Category: 2253-73-8

Isothiocyanates and glucosinolates from Sisymbrium officinale (L.) Scop. (“the singers鈥?plant”): isolation and in vitro assays on the somatosensory and pain receptor TRPA1 channel was written by Borgonovo, Gigliola;Zimbaldi, Nathan;Guarise, Marta;De Nisi, Patrizia;De Petrocellis, Luciano;Moriello, Aniello Schiano;Bassoli, Angela. And the article was included in Molecules in 2019.Formula: C4H7NS The following contents are mentioned in the article:

Sisymbrium officinale (L.) Scop. is a wild common plant of the Brassicaceae family. It is known as “the singers鈥?plant” for its traditional use in treating aphonia and vocal disability. Despite its wide use in herbal preparations, the mol. mechanism of action of S. officinale extracts is not known. The plant is rich in glucosinolates and isothiocyanates, which are supposed to be its active compounds Some members of this family, in particular allylisothiocyanate, are strong agonists of the transient receptor potential ankyrin 1 (TRPA1) channel, which is involved in the somatosensory perception of pungency as well as in the nociception pathway of inflammatory pain. This study aims to isolate the glucosinolates and isothiocianates from fresh S. officinale to identify the major components and test their activity in in vitro assays with a cloned TRPA1 channel. Samples of cultivated S. officinale have been extracted and the active compounds isolated by column chromatog., HPLC and PTLC. The main components glucoputranjivin, isopropylisothiocyanate and 2-buthylisothiocianate have been tested on TRPA1. The glucosinolates glucoputranjivin and sinigrin turned out to be inactive, while isopropylisothiocyanate and 2-buthylisothiocyanate are potent agonists of TRPA1, with an EC50 in the range of the high potency natural agonists identified so far for this somatosensory channel. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Inhibition of Escherichia coli O157:H7 and Salmonella enterica virulence factors by benzyl isothiocyanate was written by Patel, Jitendra;Yin, Hsin-Bai;Bauchan, Gary;Mowery, Joseph. And the article was included in Food Microbiology in 2020.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

Escherichia coli O157:H7 and Salmonella enterica are foodborne pathogens with major public health concern in the U.S. These pathogens utilize several virulence factors to initiate infections in humans. The antimicrobial effect of seven glucosinolate hydrolysis compounds against Salmonella and E. coli O157:H7 was investigated by the disk diffusion assay. Among the tested compounds, benzyl isothiocyanate (BIT), which exerted the highest antimicrobial activity, was evaluated for its anti-virulence properties against these pathogens. The effect of BIT on motility of Salmonella and E. coli O157:H7 and Shiga toxin production by E. coli O157:H7 was determined by the motility assay and ELISA procedure, resp. Confocal and transmission electron microscopy (TEM) procedures were used to determine bacterial damage at the cellular level. Results revealed that sub-inhibitory concentrations (SICs) of BIT significantly inhibited the motility of both bacteria (P < 0.05). Shiga toxin production by E. coli O157:H7 was decreased by 鈭?2% in the presence of BIT at SICs. TEM results showed the disruption of outer membrane, release of cytoplasmic contents, and cell lysis following BIT treatment. Results suggest that BIT could be potentially used to attenuate Salmonella and E. coli O157:H7 infections by reducing the virulence factors including bacterial motility and Shiga toxin production This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Inhibition of Escherichia coli O157:H7 and Salmonella enterica virulence factors by benzyl isothiocyanate was written by Patel, Jitendra;Yin, Hsin-Bai;Bauchan, Gary;Mowery, Joseph. And the article was included in Food Microbiology in 2020.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

Escherichia coli O157:H7 and Salmonella enterica are foodborne pathogens with major public health concern in the U.S. These pathogens utilize several virulence factors to initiate infections in humans. The antimicrobial effect of seven glucosinolate hydrolysis compounds against Salmonella and E. coli O157:H7 was investigated by the disk diffusion assay. Among the tested compounds, benzyl isothiocyanate (BIT), which exerted the highest antimicrobial activity, was evaluated for its anti-virulence properties against these pathogens. The effect of BIT on motility of Salmonella and E. coli O157:H7 and Shiga toxin production by E. coli O157:H7 was determined by the motility assay and ELISA procedure, resp. Confocal and transmission electron microscopy (TEM) procedures were used to determine bacterial damage at the cellular level. Results revealed that sub-inhibitory concentrations (SICs) of BIT significantly inhibited the motility of both bacteria (P < 0.05). Shiga toxin production by E. coli O157:H7 was decreased by 鈭?2% in the presence of BIT at SICs. TEM results showed the disruption of outer membrane, release of cytoplasmic contents, and cell lysis following BIT treatment. Results suggest that BIT could be potentially used to attenuate Salmonella and E. coli O157:H7 infections by reducing the virulence factors including bacterial motility and Shiga toxin production This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 纬-valerolactone.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Isothiocyanates and glucosinolates from Sisymbrium officinale (L.) Scop. (“the singers鈥?plant”): isolation and in vitro assays on the somatosensory and pain receptor TRPA1 channel was written by Borgonovo, Gigliola;Zimbaldi, Nathan;Guarise, Marta;De Nisi, Patrizia;De Petrocellis, Luciano;Moriello, Aniello Schiano;Bassoli, Angela. And the article was included in Molecules in 2019.Electric Literature of C4H7NS The following contents are mentioned in the article:

Sisymbrium officinale (L.) Scop. is a wild common plant of the Brassicaceae family. It is known as “the singers鈥?plant” for its traditional use in treating aphonia and vocal disability. Despite its wide use in herbal preparations, the mol. mechanism of action of S. officinale extracts is not known. The plant is rich in glucosinolates and isothiocyanates, which are supposed to be its active compounds Some members of this family, in particular allylisothiocyanate, are strong agonists of the transient receptor potential ankyrin 1 (TRPA1) channel, which is involved in the somatosensory perception of pungency as well as in the nociception pathway of inflammatory pain. This study aims to isolate the glucosinolates and isothiocianates from fresh S. officinale to identify the major components and test their activity in in vitro assays with a cloned TRPA1 channel. Samples of cultivated S. officinale have been extracted and the active compounds isolated by column chromatog., HPLC and PTLC. The main components glucoputranjivin, isopropylisothiocyanate and 2-buthylisothiocianate have been tested on TRPA1. The glucosinolates glucoputranjivin and sinigrin turned out to be inactive, while isopropylisothiocyanate and 2-buthylisothiocyanate are potent agonists of TRPA1, with an EC50 in the range of the high potency natural agonists identified so far for this somatosensory channel. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Electric Literature of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of the odor threshold concentrations and partition coefficients of isothiocyanates from Brassica vegetables in aqueous solution was written by Marcinkowska, Monika;Jelen, Henryk H.. And the article was included in LWT–Food Science and Technology in 2020.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

Isothiocyanates (ITCs) are products of the enzymic breakdown of glucosinolates and may cause pungent flavor notes in vegetables. Limited data on odor threshold concentrations (OTCs) and odor quality descriptors of ITCs exist in literature. These parameters were determined in aqueous samples for 19 isothiocyanates found mainly in Brassica vegetables. Thresholds and odor quality descriptors were ascertained by panelists using flavor profile anal. (FPA). The odor threshold concentrations of ITCs range from 0.005 x 10^-3 (octyl ITC) to 0.2 x 10^-3 (Et ITC) g/L and ITCs were mainly characterized by sulfur, garlic, and Brassica vegetable-like notes. Correlation coefficients were between 0.946 (octyl ITC) and 0.996 (3-(methylthio)propyl ITC) and proved convincing results of OTCs using FPA. Partition coefficients were determined in water, artificial saliva and human saliva to provide an insight into behavior of ITCs in two-phase liquid/air systems. Partition coefficients (K) for human saliva are significantly different from other matrixes nevertheless the profile of ITCs K values in water and saliva buffer solution were similar. In human saliva the highest K values were observed for octyl, hexyl and cyclohexyl ITCs, and the lowest for cyclopropyl, benzyl, allyl ITCs. Obtained data provide essential and previously unknown sensory properties for future flavor studies. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of the odor threshold concentrations and partition coefficients of isothiocyanates from Brassica vegetables in aqueous solution was written by Marcinkowska, Monika;Jelen, Henryk H.. And the article was included in LWT–Food Science and Technology in 2020.Category: esters-buliding-blocks The following contents are mentioned in the article:

Isothiocyanates (ITCs) are products of the enzymic breakdown of glucosinolates and may cause pungent flavor notes in vegetables. Limited data on odor threshold concentrations (OTCs) and odor quality descriptors of ITCs exist in literature. These parameters were determined in aqueous samples for 19 isothiocyanates found mainly in Brassica vegetables. Thresholds and odor quality descriptors were ascertained by panelists using flavor profile anal. (FPA). The odor threshold concentrations of ITCs range from 0.005 x 10^-3 (octyl ITC) to 0.2 x 10^-3 (Et ITC) g/L and ITCs were mainly characterized by sulfur, garlic, and Brassica vegetable-like notes. Correlation coefficients were between 0.946 (octyl ITC) and 0.996 (3-(methylthio)propyl ITC) and proved convincing results of OTCs using FPA. Partition coefficients were determined in water, artificial saliva and human saliva to provide an insight into behavior of ITCs in two-phase liquid/air systems. Partition coefficients (K) for human saliva are significantly different from other matrixes nevertheless the profile of ITCs K values in water and saliva buffer solution were similar. In human saliva the highest K values were observed for octyl, hexyl and cyclohexyl ITCs, and the lowest for cyclopropyl, benzyl, allyl ITCs. Obtained data provide essential and previously unknown sensory properties for future flavor studies. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-尾-induced toxicity was written by Park, Jung-eun;Elkamhawy, Ahmed;Hassan, Ahmed H. E.;Pae, Ae Nim;Lee, Jiyoun;Paik, Sora;Park, Beoung-Geon;Roh, Eun Joo. And the article was included in European Journal of Medicinal Chemistry in 2017.Formula: C4H7NS The following contents are mentioned in the article:

Herein, synthesis and evaluation of twenty six new pyridyl/pyrazinyl thiourea derivatives I (X = CH, N; R¹ = H, 3-F, 2-Cl, 3-Cl; R² = Et, i-Pr, Bn, etc.) against 尾 amyloid (A尾)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (螖唯m) were reported. The neuroprotective effect of seventeen compounds against A尾-induced mPTP opening was superior to that of the standard Cyclosporin A (CsA). Fifteen derivatives eliciting increased green to red fluorescence percentage less than 40.0% were evaluated for their impact on ATP production, cell viability and neuroprotection against A尾-induced neuronal cell death. Among evaluated compounds, derivatives I (X = N; R¹ = 3-F; R² = 4-MeC₆H₄), I (X = CH; R¹ = 3-Cl; R² = 3-ClC₆H₄), I (X = CH; R¹ = 3-F; R² = 1-naphthyl), had safe profile regarding ATP production and cell viability. In addition, they exhibited significant neuroprotection (69.3, 51.8 and 48.2% resp.). Mol. modeling study using CDocker algorithm predicted plausible binding modes explaining the elicited mPTP blocking activity. Hence, this study suggests compounds I (X = N; R¹ = 3-F; R² = 4-MeC₆H₄), I (X = CH; R¹ = 3-Cl; R² = 3-ClC₆H₄) and I (X = CH; R¹ = 3-F; R² = 1-naphthyl) as leads for further development of novel therapy to Alzheimer’s disease. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mass Spectra of New Heterocycles: XXIII. Electron Impact and Chemical Ionization Study of 5-[(Cyanomethyl)sulfanyl]- and 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amines was written by Klyba, L. V.;Nedolya, N. A.;Sanzheeva, E. R.;Tarasova, O. A.. And the article was included in Russian Journal of Organic Chemistry in 2021.COA of Formula: C4H7NS The following contents are mentioned in the article:

The fragmentation of pyrroles I [R¹ = R² = Me, Et, n-Pr; R³ = Me, s-Bu, c-hexyl, etc.; -R¹R²– = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂; R⁴ = CN, 1,3-dioxolan-2-yl] under electron impact (70 eV) and chem. ionization with methane as reactant gas has been studied for the first time. Electron impact ionization of 5-[(cyanomethyl)sulfanyl]-substituted pyrroles generates low-stability mol. ions {M+., I_rel 4-22%; compared to I_rel 16-69% for 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl] analogs} whose primary fragmentation involves cleavage of the C-S bond with expulsion of NCCH₂ radical. Other fragmentation pathways of the mol. ions include formation of [M – CHR⁴]^+. ions (R⁴ = CN) and substituent decomposition products. The mass spectra of 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles characteristically show [M – SCH₂R⁴]⁺ ion peak. The most intense ion peaks in the chem. ionization mass spectra of 5-[(cyanomethyl)sulfanyl] derivatives are those of M^+. (I_rel 18-69%) and [M + H]⁺ (I_rel 34-100%). Both 5-[(cyanomethyl)sulfanyl]- and 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles decompose mainly through cleavage of the CH₂-S and C⁵-S bonds with the formation of stable [M – CH₂R⁴]⁺ (I_rel 92-100%), [M + H – CH₂R⁴]^+. (I_rel 22-75%), and [M + H – SCH₂R⁴]^+. ions (I_rel 6-25%). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mass Spectra of New Heterocycles: XXIII. Electron Impact and Chemical Ionization Study of 5-[(Cyanomethyl)sulfanyl]- and 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amines was written by Klyba, L. V.;Nedolya, N. A.;Sanzheeva, E. R.;Tarasova, O. A.. And the article was included in Russian Journal of Organic Chemistry in 2021.Formula: C4H7NS The following contents are mentioned in the article:

The fragmentation of pyrroles I [R¹ = R² = Me, Et, n-Pr; R³ = Me, s-Bu, c-hexyl, etc.; -R¹R²– = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂; R⁴ = CN, 1,3-dioxolan-2-yl] under electron impact (70 eV) and chem. ionization with methane as reactant gas has been studied for the first time. Electron impact ionization of 5-[(cyanomethyl)sulfanyl]-substituted pyrroles generates low-stability mol. ions {M+., I_rel 4-22%; compared to I_rel 16-69% for 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl] analogs} whose primary fragmentation involves cleavage of the C-S bond with expulsion of NCCH₂ radical. Other fragmentation pathways of the mol. ions include formation of [M – CHR⁴]^+. ions (R⁴ = CN) and substituent decomposition products. The mass spectra of 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles characteristically show [M – SCH₂R⁴]⁺ ion peak. The most intense ion peaks in the chem. ionization mass spectra of 5-[(cyanomethyl)sulfanyl] derivatives are those of M^+. (I_rel 18-69%) and [M + H]⁺ (I_rel 34-100%). Both 5-[(cyanomethyl)sulfanyl]- and 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles decompose mainly through cleavage of the CH₂-S and C⁵-S bonds with the formation of stable [M – CH₂R⁴]⁺ (I_rel 92-100%), [M + H – CH₂R⁴]^+. (I_rel 22-75%), and [M + H – SCH₂R⁴]^+. ions (I_rel 6-25%). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, antifungal activity, and 3D-QSAR study of novel nopol-derived 1,3,4-thiadiazole-thiourea compounds was written by Chen, Ming;Duan, Wen-Gui;Lin, Gui-Shan;Fan, Zhong-Tian;Wang, Xiu. And the article was included in Molecules in 2021.Synthetic Route of C4H7NS The following contents are mentioned in the article:

A series of novel nopol derivatives bearing the 1,3,4-thiadiazole-thiourea moiety I (R = Bu, Ph, 2-MeC₆H₄, etc.) were designed and synthesized by multi-step reactions in search of potent natural product-based antifungal agents. Antifungal activity of the target compounds was evaluated by in vitro methods against Fusarium oxysporum f. sp. cucumerinum, Cercospora arachidicola, Physalospora piricola, Alternaria solani, Gibberella zeae, Rhizoeotnia solani, Bipolaris maydis, and Colleterichum orbicalare at 50渭g/mL. All the target compounds exhibited better antifungal activity against P. piricola, C. arachidicola, and A. solani. Compound I (R =3,4-di-Cl-C₆H₃) showed the best broad-spectrum antifungal activity against all the tested fungi. Compounds I (R = 3-MeC₆H₄, i-Pr, 4-ClC₆H₄) had inhibition rates of 86.1%, 86.1%, and 80.2%, resp., against P. piricola, much better than that of the pos. control chlorothalonil. Moreover, compounds I (R = 3-ClC₆H₄) and I (R = 2-CF₃C₆H₄) held inhibition rates of 80.6% and 79.0% against C. arachidicola and G. zeae, resp., much better than that of the com. fungicide chlorothalonil. In order to design more effective antifungal compounds against A. solani, anal. of the three-dimensional quant. structure-activity relationship (3D-QSAR) was carried out using the CoMFA method, and a reasonable and effective 3D-QSAR model (r² = 0.992, q² = 0.753) has been established and some intriguing structure-activity relationships were found and are discussed by theor. calculation This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics