Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2216-45-7, name is 4-Methylbenzyl acetate, A new synthetic method of this compound is introduced below., SDS of cas: 2216-45-7
General procedure: A mixture of benzonitrile (5 mmol), benzyl acetate (6 mmol),and Fe(ClO4)3·H2O (5 mol%) was placed in a round-bottomedflask. Then, the reaction mixture was heated at 80 C for 5 h.After completion of the reaction monitored by thin layer chromatography(TLC), water (10 mL) was added, and the reactionmixture was extracted with ethyl acetate (3 × 20 mL). Theorganic layers were collected, combined, washed with water(3 × 20 mL), dried with anhydrous Na2SO4, and concentratedunder vacuum. The pure product was obtained by directlypassing through a silica gel (200-300 mesh) column to give awhite powder a (0.91 g, 87% yield)..
The synthetic route of 2216-45-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Feng, Chengliang; Yan, Bin; Yin, Guibo; Chen, Junqing; Ji, Min; Synlett; vol. 29; 17; (2018); p. 2257 – 2264;,
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