {[Hg₂(μ-L3^–)₄]}_∝ (4), {[HgCl(L4^–)L4]·MeOH} (5), {[Hg₂(L4)₂(μ₂-I)₂(I)₂]·2MeOH} (6), {[Hg₂(μ₂–L5^–)₄]}_∝ (7), {[Hg₂(μ₂-Cl)₂(L6^–)₂(L6)₂]} (8), {[Hg₂(μ₂-Br)₂(L6^–)₂(L6)₂]} (9), and {[Hg₂(μ₂-I)₂(L6^–)₂(L6)₂]} (10). A reaction mechanism was suggested for the unexpected ligand rearrangement occurring in {[Hg₂I₃(μ₃–L5‘)]}_∝ (11). The ligands were fully characterized including by x-ray crystallog. and computational means. This includes six new triazole-thiourea based ligands, namely, 1-R-3-(4H-1,2,4-triazol-4-yl)thiourea (where R = Me (L1), Et (L2), Pr (L3), iso-Pr (L4), and its polymorph (L4-poly), allyl (L5), Et acetate (L6), and its solvate (L6_MeOH)). Under UV light excitation, 7, 10, and 11 exhibit visible photoluminescence of wide origin, ranging from ligand-centered (LC) fluorescence combined with organic-ligand-to-metal charge transfer (LMCT) emissive states in 7 and 10, up to halide-to-metal charge transfer (XMCT) combined with halide-to-ligand charge transfer (XLCT) emissive states in 11. The variable emission mechanisms in the obtained coordination polymers were elucidated by exptl. proofs confronted with theor. calculations of the electronic densities of states, proving that Hg(II) halide coordination polymers involving flexible 1,2,4-triazole-based ligands form a promising class of luminescent mol. materials. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Reference of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics