Category: 2216-92-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2216-92-4, name is N-Phenylglycine Ethyl Ester, This compound has unique chemical properties. The synthetic route is as follows., Safety of N-Phenylglycine Ethyl Ester

Example 71 Synthesis of 3-(2-naphthylsulfonyl)-1-(phenyl)-imidazolidin-2,4-dione (Compound 71): In a similar manner to Example 70, 470 mg (1.28 mmol; yield: 26.6%) of the title compound were obtained as white crystals from 860 mg (4.83 mmol) of ethyl N-phenylamino-acetate and 1.39 g (81%, 4.83 mmol) of 2-naphthalenesulfonyl isocyanate. Melting point: 208-210 C. PMR (delta ppm, DMSO-d6): 4.52(s,2H), 7.1-8.3(m,11H), 8.76(s,1H).

According to the analysis of related databases, 2216-92-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suntory Limited; US5691335; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2216-92-4 as follows. Recommanded Product: 2216-92-4

N-phenylglycine ethyl ester (781 mg, 4.3 [MMOL),] 4-chlorobenzyl chloride (690 mg, 4.3 [MMOL)] and sodium iodide (64 mg) were dissolved in toluene (7 mL) under argon. The reaction was heated in a graphite bath at 80 [C] for 24 h. After cooling to room temperature, the reaction was diluted with ethyl acetate and washed with [1 M HCI FOLLOWED] by brine. The solution was dried over MgS04, filtered, and concentrated in vacuo. Purification of the resultant oil by flash chromatography (10: 1 hexanes/EtOAc) afforded the title compound as a green oil (669 mg, 51 %). MS (ES+) [M/Z 304 (MH+).]

According to the analysis of related databases, 2216-92-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 2216-92-4, These common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 Preparation of N-(1-oxo-9Z-octadecenyl)-N-phenylglycine, ethyl ester STR3 Oleoyl chloride (0.01 mole), N-phenylglycine ethyl ester (0.01 mole) and triethylamine (1.4 ml) in tetrahydrofuran (100 ml) was stirred overnight at room temperature. The solvent was removed by rotary evaporator and the residue was dissolved in ethyl acetate (50 ml) and washed with water (50 ml). The ethyl acetate solution was dried over sodium sulfate, filtered and the solvent removed by a nitrogen stream to give an oil which was purified by chromatography on silica gel to give the title compound. Analysis calcd. for C28 H45 NO3 (443.65): C, 75.80; H, 10.22; N, 3.16. C, 75.51; H, 10.32; N, 2.94.

The synthetic route of 2216-92-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; G. D. Searle & Co.; US4551279; (1985); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 2216-92-4,Some common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared according to Example 2 steps 2 and 3 except with ethyl N- phenylglycinate instead of ethyl [N-PHENYLALANINATE.] Title compound was obtained as a yellow solid (74%). 1H NMR [(CDCI3)] [5] 7.46 (d, 2H), 6.64 (d, 2H), 4.12 (q, 2H), 4.01 (s, 2H), 3.30 (s, 3H), 1.17 (t, 3H). [ANAL. CALC.] for [C14H15NO3F6] : C, 46.80 ; H, 4.21 ; N, 3.90. Found: C, 47.78 ; H, 4.06 ; N, 3.86. HRMS [(MH+)] [CALC.] : 360.1047. Found: 360.1034.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Phenylglycine Ethyl Ester, its application will become more common.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2216-92-4, name is N-Phenylglycine Ethyl Ester, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

To a solution of 1 (1.0 eq.) in dioxane at room temperature were added the appropriate alpha-amino ethyl ester (1.0 eq.) and DIEA (1.2 eq.). The mixture was stirred at room temperature for 24 hours. The solvent was removed under vacuum. The residue was purified on a silica gel column to give 28.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KEMIA, INC.; WO2006/91737; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H13NO2

tert-Butyl 4-(3-(2-ethoxy-2-oxoethyl)-3-phenylureido)piperidine-1-carboxylate. 4-Amino-1-N-Boc-piperidine (760 mg, 3.79 mmol) was dissolved in a mixture of dichloromethane (40 mL) and aqueous sodium bicarbonate (30 mL). A solution of 20% phosgene in toluene (10 mL, 18.9 mmol) was added to the mixture with vigorous stirring. Reaction stirred vigorously at room temperature for 40 minutes. Reaction layers were partitioned. Organic layer was dried (magnesium sulfate), filtered and concentrated in vacuo. Residue was dissolved in toluene (30 mL). N-Phenylglycine ethyl ester was added to the mixture. Reaction was heated at reflux for 15 hours. Mixture was cooled to room temperature and diluted with ethyl acetate (50 mL). Mixture was washed successively with 1N hydrochloric acid (3×50 mL) and brine (30 mL). Organic layer was dried (magnesium sulfate), filtered and concentrated in vacuo. Silica gel chromatography afforded the title compound as pale yellow solid in 63% yield. 1H NMR (300 MHz, CDCl3): delta=7.47-7.26 (m, 5H), 4.30 (s, 1H), 4.16 (q, J=7.32, 2H), 3.88 (d, J=12.81, 2H), 3.81-3.69 (m, 1H), 2.89-2.70 (m, 2H), 1.83 (dd, J1=12.62, J2=3.11, 2H), 1.38 (s, 9H), 1.23 (t, J=7.14, 3H), 1.19-1.03 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2216-92-4, its application will become more common.

Reference:
Patent; Chaturvedula, Prasad V.; Mercer, Stephen E.; Fang, Haiquan; US2006/94707; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2216-92-4, name is N-Phenylglycine Ethyl Ester, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2216-92-4

Example 71 Synthesis of 3-(2-naphthylsulfonyl)-1-(phenyl)-imidazolidin-2,4-dione (Compound 71): In a similar manner to Example 70, 470 mg (1.28 mmol; yield: 26.6%) of the title compound were obtained as white crystals from 860 mg (4.83 mmol) of ethyl N-phenylamino-acetate and 1.39 g (81%, 4.83 mmol) of 2-naphthalenesulfonyl isocyanate. Melting point: 208-210 C. PMR (delta ppm, DMSO-d6): 4.52(s,2H), 7.1-8.3(m,11H), 8.76(s,1H).

According to the analysis of related databases, 2216-92-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suntory Limited; US5691335; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2216-92-4 as follows. SDS of cas: 2216-92-4

N-phenylglycine ethyl ester (781 mg, 4.3 [MMOL),] 4-chlorobenzyl chloride (690 mg, 4.3 [MMOL)] and sodium iodide (64 mg) were dissolved in toluene (7 mL) under argon. The reaction was heated in a graphite bath at 80 [C] for 24 h. After cooling to room temperature, the reaction was diluted with ethyl acetate and washed with [1 M HCI FOLLOWED] by brine. The solution was dried over MgS04, filtered, and concentrated in vacuo. Purification of the resultant oil by flash chromatography (10: 1 hexanes/EtOAc) afforded the title compound as a green oil (669 mg, 51 %). MS (ES+) [M/Z 304 (MH+).]

According to the analysis of related databases, 2216-92-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 2216-92-4, The chemical industry reduces the impact on the environment during synthesis 2216-92-4, name is N-Phenylglycine Ethyl Ester, I believe this compound will play a more active role in future production and life.

Example 35 1, 1-Dioxo-5-phenyl-1, 2, 5-thiadiazolidin-3-one sodium salt A. N-sulfamoylated-N-phenylglycine ethyl ester; A solution N-phenylglycine ethyl ester (1.0 g, 5.58 mmol) and TEA (1.69 g, 16. 7 mmol) in MeCN, 3mL is added dropwise to a freshly prepared solution of sulfamoyl chloride (5.58 mmol) in MeCN (5mL) over 20 min. The mixture is stirred at room temperature (RT) for 16 h. The solvent is evaporated and the residue is partitioned between EtOAc and water. The organic layer is dried over anhydrous sodium sulfate (Na2SO4) and evaporated. The residue is flash chromatographed on silica gel using 30% No. 50% EtOAc in hexanes as eluent to afford the N-sulfamoylated-N-phenylglycine ethyl ester as a yellow solid : [M+1] + = 259.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Phenylglycine Ethyl Ester, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2003/82841; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 2216-92-4, A common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared in the manner of Example 16 except 4- (trifluoromethyl) benzyl bromide was substituted for 4-chlorobenyl chloride. Purification by flash chromatography (10: 1 to 5: 1 hexanes/EtOAc) afforded the title compound as a yellow oil (30%). 1H NMR [(CDCI3)] [8] 7.62 (d, 2H), 7.52 (d, 2H), 7.43 (d, 2H), 6.68 (d, 2H), 4.73 (s, 2H), 4.25 (q, 2H), 4.14 (s, 2H), 1.30 (t, 3H). Anal. Calc. [FOR C21H18NO3FS] : C, 50.11 ; H, 3.60 ; N, 2.78. Found: C, 50.01 ; H, 3.98 ; N, 2.61. HRMS (MH+). Calc. : 504.1221. Found: 504.1227.

The synthetic route of 2216-92-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics