Category: 220141-23-1

Failli, Amedeo A. published the artcilePyridobenzodiazepines: A novel class of orally active, vasopressin V₂ receptor selective agonists, Product Details of C9H6F4O2, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(4), 954-959, database is CAplus and MEDLINE.

Our efforts in seeking low mol. weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clin. candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V₂ receptor selective agonists exemplified by the 5,11-dihydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development.

Bioorganic & Medicinal Chemistry Letters published new progress about 220141-23-1. 220141-23-1 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Benzene,Ester, name is Methyl 4-fluoro-2-(trifluoromethyl)benzoate, and the molecular formula is C9H6F4O2, Product Details of C9H6F4O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Patch, Raymond J. published the artcileIdentification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents, HPLC of Formula: 220141-23-1, the publication is Journal of Medicinal Chemistry (2011), 54(3), 788-808, database is CAplus and MEDLINE.

Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of diaryl ether based thiazolidenediones, which function as selective ligands against this receptor. Series optimization provided several potent analogs that inhibit the recruitment of a coactivator peptide fragment in in vitro biochem. assays (IC₅₀ < 150 nM) and cellular two-hybrid reporter assays against the ligand binding domain (IC₅₀ = 1-5 μM). A cocrystal structure of the ligand-binding domain of ERRα with lead compound 29 (I) revealed the presence of a covalent interaction between the protein and ligand, which has been shown to be reversible. In diet-induced murine models of obesity and in an overt diabetic rat model, oral administration of 29 normalized insulin and circulating triglyceride levels, improved insulin sensitivity, and was body weight neutral. This provides the first demonstration of functional activities of an ERRα ligand in metabolic animal models.

Journal of Medicinal Chemistry published new progress about 220141-23-1. 220141-23-1 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Benzene,Ester, name is Methyl 4-fluoro-2-(trifluoromethyl)benzoate, and the molecular formula is C9H6F4O2, HPLC of Formula: 220141-23-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tsukamoto, Issei published the artcileOptimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V₂ receptor agonists and discussion of their binding modes, Name: Methyl 4-fluoro-2-(trifluoromethyl)benzoate, the publication is Bioorganic & Medicinal Chemistry (2009), 17(24), 8161-8167, database is CAplus and MEDLINE.

A series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives were optimized to achieve potent agonistic activity, both in vitro and in vivo, for the arginine vasopressin V₂ receptor, resulting in the eventual discovery of compound 1g. Mol. modeling of compound 1g with V₂ receptor was also examined to evaluate the binding mode of this series of compounds

Bioorganic & Medicinal Chemistry published new progress about 220141-23-1. 220141-23-1 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Benzene,Ester, name is Methyl 4-fluoro-2-(trifluoromethyl)benzoate, and the molecular formula is C7H13BrSi, Name: Methyl 4-fluoro-2-(trifluoromethyl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics