Bolade, Oladotun P. et al. published their research in Data in Brief in 2021 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 2253-73-8

Dataset on analytical characterization of bioactive components from Azadirachta indica, Canna indica, Magnifera indica and Moringa oleifera leaf extracts and their applications in nanoparticles biosynthesis was written by Bolade, Oladotun P.;Williams, Akan B.;Benson, Nsikak U.. And the article was included in Data in Brief in 2021.Recommanded Product: 2253-73-8 The following contents are mentioned in the article:

This paper presents data on the bioactive phytoconstituents in Azadirachta indica, Canna indica, Magnifera indica, and Moringa oleifera analyzed using quant. and qual. phytochem. screening methods, Fourier Transform IR Spectroscopy and Gas Chromatog.-Mass Spectrometry (GC-MS). Extracts were prepared in water, ethanol (EtOH) and EtOH:water mix. Identification of bioactive components was based on their spectral data and retention times compared with National Institute of Standards and Technol. (NIST) mass spectral library. The most prominent absorption bands indicated are O-H stretching vibration, C-H stretch of polyols, aromatic C=C stretching vibration, O-H stretch of polyols, C-H stretching vibration and C-OH polyols. The GC-MS characterization for A. indica showed the presence of phenols, organic acids and carbohydrates with cannabidiol as the most abundant. Crude extracts of M. oleifera showed six phenolic compounds with 4-hydroxy-bezoic acid and cannabidiol present prominently. Six phenolic phytoconstituents were identified in M. indica extracts with 1,2,3-benzenetriol as the major polyphenolic compound Biogenic iron oxide nanoparticles were synthesized and the formation was confirmed using a UV spectrometer (UV-3000 ORI, Germany) between 200 and 800 nm spectral range. X-ray diffraction (XRD) characterization of the biosynthesized iron oxide nanoparticles was carried out using Empyrean, Malvern PanAnal. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ai, Chongyi et al. published their research in Journal of Molecular Structure in 2021 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Isopropylisothiocyanate

Molecular modeling of three-dimensional structure of hTRPV4 protein and experimental verification of its antagonist binding sites was written by Ai, Chongyi;Zhang, Wenjuan;Zhou, Lulu;Cai, Xu;Zheng, Zhibing. And the article was included in Journal of Molecular Structure in 2021.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

The transient receptor potential vanilloid type 4 (TRPV4) is a polymodal receptor. Antagonists of human TRPV4 (hTRPV4) represent a novel therapeutic approach for acute lung injury (ALI). However, the discovery of various hTRPV4 antagonists has been difficult due to the unavailability of 3D-structure of hTRPV4 protein. We constructed the 3D-structure of hTRPV4 protein by homol. modeling, and the binding pocket of antagonist with hTRPV4 was predicted for the first time. The pocket was consistent with the same subfamily rabbit TRPV5. The detailed interactions of different protein-ligand complexes were calculated by mol. docking and mol. dynamics (MD) simulation, and the outcome revealed the rationality of the binding pocket. Based on the docking and MD results of this model and the structure of compound A2, a TRPV4 antagonist reported in literature, two small mol. compounds, B1 and B2, were designed and synthesized as hTRPV4 antagonists. The results of biol. evaluation in vitro showed that these compounds have good inhibitory activity on hTRPV4. Moreover, the results were in good agreement with those predicted by mol. simulation, which in turn suggested that the modeling 3D structure and the predicted active sites of hTRPV4 are reasonable and reliable. The compound B2, with novel structure and potent inhibitory activity against hTRPV4, can be a promising lead compound for discovering new hTRPV4 antagonists in the future. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ai, Chongyi et al. published their research in Journal of Molecular Structure in 2021 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C4H7NS

Molecular modeling of three-dimensional structure of hTRPV4 protein and experimental verification of its antagonist binding sites was written by Ai, Chongyi;Zhang, Wenjuan;Zhou, Lulu;Cai, Xu;Zheng, Zhibing. And the article was included in Journal of Molecular Structure in 2021.Electric Literature of C4H7NS The following contents are mentioned in the article:

The transient receptor potential vanilloid type 4 (TRPV4) is a polymodal receptor. Antagonists of human TRPV4 (hTRPV4) represent a novel therapeutic approach for acute lung injury (ALI). However, the discovery of various hTRPV4 antagonists has been difficult due to the unavailability of 3D-structure of hTRPV4 protein. We constructed the 3D-structure of hTRPV4 protein by homol. modeling, and the binding pocket of antagonist with hTRPV4 was predicted for the first time. The pocket was consistent with the same subfamily rabbit TRPV5. The detailed interactions of different protein-ligand complexes were calculated by mol. docking and mol. dynamics (MD) simulation, and the outcome revealed the rationality of the binding pocket. Based on the docking and MD results of this model and the structure of compound A2, a TRPV4 antagonist reported in literature, two small mol. compounds, B1 and B2, were designed and synthesized as hTRPV4 antagonists. The results of biol. evaluation in vitro showed that these compounds have good inhibitory activity on hTRPV4. Moreover, the results were in good agreement with those predicted by mol. simulation, which in turn suggested that the modeling 3D structure and the predicted active sites of hTRPV4 are reasonable and reliable. The compound B2, with novel structure and potent inhibitory activity against hTRPV4, can be a promising lead compound for discovering new hTRPV4 antagonists in the future. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Electric Literature of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bae, Dawon et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2018 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: Isopropylisothiocyanate

Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells was written by Bae, Dawon;Gautam, Jaya;Jang, Hyeonjin;Banskota, Suhrid;Lee, Sang Yeul;Jeong, Min-Ji;Kim, A.-Sol;Kim, Hong Chul;Lee, Iyn-Hyang;Nam, Tae-gyu;Kim, Jung-Ae;Jeong, Byeong-Seon. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Name: Isopropylisothiocyanate The following contents are mentioned in the article:

Dysfunction or progressive degeneration of retinal pigment epithelium (RPE) contributes in the initial pathogenesis of age-related macular degeneration (AMD) causing irreversible vision loss, which makes RPE the prime target of the disease. The present study aimed to identify compounds to protect 4-hydroxynonenal (4-HNE)-induced RPE cell death by inhibiting NADPH oxidase 4 (NOX4) activity, not just as free radical scavengers, using ARPE-19, a human adult retinal pigment epithelial cell line, as a RPE representative. Novel thirty-two 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ol derivatives were synthesized and tested. The authors found that there was a strong correlation between level of protective effect of novel compounds against 4-HNE-induced APRE-19 cell death and that of inhibitory activity against 4-HNE-induced superoxide production, and that most of the novel compounds showed minimal DPPH radical scavenging activity. Compound 17-28 (1-butyl-3-(5-hydroxy-3,4,6-trimethylpyridin-2-yl)thiourea) showed the best protective activity against 4-HNE-induced superoxide production (79.5% inhibition) and cell death (85.1% recovery) at 10 μM concentration, which was better than that of VAS2870, a NOX2/4 inhibitor. In addition, compound 17-28 blocked 4-HNE-induced apoptosis of ARPE-19 cells in a concentration-dependent manner. The results indicate that compound 17-28 may be a lead compound to develop AMD therapeutics. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Name: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patel, Dhaval B. et al. published their research in Journal of Heterocyclic Chemistry in 2018 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 2253-73-8

Synthesis, Docking, ADME-Tox Study of 2-(2-(2-Chlorophenyl)quinoline-4-carbonyl)-N-substituted hydrazinecarbothioamide Derivatives and Their Biological Evaluation was written by Patel, Dhaval B.;Vekariya, Rajesh H.;Patel, Kinjal D.;Vasava, Mahesh S.;Rajani, Dhanji P.;Rajani, Smita D.;Patel, Hitesh D.. And the article was included in Journal of Heterocyclic Chemistry in 2018.Reference of 2253-73-8 The following contents are mentioned in the article:

A series of 2-(2-(2-chlorophenyl)quinoline-4-carbonyl)-N-substituted hydrazinecarbothioamide derivatives were synthesized by facile and efficient conventional method. The structures of the compounds were elucidated with the aid of an elemental anal., IR, ESI-MS, 1H-NMR, and 13C-NMR spectral data. The synthesized compounds were evaluated for their in vitro antibacterial, antifungal, antimalarial, and antituberculosis activity against standard drugs. The bacterial studies were determined against gram-pos. and neg. bacteria. These compounds were found to a broad spectrum of activity against the screened bacteria, but poor activity was observed against Pseudomonas aeruginosa and Escherichia coli. Compounds I (R = cyclohexyl, 4-ClPh, i-Pr, 2-OMePh, and benzoyl) showed the potent activity against Staphylococcus aureus. Compounds I (R = cyclohexyl, 4-NO2Ph, 2,4-Cl2Ph, 2-OMePh, and 3-ClPh) show the potent activity against antimalarial as compared with the standard drugs Chloroquine, Quinine and compounds I (R = 4-OMePh, benzoyl, and 4-FPh) shows mild activity against H37Rv strain. Mol. docking revealed that synthesized derivatives and target proteins were actively involved in a binding pattern and had a significant corelation with biol. activity. We have also performed a mol. dynamics and ADME-Tox parameters for the synthesized compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Nisi, Patrizia et al. published their research in Foods in 2021 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C4H7NS

Sisymbrium officinale (the singers’ plant) as an ingredient: analysis of somatosensory active volatile isothiocyanates in model food and drinks was written by De Nisi, Patrizia;Borgonovo, Gigliola;Tramontana, Samuele;Grassi, Silvia;Picozzi, Claudia;Scaglioni, Leonardo;Mazzini, Stefania;Mangieri, Nicola;Bassoli, Angela. And the article was included in Foods in 2021.Formula: C4H7NS The following contents are mentioned in the article:

Sisymbrium officinale (L.) Scop. (hedge mustard) is a wild common plant of the Brassicaceae family. It is known as “the singers’ plant” for its traditional use in treating aphonia and vocal disability. The plant is rich in glucosinolates and isothiocyanates; the latter has been demonstrated to be a strong agonist in vitro of the Transient Receptor Potential Ankirine 1 (TRPA1) channel, which is involved in the somatosensory perception of pungency as well as in the nociception pathway of inflammatory pain. Volatile ITCs are released by the enzymic or chem. hydrolysis of GLSs (glucosinolates) during sample crushing and/or by the mastication of fresh plant tissues when the plant is used as an ingredient. Some functional food and drink model preparations have been realized: honey enriched with seeds and flowers, infusions, cold drink (voice drink), artisanal beer, and a fermented tea (kombucha). Using SPME-GCMS chromatog., we analyzed samples of the plant and of the food preparations adopting conditions that simulate the release of isothiocyanates (ITCs) during oral assumption. Two active compounds, iso-propylisothiocyanate and 2-butylisothiocyanate, have been assayed. The concentration of ITCs varies according to temperature, pH, grinding conditions, and different plant organs used. Kombucha-type fermentation seems to eliminate the ITCs, whereas they are retained in beer. The ITCs’ concentration is higher when entire seeds and flowers are used. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Nisi, Patrizia et al. published their research in Foods in 2021 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of Isopropylisothiocyanate

Sisymbrium officinale (the singers’ plant) as an ingredient: analysis of somatosensory active volatile isothiocyanates in model food and drinks was written by De Nisi, Patrizia;Borgonovo, Gigliola;Tramontana, Samuele;Grassi, Silvia;Picozzi, Claudia;Scaglioni, Leonardo;Mazzini, Stefania;Mangieri, Nicola;Bassoli, Angela. And the article was included in Foods in 2021.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

Sisymbrium officinale (L.) Scop. (hedge mustard) is a wild common plant of the Brassicaceae family. It is known as “the singers’ plant” for its traditional use in treating aphonia and vocal disability. The plant is rich in glucosinolates and isothiocyanates; the latter has been demonstrated to be a strong agonist in vitro of the Transient Receptor Potential Ankirine 1 (TRPA1) channel, which is involved in the somatosensory perception of pungency as well as in the nociception pathway of inflammatory pain. Volatile ITCs are released by the enzymic or chem. hydrolysis of GLSs (glucosinolates) during sample crushing and/or by the mastication of fresh plant tissues when the plant is used as an ingredient. Some functional food and drink model preparations have been realized: honey enriched with seeds and flowers, infusions, cold drink (voice drink), artisanal beer, and a fermented tea (kombucha). Using SPME-GCMS chromatog., we analyzed samples of the plant and of the food preparations adopting conditions that simulate the release of isothiocyanates (ITCs) during oral assumption. Two active compounds, iso-propylisothiocyanate and 2-butylisothiocyanate, have been assayed. The concentration of ITCs varies according to temperature, pH, grinding conditions, and different plant organs used. Kombucha-type fermentation seems to eliminate the ITCs, whereas they are retained in beer. The ITCs’ concentration is higher when entire seeds and flowers are used. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kala, Chandra et al. published their research in Molecules in 2022 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Isopropylisothiocyanate

Formulation of Isopropyl Isothiocyanate Loaded Nano Vesicles Delivery Systems: In Vitro Characterization and In Vivo Assessment was written by Kala, Chandra;Asif, Mohammad;Gilani, Sadaf Jamal;Imam, Syed Sarim;Khan, Najam Ali;Taleuzzaman, Mohamad;Zafar, Ameeduzzafar;Ahmed, Mohammed Muqtader;Alshehri, Sultan;Ghoneim, Mohammed M.. And the article was included in Molecules in 2022.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

Iso-Pr Isothiocyanate (IPI) is a poorly water-soluble drug used in different biol. activities. So, the present work was designed to prepare and evaluate IPI loaded vesicles and evaluated for vesicle size, polydispersity index (PDI) and zeta potential, encapsulation efficiency, drug release, and drug permeation. The selected formulation was coated with chitosan and further assessed for the anti-platelet and anti-thrombotic activity. The prepared IPI vesicles (F3) exhibited a vesicle size of 298 nm ± 5.1, the zeta potential of -18.7 mV, encapsulation efficiency of 86.2 ± 5.3% and PDI of 0.33. The chitosan-coated IPI vesicles (F3C) exhibited an increased size of 379 ± 4.5 nm, a pos. zeta potential of 23.5 ± 2.8 mV and encapsulation efficiency of 77.3 ± 4.1%. IPI chitosan vesicle (F3C) showed enhanced mucoadhesive property (2.7 folds) and intestinal permeation (∼1.8-fold) higher than IPI vesicles (F3). There was a significant (p < 0.05) enhancement in size, muco-adhesion, and permeation flux achieved after coating with chitosan. The IPI chitosan vesicle (F3C) demonstrated an enhanced bleeding time of 525.33 ± 12.43 s, anti-thrombin activity of 59.72 ± 4.21, and inhibition of platelet aggregation 68.64 ± 3.99%, and anti-platelet activity of 99.47%. The results of the study suggest that IPI chitosan vesicles showed promising in vitro results, as well as improved anti-platelet and anti-thrombotic activity compared to pure IPI and IPI vesicles. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haji Ali, Sazan et al. published their research in Molecules in 2022 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Isopropylisothiocyanate

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors was written by Haji Ali, Sazan;Osmaniye, Derya;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim. And the article was included in Molecules in 2022.Name: Isopropylisothiocyanate The following contents are mentioned in the article:

Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disease that causes dementia in people aged 65 and over. In the present study, a series of thiadiazole hybrid compounds with benzothiazine derivatives I (R = Et, Pr, t-Bu, etc.) as acetylcholinesterase inhibitors were developed and evaluated for their biol. activity. The AChE and BChE inhibition potentials of all compounds were evaluated by using the in vitro Ellman method. The biol. evaluation showed that compounds I (R = 4-OMeC6H4) and I (R = 4-ClC6H4) displayed significant inhibitory activity against AChE and showed IC50 values of 0.027μM and 0.025μM against AChE, resp. The reference drug donepezil (IC50 = 0.021μM) also showed significant inhibition against AChE. Further docking simulation also revealed that the above compounds interacted with the active site of the enzyme similarly to donepezil. The antioxidant study revealed that the above two compounds exhibited greater antioxidant effects. An in vitro blood-brain barrier permeability study showed that compounds I (R = 4-OMeC6H4) and I (R = 4-ClC6H4) are promising compounds against AD. The cytotoxicity study of the above compounds showed non-cytotoxic with an IC50 value of 98.29 ± 3.98μM and 159.68 ± 5.53μM against NIH/3T3 cells, resp. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Name: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haji Ali, Sazan et al. published their research in Molecules in 2022 | CAS: 2253-73-8

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Isopropylisothiocyanate

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors was written by Haji Ali, Sazan;Osmaniye, Derya;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim. And the article was included in Molecules in 2022.Quality Control of Isopropylisothiocyanate The following contents are mentioned in the article:

Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disease that causes dementia in people aged 65 and over. In the present study, a series of thiadiazole hybrid compounds with benzothiazine derivatives I (R = Et, Pr, t-Bu, etc.) as acetylcholinesterase inhibitors were developed and evaluated for their biol. activity. The AChE and BChE inhibition potentials of all compounds were evaluated by using the in vitro Ellman method. The biol. evaluation showed that compounds I (R = 4-OMeC6H4) and I (R = 4-ClC6H4) displayed significant inhibitory activity against AChE and showed IC50 values of 0.027μM and 0.025μM against AChE, resp. The reference drug donepezil (IC50 = 0.021μM) also showed significant inhibition against AChE. Further docking simulation also revealed that the above compounds interacted with the active site of the enzyme similarly to donepezil. The antioxidant study revealed that the above two compounds exhibited greater antioxidant effects. An in vitro blood-brain barrier permeability study showed that compounds I (R = 4-OMeC6H4) and I (R = 4-ClC6H4) are promising compounds against AD. The cytotoxicity study of the above compounds showed non-cytotoxic with an IC50 value of 98.29 ± 3.98μM and 159.68 ± 5.53μM against NIH/3T3 cells, resp. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Quality Control of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics