Category: 2216-94-6

Application of 2216-94-6,Some common heterocyclic compound, 2216-94-6, name is Ethyl phenylpropiolate, molecular formula is C11H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Catalytic tests of Ni3N/NC or Ni/NC were performed as follows: 1,2-diphenylethyne (5.38mmol), Ni/NC or Ni3N/NC catalyst (7.8mol%, based on ICP results) and solvent (70mL) were mixed in a stainless-steel autoclave (100mL) equipped with an electric heating system and a magnetically driven mechanical stirrer. The reaction system was flushed with hydrogen three times and pressurized with hydrogen (2.0MPa), and then heated to 100C for hydrogenation. After the completion of reaction, it was allowed to cool to room temperature and the residual hydrogen was released. The solvent was removed under reduced pressure, and the crude products were purified by column chromatography on silica gel to withhold the catalyst. For the substrate scope, the semi-hydrogenation of alkynes was conducted using a similar method. For a typical run: the alkyne (0.3mmol), 7.8mol% Ni3N/NC-6/5-550 and ethanol (3mL) were placed in a glass vial (4mL) with cap, septum, and needle, and then two glass vials were sealed in a stainless steel autoclave (100mL) equipped with an electrical heating system, where a certain amount of ethanol was added to keep the same horizontal level of ethanol inside and outside the glass vials. Then, the reaction system was treated following the same steps as described above.

The synthetic route of 2216-94-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shi, Xiaozhen; Wen, Xin; Nie, Shilin; Dong, Jie; Li, Jingde; Shi, Yongqing; Zhang, Huiling; Bai, Guoyi; Journal of Catalysis; vol. 382; (2020); p. 22 – 30;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2216-94-6, name is Ethyl phenylpropiolate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2216-94-6, Formula: C11H10O2

General procedure: In a flame-dried Young-tube ethyl 3-arylpropiolate (16, 1.00 eq.), arylboronic acid (3.00 eq.) and CuOAc (2 mol%) were dissolved in MeOH (0.5 M). The solution was degassed by three freeze-pump-thaw cycles and then stirred over night at room temperature. The resulting suspension was filtered over celite and the solvent was removed under reduced pressure. Purification by column chromatography (Si02, 5 x 20 cm, eluent as listed for the Revalue) afforded the desired ethyl 3,3-diarylacrylate.’

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl phenylpropiolate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ebner, Christian; Pfaltz, Andreas; Tetrahedron; vol. 67; 52; (2011); p. 10287 – 10290;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2216-94-6, name is Ethyl phenylpropiolate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Ethyl phenylpropiolate

General procedure: The reaction was performed in a 20-mL round-bottomed flask equipped with a Teflon-coated magnetic stirrer bar. A solution of Pd(TPP) (3.6 mg, 0.005 mumol) and DMAP (0.01 mmol, 1.2 mg) in pyridine (1 mL) was stirred at 25 C for 0.5 h under H2(1 atm, balloon). A soln of alkyne 1(0.5 mmol) in pyridine (4 mL) was added,and the mixture was stirred for the indicated time. H2O (20 mL) was added, and the aqueous phase was extracted with EtOAc (3 ¡Á 50 mL). The organic phases were combined, dried (Na2SO4), and concentrated in vacuo. The residue was purified by flash column chromatography [silica gel (20 g, 2 ¡Á 15 cm), hexane-EtOAc (40:1)] to give an alkene 2.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2216-94-6.

Reference:
Article; Nishibayashi, Ryo; Kurahashi, Takuya; Matsubara, Seijiro; Synlett; vol. 25; 9; (2014); p. 1287 – 1290;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics